Detailed information for compound 1524662

Basic information

Technical information
  • TDR Targets ID: 1524662
  • Name: 4-chloro-N-[[3-methoxy-4-[2-(4-methyl-1,3-thi azol-5-yl)ethoxy]phenyl]methyl]-N-(2-oxoazepa n-3-yl)benzenesulfonamide
  • MW: 564.116 | Formula: C26H30ClN3O5S2
  • H donors: 1 H acceptors: 4 LogP: 4.78 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1cc(ccc1OCCc1scnc1C)CN(S(=O)(=O)c1ccc(cc1)Cl)C1CCCCNC1=O
  • InChi: 1S/C26H30ClN3O5S2/c1-18-25(36-17-29-18)12-14-35-23-11-6-19(15-24(23)34-2)16-30(22-5-3-4-13-28-26(22)31)37(32,33)21-9-7-20(27)8-10-21/h6-11,15,17,22H,3-5,12-14,16H2,1-2H3,(H,28,31)
  • InChiKey: ARHFHGURVXFXEN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-chloro-N-[[3-methoxy-4-[2-(4-methylthiazol-5-yl)ethoxy]phenyl]methyl]-N-(2-oxoazepan-3-yl)benzenesulfonamide
  • 4-chloro-N-[[3-methoxy-4-[2-(4-methyl-5-thiazolyl)ethoxy]phenyl]methyl]-N-(2-oxo-3-azepanyl)benzenesulfonamide
  • 4-chloro-N-(2-ketoazepan-3-yl)-N-[3-methoxy-4-[2-(4-methylthiazol-5-yl)ethoxy]benzyl]benzenesulfonamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0328 0.4071 0.4071
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0074 0.0792 0.0791
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0074 0.0792 0.0791
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0345 0.0344
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.0792 0.0791
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0074 0.0792 0.0792
Echinococcus granulosus muscleblind protein 0.0297 0.3678 0.3677
Schistosoma mansoni pol-related 0.0787 1 1
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0053 0.0529 0.0529
Schistosoma mansoni thyroid hormone receptor 0.0083 0.0911 0.0911
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0083 0.0911 0.0909
Entamoeba histolytica alcohol dehydrogenase, putative 0.0228 0.2784 0.2783
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0045 0.0043
Loa Loa (eye worm) hypothetical protein 0.0039 0.0346 0.0346
Loa Loa (eye worm) acetyltransferase 0.0145 0.1709 0.1709
Echinococcus multilocularis voltage gated potassium channel subunit 0.0228 0.2784 0.2783
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0113 0.0113
Loa Loa (eye worm) hypothetical protein 0.0044 0.0407 0.0407
Loa Loa (eye worm) hypothetical protein 0.0083 0.0911 0.0911
Onchocerca volvulus 0.0083 0.0911 0.0657
Plasmodium vivax aldehyde reductase, putative 0.0228 0.2784 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0083 0.0911 0.0909
Onchocerca volvulus 0.0787 1 1
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0118 0.1365 0.1365
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0787 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0228 0.2784 0.2783
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0428 0.0426
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0787 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0428 0.0428
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0145 0.1709 0.1708
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0787 1 1
Giardia lamblia Aldose reductase 0.0787 1 1
Loa Loa (eye worm) oxidoreductase 0.0787 1 1
Echinococcus multilocularis FTZ F1 alpha 0.0083 0.0911 0.0909
Mycobacterium tuberculosis Conserved protein 0.0228 0.2784 0.2702
Mycobacterium tuberculosis Probable oxidoreductase 0.0787 1 1
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0214 0.2603 0.2601
Brugia malayi nuclear receptor NHR-67 0.0039 0.0346 0.0344
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0787 1 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0039 0.0346 0.0344
Schistosoma mansoni nuclear hormone receptor 0.0083 0.0911 0.0911
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0083 0.0911 0.0911
Loa Loa (eye worm) hypothetical protein 0.0061 0.0624 0.0624
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0083 0.0911 0.0911
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0083 0.0911 0.0909
Trypanosoma cruzi aldo-keto reductase 0.0787 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0787 1 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0045 0.0043
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0083 0.0911 0.0657
Trypanosoma brucei prostaglandin f synthase 0.0787 1 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0391 0.0389
Brugia malayi steroid hormone receptor 0.0083 0.0911 0.0909
Trichomonas vaginalis aldo-keto reductase, putative 0.0787 1 1
Schistosoma mansoni hypothetical protein 0.0016 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0033 0.0272 0.0272
Onchocerca volvulus 0.0787 1 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0039 0.0346 0.0344
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0039 0.0346 0.0346
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0083 0.0911 0.0909
Trichomonas vaginalis aldo-keto reductase, putative 0.0787 1 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0083 0.0911 0.0911
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0083 0.0911 0.0911
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0787 1 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0145 0.1709 0.1709
Loa Loa (eye worm) hypothetical protein 0.0039 0.0346 0.0346
Entamoeba histolytica aldose reductase, putative 0.0787 1 1
