TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 452.932 | Formula: C28H21ClN2O2
H donors: 2 H acceptors: 2 LogP: 7.04 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(cc1)/C=C/c1ccc(cc1)NC(=O)c1ccccc1NC(=O)c1ccccc1
InChi: 1S/C28H21ClN2O2/c29-23-16-12-20(13-17-23)10-11-21-14-18-24(19-15-21)30-28(33)25-8-4-5-9-26(25)31-27(32)22-6-2-1-3-7-22/h1-19H,(H,30,33)(H,31,32)/b11-10+
InChiKey: PXLQYDRXLBYRTA-ZHACJKMWSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0301	0.0301
Loa Loa (eye worm)	hypothetical protein	0.0296	0.384	0.384
Plasmodium vivax	oxidoreductase, aldo/keto reductase domain containing protein	0.0217	0.2779	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0296	0.0294
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0824	0.0824
Trichomonas vaginalis	conserved hypothetical protein	0.0217	0.2779	0.2777
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0043	0.0411	0.0409
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0141	0.1743	0.1741
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0441	0.0441
Entamoeba histolytica	alcohol dehydrogenase, putative	0.0217	0.2779	0.2777
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.075	1	1
Trypanosoma cruzi	aldo/keto reductase, putative	0.075	1	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0073	0.0824	0.0822
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0118	0.1436	0.1434
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.075	1	1
Brugia malayi	ecdysone receptor	0.0034	0.0301	0.0299
Toxoplasma gondii	aldose reductase, putative	0.075	1	1
Loa Loa (eye worm)	oxidoreductase	0.075	1	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0301	0.0301
Brugia malayi	Nuclear hormone receptor E75	0.0034	0.0301	0.0299
Schistosoma mansoni	hypothetical protein	0.0034	0.0296	0.0296
Brugia malayi	Nuclear hormone receptor-like 1	0.0039	0.0357	0.0355
Trichomonas vaginalis	aldo-keto reductase, putative	0.0217	0.2779	0.2777
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.075	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.075	1	1
Onchocerca volvulus		0.075	1	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0357	0.0357
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0073	0.0824	0.0822
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0073	0.0824	0.0822
Brugia malayi	hypothetical protein	0.0034	0.0301	0.0299
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0073	0.0824	0.0824
Schistosoma mansoni	hypothetical protein	0.0016	0.0048	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0301	0.0301
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.0509	0.0509
Trichomonas vaginalis	aldo-keto reductase, putative	0.0217	0.2779	0.2777
Mycobacterium leprae	PROBABLE OXIDOREDUCTASE	0.075	1	1
Brugia malayi	nuclear receptor NHR-88	0.0073	0.0824	0.0822
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0073	0.0824	0.0824
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0441	0.0441
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0048	0.0046
Schistosoma mansoni	nuclear hormone receptor	0.0034	0.0301	0.0301
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0073	0.0824	0.0822
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0034	0.0301	0.0299
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0357	0.0357
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0039	0.0357	0.0357
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.075	1	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0048	0.0046
Schistosoma mansoni	hypothetical protein	0.0016	0.0048	0.0048
Entamoeba histolytica	aldose reductase, putative	0.075	1	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.075	1	1
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0073	0.0824	0.0822
Trichomonas vaginalis	aldo-keto reductase, putative	0.075	1	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0073	0.0824	0.0822
Trichomonas vaginalis	aldo-keto reductase, putative	0.075	1	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0296	0.0296
Brugia malayi	acetyltransferase, GNAT family protein	0.0145	0.1798	0.1796
Plasmodium falciparum	aldehyde reductase, putative	0.0217	0.2779	1
Brugia malayi	Muscleblind-like protein	0.0296	0.384	0.3838
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0441	0.0439
Trichomonas vaginalis	aldo-keto reductase, putative	0.075	1	1
Trypanosoma cruzi	aldo-keto reductase	0.075	1	1
Giardia lamblia	Histone acetyltransferase GCN5	0.0039	0.0363	0.0361
