Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | putative neuropeptide receptor NPR1 | 0.0067 | 0.0653 | 0.0653 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0653 | 0.0653 |
Echinococcus multilocularis | acetylcholinesterase | 0.0291 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0051 | 0 | 0.5 |
Brugia malayi | putative neuropeptide receptor | 0.0067 | 0.0653 | 0.0653 |
Echinococcus multilocularis | acetylcholinesterase | 0.0291 | 1 | 1 |
Brugia malayi | Serotonin receptor | 0.0067 | 0.0653 | 0.0653 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0653 | 0.0653 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0291 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0653 | 0.0653 |
Brugia malayi | Unidentified vitellogenin-linked transcript protein 6, putative | 0.0067 | 0.0653 | 0.0653 |
Onchocerca volvulus | 0.0067 | 0.0653 | 0.5 | |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0067 | 0.0653 | 0.0653 |
Brugia malayi | ORL1-like opioid receptor | 0.0067 | 0.0653 | 0.0653 |
Trypanosoma brucei | cytochrome P450, putative | 0.0051 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0653 | 0.0653 |
Leishmania major | cytochrome p450-like protein | 0.0051 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0653 | 0.0653 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0653 | 0.0653 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0067 | 0.0653 | 0.0653 |
Loa Loa (eye worm) | hypothetical protein | 0.0291 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0653 | 0.0653 |
Onchocerca volvulus | 0.0067 | 0.0653 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0653 | 0.0653 |
Loa Loa (eye worm) | unidentified vitellogenin-linked transcript protein 6 | 0.0067 | 0.0653 | 0.0653 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0653 | 0.0653 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0291 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0067 | 0.0653 | 0.0653 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0653 | 0.0653 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0653 | 0.0653 |
Brugia malayi | G-protein-linked acetylcholine receptor protein 2, putative | 0.0067 | 0.0653 | 0.0653 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0653 | 0.0653 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0653 | 0.0653 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0653 | 0.0653 |
Brugia malayi | larval opioid receptor | 0.0067 | 0.0653 | 0.0653 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0653 | 0.0653 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0653 | 0.0653 |
Brugia malayi | neuropeptide F receptor | 0.0067 | 0.0653 | 0.0653 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0653 | 0.0653 |
Brugia malayi | AKH receptor | 0.0067 | 0.0653 | 0.0653 |
Brugia malayi | Tachykinin-like peptides receptor 99D | 0.0067 | 0.0653 | 0.0653 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0653 | 0.0653 |
Brugia malayi | Dopamine receptor | 0.0067 | 0.0653 | 0.0653 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0653 | 0.0653 |
Brugia malayi | follicle stimulating hormone receptor | 0.0067 | 0.0653 | 0.0653 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0653 | 0.0653 |
Onchocerca volvulus | 0.0067 | 0.0653 | 0.5 | |
Trypanosoma cruzi | cytochrome P450, putative | 0.0051 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0291 | 1 | 1 |
Brugia malayi | G protein-coupled receptor F59B2.13 | 0.0067 | 0.0653 | 0.0653 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0653 | 0.0653 |
Echinococcus granulosus | carboxylesterase 5A | 0.0291 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0067 | 0.0653 | 0.0653 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0653 | 0.0653 |
Brugia malayi | G-protein coupled receptor | 0.0067 | 0.0653 | 0.0653 |
Onchocerca volvulus | 0.0067 | 0.0653 | 0.5 | |
Onchocerca volvulus | 0.0067 | 0.0653 | 0.5 | |
Brugia malayi | Serotonin receptor | 0.0067 | 0.0653 | 0.0653 |
Brugia malayi | Melatonin receptor type 1A | 0.0067 | 0.0653 | 0.0653 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0653 | 0.0653 |
Loa Loa (eye worm) | G-protein-linked acetylcholine receptor protein 2 | 0.0067 | 0.0653 | 0.0653 |
Brugia malayi | Dopamine receptor protein 2 | 0.0067 | 0.0653 | 0.0653 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0653 | 0.0653 |
Brugia malayi | Dopamine receptor protein 1 | 0.0067 | 0.0653 | 0.0653 |
Echinococcus granulosus | acetylcholinesterase | 0.0291 | 1 | 1 |
Brugia malayi | G-protein coupled receptor | 0.0067 | 0.0653 | 0.0653 |
