Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0061 | 0.0061 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0484 | 0.1986 | 0.1489 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.0773 | 0.3437 | 0.2681 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 | 0.0484 | 0.1986 | 0.1937 |
Toxoplasma gondii | fructose-bisphospatase II | 0.2078 | 1 | 1 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.2078 | 1 | 1 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0484 | 0.1986 | 0.1489 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.2078 | 1 | 1 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu | 0.0484 | 0.1986 | 0.1937 |
Echinococcus granulosus | voltage dependent L type calcium channel subunit|voltage dependent calcium channel | 0.0484 | 0.1986 | 0.1937 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0484 | 0.1986 | 0.1489 |
Mycobacterium tuberculosis | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA | 0.0158 | 0.0344 | 0.5 |
Mycobacterium tuberculosis | Probable aminotransferase | 0.0158 | 0.0344 | 0.5 |
Trypanosoma brucei | sedoheptulose-1,7-bisphosphatase | 0.0773 | 0.3437 | 0.2681 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.2078 | 1 | 1 |
Toxoplasma gondii | transporter, cation channel family protein | 0.0101 | 0.0061 | 0.0061 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0484 | 0.1986 | 0.1489 |
Mycobacterium ulcerans | hypothetical protein | 0.0158 | 0.0344 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0484 | 0.1986 | 0.1986 |
Trichomonas vaginalis | acetylornithine aminotransferase, putative | 0.0158 | 0.0344 | 0.5 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.2078 | 1 | 1 |
Mycobacterium leprae | PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA | 0.0158 | 0.0344 | 0.5 |
Loa Loa (eye worm) | calcium channel | 0.0484 | 0.1986 | 0.1986 |
Toxoplasma gondii | fructose-bisphospatase I | 0.0773 | 0.3437 | 0.3437 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0205 | 0.0584 | 0.0526 |
Mycobacterium ulcerans | adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 0.0158 | 0.0344 | 0.5 |
Leishmania major | 0.2078 | 1 | 0.5 | |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0484 | 0.1986 | 0.1489 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0484 | 0.1986 | 0.1489 |
Echinococcus granulosus | voltage dependent calcium channel | 0.0484 | 0.1986 | 0.1937 |
Loa Loa (eye worm) | voltage-dependent calcium channel | 0.0101 | 0.0061 | 0.0061 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.2078 | 1 | 1 |
Toxoplasma gondii | sedoheptulose-1,7-bisphosphatase | 0.0773 | 0.3437 | 0.3437 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.2078 | 1 | 1 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.2078 | 1 | 1 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.0773 | 0.3437 | 0.2681 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 59 % | Activation of UTRN promoter in mouse H2K cells assessed as upregulation of UTRN production at 3 uM after 48 hrs by luciferase reporter linked assay | ChEMBL. | 21456623 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.