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0048	0.0046
Loa Loa (eye worm)	hypothetical protein	0.075	1	1
Brugia malayi	nuclear receptor RXR	0.0039	0.0357	0.0355
Trichomonas vaginalis	aldo-keto reductase, putative	0.075	1	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.075	1	1
Leishmania major	prostaglandin f2-alpha synthase/D-arabinose dehydrogenase	0.075	1	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0073	0.0824	0.0824
Onchocerca volvulus	Protein ultraspiracle homolog	0.0073	0.0824	0.0539
Loa Loa (eye worm)	hypothetical protein	0.005	0.0509	0.0509
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0301	0.0301
Entamoeba histolytica	acetyltransferase, GNAT family	0.0039	0.0363	0.0361
Brugia malayi	nuclear hormone receptor	0.0073	0.0824	0.0822
Entamoeba histolytica	aldose reductase, putative	0.075	1	1
Schistosoma mansoni	thyroid hormone receptor	0.0073	0.0824	0.0824
Brugia malayi	hypothetical protein	0.0039	0.0357	0.0355
Schistosoma mansoni	aldo-keto reductase	0.075	1	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0118	0.1436	0.1434
Echinococcus granulosus	GPCR family 2	0.0016	0.0048	0.0046
Leishmania major	aldo/keto reductase, putative,aldo/keto reductase family-like protein	0.0217	0.2779	0.2777
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.075	1	1
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0039	0.0357	0.0355
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0145	0.1798	0.1798
Schistosoma mansoni	hypothetical protein	0.0016	0.0048	0.0048
Echinococcus granulosus	voltage gated potassium channel subunit	0.0217	0.2779	0.2777
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0357	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0301	0.0301
Mycobacterium ulcerans	oxidoreductase	0.075	1	1
Schistosoma mansoni	nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if)	0.0012	0.0002	0.0002
Echinococcus multilocularis	muscleblind protein	0.0296	0.384	0.3838
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0441	0.0439
Onchocerca volvulus		0.075	1	1
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0824	0.0824
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0824	0.0824
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0034	0.0301	0.0301
Brugia malayi	Steroid receptor seven-up type 2	0.0073	0.0824	0.0822
Toxoplasma gondii	aldo-keto reductase	0.0217	0.2779	0.2777
Onchocerca volvulus		0.0073	0.0824	0.0539
Brugia malayi	hypothetical protein	0.0039	0.0357	0.0355
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0118	0.1436	0.1436
Brugia malayi	Nuclear hormone receptor-like 1	0.0073	0.0824	0.0822
Onchocerca volvulus		0.075	1	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0301	0.0301
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0048	0.0046
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0043	0.0411	0.1475
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.075	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.075	1	1
Schistosoma mansoni	aldo-keto reductase	0.075	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.075	1	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0073	0.0824	0.0822
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0073	0.0824	0.0822
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.0509	0.0507
Echinococcus multilocularis	ecdysone induced protein 78C	0.0073	0.0824	0.0822
Schistosoma mansoni	nuclear receptor	0.0034	0.0301	0.0301
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0048	0.0046
Echinococcus multilocularis	aldo keto reductase	0.075	1	1
Trichomonas vaginalis	alcohol dehydrogenase, putative	0.0217	0.2779	0.2777
Trypanosoma brucei	aldo-keto reductase, putative	0.075	1	1
Brugia malayi	nuclear receptor RXR	0.0034	0.0301	0.0299
Trichomonas vaginalis	aldo/keto reductase, putative	0.075	1	1
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0034	0.0301	0.0301
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0073	0.0824	0.0824
Echinococcus granulosus	aldo keto reductase	0.075	1	1
Mycobacterium leprae	Conserved hypothetical protein	0.0533	0.7055	0.5922
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0034	0.0301	0.0299
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0043	0.0411	0.0409
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.075	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0073	0.0824	0.0822
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0048	0.0046
Brugia malayi	Nuclear hormone receptor-like 1	0.0039	0.0357	0.0355
