TDR Targets

Basic information

Technical information

TDR Targets ID: 152480
Name: N-[4-[(3-butanoyl-8-methoxyquinolin-4-yl)amin o]-3-methylphenyl]acetamide
MW: 391.463 | Formula: C23H25N3O3
H donors: 2 H acceptors: 3 LogP: 4.31 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCCC(=O)c1cnc2c(c1Nc1ccc(cc1C)NC(=O)C)cccc2OC
InChi: 1S/C23H25N3O3/c1-5-7-20(28)18-13-24-23-17(8-6-9-21(23)29-4)22(18)26-19-11-10-16(12-14(19)2)25-15(3)27/h6,8-13H,5,7H2,1-4H3,(H,24,26)(H,25,27)
InChiKey: YUCYRFMYSRXTAI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[4-[(3-butanoyl-8-methoxy-4-quinolyl)amino]-3-methyl-phenyl]acetamide
N-[4-[[8-methoxy-3-(1-oxobutyl)-4-quinolyl]amino]-3-methylphenyl]acetamide
N-[4-[(3-butanoyl-8-methoxy-quinolin-4-yl)amino]-3-methyl-phenyl]ethanamide
N-[4-[(3-butyryl-8-methoxy-4-quinolyl)amino]-3-methyl-phenyl]acetamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Sus scrofa	Potassium-transporting ATPase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Drosophila melanogaster	nervana 1	Potassium-transporting ATPase	290 aa	305 aa	23.9 %
Schistosoma japonicum	ko:K01540 Na+/K+-exchanging ATPase beta subunit [EC3.6.3.9B], putative	Potassium-transporting ATPase	290 aa	258 aa	23.6 %
Echinococcus multilocularis	nervana 2	Potassium-transporting ATPase	290 aa	280 aa	29.6 %
Schistosoma mansoni	sodium/potassium-dependent atpase beta subunit	Potassium-transporting ATPase	290 aa	267 aa	21.3 %
Echinococcus granulosus	nervana 2	Potassium-transporting ATPase	290 aa	280 aa	29.3 %
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	Potassium-transporting ATPase	290 aa	266 aa	24.1 %
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	Potassium-transporting ATPase	290 aa	267 aa	27.3 %
Schistosoma japonicum	Sodium/potassium-transporting ATPase subunit beta-1, putative	Potassium-transporting ATPase	290 aa	258 aa	24.4 %
Onchocerca volvulus	Glutamate carboxypeptidase 2 homolog	Potassium-transporting ATPase	290 aa	301 aa	25.9 %
Schistosoma mansoni	sodium/potassium-dependent atpase beta subunit	Potassium-transporting ATPase	290 aa	254 aa	23.6 %
Schistosoma japonicum	Sodium/potassium-transporting ATPase subunit beta, putative	Potassium-transporting ATPase	290 aa	256 aa	25.4 %
Echinococcus multilocularis	nervana 2	Potassium-transporting ATPase	290 aa	265 aa	22.3 %
Schistosoma mansoni	sodium/potassium-dependent atpase beta subunit	Potassium-transporting ATPase	290 aa	306 aa	26.1 %
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	Potassium-transporting ATPase	290 aa	267 aa	27.3 %
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	Potassium-transporting ATPase	290 aa	266 aa	25.6 %
Loa Loa (eye worm)	hypothetical protein	Potassium-transporting ATPase	290 aa	301 aa	25.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.004	0.0827	0.3708
Loa Loa (eye worm)	hypothetical protein	0.0085	0.2096	1
Trypanosoma brucei	vacuolar-type Ca2+-ATPase, putative	0.0017	0.0175	0.0258
Brugia malayi	Nuclear hormone receptor-like 1	0.0045	0.0963	0.4593
Brugia malayi	Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type	0.0014	0.0079	0.0377
Leishmania major	thymidine kinase, putative	0.0251	0.6795	1
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0085	0.2096	1
Brugia malayi	hypothetical protein	0.004	0.0827	0.3945
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0175	0.0836
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0085	0.2096	1
Plasmodium vivax	P-type ATPase4, putative	0.0017	0.0175	0.5
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0085	0.2096	1
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0017	0.0175	0.0258
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0085	0.2096	1
Leishmania major	P-type ATPase, putative	0.0014	0.0079	0.0116
