Detailed information for compound 1524760

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 238.366 | Formula: C15H26O2
  • H donors: 2 H acceptors: 2 LogP: 3.29 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=CCC[C@@H]([C@@H]1C=C[C@]([C@H](C1)O)(C)O)C)C
  • InChi: 1S/C15H26O2/c1-11(2)6-5-7-12(3)13-8-9-15(4,17)14(16)10-13/h6,8-9,12-14,16-17H,5,7,10H2,1-4H3/t12-,13+,14-,15-/m0/s1
  • InChiKey: YRFJMOGROZTYPC-XGUBFFRZSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major polypeptide deformylase-like protein, putative 0.1354 0.3768 1
Echinococcus granulosus sterol O acyltransferase 1 0.0741 0.2029 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0072 0.0267
Trypanosoma cruzi glycerol uptake protein, putative 0.0132 0.0298 0.0778
Toxoplasma gondii hypothetical protein 0.0132 0.0298 0.0293
Echinococcus granulosus muscleblind protein 0.017 0.0406 0.1931
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0614 0.1667 0.4416
Echinococcus multilocularis sterol O acyltransferase 1 0.0741 0.2029 1
Leishmania major heat shock protein 83-1 0.0033 0.0018 0.0048
Leishmania major DNA topoisomerase III, putative 0.0076 0.0139 0.0369
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0132 0.0298 0.1393
Trypanosoma brucei heat shock protein, putative 0.0033 0.0018 0.0034
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0033 0.0018 0.0018
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.1354 0.3768 1
Leishmania major DNA topoisomerase 1A 0.0076 0.0139 0.0369
Plasmodium falciparum DNA topoisomerase 2 0.0248 0.0628 0.0624
Toxoplasma gondii heat shock protein HSP90 0.0033 0.0018 0.0013
Brugia malayi Muscleblind-like protein 0.017 0.0406 0.3315
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.004 0.0356
Brugia malayi DNA topoisomerase III beta-1 0.0076 0.0139 0.1135
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0132 0.0298 0.1393
Mycobacterium ulcerans two component regulator - sensor kinase 0.0033 0.0018 0.0018
Leishmania major heat shock protein 83-1 0.0033 0.0018 0.0048
Trypanosoma cruzi heat shock protein 90, putative 0.0033 0.0018 0.0034
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.012 0.012
Trypanosoma brucei heat shock protein 90, putative 0.0033 0.0018 0.0034
Loa Loa (eye worm) hhat protein 0.0132 0.0298 0.1469
Trichomonas vaginalis conserved hypothetical protein 0.0132 0.0298 0.4589
Leishmania major heat shock protein 83-1 0.0033 0.0018 0.0048
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0076 0.0139 0.0356
Loa Loa (eye worm) hypothetical protein 0.0132 0.0298 0.1469
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0262 0.0667 0.0667
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0458 0.1225 0.6004
Trypanosoma cruzi GUP1, putative 0.0132 0.0298 0.0778
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.004 0.0356
Mycobacterium leprae Probable two component sensor kinase MprB 0.0033 0.0018 0.0018
Trypanosoma brucei DNA topoisomerase ii 0.0614 0.1667 0.4416
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.1062 0.294 0.2927
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0018 0.0034
Echinococcus granulosus o acyltransferase membrane bound domain 0.0132 0.0298 0.1393
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.004 0.0356
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0132 0.0298 0.1393
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.004 0.0092
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0072 0.0267
Onchocerca volvulus 0.0132 0.0298 0.4744
Plasmodium falciparum DNA topoisomerase 3, putative 0.0076 0.0139 0.0134
Brugia malayi MBOAT family protein 0.0132 0.0298 0.2432
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.012 0.0505
Mycobacterium tuberculosis Conserved protein 0.0033 0.0018 0.0018
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0172 0.0413 0.1083
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0458 0.1225 0.1221
Trypanosoma brucei DNA topoisomerase IA, putative 0.0076 0.0139 0.0356
Echinococcus granulosus o acyltransferase membrane bound domain 0.0132 0.0298 0.1393
Mycobacterium tuberculosis Conserved protein 0.0041 0.004 0.004
Loa Loa (eye worm) TOPoisomerase family member 0.0248 0.0628 0.3097
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0132 0.0298 0.1393
Leishmania major heat shock protein 83-1 0.0033 0.0018 0.0048
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0132 0.0298 0.1393
Loa Loa (eye worm) hhat protein 0.0132 0.0298 0.1469
Toxoplasma gondii hypothetical protein 0.3547 1 1
Brugia malayi MBOAT family protein 0.0132 0.0298 0.2432
Trypanosoma brucei glycerol uptake protein, putative 0.0132 0.0298 0.0778
