Detailed information for compound 1525553

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 206.284 | Formula: C12H18N2O
  • H donors: 1 H acceptors: 1 LogP: 1.93 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1CCN([C@H](C1)C)c1cccc(c1)O
  • InChi: 1S/C12H18N2O/c1-10-9-13(2)6-7-14(10)11-4-3-5-12(15)8-11/h3-5,8,10,15H,6-7,9H2,1-2H3/t10-/m0/s1
  • InChiKey: TVGXOOZPDLJTGP-JTQLQIEISA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0023 0.0032 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0023 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.0019
Leishmania major hypothetical protein, conserved 0.0103 0.0324 0.0324
Toxoplasma gondii fructose-bisphospatase II 0.2728 1 1
Plasmodium falciparum glutathione reductase 0.0043 0.0104 0.4745
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0015 0.0001 0.0001
Brugia malayi Importin beta-1 subunit 0.002 0.0019 0.0019
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0021 0.0022 0.0022
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0135 0.0444 0.0444
Echinococcus multilocularis cpg binding protein 0.0067 0.0192 0.0192
Mycobacterium ulcerans beta-lactamase 0.0103 0.0324 0.7199
Echinococcus granulosus thioredoxin glutathione reductase 0.0043 0.0104 0.0104
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0109 0.0347 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0001 0.0001
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0103 0.0324 0.1369
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0058 0.0161 0.0161
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0021 0.0023 0.0449
Toxoplasma gondii fructose-bisphospatase I 0.1014 0.3685 0.3685
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0032 0.0032
Trichomonas vaginalis penicillin-binding protein, putative 0.0103 0.0324 0.6271
Trichomonas vaginalis D-aminoacylase, putative 0.0103 0.0324 0.6271
Schistosoma mansoni cpg binding protein 0.0063 0.0179 0.0179
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0098 0.0307 0.1296
Loa Loa (eye worm) inositol-1 0.0027 0.0044 0.0044
Onchocerca volvulus 0.0023 0.0032 0.0197
Loa Loa (eye worm) hypothetical protein 0.0023 0.0032 0.0032
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0037 0.008 0.008
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0135 0.0444 0.0444
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0135 0.0443 0.0443
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0032 0.0032
Echinococcus multilocularis importin subunit beta 1 0.002 0.0019 0.0019
Trypanosoma brucei fructose-1,6-bisphosphatase 0.2728 1 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0023 0.0032 0.0032
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0022 0.0028 0.0028
Mycobacterium tuberculosis Probable oxidoreductase 0.0109 0.0347 0.1467
Toxoplasma gondii histone lysine methyltransferase SET1 0.0121 0.039 0.039
Echinococcus granulosus lamin 0.0044 0.0107 0.0107
Echinococcus granulosus geminin 0.0526 0.1885 0.1885
Trypanosoma brucei sedoheptulose-1,7-bisphosphatase 0.1014 0.3685 0.3685
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0315 0.1106 0.1106
Onchocerca volvulus 0.0147 0.0487 0.9398
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0135 0.0444 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0023 0.0032 0.0197
Plasmodium falciparum thioredoxin reductase 0.0015 0.0001 0.0032
Trypanosoma brucei PAB1-binding protein , putative 0.0074 0.0219 0.0219
Schistosoma mansoni importin beta-1 0.002 0.0019 0.0019
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0123 0.0399 0.0399
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0015 0.0001 0.0001
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.2728 1 1
Brugia malayi RNA, U transporter 1 0.0057 0.0155 0.0155
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0098 0.0307 0.1296
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0315 0.1106 0.1106
Brugia malayi nuclear hormone receptor 0.0023 0.0032 0.0032
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0027 0.0044 0.0969
Entamoeba histolytica hypothetical protein 0.0023 0.0032 0.0717
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0056 0.0154 0.3458
Loa Loa (eye worm) thioredoxin reductase 0.0043 0.0104 0.0104
Schistosoma mansoni transcription factor LCR-F1 0.0023 0.0032 0.0032
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0001 0.0001
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0254 0.0882 0.0882
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0023 0.0032 0.0032
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0001 0.0001
Loa Loa (eye worm) histone methyltransferase 0.002 0.0021 0.0021
Schistosoma mansoni retinoic acid receptor RXR 0.0023 0.0032 0.0032
Trichomonas vaginalis alpha-glucosidase, putative 0.0021 0.0023 0.0449
Brugia malayi cytoplasmic intermediate filament protein 0.0023 0.0032 0.0032
Brugia malayi hypothetical protein 0.0023 0.0032 0.0032
