Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.0088 | 0.5 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0088 | 0.0105 |
Loa Loa (eye worm) | carboxylesterase | 0.0048 | 0.0417 | 0.1159 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0048 | 0.0417 | 0.1059 |
Echinococcus multilocularis | acetylcholinesterase | 0.0287 | 0.3505 | 0.3472 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0048 | 0.0417 | 0.0591 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.002 | 0.0051 | 0.0965 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0242 | 0.0553 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0041 | 0.0321 | 0.0884 |
Echinococcus multilocularis | neuroligin | 0.0048 | 0.0417 | 0.0368 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0417 | 0.1159 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0038 | 0.0282 | 0.0232 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0038 | 0.0282 | 0.6317 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0.0051 | 0.0112 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0302 | 0.0726 |
Brugia malayi | hypothetical protein | 0.0255 | 0.3085 | 0.8784 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0048 | 0.0417 | 0.1059 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0302 | 0.0726 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0048 | 0.0417 | 0.0368 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0498 | 0.6235 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0287 | 0.3505 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0287 | 0.3505 | 0.5586 |
Brugia malayi | Carboxylesterase family protein | 0.0287 | 0.3505 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0137 | 0.1561 | 0.1517 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0172 | 0.2012 | 0.1971 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0088 | 0.1505 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0038 | 0.0282 | 0.6317 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0023 | 0.0088 | 0.0372 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0048 | 0.0417 | 1 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0041 | 0.0321 | 0.0436 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0148 | 0.0389 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0017 | 0.0012 | 0.0292 |
Onchocerca volvulus | 0.0048 | 0.0417 | 0.2647 | |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0038 | 0.0282 | 0.0374 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0242 | 0.0309 |
Onchocerca volvulus | 0.0048 | 0.0417 | 0.2647 | |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0302 | 0.0726 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0172 | 0.2012 | 0.1971 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0039 | 0.0293 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 0.3085 | 0.8798 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.1029 | 0.2911 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0039 | 0.0293 | 0.0804 |
Brugia malayi | Carboxylesterase family protein | 0.0287 | 0.3505 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0287 | 0.3505 | 0.5586 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0038 | 0.0282 | 0.0669 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0039 | 0.0293 | 0.6939 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0038 | 0.0282 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0048 | 0.0417 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0287 | 0.3505 | 0.5586 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0242 | 0.0553 |
Brugia malayi | Carboxylesterase family protein | 0.0048 | 0.0417 | 0.1059 |
Onchocerca volvulus | Huntingtin homolog | 0.0119 | 0.1332 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0048 | 0.0417 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0287 | 0.3505 | 0.3472 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0242 | 0.1953 |
Echinococcus granulosus | neuropeptide s receptor | 0.0498 | 0.6235 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0148 | 0.1702 | 0.478 |
Brugia malayi | Carboxylesterase family protein | 0.0048 | 0.0417 | 0.1059 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0039 | 0.0293 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.0427 | 0.0377 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0096 | 0.1029 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0287 | 0.3505 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0088 | 0.1505 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0049 | 0.0427 | 0.1087 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0096 | 0.1029 | 0.0983 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0427 | 0.1087 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.0088 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0287 | 0.3505 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0417 | 0.1159 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0038 | 0.0282 | 0.6317 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0088 | 0.1505 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0242 | 0.1953 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0096 | 0.1029 | 0.283 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.0088 | 0.2102 |
Schistosoma mansoni | acetylcholinesterase | 0.0048 | 0.0417 | 0.1059 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.0088 | 0.0372 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0441 | 0.1227 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0417 | 0.1159 |
Schistosoma mansoni | survival motor neuron protein | 0.0052 | 0.0461 | 0.1188 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0051 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0048 | 0.0417 | 0.1059 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0048 | 0.0417 | 0.0368 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0137 | 0.1561 | 0.2441 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.002 | 0.0051 | 0.1229 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0255 | 0.3085 | 0.305 |
Brugia malayi | Cytochrome P450 family protein | 0.0039 | 0.0293 | 0.07 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.0427 | 0.0607 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0417 | 0.1159 |
Schistosoma mansoni | alpha-glucosidase | 0.0148 | 0.1702 | 0.478 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0096 | 0.1029 | 0.1581 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0048 | 0.0417 | 0.0591 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.0088 | 0.0372 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0.0088 | 0.1864 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0038 | 0.0282 | 0.6317 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0041 | 0.0321 | 0.0436 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0088 | 0.1864 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.1332 | 0.3778 |