Entamoeba histolytica	alcohol dehydrogenase, putative	0.0217	0.2779	0.2777
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.075	1	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0073	0.0824	0.0824
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.075	1	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0073	0.0824	0.0824
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0073	0.0824	0.0822
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0073	0.0824	0.0822
Loa Loa (eye worm)	nuclear hormone receptor	0.0034	0.0301	0.0301
Brugia malayi	nuclear hormone receptor	0.0034	0.0301	0.0299
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0034	0.0301	0.0299
Leishmania major	aldo-keto reductase-like protein	0.075	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0073	0.0824	0.0824
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0073	0.0824	0.0822
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0034	0.0301	0.0301
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0034	0.0301	0.0299
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0073	0.0824	0.0539
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.075	1	1
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0824	0.0824
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0073	0.0824	0.0824
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0034	0.0301	0.0299
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0073	0.0824	0.0824
Echinococcus multilocularis	voltage gated potassium channel subunit	0.0217	0.2779	0.2777
Echinococcus multilocularis	aldehyde reductase	0.0533	0.7055	0.7055
Schistosoma mansoni	hypothetical protein	0.0016	0.0048	0.0048
Onchocerca volvulus		0.0217	0.2779	0.2555
Giardia lamblia	Aldose reductase	0.075	1	1
Plasmodium falciparum	histone acetyltransferase GCN5	0.0039	0.0363	0.1301
Echinococcus granulosus	aldo keto reductase	0.075	1	1
Brugia malayi	Nuclear hormone receptor E75	0.0034	0.0301	0.0299
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0073	0.0824	0.0822
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0043	0.0411	0.0409
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.075	1	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0357	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0002	0.0002
Echinococcus multilocularis	muscleblind protein 1	0.0296	0.384	0.3838
Echinococcus granulosus	aldo keto reductase family 1, member B4	0.0217	0.2779	0.2777
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0034	0.0301	0.0299
Echinococcus granulosus	aldo keto reductase	0.075	1	1
Leishmania major	prostaglandin f synthase, putative	0.075	1	1
Echinococcus granulosus	thyroid hormone receptor alpha	0.0034	0.0301	0.0299
Echinococcus granulosus	aldehyde reductase	0.0533	0.7055	0.7055
Schistosoma mansoni	nuclear receptor nhr-48	0.0034	0.0301	0.0301
Loa Loa (eye worm)	DR-78	0.0034	0.0301	0.0301
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.075	1	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0118	0.1436	0.1434
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.075	1	1
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0034	0.0301	0.0299
Toxoplasma gondii	aldo/keto reductase family oxidoreductase	0.0217	0.2779	0.2777
Onchocerca volvulus		0.075	1	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0441	0.0441
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.075	1	1
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0043	0.0411	0.0409
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.075	1	1
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0034	0.0301	0.0299
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0073	0.0824	0.0822
Echinococcus granulosus	FTZ F1 alpha	0.0073	0.0824	0.0822
Loa Loa (eye worm)	oxidoreductase	0.075	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.075	1	1
Trypanosoma brucei	prostaglandin f synthase	0.075	1	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0441	0.0441
Echinococcus multilocularis	FTZ F1 alpha	0.0073	0.0824	0.0822
Trichomonas vaginalis	pps1 dual specificty phosphatase, putative	0.058	0.7689	0.7688
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0034	0.0301	0.0301
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.075	1	1
Brugia malayi	steroid hormone receptor	0.0073	0.0824	0.0822
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0073	0.0824	0.0822
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0301	0.0301
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0441	0.0439