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0132 0.0298 0.4744
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0033 0.0018 0.0034
Mycobacterium tuberculosis Possible two component sensor kinase 0.0033 0.0018 0.0018
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.004 0.004
Brugia malayi heat shock protein 90 0.0033 0.0018 0.0147
Loa Loa (eye worm) hypothetical protein 0.0172 0.0413 0.2034
Mycobacterium ulcerans peptide deformylase 0.3547 1 1
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0458 0.1225 0.6004
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0132 0.0298 0.1393
Loa Loa (eye worm) hypothetical protein 0.0132 0.0298 0.1469
Leishmania major heat shock protein 83-1 0.0033 0.0018 0.0048
Toxoplasma gondii DNA topoisomerase 2, putative 0.0248 0.0628 0.0624
Leishmania major heat shock protein 83-1 0.0033 0.0018 0.0048
Mycobacterium tuberculosis Conserved protein 0.0041 0.004 0.004
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0132 0.0298 0.1393
Trypanosoma brucei heat shock protein, putative 0.0033 0.0018 0.0034
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0366 0.0962 0.0962
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0132 0.0298 0.1393
Plasmodium vivax DNA gyrase subunit B, putative 0.1062 0.294 0.2936
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0458 0.1225 0.1221
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0132 0.0298 0.1393
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0072 0.0267
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0033 0.0018 0.0013
Plasmodium falciparum peptide deformylase 0.3547 1 1
Echinococcus multilocularis rho GTPase activating protein 20 0.0076 0.0139 0.0602
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0072 0.0267
Trichomonas vaginalis DNA topoisomerase II, putative 0.0248 0.0628 1
Loa Loa (eye worm) hypothetical protein 0.0132 0.0298 0.1469
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0248 0.0628 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0072 0.0267
Echinococcus granulosus DNA topoisomerase 3 beta 1 0.0076 0.0139 0.0602
Mycobacterium ulcerans DNA topoisomerase I 0.0076 0.0139 0.0139
Brugia malayi GRF zinc finger family protein 0.0076 0.0139 0.1135
Leishmania major hypothetical protein, conserved 0.0132 0.0298 0.0791
Mycobacterium tuberculosis Probable two component sensor kinase 0.0033 0.0018 0.0018
Onchocerca volvulus 0.0041 0.004 0.0633
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.1354 0.3768 1
Mycobacterium ulcerans lipase LipD 0.0041 0.004 0.004
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0458 0.1225 0.604
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0069 0.012 0.012
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.004 0.0108
Trypanosoma brucei heat shock protein, putative 0.0033 0.0018 0.0034
Trypanosoma cruzi glycerol uptake protein, putative 0.0132 0.0298 0.0778
Trypanosoma brucei glycerol uptake protein, putative 0.0132 0.0298 0.0778
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.004 0.004
Wolbachia endosymbiont of Brugia malayi topoisomerase IA, TopA 0.0076 0.0139 0.0121
Leishmania major DNA topoisomerase III, putative 0.0076 0.0139 0.0369
Giardia lamblia DNA topoisomerase II 0.0215 0.0534 1
Trypanosoma cruzi DNA topoisomerase III, putative 0.0076 0.0139 0.0356
Toxoplasma gondii heat shock protein 90, putative 0.0033 0.0018 0.0013
Plasmodium vivax DNA topoisomerase 3, putative 0.0076 0.0139 0.0134
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.3547 1 1
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0033 0.0018 0.0018
Leishmania major mitochondrial DNA topoisomerase II 0.0614 0.1667 0.4423
Trypanosoma brucei Polypeptide deformylase 1 0.1354 0.3768 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0069 0.012 0.0505
Plasmodium falciparum endoplasmin, putative 0.0033 0.0018 0.0013
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0033 0.0018 0.0018
Loa Loa (eye worm) MBOAT family protein 0.0132 0.0298 0.1469
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.012 0.0505
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0033 0.0018 0.0018
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0033 0.0018 0.0018
Schistosoma mansoni sterol O-acyltransferase 1 0.0741 0.2029 1
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.004 0.0092
Loa Loa (eye worm) MBOAT family protein 0.0132 0.0298 0.1469
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.004 0.0108
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0033 0.0018 0.0018
Toxoplasma gondii DNA topoisomerase family protein 0.0076 0.0139 0.0134
Leishmania major glycerol uptake protein, putative 0.0132 0.0298 0.0791