Brugia malayi ecdysteroid receptor 0.0023 0.0032 0.0032
Onchocerca volvulus 0.0044 0.0107 0.1715
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0001 0.0001
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0015 0.0001 0.0001
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0032 0.0032
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0015 0.0001 0.5
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0103 0.0324 0.7199
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0019 0.0015 0.0015
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0015 0.0001 0.0001
Toxoplasma gondii exonuclease III APE 0.0058 0.0161 0.0161
Echinococcus multilocularis GPCR, family 2 0.0059 0.0164 0.0164
Brugia malayi Isocitrate dehydrogenase 0.0022 0.0028 0.0028
Schistosoma mansoni hypothetical protein 0.0526 0.1885 0.1885
Loa Loa (eye worm) hypothetical protein 0.0023 0.0032 0.0032
Echinococcus multilocularis musashi 0.0044 0.0107 0.0107
Giardia lamblia NADH oxidase lateral transfer candidate 0.0015 0.0001 0.0016
Leishmania major importin beta-1 subunit, putative 0.0016 0.0006 0.0006
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 0.2728 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0315 0.1106 0.1106
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0337 0.1188 0.1188
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0103 0.0324 0.0324
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0033 0.0069 0.0069
Toxoplasma gondii LsmAD domain-containing protein 0.0074 0.0219 0.0219
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0027 0.0044 0.2708
Schistosoma mansoni hypothetical protein 0.0059 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0135 0.0444 0.0444
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0056 0.0154 0.0154
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0023 0.0032 0.0032
Echinococcus multilocularis thyroid hormone receptor alpha 0.0023 0.0032 0.0032
Trichomonas vaginalis maltase-glucoamylase, putative 0.0021 0.0023 0.0449
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0136 0.0448 0.0448
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0023 0.0032 0.0032
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0187 0.0635 0.0635
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0001 0.0001
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0015 0.0001 0.0001
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0021 0.0023 0.0449
Loa Loa (eye worm) beta-lactamase 0.0103 0.0324 0.0324
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0032 0.0032
Brugia malayi glutathione reductase 0.0043 0.0104 0.0104
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0037 0.008 0.008
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0032 0.0032
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0315 0.1106 0.1106
Loa Loa (eye worm) hypothetical protein 0.002 0.0021 0.0021
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0015 0.0001 0.0001
Brugia malayi isocitrate dehydrogenase 0.0022 0.0028 0.0028
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0123 0.0399 0.0399
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0022 0.0028 0.0028
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0015 0.0001 0.0022
Toxoplasma gondii thioredoxin reductase 0.0043 0.0104 0.0104
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0315 0.1106 0.1106
Schistosoma mansoni hypothetical protein 0.0213 0.0731 0.0731
Echinococcus granulosus inositol monophosphatase 1 0.0027 0.0044 0.0044
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0161 0.3124
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0161 0.4982
Trypanosoma brucei trypanothione reductase 0.0043 0.0104 0.0104
Brugia malayi Intermediate filament tail domain containing protein 0.0044 0.0107 0.0107
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0058 0.0161 0.0161
Mycobacterium tuberculosis Conserved protein 0.0103 0.0324 0.1369
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.002 0.002
Echinococcus granulosus fructose 16 bisphosphatase 1 0.2728 1 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0213 0.0731 0.0731
Schistosoma mansoni hypothetical protein 0.0023 0.0032 0.0032
Brugia malayi exodeoxyribonuclease III family protein 0.0058 0.0161 0.0161
Loa Loa (eye worm) hypothetical protein 0.0074 0.0219 0.0219
Echinococcus granulosus ubiquitin specific protease 41 0.0135 0.0444 0.0444
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0058 0.0161 0.0161
Brugia malayi Calcitonin receptor-like protein seb-1 0.0187 0.0635 0.0635
Loa Loa (eye worm) hypothetical protein 0.0103 0.0324 0.0324
Echinococcus multilocularis ubiquitin specific protease 41 0.0135 0.0444 0.0444
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0128 0.0417 0.0417
Brugia malayi follicle stimulating hormone receptor 0.0337 0.1188 0.1188
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0027 0.0044 0.0044