Trichomonas vaginalis	aldo-keto reductase, putative	0.075	1	1
Trichomonas vaginalis	aldo/keto reductase, putative	0.075	1	1
Brugia malayi	hypothetical protein	0.0034	0.0301	0.0299
Echinococcus multilocularis	aldo keto reductase	0.075	1	1
Echinococcus granulosus	muscleblind protein	0.0296	0.384	0.3838
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0301	0.0301
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0073	0.0824	0.0824
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0441	0.0439
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0073	0.0824	0.0822
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.075	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0217	0.2779	0.2777
Loa Loa (eye worm)	steroid hormone receptor	0.0073	0.0824	0.0824
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0073	0.0824	0.0824
Echinococcus multilocularis	nuclear receptor nhr 48	0.0034	0.0301	0.0299
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0301	0.0301
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0034	0.0301	0.0299
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0441	0.0439
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0048	0.0048
Trichomonas vaginalis	aldo-keto reductase, putative	0.075	1	1
Schistosoma mansoni	thyroid hormone receptor	0.0073	0.0824	0.0824
Loa Loa (eye worm)	acetyltransferase	0.0145	0.1798	0.1798
Brugia malayi	NADH-dependent xylose reductase	0.0217	0.2779	0.2777
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0073	0.0824	0.0822
Echinococcus granulosus	hypothetical protein	0.075	1	1
Trichomonas vaginalis	aldo/keto reductase, putative	0.075	1	1
Brugia malayi	nuclear receptor NHR-88	0.0034	0.0301	0.0299
Brugia malayi	nuclear receptor NHR-67	0.0034	0.0301	0.0299
Schistosoma mansoni	zinc finger protein	0.0034	0.0301	0.0301
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.0509	0.0507
Loa Loa (eye worm)	oxidoreductase	0.075	1	1
Plasmodium falciparum	aldo-keto reductase, putative	0.0217	0.2779	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0073	0.0824	0.0824
Echinococcus granulosus	nuclear receptor nhr 48	0.0034	0.0301	0.0299
Brugia malayi	nuclear hormone receptor family member odr-7	0.0034	0.0301	0.0299
Plasmodium vivax	aldehyde reductase, putative	0.0217	0.2779	1
Schistosoma mansoni	coup transcription factor	0.0073	0.0824	0.0824
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0073	0.0824	0.0822
Schistosoma mansoni	nuclear hormone receptor	0.0034	0.0301	0.0301
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.075	1	1
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0824	0.0824
Trypanosoma brucei	aldo/keto reductase, putative	0.0217	0.2779	0.2777
Schistosoma mansoni	nuclear hormone receptor	0.0073	0.0824	0.0824
Brugia malayi	tailless protein	0.0034	0.0301	0.0299
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0073	0.0824	0.0824
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.075	1	1
Schistosoma mansoni	nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if)	0.0012	0.0002	0.0002
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0039	0.0357	0.0357
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0034	0.0301	0.0299
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0301	0.0301
Onchocerca volvulus		0.075	1	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.075	1	1
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0824	0.0824
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0824	0.0824
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0048	0.0048
Trypanosoma cruzi	aldo/keto reductase, putative	0.0217	0.2779	0.2777
Schistosoma mansoni	nuclear receptor	0.0034	0.0301	0.0301
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0048	0.0046
Schistosoma mansoni	pol-related	0.075	1	1
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0118	0.1436	0.1436
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0145	0.1798	0.1796
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0118	0.1436	0.1434
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0034	0.0301	0.0299
Brugia malayi	orphan nuclear receptor NR2E1	0.0034	0.0301	0.0299
Leishmania major	aldehyde reductase, putative,oxidoreductase, putative	0.075	1	1
Loa Loa (eye worm)	oxidoreductase	0.075	1	1
Entamoeba histolytica	dual specificity protein phosphatase, putative	0.058	0.7689	0.7688
Onchocerca volvulus		0.075	1	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0301	0.0301