Loa Loa (eye worm) hypothetical protein 0.0033 0.0018 0.0089
Schistosoma mansoni DNA topoisomerase II 0.0248 0.0628 0.3035
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0076 0.0139 0.1983
Toxoplasma gondii aldehyde dehydrogenase 0.0069 0.012 0.0115
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0248 0.0628 0.3035
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0033 0.0018 0.0018
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0033 0.0018 0.0018
Toxoplasma gondii ABC1 family protein 0.0041 0.004 0.0035
Trypanosoma brucei heat shock protein, putative 0.0033 0.0018 0.0034
Chlamydia trachomatis DNA topoisomerase I 0.0076 0.0139 0.0121
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0458 0.1225 0.6004
Leishmania major heat shock protein 83-1 0.0033 0.0018 0.0048
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0033 0.0018 0.0018
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0033 0.0018 0.0018
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.004 0.004
Entamoeba histolytica DNA topoisomerase III, putative 0.0076 0.0139 0.2213
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0069 0.012 0.0505
Onchocerca volvulus 0.0041 0.004 0.0633
Loa Loa (eye worm) hypothetical protein 0.0041 0.004 0.0196
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.0072 0.0585
Leishmania major glycerol uptake protein, putative 0.0132 0.0298 0.0791
Brugia malayi Hhat protein 0.0132 0.0298 0.2432
Echinococcus multilocularis muscleblind protein 0.017 0.0406 0.1931
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.004 0.0108
Mycobacterium leprae Probable lipase LipE 0.0041 0.004 0.004
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.004 0.004
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.004 0.004
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0614 0.1667 0.1663
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0033 0.0018 0.0018
Treponema pallidum polypeptide deformylase (def) 0.3547 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.004 0.0196
Plasmodium falciparum DNA gyrase subunit B 0.1062 0.294 0.2936
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0018 0.0034
Trichomonas vaginalis esterase, putative 0.0041 0.004 0.0356
Treponema pallidum DNA topoisomerase I (topA) 0.0076 0.0139 0.0121
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0033 0.0018 0.0018
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0033 0.0018 0.0018
Loa Loa (eye worm) endoplasmin 0.0033 0.0018 0.0089
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.004 0.004
Plasmodium falciparum heat shock protein 90 0.0033 0.0018 0.0013
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.1062 0.294 0.2927
Loa Loa (eye worm) hypothetical protein 0.0041 0.004 0.0196
Trypanosoma cruzi GUP1, putative 0.0132 0.0298 0.0778
Loa Loa (eye worm) hypothetical protein 0.0041 0.004 0.0196
Plasmodium vivax DNA topoisomerase II, putative 0.0248 0.0628 0.0624
Brugia malayi beta-lactamase family protein 0.0041 0.004 0.0324
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0076 0.0139 0.0602
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0248 0.0628 0.5127
Giardia lamblia DNA topoisomerase III 0.0076 0.0139 0.2347
Trypanosoma brucei heat shock protein, putative 0.0033 0.0018 0.0034
Mycobacterium ulcerans putative regultory protein 0.0033 0.0018 0.0018
Brugia malayi MBOAT family protein 0.0132 0.0298 0.2432
Leishmania major glycerol uptake protein, putative 0.0132 0.0298 0.0791
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0248 0.0628 0.5127
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.004 0.0356
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0172 0.0413 0.1083
Loa Loa (eye worm) hypothetical protein 0.0029 0.0005 0.0025
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0033 0.0018 0.0018
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0033 0.0018 0.0034
Loa Loa (eye worm) hypothetical protein 0.0609 0.1654 0.8153
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0076 0.0139 0.0356
Trypanosoma brucei DNA topoisomerase III, putative 0.0076 0.0139 0.0356
Onchocerca volvulus 0.0041 0.004 0.0633
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0132 0.0298 0.1393
Mycobacterium leprae Probable DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) ( 0.0076 0.0139 0.0139
Leishmania major developmentally regulated phosphoprotein-like protein 0.0033 0.0018 0.0048
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0132 0.0298 0.4744
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0248 0.0628 1
Giardia lamblia DNA topoisomerase III 0.0076 0.0139 0.2347
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0033 0.0018 0.0018