Trypanosoma brucei | cytochrome P450, putative | 0.0039 | 0.0293 | 1 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0048 | 0.0417 | 0.1059 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0038 | 0.0282 | 0.2364 |
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.0461 | 0.1188 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0427 | 0.1087 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0038 | 0.0282 | 0.2364 |
Brugia malayi | hypothetical protein | 0.0048 | 0.0417 | 0.1059 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0048 | 0.0417 | 1 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0097 | 0.1048 | 0.2886 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0.0088 | 0.1864 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0242 | 0.0553 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0017 | 0.0012 | 0.5 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0088 | 0.0105 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0049 | 0.0427 | 0.1187 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.0282 | 0.9555 |
Echinococcus multilocularis | acetylcholinesterase | 0.0287 | 0.3505 | 0.3472 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0.0088 | 0.2102 |
Leishmania major | cytochrome p450-like protein | 0.0039 | 0.0293 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0088 | 0.1864 |
Schistosoma mansoni | patched 1 | 0.0041 | 0.0321 | 0.0781 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0038 | 0.0282 | 0.0773 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0039 | 0.0293 | 0.0804 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0048 | 0.0417 | 0.0591 |
Brugia malayi | Carboxylesterase family protein | 0.0048 | 0.0417 | 0.1059 |
Echinococcus granulosus | neuroligin | 0.0048 | 0.0417 | 0.0591 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0302 | 0.0726 |
Echinococcus multilocularis | protein dispatched 1 | 0.0047 | 0.0396 | 0.0347 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0088 | 0.0216 |
Brugia malayi | CHE-14 protein | 0.0041 | 0.0321 | 0.0781 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0417 | 0.1159 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0088 | 0.0216 |
Loa Loa (eye worm) | hypothetical protein | 0.0287 | 0.3505 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0.0088 | 0.1864 |
Onchocerca volvulus | 0.0048 | 0.0417 | 0.2647 | |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0255 | 0.3085 | 0.4906 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0038 | 0.0282 | 0.6317 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0052 | 0.0461 | 0.1188 |
Onchocerca volvulus | 0.0099 | 0.1075 | 0.7933 | |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0242 | 0.0192 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0048 | 0.0417 | 0.0368 |
Loa Loa (eye worm) | carboxylesterase | 0.0048 | 0.0417 | 0.1159 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0038 | 0.0282 | 0.9555 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0498 | 0.6235 | 0.6215 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0172 | 0.2012 | 0.5725 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0048 | 0.0417 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0038 | 0.0282 | 0.6317 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0417 | 0.1159 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0088 | 0.1864 |
Echinococcus granulosus | expressed conserved protein | 0.009 | 0.0954 | 0.1459 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0041 | 0.0321 | 0.7379 |
Echinococcus multilocularis | expressed conserved protein | 0.009 | 0.0954 | 0.0907 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0321 | 0.0884 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0041 | 0.0321 | 0.0271 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0417 | 0.1159 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0048 | 0.0417 | 0.1059 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0.0051 | 0.5 |
Schistosoma mansoni | gliotactin | 0.0048 | 0.0417 | 0.1059 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0.0051 | 0.5 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0498 | 0.6235 | 0.6215 |
Onchocerca volvulus | 0.0048 | 0.0417 | 0.2647 | |
Onchocerca volvulus | 0.0052 | 0.0461 | 0.3004 | |
Echinococcus multilocularis | protein patched | 0.0041 | 0.0321 | 0.0271 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.0282 | 0.9555 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0.0088 | 0.1864 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.0051 | 0.5 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0051 | 1 |
Brugia malayi | hypothetical protein | 0.0119 | 0.1332 | 0.3707 |
Schistosoma mansoni | alpha glucosidase | 0.0038 | 0.0282 | 0.0669 |
Onchocerca volvulus | Huntingtin homolog | 0.0119 | 0.1332 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0242 | 0.1953 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0.0088 | 0.1864 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.0427 | 0.0607 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0242 | 0.1953 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0172 | 0.2012 | 0.5676 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0088 | 0.0216 |
Trypanosoma brucei | glucosidase, putative | 0.0038 | 0.0282 | 0.9555 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0039 | 0.0293 | 0.0804 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0172 | 0.2012 | 0.3171 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0048 | 0.0417 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.0427 | 0.0377 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.1332 | 0.3778 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0427 | 0.1087 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0088 | 0.0105 |
Brugia malayi | Cytochrome P450 family protein | 0.0039 | 0.0293 | 0.07 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0038 | 0.0282 | 0.6317 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0048 | 0.0417 | 0.1059 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0038 | 0.0282 | 0.6317 |
Onchocerca volvulus | 0.0048 | 0.0417 | 0.2647 | |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0038 | 0.0282 | 0.6317 |
Loa Loa (eye worm) | carboxylesterase | 0.0287 | 0.3505 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | = 0.51 % | Cytotoxicity against human MRC5 cells assessed as cell viability at 100 uM after 72 hrs by XTT assay | ChEMBL. | 21429630 |
Activity (ADMET) | = 10.93 % | Cytotoxicity against human MRC5 cells assessed as cell viability at 30 uM after 72 hrs by XTT assay | ChEMBL. | 21429630 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.