Loa Loa (eye worm) hypothetical protein 0.0787 1 1
Echinococcus granulosus voltage gated potassium channel subunit 0.0228 0.2784 0.2783
Schistosoma mansoni potassium channel beta 0.0228 0.2784 0.2784
Brugia malayi tailless protein 0.0039 0.0346 0.0344
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0787 1 1
Entamoeba histolytica dual specificity protein phosphatase, putative 0.0579 0.7311 0.731
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0228 0.2784 0.2783
Trichomonas vaginalis aldo/keto reductase, putative 0.0787 1 1
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0391 0.0389
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0484 0.0484
Brugia malayi hypothetical protein 0.0039 0.0346 0.0344
Loa Loa (eye worm) hypothetical protein 0.0016 0.0045 0.0045
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0044 0.0407 0.0405
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0118 0.1365 0.1363
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0083 0.0911 0.0911
Schistosoma mansoni ap endonuclease 0.0021 0.0113 0.0113
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0391 0.0389
Echinococcus granulosus GPCR family 2 0.0016 0.0045 0.0043
Brugia malayi Nuclear hormone receptor E75 0.0039 0.0346 0.0344
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0228 0.2784 1
Toxoplasma gondii aldose reductase, putative 0.0787 1 1
Schistosoma mansoni RAR-like nuclear receptor 0.0083 0.0911 0.0911
Trichomonas vaginalis set domain proteins, putative 0.0264 0.3252 0.3251
Loa Loa (eye worm) hypothetical protein 0.0169 0.2017 0.2017
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0045 0.0043
Loa Loa (eye worm) hypothetical protein 0.0083 0.0911 0.0911
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0045 0.0045
Brugia malayi Pre-SET motif family protein 0.0232 0.2838 0.2837
Brugia malayi orphan nuclear receptor NR2E1 0.0039 0.0346 0.0344
Trichomonas vaginalis aldo-keto reductase, putative 0.0228 0.2784 0.2783
Onchocerca volvulus 0.0039 0.0346 0.0077
Echinococcus multilocularis aldo keto reductase 0.0787 1 1
Brugia malayi hypothetical protein 0.0169 0.2017 0.2016
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0787 1 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0346 0.0346
Echinococcus multilocularis muscleblind protein 0.0297 0.3678 0.3677
Brugia malayi hypothetical protein 0.0044 0.0407 0.0405
Loa Loa (eye worm) hypothetical protein 0.0039 0.0346 0.0346
Trichomonas vaginalis aldo-keto reductase, putative 0.0787 1 1
Loa Loa (eye worm) oxidoreductase 0.0787 1 1
Onchocerca volvulus 0.0787 1 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0083 0.0911 0.0909
Trichomonas vaginalis aldo-keto reductase, putative 0.0787 1 1
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0113 0.0111
Brugia malayi ecdysteroid receptor 0.0083 0.0911 0.0909
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0074 0.0792 0.0792
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0083 0.0911 0.0909
Onchocerca volvulus Protein ultraspiracle homolog 0.0083 0.0911 0.0657
Schistosoma mansoni ap endonuclease 0.0021 0.0113 0.0113
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0228 0.2784 0.2783
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0083 0.0911 0.0909
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0118 0.1365 0.1363
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0083 0.0911 0.0909
Schistosoma mansoni thyroid hormone receptor 0.0083 0.0911 0.0911
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0061 0.0624 0.0622
Loa Loa (eye worm) hypothetical protein 0.0083 0.0911 0.0911
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0044 0.0407 0.0405
Loa Loa (eye worm) oxidoreductase 0.0787 1 1
Trypanosoma cruzi aldo/keto reductase, putative 0.0228 0.2784 0.2783
Echinococcus multilocularis muscleblind protein 1 0.0297 0.3678 0.3677
Loa Loa (eye worm) oxidoreductase 0.0787 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0272 0.0272
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0228 0.2784 0.2783
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0113 0.0111
Trichomonas vaginalis aldo-keto reductase, putative 0.0228 0.2784 0.2783
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0045 0.0043
Loa Loa (eye worm) mbt repeat family protein 0.0053 0.0529 0.0529
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0045 0.0043
Loa Loa (eye worm) hypothetical protein 0.0039 0.0346 0.0346
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0083 0.0911 0.0911
Brugia malayi conserved hypotetical protein 0.0039 0.0346 0.0344
Echinococcus granulosus thyroid hormone receptor alpha 0.0039 0.0346 0.0344
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0083 0.0911 0.0909
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0787 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0787 1 1
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0281 0.0279
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0012 0.0002 0.0002
Echinococcus multilocularis aldo keto reductase 0.0787 1 1
Brugia malayi nuclear receptor NHR-88 0.0083 0.0911 0.0909
Echinococcus granulosus FTZ F1 alpha 0.0083 0.0911 0.0909
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.0792 0.0791
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0074 0.0792 0.0791