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0026	0.0418	0.1683
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0017	0.0175	0.0258
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0085	0.2096	1
Echinococcus granulosus	nervana 2	0.0026	0.0418	0.1683
Onchocerca volvulus		0.004	0.0827	0.3393
Echinococcus granulosus	calcium transporting ATPase type 2C member	0.0017	0.0175	0.0477
Brugia malayi	nuclear hormone receptor	0.0085	0.2096	1
Brugia malayi	Steroid receptor seven-up type 2	0.0085	0.2096	1
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0085	0.2096	1
Echinococcus multilocularis	sodium:potassium transporting ATPase subunit	0.0026	0.0418	0.1683
Echinococcus granulosus	nuclear receptor nhr 48	0.004	0.0827	0.3708
Echinococcus granulosus	sarco:endoplasmic reticulum calcium ATPase	0.0017	0.0175	0.0477
Trypanosoma cruzi	plasma membrane Ca2+ ATPase	0.0017	0.0175	0.0258
Schistosoma mansoni	thyroid hormone receptor	0.0085	0.2096	1
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.004	0.0827	0.3708
Loa Loa (eye worm)	nuclear hormone receptor	0.004	0.0827	0.3945
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0963	0.4593
Schistosoma mansoni	sodium / potassium ATPase beta chain	0.0026	0.0418	0.1683
Schistosoma mansoni	nuclear receptor nhr-48	0.004	0.0827	0.3708
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0085	0.2096	1
Onchocerca volvulus	Bile acid receptor homolog	0.0085	0.2096	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0963	0.4593
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0045	0.0963	0.4381
Schistosoma mansoni	RAR-like nuclear receptor	0.0085	0.2096	1
Schistosoma mansoni	nuclear receptor	0.004	0.0827	0.3708
Brugia malayi	Nuclear hormone receptor E75	0.004	0.0827	0.3945
Schistosoma mansoni	zinc finger protein	0.004	0.0827	0.3708
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.004	0.0827	0.3945
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0085	0.2096	1
Trichomonas vaginalis	thymidine kinase, putative	0.0251	0.6795	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0085	0.2096	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0085	0.2096	1
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0017	0.0175	0.0258
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0085	0.2096	1
Schistosoma mansoni	sodium/potassium-dependent atpase beta subunit	0.0026	0.0418	0.1683
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0085	0.2096	1
Brugia malayi	Nuclear hormone receptor E75	0.004	0.0827	0.3945
Loa Loa (eye worm)	DR-78	0.004	0.0827	0.3945
Leishmania major	calcium-transporting ATPase, putative	0.0014	0.0079	0.0116
Plasmodium falciparum	non-SERCA-type Ca2+ -transporting P-ATPase	0.0017	0.0175	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0085	0.2096	1
Plasmodium vivax	calcium-transporting ATPase, putative	0.0017	0.0175	0.5
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0045	0.0963	0.4593
Echinococcus granulosus	Nuclear hormone receptor HR96	0.004	0.0827	0.3708
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0085	0.2096	1
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0026	0.0418	0.1683
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0418	0.1996
Echinococcus granulosus	FTZ F1 alpha	0.0085	0.2096	1
Schistosoma mansoni	transmemberane protein	0.0026	0.0418	0.1683
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0085	0.2096	1
Trypanosoma cruzi	thymidine kinase, putative	0.0251	0.6795	1
Schistosoma mansoni	nuclear receptor	0.004	0.0827	0.3708
Echinococcus multilocularis	nervana 2	0.0026	0.0418	0.1683
Trypanosoma brucei	vacuolar-type Ca2+-ATPase 1	0.0017	0.0175	0.0258
Loa Loa (eye worm)	steroid hormone receptor	0.0085	0.2096	1
Trypanosoma brucei	vacuolar-type Ca2+-ATPase 2	0.0017	0.0175	0.0258
