Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.2553 | 0.5 | 0.5 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.2553 | 0.5 | 0.5 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.2553 | 0.5 | 0.5 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.2553 | 0.5 | 0.5 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.2553 | 0.5 | 0.5 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.2553 | 0.5 | 0.5 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.2553 | 0.5 | 0.5 |
Leishmania major | 0.2553 | 0.5 | 0.5 | |
Toxoplasma gondii | fructose-bisphospatase II | 0.2553 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MFC (functional) | > 250 ug ml-1 | Antifungal activity against Candida albicans ATCC 10213 | ChEMBL. | 21481593 |
MFC (functional) | > 250 ug ml-1 | Antifungal activity against Saccharomyces cerevisiae ATCC 9763 | ChEMBL. | 21481593 |
MFC (functional) | > 250 ug ml-1 | Antifungal activity against Cryptococcus neoformans ATCC 32264 | ChEMBL. | 21481593 |
MIC (functional) | > 250 ug ml-1 | Antifungal activity against Candida albicans ATCC 10213 | ChEMBL. | 21481593 |
MIC (functional) | > 250 ug ml-1 | Antifungal activity against Saccharomyces cerevisiae ATCC 9763 | ChEMBL. | 21481593 |
MIC (functional) | > 250 ug ml-1 | Antifungal activity against Cryptococcus neoformans ATCC 32264 | ChEMBL. | 21481593 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.