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0428 0.0426
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0113 0.0111
Trichomonas vaginalis aldo/keto reductase, putative 0.0787 1 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0345 0.0344
Loa Loa (eye worm) hypothetical protein 0.0083 0.0911 0.0911
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0214 0.2603 0.2601
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0083 0.0911 0.0911
Entamoeba histolytica alcohol dehydrogenase, putative 0.0228 0.2784 0.2783
Loa Loa (eye worm) hypothetical protein 0.0044 0.0407 0.0407
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0787 1 1
Mycobacterium leprae Conserved hypothetical protein 0.0559 0.7058 0.5922
Onchocerca volvulus 0.0053 0.0529 0.0264
Brugia malayi Nuclear hormone receptor E75 0.0039 0.0346 0.0344
Loa Loa (eye worm) hypothetical protein 0.0039 0.0346 0.0346
Loa Loa (eye worm) MBCTL1 0.0061 0.0624 0.0624
Loa Loa (eye worm) hypothetical protein 0.0039 0.0346 0.0346
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0083 0.0911 0.0909
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0083 0.0911 0.0911
Toxoplasma gondii aldo-keto reductase 0.0228 0.2784 0.2783
Echinococcus multilocularis ecdysone induced protein 78C 0.0083 0.0911 0.0909
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0787 1 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0428 0.0428
Brugia malayi nuclear hormone receptor 0.0039 0.0346 0.0344
Schistosoma mansoni hypothetical protein 0.0016 0.0045 0.0045
Brugia malayi nuclear hormone receptor 0.0083 0.0911 0.0909
Echinococcus granulosus aldo keto reductase 0.0787 1 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.0911 0.0911
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0232 0.2838 0.2838
Schistosoma mansoni hypothetical protein 0.0016 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0053 0.0529 0.0529
Plasmodium vivax SET domain protein, putative 0.0033 0.0272 0.097
Brugia malayi hypothetical protein 0.0044 0.0407 0.0405
Schistosoma mansoni retinoic acid receptor RXR 0.0083 0.0911 0.0911
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0039 0.0346 0.0344
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0083 0.0911 0.0909
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0272 0.0272
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0083 0.0911 0.0909
Loa Loa (eye worm) hypothetical protein 0.005 0.0484 0.0484
Loa Loa (eye worm) hypothetical protein 0.0044 0.0407 0.0407
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0039 0.0346 0.0346
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0428 0.0426
Brugia malayi Nuclear hormone receptor-like 1 0.0044 0.0407 0.0405
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0428 0.0428
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0118 0.1365 0.1363
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0083 0.0911 0.0909
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0272 0.027
Trichomonas vaginalis aldo-keto reductase, putative 0.0787 1 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0083 0.0911 0.0909
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0228 0.2784 0.2783
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0787 1 1
Brugia malayi nuclear receptor NHR-88 0.0039 0.0346 0.0344
Schistosoma mansoni nuclear receptor 0.0039 0.0346 0.0346
Trichomonas vaginalis aldo/keto reductase, putative 0.0787 1 1
Loa Loa (eye worm) hypothetical protein 0.0297 0.3678 0.3678
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0118 0.1365 0.1363
Echinococcus granulosus aldo keto reductase 0.0787 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0787 1 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0039 0.0346 0.0077
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0484 0.0482
Echinococcus multilocularis transcription factor Dp 1 0.0043 0.0392 0.039
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0272 0.027
Echinococcus granulosus ecdysone induced protein 78C 0.0083 0.0911 0.0909
Schistosoma mansoni aldo-keto reductase 0.0787 1 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0039 0.0346 0.0346
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0113 0.0111
Loa Loa (eye worm) hypothetical protein 0.0083 0.0911 0.0911
Trichomonas vaginalis pps1 dual specificty phosphatase, putative 0.0579 0.7311 0.731
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0391 0.0389
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0053 0.0529 0.0264
Mycobacterium ulcerans hypothetical protein 0.0228 0.2784 0.2702
Leishmania major prostaglandin f synthase, putative 0.0787 1 1
Brugia malayi mbt repeat family protein 0.0053 0.0529 0.0527
Loa Loa (eye worm) hypothetical protein 0.0297 0.3678 0.3678
Schistosoma mansoni aldo-keto reductase 0.0787 1 1
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0012 0.0002 0.0002
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0083 0.0911 0.0909
Loa Loa (eye worm) hypothetical protein 0.0039 0.0346 0.0346
Echinococcus granulosus aldo keto reductase 0.0787 1 1
Loa Loa (eye worm) oxidoreductase 0.0787 1 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0272 0.027
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0083 0.0911 0.0911