Entamoeba histolytica	aldose reductase, putative	0.075	1	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.075	1	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0118	0.1436	0.1434
Schistosoma mansoni	potassium channel beta	0.0217	0.2779	0.2779
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0043	0.0411	0.0409
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0039	0.0357	0.0355
Echinococcus multilocularis	aldo keto reductase	0.075	1	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0073	0.0824	0.0822
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0824	0.0824
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0073	0.0824	0.0822
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0073	0.0824	0.0822
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.075	1	1
Loa Loa (eye worm)	glutamate-cysteine ligase modifier subunit	0.0217	0.2779	0.2779
Brugia malayi	conserved hypotetical protein	0.0034	0.0301	0.0299
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0073	0.0824	0.0822
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0073	0.0824	0.0822
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0073	0.0824	0.0824
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0073	0.0824	0.0824
Loa Loa (eye worm)	oxidoreductase	0.075	1	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0039	0.0357	0.0357
Trichomonas vaginalis	aldo-keto reductase, putative	0.075	1	1
Onchocerca volvulus	Bile acid receptor homolog	0.0073	0.0824	0.0539
Schistosoma mansoni	retinoic acid receptor RXR	0.0073	0.0824	0.0824
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.075	1	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0073	0.0824	0.0822
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.075	1	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0073	0.0824	0.0822
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0073	0.0824	0.0822
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0073	0.0824	0.0822
Echinococcus multilocularis	aldo keto reductase	0.075	1	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.075	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.075	1	1
Brugia malayi	photoreceptor-specific nuclear receptor	0.0073	0.0824	0.0822
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0357	0.0357
Giardia lamblia	Aldose reductase	0.075	1	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0073	0.0824	0.0822
Brugia malayi	ecdysteroid receptor	0.0073	0.0824	0.0822
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0301	0.0301
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0301	0.0301
Toxoplasma gondii	oxidoreductase, aldo/keto reductase family protein	0.0217	0.2779	0.2777
Brugia malayi	glutamate-cysteine ligase modifier subunit	0.0217	0.2779	0.2777
Loa Loa (eye worm)	hypothetical protein	0.0296	0.384	0.384

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 49.35 %	Anticancer activity against human HCT116 cells assessed as cell growth promotion at 10'-5 M after 48 hrs by SRB assay relative to control	ChEMBL.	21458891
Activity (functional)	= 52.07 %	Anticancer activity against human SF295 cells assessed as cell growth promotion at 10'-5 M after 48 hrs by SRB assay relative to control	ChEMBL.	21458891
Activity (functional)	= 52.41 %	Anticancer activity against human CCRF-CEM cells assessed as cell growth promotion at 10'-5 M after 48 hrs by SRB assay relative to control	ChEMBL.	21458891
Activity (functional)	= 52.88 %	Anticancer activity against human UO31 cells assessed as cell growth promotion at 10'-5 M after 48 hrs by SRB assay relative to control	ChEMBL.	21458891
Activity (functional)	= 57.81 %	Anticancer activity against human K562 cells assessed as cell growth promotion at 10'-5 M after 48 hrs by SRB assay relative to control	ChEMBL.	21458891
Activity (functional)	= 59.17 %	Anticancer activity against human MOLT4 cells assessed as cell growth promotion at 10'-5 M after 48 hrs by SRB assay relative to control	ChEMBL.	21458891
Activity (functional)	= 60.68 %	Anticancer activity against human U251 cells assessed as cell growth promotion at 10'-5 M after 48 hrs by SRB assay relative to control	ChEMBL.	21458891
Activity (functional)	= 64.38 %	Anticancer activity against human KM12 cells assessed as cell growth promotion at 10'-5 M after 48 hrs by SRB assay relative to control	ChEMBL.	21458891
Activity (functional)	= 65.2 %	Anticancer activity against human PC3 cells assessed as cell growth promotion at 10'-5 M after 48 hrs by SRB assay relative to control	ChEMBL.	21458891