Brugia malayi | hypothetical protein | 0.0067 | 0.0653 | 0.0653 |
Loa Loa (eye worm) | gonadotropin-releasing hormone receptor 2 | 0.0067 | 0.0653 | 0.0653 |
Onchocerca volvulus | 0.0067 | 0.0653 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0653 | 0.0653 |
Onchocerca volvulus | 0.0067 | 0.0653 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0653 | 0.0653 |
Onchocerca volvulus | 0.0067 | 0.0653 | 0.5 | |
Brugia malayi | neuropeptide F receptor | 0.0067 | 0.0653 | 0.0653 |
Loa Loa (eye worm) | melatonin receptor type 1A | 0.0067 | 0.0653 | 0.0653 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0653 | 0.0653 |
Brugia malayi | RE15519p | 0.0067 | 0.0653 | 0.0653 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0067 | 0.0653 | 0.0653 |
Brugia malayi | hypothetical protein | 0.0067 | 0.0653 | 0.0653 |
Brugia malayi | hypothetical protein | 0.0067 | 0.0653 | 0.0653 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0653 | 0.0653 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0653 | 0.0653 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0653 | 0.0653 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0067 | 0.0653 | 0.0653 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0653 | 0.0653 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0653 | 0.0653 |
Onchocerca volvulus | 0.0067 | 0.0653 | 0.5 | |
Onchocerca volvulus | 0.0067 | 0.0653 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0067 | 0.0653 | 0.0653 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0291 | 1 | 1 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0067 | 0.0653 | 0.0653 |
Onchocerca volvulus | 0.0067 | 0.0653 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0653 | 0.0653 |
Echinococcus granulosus | acetylcholinesterase | 0.0291 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0067 | 0.0653 | 0.0653 |
Brugia malayi | hypothetical protein | 0.0067 | 0.0653 | 0.0653 |
Loa Loa (eye worm) | hypothetical protein | 0.0291 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0653 | 0.0653 |
Brugia malayi | sulfakinin receptor protein | 0.0067 | 0.0653 | 0.0653 |
Brugia malayi | gonadotropin-releasing hormone receptor 2 | 0.0067 | 0.0653 | 0.0653 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0067 | 0.0653 | 0.0653 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0653 | 0.0653 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0051 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0653 | 0.0653 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0653 | 0.0653 |
Loa Loa (eye worm) | carboxylesterase | 0.0291 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0653 | 0.0653 |
Onchocerca volvulus | 0.0067 | 0.0653 | 0.5 | |
Onchocerca volvulus | 0.0067 | 0.0653 | 0.5 | |
Brugia malayi | GnHR receptor homolog | 0.0067 | 0.0653 | 0.0653 |
Onchocerca volvulus | 0.0067 | 0.0653 | 0.5 | |
Loa Loa (eye worm) | 5-hydroxytryptamine 2C receptor | 0.0067 | 0.0653 | 0.0653 |
Brugia malayi | hypothetical protein | 0.0067 | 0.0653 | 0.0653 |
Onchocerca volvulus | 0.0067 | 0.0653 | 0.5 | |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0067 | 0.0653 | 0.5 |
Brugia malayi | Dopamine receptor protein 1, putative (partial) | 0.0067 | 0.0653 | 0.0653 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0653 | 0.0653 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0653 | 0.0653 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0653 | 0.0653 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0067 | 0.0653 | 0.5 |
Brugia malayi | hypothetical protein | 0.0067 | 0.0653 | 0.0653 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0653 | 0.0653 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0653 | 0.0653 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0653 | 0.0653 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0653 | 0.0653 |
Onchocerca volvulus | 0.0067 | 0.0653 | 0.5 | |
Brugia malayi | G protein-coupled receptor | 0.0067 | 0.0653 | 0.0653 |
Onchocerca volvulus | 0.0067 | 0.0653 | 0.5 | |
Loa Loa (eye worm) | TYRA-2 protein | 0.0067 | 0.0653 | 0.0653 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | = 0.6 % | Cytotoxicity against human MRC5 cells assessed as cell viability at 100 uM after 72 hrs by XTT assay | ChEMBL. | 21429630 |
Activity (ADMET) | = 100 % | Cytotoxicity against human MRC5 cells assessed as cell viability at 30 uM after 72 hrs by XTT assay | ChEMBL. | 21429630 |
IC50 (ADMET) | = 52.9 uM | Cytotoxicity against human MRC5 cells assessed as cell viability after 72 hrs by XTT assay | ChEMBL. | 21429630 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.