Echinococcus granulosus	nervana 2	0.0026	0.0418	0.1683
Loa Loa (eye worm)	hypothetical protein	0.0085	0.2096	1
Mycobacterium ulcerans	metal cation transporter p-type ATPase a	0.0017	0.0175	1
Echinococcus granulosus	nervana 2	0.0026	0.0418	0.1683
Loa Loa (eye worm)	hypothetical protein	0.004	0.0827	0.3945
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0085	0.2096	1
Schistosoma mansoni	sodium/potassium-dependent atpase beta subunit	0.0026	0.0418	0.1683
Brugia malayi	Membrane calcium atpase protein 3	0.0014	0.0079	0.0377
Echinococcus multilocularis	ecdysone induced protein 78C	0.0085	0.2096	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0963	0.4593
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.004	0.0827	0.3708
Mycobacterium ulcerans	metal cation-transporting p-type ATPase F, CtpF	0.0017	0.0175	1
Loa Loa (eye worm)	hypothetical protein	0.0085	0.2096	1
Trypanosoma cruzi	Calcium ATPase SERCA-like	0.0017	0.0175	0.0258
Brugia malayi	nuclear receptor NHR-67	0.004	0.0827	0.3945
Brugia malayi	nuclear receptor RXR	0.004	0.0827	0.3945
Brugia malayi	nuclear hormone receptor family member odr-7	0.004	0.0827	0.3945
Loa Loa (eye worm)	Na,K-ATPase alpha subunit	0.0017	0.0175	0.0836
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0085	0.2096	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0085	0.2096	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0085	0.2096	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0827	0.3945
Echinococcus granulosus	plasma membrane calcium transporting ATPase 2	0.0017	0.0175	0.0477
Loa Loa (eye worm)	hypothetical protein	0.004	0.0827	0.3945
Echinococcus multilocularis	nervana 2	0.0026	0.0418	0.1683
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.004	0.0827	0.3708
Toxoplasma gondii	calcium-translocating P-type ATPase, PMCA-type protein	0.0017	0.0175	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0827	0.3945
Trypanosoma cruzi	calcium motive p-type ATPase, putative	0.0014	0.0079	0.0116
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.004	0.0827	0.3708
Schistosoma mansoni	nuclear hormone receptor	0.004	0.0827	0.3708
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0418	0.1996
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0085	0.2096	1
Echinococcus multilocularis	calcium transporting ATPase type 2C member	0.0017	0.0175	0.0477
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0085	0.2096	1
Schistosoma mansoni	ATPase	0.0017	0.0175	0.0477
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0085	0.2096	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0827	0.3945
Trichomonas vaginalis	thymidine kinase, putative	0.0251	0.6795	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0827	0.3945
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0017	0.0175	0.0258
Loa Loa (eye worm)	sodium/potassium-transporting ATPase subunit alpha	0.0012	0.0021	0.0099
Schistosoma mansoni	coup transcription factor	0.0085	0.2096	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0085	0.2096	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0085	0.2096	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0827	0.3945
Mycobacterium tuberculosis	Possible metal cation transporting P-type ATPase CtpH	0.0012	0.0021	0.5
Leishmania major	vacuolar-type Ca2 -ATPase, putative	0.0017	0.0175	0.0258
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.004	0.0827	0.3708
Loa Loa (eye worm)	hypothetical protein	0.004	0.0827	0.3945
Brugia malayi	orphan nuclear receptor NR2E1	0.004	0.0827	0.3945
Loa Loa (eye worm)	hypothetical protein	0.004	0.0827	0.3945
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0014	0.0079	0.0116
Trichomonas vaginalis	thymidine kinase, putative	0.0251	0.6795	1
Onchocerca volvulus		0.0085	0.2096	1