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0787 1 1
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0787 1 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0083 0.0911 0.0909
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0787 1 1
Brugia malayi Pre-SET motif family protein 0.0033 0.0272 0.027
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0345 0.1235
Loa Loa (eye worm) hypothetical protein 0.0083 0.0911 0.0911
Loa Loa (eye worm) hypothetical protein 0.0039 0.0346 0.0346
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0113 0.0111
Trichomonas vaginalis aldo-keto reductase, putative 0.0787 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0083 0.0911 0.0909
Echinococcus multilocularis aldo keto reductase 0.0787 1 1
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0529 0.0529
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0787 1 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0391 0.0389
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0039 0.0346 0.0077
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0113 0.5
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0787 1 1
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0061 0.0624 0.0622
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0039 0.0346 0.0344
Loa Loa (eye worm) hypothetical protein 0.0083 0.0911 0.0911
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0228 0.2784 0.2783
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0787 1 1
Plasmodium falciparum aldo-keto reductase, putative 0.0228 0.2784 1
Brugia malayi Steroid receptor seven-up type 2 0.0083 0.0911 0.0909
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0391 0.1399
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0083 0.0911 0.0911
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0044 0.0407 0.0407
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0228 0.2784 0.2783
Loa Loa (eye worm) hypothetical protein 0.0044 0.0407 0.0407
Echinococcus multilocularis thyroid hormone receptor alpha 0.0083 0.0911 0.0909
Leishmania major aldo-keto reductase-like protein 0.0787 1 1
Onchocerca volvulus 0.0787 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0787 1 1
Brugia malayi Muscleblind-like protein 0.0297 0.3678 0.3677
Brugia malayi ecdysone receptor 0.0039 0.0346 0.0344
Brugia malayi acetyltransferase, GNAT family protein 0.0145 0.1709 0.1708
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0113 0.0111
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0074 0.0792 0.0791
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0113 0.0111
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0787 1 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0113 0.5
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.0792 0.0791
Brugia malayi nuclear receptor RXR 0.0044 0.0407 0.0405
Brugia malayi nuclear hormone receptor family member odr-7 0.0039 0.0346 0.0344
Onchocerca volvulus Bile acid receptor homolog 0.0083 0.0911 0.0657
Trichomonas vaginalis aldo-keto reductase, putative 0.0787 1 1
Onchocerca volvulus 0.0228 0.2784 0.2583
Loa Loa (eye worm) hypothetical protein 0.0044 0.0407 0.0407
Schistosoma mansoni hypothetical protein 0.0016 0.0045 0.0045
Loa Loa (eye worm) DR-78 0.0039 0.0346 0.0346
Entamoeba histolytica aldose reductase, putative 0.0787 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0039 0.0346 0.0344
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0061 0.0624 0.0622
Schistosoma mansoni zinc finger protein 0.0039 0.0346 0.0346
Loa Loa (eye worm) hypothetical protein 0.0039 0.0346 0.0346
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0118 0.1365 0.1363
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0787 1 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0044 0.0407 0.0407
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0428 0.0426
Echinococcus granulosus nuclear receptor nhr 48 0.0039 0.0346 0.0344
Echinococcus granulosus polycomb protein SCMH1 0.0053 0.0529 0.0527
Plasmodium falciparum aldehyde reductase, putative 0.0228 0.2784 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0272 0.027
Brugia malayi hypothetical protein 0.0039 0.0346 0.0344
Echinococcus multilocularis aldo keto reductase 0.0787 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0083 0.0911 0.0909
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0083 0.0911 0.0911
Onchocerca volvulus 0.0169 0.2017 0.1794
Echinococcus granulosus Nuclear hormone receptor HR96 0.0039 0.0346 0.0344
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0083 0.0911 0.0909
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0039 0.0346 0.0344
Brugia malayi mbt repeat family protein 0.0053 0.0529 0.0527
Schistosoma mansoni myelin transcription factor 1 myt1 0.0061 0.0624 0.0624
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0083 0.0911 0.0909
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0113 0.0111
Echinococcus granulosus aldehyde reductase 0.0559 0.7058 0.7057
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0083 0.0911 0.0911
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0787 1 1
Schistosoma mansoni nuclear hormone receptor 0.0039 0.0346 0.0346
Brugia malayi nuclear receptor RXR 0.0039 0.0346 0.0344