Activity (functional)	= 65.81 %	Anticancer activity against human HCT15 cells assessed as cell growth promotion at 10'-5 M after 48 hrs by SRB assay relative to control	ChEMBL.	21458891
Activity (functional)	= 70.02 %	Anticancer activity against human A549 cells assessed as cell growth promotion at 10'-5 M after 48 hrs by SRB assay relative to control	ChEMBL.	21458891
Activity (functional)	= 70.95 %	Anticancer activity against human NCI-H522 cells assessed as cell growth promotion at 10'-5 M after 48 hrs by SRB assay relative to control	ChEMBL.	21458891
Activity (functional)	= 72.92 %	Anticancer activity against human NCI-H460 cells assessed as cell growth promotion at 10'-5 M after 48 hrs by SRB assay relative to control	ChEMBL.	21458891
Activity (functional)	= 73.51 %	Anticancer activity against human NCI-H23 cells assessed as cell growth promotion at 10'-5 M after 48 hrs by SRB assay relative to control	ChEMBL.	21458891
Activity (functional)	= 74.25 %	Anticancer activity against human SNB19 cells assessed as cell growth promotion at 10'-5 M after 48 hrs by SRB assay relative to control	ChEMBL.	21458891
Activity (functional)	= 74.93 %	Anticancer activity against human LOXIMVI cells assessed as cell growth promotion at 10'-5 M after 48 hrs by SRB assay relative to control	ChEMBL.	21458891
Activity (functional)	= 75.14 %	Anticancer activity against human 786-0 cells assessed as cell growth promotion at 10'-5 M after 48 hrs by SRB assay relative to control	ChEMBL.	21458891
Activity (functional)	= 76.41 %	Anticancer activity against human BT549 cells assessed as cell growth promotion at 10'-5 M after 48 hrs by SRB assay relative to control	ChEMBL.	21458891
Activity (functional)	= 78.38 %	Anticancer activity against human HCC2998 cells assessed as cell growth promotion at 10'-5 M after 48 hrs by SRB assay relative to control	ChEMBL.	21458891
Activity (functional)	= 78.5 %	Anticancer activity against human M14 cells assessed as cell growth promotion at 10'-5 M after 48 hrs by SRB assay relative to control	ChEMBL.	21458891
Activity (functional)	= 79.67 %	Anticancer activity against human UACC62 cells assessed as cell growth promotion at 10'-5 M after 48 hrs by SRB assay relative to control	ChEMBL.	21458891
Activity (functional)	= 79.73 %	Anticancer activity against human SN12C cells assessed as cell growth promotion at 10'-5 M after 48 hrs by SRB assay relative to control	ChEMBL.	21458891
Activity (functional)	= 81.11 %	Anticancer activity against human MDA-MB-231 cells assessed as cell growth promotion at 10'-5 M after 48 hrs by SRB assay relative to control	ChEMBL.	21458891
Activity (functional)	= 81.19 %	Anticancer activity against human SR cells assessed as cell growth promotion at 10'-5 M after 48 hrs by SRB assay relative to control	ChEMBL.	21458891
Activity (functional)	= 82.14 %	Anticancer activity against human T47D cells assessed as cell growth promotion at 10'-5 M after 48 hrs by SRB assay relative to control	ChEMBL.	21458891
Activity (functional)	= 82.15 %	Anticancer activity against human MDA-MB-435 cells assessed as cell growth promotion at 10'-5 M after 48 hrs by SRB assay relative to control	ChEMBL.	21458891
Activity (functional)	= 82.15 %	Anticancer activity against human SK-MEL-5 cells assessed as cell growth promotion at 10'-5 M after 48 hrs by SRB assay relative to control	ChEMBL.	21458891
Activity (functional)	= 82.15 %	Anticancer activity against human RXF393 cells assessed as cell growth promotion at 10'-5 M after 48 hrs by SRB assay relative to control	ChEMBL.	21458891
Activity (functional)	= 82.68 %	Anticancer activity against human ACHN cells assessed as cell growth promotion at 10'-5 M after 48 hrs by SRB assay relative to control	ChEMBL.	21458891
Activity (functional)	= 82.72 %	Anticancer activity against human MCF7 cells assessed as cell growth promotion at 10'-5 M after 48 hrs by SRB assay relative to control	ChEMBL.	21458891
Activity (functional)	= 82.84 %	Anticancer activity against human SF268 cells assessed as cell growth promotion at 10'-5 M after 48 hrs by SRB assay relative to control	ChEMBL.	21458891
Activity (functional)	= 83.46 %	Anticancer activity against human MDA-MB-468 cells assessed as cell growth promotion at 10'-5 M after 48 hrs by SRB assay relative to control	ChEMBL.	21458891
Activity (functional)	= 84.55 %	Anticancer activity against human SNB75 cells assessed as cell growth promotion at 10'-5 M after 48 hrs by SRB assay relative to control	ChEMBL.	21458891