Schistosoma mansoni	Na+/K+ transporting ATPase subunit alpha	0.0017	0.0175	0.0477
Giardia lamblia	Plasma membrane calcium-transporting ATPase 2	0.0017	0.0175	0.0097
Brugia malayi	ecdysteroid receptor	0.0085	0.2096	1
Brugia malayi	hypothetical protein	0.0045	0.0963	0.4593
Echinococcus granulosus	Nuclear hormone receptor HR96	0.004	0.0827	0.3708
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0026	0.0418	0.1683
Echinococcus multilocularis	FTZ F1 alpha	0.0085	0.2096	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0085	0.2096	1
Entamoeba histolytica	thymidine kinase, putative	0.0251	0.6795	1
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0026	0.0418	0.1683
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0085	0.2096	1
Toxoplasma gondii	sarco/endoplasmic reticulum Ca2+-ATPase	0.0017	0.0175	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0045	0.0963	0.4381
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0085	0.2096	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0085	0.2096	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0085	0.2096	1
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.004	0.0827	0.3708
Echinococcus multilocularis	sarco:endoplasmic reticulum calcium ATPase	0.0017	0.0175	0.0477
Brugia malayi	conserved hypotetical protein	0.004	0.0827	0.3945
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0017	0.0175	0.0258
Schistosoma mansoni	thyroid hormone receptor	0.0085	0.2096	1
Trypanosoma cruzi	plasma membrane Ca2+ ATPase	0.0017	0.0175	0.0258
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.004	0.0827	0.3708
Brugia malayi	nuclear hormone receptor family member nhr-6	0.004	0.0827	0.3945
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0026	0.0418	0.1683
Trypanosoma brucei	calcium-translocating P-type ATPase	0.0014	0.0079	0.0116
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0085	0.2096	1
Trypanosoma cruzi	calcium motive p-type ATPase, putative	0.0014	0.0079	0.0116
Brugia malayi	Na,K-ATPase alpha subunit	0.0017	0.0175	0.0836
Loa Loa (eye worm)	nuclear receptor NHR-67	0.004	0.0827	0.3945
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0085	0.2096	1
Schistosoma mansoni	ATPase	0.0017	0.0175	0.0477
Echinococcus granulosus	sodium:potassium transporting ATPase subunit	0.0026	0.0418	0.1683
Loa Loa (eye worm)	hypothetical protein	0.0085	0.2096	1
Mycobacterium leprae	PROBABLE CATION-TRANSPORTER ATPASE I CTPI	0.0012	0.0021	0.5
Brugia malayi	steroid hormone receptor	0.0085	0.2096	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0085	0.2096	1
Onchocerca volvulus	Protein ultraspiracle homolog	0.0085	0.2096	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0085	0.2096	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0175	0.0836
Leishmania major	vacuolar-type Ca2 -ATPase, putative	0.0017	0.0175	0.0258
Brugia malayi	nuclear receptor NHR-88	0.0085	0.2096	1
Giardia lamblia	Thymidine kinase	0.0251	0.6795	0.6769
Loa Loa (eye worm)	hypothetical protein	0.0085	0.2096	1
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0045	0.0963	0.4381
Loa Loa (eye worm)	hypothetical protein	0.004	0.0827	0.3945
Echinococcus granulosus	thyroid hormone receptor alpha	0.004	0.0827	0.3708
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0017	0.0175	0.0258
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0085	0.2096	1
Brugia malayi	nuclear receptor NHR-88	0.004	0.0827	0.3945
Onchocerca volvulus		0.0026	0.0418	0.1266
Toxoplasma gondii	P-type ATPase4, putative	0.0017	0.0175	1
Loa Loa (eye worm)	hypothetical protein	0.0085	0.2096	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0085	0.2096	1
Trypanosoma cruzi	thymidine kinase, putative	0.0251	0.6795	1
Brugia malayi	hypothetical protein	0.0045	0.0963	0.4593