Leishmania major glycerol uptake protein, putative 0.0132 0.0298 0.0791
Brugia malayi diacylglycerol acyltransferase 0.0458 0.1225 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.004 0.004
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0132 0.0298 0.1393
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.004 0.0356
Mycobacterium tuberculosis Conserved protein 0.0041 0.004 0.004
Onchocerca volvulus 0.0076 0.0139 0.2213
Brugia malayi kinase, mitochondrial precursor 0.0033 0.0018 0.0147
Plasmodium vivax endoplasmin, putative 0.0033 0.0018 0.0013
Trypanosoma brucei developmentally regulated phosphoprotein 0.0033 0.0018 0.0034
Leishmania major heat shock protein 83-1 0.0033 0.0018 0.0048
Entamoeba histolytica vacuolar protein sorting 26 0.0132 0.0298 0.4744
Loa Loa (eye worm) hypothetical protein 0.0741 0.2029 1
Echinococcus multilocularis DNA topoisomerase 3 beta 1 0.0076 0.0139 0.0602
Loa Loa (eye worm) hypothetical protein 0.0172 0.0413 0.2034
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.004 0.0108
Leishmania major heat shock protein 83-1 0.0033 0.0018 0.0048
Trypanosoma brucei DNA topoisomerase III, putative 0.0076 0.0139 0.0356
Leishmania major hypothetical protein, conserved 0.0033 0.0018 0.0048
Leishmania major heat shock protein 83-1 0.0033 0.0018 0.0048
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0018 0.0013
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0614 0.1667 0.4416
Mycobacterium ulcerans hypothetical protein 0.0041 0.004 0.004
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0458 0.1225 0.1221
Entamoeba histolytica heat shock protein 90, putative 0.0033 0.0018 0.0287
Entamoeba histolytica DNA topoisomerase III, putative 0.0076 0.0139 0.2213
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.012 0.012
Leishmania major heat shock protein 83-1 0.0033 0.0018 0.0048
Leishmania major glycerol uptake protein, putative 0.0132 0.0298 0.0791
Trypanosoma cruzi Peptide deformylase 2, putative 0.1354 0.3768 1
Brugia malayi MBOAT family protein 0.0132 0.0298 0.2432
Leishmania major hypothetical protein, conserved 0.0041 0.004 0.0105
Plasmodium vivax hypothetical protein, conserved 0.0041 0.004 0.0035
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0132 0.0298 0.1393
Trypanosoma cruzi DNA topoisomerase II, putative 0.0172 0.0413 0.1083
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0033 0.0018 0.0034
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.004 0.004
Mycobacterium ulcerans DNA gyrase subunit B 0.1062 0.294 0.294
Trichomonas vaginalis transmembrane protein nessy, putative 0.0132 0.0298 0.4589
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0033 0.0018 0.0013
Echinococcus multilocularis muscleblind protein 1 0.017 0.0406 0.1931
Loa Loa (eye worm) hypothetical protein 0.017 0.0406 0.2002
Leishmania major heat shock protein 83-1 0.0033 0.0018 0.0048
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0018 0.0034
Trypanosoma brucei heat shock protein, putative 0.0033 0.0018 0.0034
Leishmania major heat shock protein 83-1 0.0033 0.0018 0.0048
Mycobacterium leprae Probable two-component sensor kinase 0.0033 0.0018 0.0018
Entamoeba histolytica DNA topoisomerase II, putative 0.0248 0.0628 1
Trypanosoma cruzi heat shock protein 90, putative 0.0033 0.0018 0.0034
Brugia malayi MBOAT family protein 0.0132 0.0298 0.2432
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0132 0.0298 0.1469
Plasmodium vivax heat shock protein 86, putative 0.0033 0.0018 0.0013
Entamoeba histolytica hypothetical protein 0.0132 0.0298 0.4744
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0132 0.0298 0.4744
Entamoeba histolytica heat shock protein 90, putative 0.0033 0.0018 0.0287
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0069 0.012 0.0317
Echinococcus granulosus o acyltransferase membrane bound domain 0.0132 0.0298 0.1393
Brugia malayi beta-lactamase family protein 0.0041 0.004 0.0324
Schistosoma mansoni hypothetical protein 0.0132 0.0298 0.1393
Leishmania major DNA topoisomerase ii 0.0172 0.0413 0.1095
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.004 0.0324
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0033 0.0018 0.0018
Leishmania major heat shock protein 83-1 0.0033 0.0018 0.0048
Echinococcus granulosus DNA topoisomerase 3 alpha 0.0076 0.0139 0.0602
Trypanosoma brucei Peptide deformylase 2 0.1354 0.3768 1
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0132 0.0298 0.1393
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0248 0.0628 1
Trypanosoma cruzi DNA topoisomerase III, putative 0.0076 0.0139 0.0356
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.3547 1 1
