Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | aurora kinase A | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0133 | 0.3277 | 0.5214 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0244 | 0.6454 | 1 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0244 | 0.6454 | 1 |
Trypanosoma brucei | thymidine kinase | 0.0244 | 0.6454 | 1 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0244 | 0.6454 | 1 |
Brugia malayi | serine/threonine protein kinase 6 | 0.0068 | 0.1424 | 1 |
Loa Loa (eye worm) | AUR protein kinase | 0.0068 | 0.1424 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.0068 | 0.1424 | 0.2265 |
Entamoeba histolytica | thymidine kinase, putative | 0.0244 | 0.6454 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0 | 0.5 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0244 | 0.6454 | 1 |
Echinococcus multilocularis | thymidine kinase | 0.0238 | 0.6285 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0068 | 0.1424 | 0.2206 |
Brugia malayi | serine/threonine kinase 12 | 0.0068 | 0.1424 | 1 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.0068 | 0.1424 | 0.2206 |
Schistosoma mansoni | thymidine kinase | 0.0238 | 0.6285 | 1 |
Schistosoma mansoni | protein kinase | 0.0068 | 0.1424 | 0.2265 |
Trypanosoma brucei | aurora B kinase | 0.0068 | 0.1424 | 0.2206 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0 | 0.5 |
Echinococcus granulosus | thymidine kinase | 0.0238 | 0.6285 | 1 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0068 | 0.1424 | 1 |
Entamoeba histolytica | protein kinase , putative | 0.0068 | 0.1424 | 0.2206 |
Trypanosoma cruzi | aurora B kinase, putative | 0.0068 | 0.1424 | 0.2206 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0123 | 0.2995 | 0.4765 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0068 | 0.1424 | 0.2265 |
Schistosoma mansoni | thyroid hormone receptor | 0.0133 | 0.3277 | 0.5214 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.0068 | 0.1424 | 1 |
Echinococcus granulosus | aurora kinase A | 0.0068 | 0.1424 | 0.2265 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0133 | 0.3277 | 0.5214 |
Leishmania major | thymidine kinase, putative | 0.0244 | 0.6454 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0068 | 0.1424 | 0.2206 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0 | 0.5 |
Echinococcus granulosus | Thymidine kinase 2 mitochondrial | 0.0238 | 0.6285 | 1 |
Giardia lamblia | Aurora kinase | 0.0068 | 0.1424 | 0.1424 |
Leishmania major | protein kinase, putative | 0.0068 | 0.1424 | 0.2206 |
Echinococcus granulosus | thymidine kinase | 0.0238 | 0.6285 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0068 | 0.1424 | 0.2206 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.092 | 0.1464 |
Echinococcus multilocularis | transfer RNA-Ile | 0.0238 | 0.6285 | 1 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.0068 | 0.1424 | 0.2265 |
Entamoeba histolytica | protein kinase, putative | 0.0068 | 0.1424 | 0.2206 |
Echinococcus multilocularis | aurora kinase A | 0.0068 | 0.1424 | 0.2265 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.0068 | 0.1424 | 1 |
Loa Loa (eye worm) | AUR protein kinase | 0.0068 | 0.1424 | 1 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.0068 | 0.1424 | 0.2206 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0244 | 0.6454 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0068 | 0.1424 | 0.2206 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.0068 | 0.1424 | 0.2206 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0123 | 0.2995 | 0.4765 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0068 | 0.1424 | 0.2206 |
Toxoplasma gondii | aurora kinase | 0.0068 | 0.1424 | 1 |
Giardia lamblia | Thymidine kinase | 0.0244 | 0.6454 | 0.6454 |
Loa Loa (eye worm) | AUR protein kinase | 0.0068 | 0.1424 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0068 | 0.1424 | 0.2206 |
Echinococcus multilocularis | thymidine kinase | 0.0238 | 0.6285 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0123 | 0.2995 | 0.4765 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.27 uM | Inhibition of Aurora A by ELISA | ChEMBL. | 21128645 |
IC50 (functional) | = 13 uM | Cytotoxicity against human COLO205 cells | ChEMBL. | 21128645 |
IC50 (functional) | = 20.2 uM | Cytotoxicity against human HCT116 cells after 5 days by celltiter-glo assay | ChEMBL. | 21128645 |
IC50 (binding) | = 27 uM | Inhibition of Aurora B by ELISA | ChEMBL. | 21128645 |
IC50 (functional) | > 30 uM | Cytotoxicity against human MCF7 cells | ChEMBL. | 21128645 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 21128645 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.