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.004	0.0827	0.3708
Brugia malayi	Nuclear hormone receptor-like 1	0.0045	0.0963	0.4593
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0085	0.2096	1
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0085	0.2096	1
Toxoplasma gondii	plasma membrane-type Ca(2+)-ATPase A1 PMCAA1	0.0014	0.0079	0.4509
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0085	0.2096	1
Echinococcus multilocularis	nuclear receptor nhr 48	0.004	0.0827	0.3708
Brugia malayi	Sodium/potassium-transporting ATPase alpha chain, putative	0.0012	0.0021	0.0099
Schistosoma mansoni	retinoic acid receptor RXR	0.0085	0.2096	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0085	0.2096	1
Leishmania major	calcium-translocating P-type ATPase	0.0017	0.0175	0.0258
Brugia malayi	hypothetical protein	0.004	0.0827	0.3945
Echinococcus multilocularis	Tetracycline resistance leader peptide, TetL	0.0017	0.0175	0.0477
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0963	0.4593
Trypanosoma brucei	thymidine kinase	0.0251	0.6795	1
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0026	0.0418	0.1683
Loa Loa (eye worm)	hypothetical protein	0.004	0.0827	0.3945
Echinococcus multilocularis	nervana 2	0.0026	0.0418	0.1683
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0085	0.2096	1
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0017	0.0175	0.0258
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0085	0.2096	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0827	0.3945
Echinococcus multilocularis	nervana 2	0.0026	0.0418	0.1683
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0085	0.2096	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0963	0.4593
Onchocerca volvulus		0.0026	0.0418	0.1266
Echinococcus granulosus	nervana 2	0.0026	0.0418	0.1683
Loa Loa (eye worm)	hypothetical protein	0.004	0.0827	0.3945
Trichomonas vaginalis	cation-transporting ATPase fungi, putative	0.0017	0.0175	0.0258
Onchocerca volvulus		0.004	0.0827	0.3393
Brugia malayi	ecdysone receptor	0.004	0.0827	0.3945
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.004	0.0827	0.3945
Brugia malayi	photoreceptor-specific nuclear receptor	0.0085	0.2096	1
Trypanosoma brucei	calcium motive p-type ATPase, putative	0.0014	0.0079	0.0116
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.004	0.0827	0.3393
Brugia malayi	nuclear hormone receptor	0.004	0.0827	0.3945
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0045	0.0963	0.4381
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.004	0.0827	0.3393
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0017	0.0175	0.0258
Loa Loa (eye worm)	hypothetical protein	0.0085	0.2096	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0085	0.2096	1
Schistosoma mansoni	sodium/potassium-dependent atpase beta subunit	0.0026	0.0418	0.1683
Loa Loa (eye worm)	hypothetical protein	0.0085	0.2096	1
Brugia malayi	tailless protein	0.004	0.0827	0.3945
Schistosoma mansoni	nuclear hormone receptor	0.004	0.0827	0.3708
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0085	0.2096	1
Brugia malayi	nuclear receptor RXR	0.0045	0.0963	0.4593
Schistosoma mansoni	nuclear hormone receptor	0.0085	0.2096	1
Leishmania major	calcium motive p-type ATPase, putative	0.0014	0.0079	0.0116

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 12 uM	Inhibition of K+ -stimulated gastric ATPase activity was measured using lyophilized gastric vesicles at pH 7	ChEMBL.	7629813
IC50 (binding)	= 12 uM	Inhibition of K+ -stimulated gastric ATPase activity was measured using lyophilized gastric vesicles at pH 7	ChEMBL.	7629813

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

PubChem: 10363049

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 152480