Mycobacterium ulcerans beta-lactamase 0.0041 0.004 0.004
Brugia malayi Probable DNA topoisomerase II 0.0248 0.0628 0.5127
Trypanosoma cruzi Peptide deformylase 2, putative 0.1354 0.3768 1
Loa Loa (eye worm) heat shock protein 90 0.0033 0.0018 0.0089
Schistosoma mansoni zinc finger protein 0.0132 0.0298 0.1393
Leishmania major hypothetical protein, conserved 0.0029 0.0005 0.0014
Loa Loa (eye worm) beta-lactamase 0.0041 0.004 0.0196
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0132 0.0298 0.1393
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0248 0.0628 0.3035
Trypanosoma brucei heat shock protein 90, putative 0.0033 0.0018 0.0034
Trypanosoma brucei heat shock protein, putative 0.0033 0.0018 0.0034
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.1062 0.294 0.294
Trypanosoma cruzi Heat shock protein 83, putative 0.0033 0.0018 0.0034
Plasmodium vivax peptide deformylase, putative 0.3547 1 1
Leishmania major heat shock protein 83-1 0.0033 0.0018 0.0048
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.004 0.004
Loa Loa (eye worm) DNA topoisomerase III beta-1 0.0076 0.0139 0.0685
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0072 0.0267
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.004 0.0092
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0132 0.0298 0.1393
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0033 0.0018 0.0018
Loa Loa (eye worm) MBOAT family protein 0.0132 0.0298 0.1469
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0458 0.1225 0.1221
Leishmania major heat shock protein 83-1 0.0033 0.0018 0.0048
Brugia malayi Endoplasmin precursor 0.0033 0.0018 0.0147
Trypanosoma cruzi DNA topoisomerase II, putative 0.0172 0.0413 0.1083
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0072 0.0267
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.004 0.0196
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0076 0.0139 0.0602
Loa Loa (eye worm) hypothetical protein 0.017 0.0406 0.2002
Brugia malayi hypothetical protein 0.0029 0.0005 0.0042
Trypanosoma brucei heat shock protein, putative 0.0033 0.0018 0.0034
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0033 0.0018 0.0013
Loa Loa (eye worm) DNA topoisomerase III 0.0076 0.0139 0.0685
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0076 0.0139 0.1983
Leishmania major heat shock protein 83-1 0.0033 0.0018 0.0048
Loa Loa (eye worm) hypothetical protein 0.0041 0.004 0.0196
Trichomonas vaginalis porcupine, putative 0.0132 0.0298 0.4589
Chlamydia trachomatis DNA gyrase subunit B 0.0696 0.1901 0.1887
Brugia malayi beta-lactamase 0.0041 0.004 0.0324
Trypanosoma cruzi glycerol uptake protein, putative 0.0132 0.0298 0.0778
Chlamydia trachomatis DNA gyrase subunit B 0.1062 0.294 0.2927
Entamoeba histolytica hypothetical protein, conserved 0.0132 0.0298 0.4744
Trypanosoma brucei Heat shock protein 83, putative 0.0033 0.0018 0.0034
Mycobacterium ulcerans two component sensor kinase MprB 0.0033 0.0018 0.0018
Brugia malayi DNA topoisomerase III 0.0076 0.0139 0.1135
Trichomonas vaginalis conserved hypothetical protein 0.0132 0.0298 0.4589
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0076 0.0139 0.0134
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0033 0.0018 0.0018
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0132 0.0298 0.1393
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.0072 0.0354
Trypanosoma cruzi DNA topoisomerase III, putative 0.0076 0.0139 0.0356
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.3547 1 1
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0033 0.0018 0.0018
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.012 0.012
Trichomonas vaginalis conserved hypothetical protein 0.0132 0.0298 0.4589
Loa Loa (eye worm) hypothetical protein 0.0041 0.004 0.0196
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0033 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0326 0.0851 0.4193
Treponema pallidum alginate O-acetylation protein (algI) 0.0132 0.0298 0.0281
Mycobacterium leprae conserved hypothetical protein 0.0041 0.004 0.004

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 20 uM Antiplasmodial activity against chloroquine- and pyrimethamine-resistant Plasmodium falciparum K1 infected in human red blood cells assessed as [3H]hypoxanthine incorporation after 48 hrs by liquid scintillation counting ChEMBL. 21438586
IC50 (functional) = 61.3 uM Antiparasitic activity against Trypanosoma brucei rhodesiense STIB 900 bloodstream form after 72 hrs by microplate fluorimetry ChEMBL. 21438586

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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