Trichomonas vaginalis aldo-keto reductase, putative 0.0787 1 1
Schistosoma mansoni nuclear hormone receptor 0.0039 0.0346 0.0346
Schistosoma mansoni nuclear receptor 0.0039 0.0346 0.0346
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0002
Schistosoma mansoni coup transcription factor 0.0083 0.0911 0.0911
Entamoeba histolytica aldose reductase, putative 0.0787 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0083 0.0911 0.0911
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0039 0.0346 0.0344
Trichomonas vaginalis aldo-keto reductase, putative 0.0228 0.2784 0.2783
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0083 0.0911 0.0909
Loa Loa (eye worm) hypothetical protein 0.0039 0.0346 0.0346
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0272 0.0272
Echinococcus granulosus histone acetyltransferase MYST2 0.0061 0.0624 0.0622
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0074 0.0792 0.0791
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0083 0.0911 0.0909
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0787 1 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0083 0.0911 0.0909
Loa Loa (eye worm) steroid hormone receptor 0.0083 0.0911 0.0911
Echinococcus granulosus SAM and MBT domain containing protein 0.0053 0.0529 0.0527
Mycobacterium ulcerans oxidoreductase 0.0787 1 1
Brugia malayi NADH-dependent xylose reductase 0.0228 0.2784 0.2783
Loa Loa (eye worm) hypothetical protein 0.0039 0.0346 0.0346
Echinococcus granulosus transcription factor Dp 1 0.0043 0.0392 0.039
Echinococcus multilocularis aldehyde reductase 0.0559 0.7058 0.7057
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0083 0.0911 0.0909
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0083 0.0911 0.0909
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0787 1 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0484 0.0482
Onchocerca volvulus 0.0787 1 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0272 0.0272
Onchocerca volvulus 0.0787 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0044 0.0407 0.0405
Brugia malayi Nuclear hormone receptor-like 1 0.0083 0.0911 0.0909
Brugia malayi nuclear hormone receptor family member nhr-6 0.0039 0.0346 0.0344
Echinococcus granulosus histone acetyltransferase KAT2B 0.0141 0.1657 0.1655
Schistosoma mansoni nuclear receptor nhr-48 0.0039 0.0346 0.0346
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0045 0.0043
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0083 0.0911 0.0911
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0787 1 1
Trypanosoma cruzi aldo/keto reductase, putative 0.0787 1 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0039 0.0346 0.0346
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0428 0.0428
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0044 0.0407 0.0407
Loa Loa (eye worm) hypothetical protein 0.0039 0.0346 0.0346
Trichomonas vaginalis aldo-keto reductase, putative 0.0787 1 1
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0787 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0787 1 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0113 0.0398
Onchocerca volvulus 0.0264 0.3252 0.3063
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0113 0.0111
Echinococcus granulosus hypothetical protein 0.0787 1 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0256 0.0254
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0113 0.0111
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0228 0.2784 0.2784
Echinococcus multilocularis histone acetyltransferase MYST2 0.0061 0.0624 0.0622
Trypanosoma brucei aldo/keto reductase, putative 0.0228 0.2784 0.2783
Giardia lamblia Aldose reductase 0.0787 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0787 1 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0281 0.0281
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0428 0.0426
Toxoplasma gondii exonuclease III APE 0.0021 0.0113 0.0111
Echinococcus multilocularis SAM and MBT domain containing protein 0.0053 0.0529 0.0527
Onchocerca volvulus 0.0039 0.0346 0.0077
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0529 0.0529
Schistosoma mansoni hypothetical protein 0.0034 0.0281 0.0281
Echinococcus multilocularis GPCR, family 2 0.0016 0.0045 0.0043
Echinococcus multilocularis polycomb protein SCMH1 0.0053 0.0529 0.0527
Loa Loa (eye worm) nuclear hormone receptor 0.0039 0.0346 0.0346
Echinococcus multilocularis nuclear receptor nhr 48 0.0039 0.0346 0.0344
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0083 0.0911 0.0909
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0113 0.0111
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0083 0.0911 0.0909
Trypanosoma brucei aldo-keto reductase, putative 0.0787 1 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0118 0.1365 0.1365
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0113 0.0398
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0787 1 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0039 0.0346 0.0344
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0787 1 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0039 0.0346 0.0344

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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