Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | fibroblast growth factor receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0016 | 0.0326 |
Echinococcus granulosus | basic fibroblast growth factor receptor 1 A | 0.012 | 0.0482 | 0.1248 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0866 | 0.3866 | 1 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.2218 | 1 | 0.5 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.2218 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0866 | 0.3866 | 0.5 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.2218 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.2218 | 1 | 0.5 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.2218 | 1 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.2218 | 1 | 1 |
Echinococcus granulosus | twitchin | 0.0018 | 0.0016 | 0.0042 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0866 | 0.3866 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0866 | 0.3866 | 0.5 |
Echinococcus multilocularis | basic fibroblast growth factor receptor 1 A | 0.012 | 0.0482 | 0.1248 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.2218 | 1 | 1 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0866 | 0.3866 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0015 | 0.0006 | 0.0006 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.2218 | 1 | 1 |
Schistosoma mansoni | nephrin | 0.0018 | 0.0016 | 0.0016 |
Echinococcus multilocularis | neuroglian | 0.0018 | 0.0016 | 0.0042 |
Leishmania major | dihydroorotate dehydrogenase | 0.2218 | 1 | 0.5 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0866 | 0.3866 | 0.5 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0015 | 0.0006 | 0.0116 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.2218 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0866 | 0.3866 | 0.5 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0866 | 0.3866 | 0.3866 |
Echinococcus granulosus | fibroblast growth factor receptor 4 | 0.012 | 0.0482 | 0.1248 |
Echinococcus multilocularis | roundabout 2 | 0.0018 | 0.0016 | 0.0042 |
Echinococcus granulosus | roundabout 2 | 0.0018 | 0.0016 | 0.0042 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0866 | 0.3866 | 0.5 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.2218 | 1 | 0.5 |
Loa Loa (eye worm) | TK protein kinase | 0.0124 | 0.0499 | 1 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.2218 | 1 | 0.5 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0866 | 0.3866 | 1 |
Echinococcus multilocularis | fibroblast growth factor receptor 4 | 0.012 | 0.0482 | 0.1248 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0866 | 0.3866 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.012 | 0.0482 | 0.0482 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0124 | 0.0499 | 0.0499 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.2218 | 1 | 1 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.2218 | 1 | 0.5 |
Echinococcus granulosus | neuroglian | 0.0018 | 0.0016 | 0.0042 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0016 | 0.0326 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0866 | 0.3866 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3.6 uM | Inhibition of FGFR1 using poly(Glu-Tyr)4:1 as substrate after 60 mins by ELISA | ChEMBL. | 21517068 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.