Activity (functional)	= 85.63 %	Anticancer activity against human OVCAR4 cells assessed as cell growth promotion at 10'-5 M after 48 hrs by SRB assay relative to control	ChEMBL.	21458891
Activity (functional)	= 85.77 %	Anticancer activity against human NCI-H226 cells assessed as cell growth promotion at 10'-5 M after 48 hrs by SRB assay relative to control	ChEMBL.	21458891
Activity (functional)	= 86.68 %	Anticancer activity against human EKVX cells assessed as cell growth promotion at 10'-5 M after 48 hrs by SRB assay relative to control	ChEMBL.	21458891
Activity (functional)	= 86.93 %	Anticancer activity against human OVCAR3 cells assessed as cell growth promotion at 10'-5 M after 48 hrs by SRB assay relative to control	ChEMBL.	21458891
Activity (functional)	= 88.85 %	Anticancer activity against human OVCAR8 cells assessed as cell growth promotion at 10'-5 M after 48 hrs by SRB assay relative to control	ChEMBL.	21458891
Activity (functional)	= 89.27 %	Anticancer activity against human NCI-H322M cells assessed as cell growth promotion at 10'-5 M after 48 hrs by SRB assay relative to control	ChEMBL.	21458891
Activity (functional)	= 89.85 %	Anticancer activity against human IGROV1 cells assessed as cell growth promotion at 10'-5 M after 48 hrs by SRB assay relative to control	ChEMBL.	21458891
Activity (functional)	= 89.94 %	Anticancer activity against human HT-29 cells assessed as cell growth promotion at 10'-5 M after 48 hrs by SRB assay relative to control	ChEMBL.	21458891
Activity (functional)	= 90.6 %	Anticancer activity against human Caki1 cells assessed as cell growth promotion at 10'-5 M after 48 hrs by SRB assay relative to control	ChEMBL.	21458891
Activity (functional)	= 90.64 %	Anticancer activity against human SK-MEL-2 cells assessed as cell growth promotion at 10'-5 M after 48 hrs by SRB assay relative to control	ChEMBL.	21458891
Activity (functional)	= 91.75 %	Anticancer activity against human MALME-3M cells assessed as cell growth promotion at 10'-5 M after 48 hrs by SRB assay relative to control	ChEMBL.	21458891
Activity (functional)	= 91.8 %	Anticancer activity against human SF539 cells assessed as cell growth promotion at 10'-5 M after 48 hrs by SRB assay relative to control	ChEMBL.	21458891
Activity (functional)	= 94.11 %	Anticancer activity against human HL-60(TB) cells assessed as cell growth promotion at 10'-5 M after 48 hrs by SRB assay relative to control	ChEMBL.	21458891
Activity (functional)	= 94.73 %	Anticancer activity against human UACC257 cells assessed as cell growth promotion at 10'-5 M after 48 hrs by SRB assay relative to control	ChEMBL.	21458891
Activity (functional)	= 95.06 %	Anticancer activity against human NCI/ADR-RES cells assessed as cell growth promotion at 10'-5 M after 48 hrs by SRB assay relative to control	ChEMBL.	21458891
Activity (functional)	= 95.35 %	Anticancer activity against human SKOV3 cells assessed as cell growth promotion at 10'-5 M after 48 hrs by SRB assay relative to control	ChEMBL.	21458891
Activity (functional)	= 99.16 %	Anticancer activity against human SW620 cells assessed as cell growth promotion at 10'-5 M after 48 hrs by SRB assay relative to control	ChEMBL.	21458891
Activity (functional)	= 101 %	Anticancer activity against human SK-MEL-28 cells assessed as cell growth promotion at 10'-5 M after 48 hrs by SRB assay relative to control	ChEMBL.	21458891
Activity (functional)	= 105 %	Anticancer activity against human HOP62 cells assessed as cell growth promotion at 10'-5 M after 48 hrs by SRB assay relative to control	ChEMBL.	21458891
Activity (functional)	= 107 %	Anticancer activity against human DU145 cells assessed as cell growth promotion at 10'-5 M after 48 hrs by SRB assay relative to control	ChEMBL.	21458891
Activity (functional)	= 123 %	Anticancer activity against human OVCAR5 cells assessed as cell growth promotion at 10'-5 M after 48 hrs by SRB assay relative to control	ChEMBL.	21458891
Activity (functional)	= 123 %	Anticancer activity against human TK10 cells assessed as cell growth promotion at 10'-5 M after 48 hrs by SRB assay relative to control	ChEMBL.	21458891
Activity (functional)	= 124 %	Anticancer activity against human COLO205 cells assessed as cell growth promotion at 10'-5 M after 48 hrs by SRB assay relative to control	ChEMBL.	21458891

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1782697

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1524660