Brugia malayi photoreceptor-specific nuclear receptor 0.0023 0.0032 0.0032
Schistosoma mansoni ap endonuclease 0.0058 0.0161 0.0161
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0015 0.0001 0.0001
Schistosoma mansoni steroid hormone receptor ad4bp 0.0023 0.0032 0.0032
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0021 0.0023 0.0023
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0022 0.0028 0.086
Loa Loa (eye worm) hypothetical protein 0.0044 0.0107 0.0107
Trichomonas vaginalis alpha-glucosidase, putative 0.0056 0.0154 0.297
Echinococcus multilocularis lamin 0.0044 0.0107 0.0107
Brugia malayi Steroid receptor seven-up type 2 0.0023 0.0032 0.0032
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.026 0.0903 0.0903
Loa Loa (eye worm) intermediate filament protein 0.0044 0.0107 0.0107
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0015 0.0001 0.0001
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0023 0.0032 0.0032
Plasmodium falciparum ataxin-2 like protein, putative 0.0074 0.0219 1
Brugia malayi Pre-SET motif family protein 0.0136 0.0448 0.0448
Echinococcus granulosus GPCR family 2 0.0059 0.0164 0.0164
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0058 0.0161 0.3638
Echinococcus granulosus cpg binding protein 0.0067 0.0192 0.0192
Schistosoma mansoni RAR-like nuclear receptor 0.0023 0.0032 0.0032
Brugia malayi hypothetical protein 0.0048 0.0122 0.0122
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0023 0.0032 0.0032
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0135 0.0444 0.0444
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0059 0.0164 0.0164
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0032 0.0032
Trypanosoma brucei glucosidase, putative 0.0056 0.0154 0.0154
Echinococcus granulosus lamin dm0 0.0044 0.0107 0.0107
Toxoplasma gondii sedoheptulose-1,7-bisphosphatase 0.1014 0.3685 0.3685
Mycobacterium tuberculosis Conserved protein 0.0103 0.0324 0.1369
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0027 0.0044 0.0044
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0109 0.0347 0.1467
Trichomonas vaginalis conserved hypothetical protein 0.0135 0.0444 0.8589
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0015 0.0001 0.0032
Onchocerca volvulus 0.0155 0.0517 1
Echinococcus multilocularis dnaJ subfamily B 0.0901 0.3266 0.3266
Schistosoma mansoni fructose-16-bisphosphatase-related 0.2728 1 1
Echinococcus multilocularis neutral alpha glucosidase AB 0.0056 0.0154 0.0154
Echinococcus multilocularis inositol monophosphatase 1 0.0027 0.0044 0.0044
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0022 0.0028 0.0115
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0103 0.0324 0.0324
Loa Loa (eye worm) hypothetical protein 0.0103 0.0324 0.0324
Brugia malayi Glycosyl hydrolases family 31 protein 0.0254 0.0882 0.0882
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0135 0.0444 0.0444
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0022 0.0028 0.0028
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0059 0.0164 0.0164
Mycobacterium tuberculosis Probable lipase LipE 0.0103 0.0324 0.1369
Schistosoma mansoni hypothetical protein 0.0526 0.1885 0.1885
Trichomonas vaginalis inositol monophosphatase, putative 0.0027 0.0044 0.0856
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0059 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0023 0.0032 0.0032
Loa Loa (eye worm) isocitrate dehydrogenase 0.0022 0.0028 0.0028
Trichomonas vaginalis alpha-glucosidase, putative 0.0056 0.0154 0.297
Brugia malayi hypothetical protein 0.0108 0.0343 0.0343
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0023 0.0032 0.0032
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0023 0.0032 0.0032
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0023 0.0032 0.0032
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0022 0.0022
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0001 0.0001
Trichomonas vaginalis alpha-glucosidase, putative 0.0056 0.0154 0.297
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0103 0.0324 0.0324
Onchocerca volvulus 0.0108 0.0343 0.6478
Loa Loa (eye worm) hypothetical protein 0.0103 0.0324 0.0324
Mycobacterium tuberculosis Probable dehydrogenase 0.0098 0.0307 0.1296
Trichomonas vaginalis importin beta-1, putative 0.0016 0.0006 0.0107
Trichomonas vaginalis alpha-glucosidase, putative 0.0021 0.0023 0.0449
Trichomonas vaginalis penicillin-binding protein, putative 0.0103 0.0324 0.6271
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0006 0.0006
Schistosoma mansoni inositol monophosphatase 0.0027 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0103 0.0324 0.0324
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0058 0.0161 0.0161
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0022 0.0028 0.0028
Leishmania major alpha glucosidase II subunit, putative 0.0056 0.0154 0.0154
Onchocerca volvulus 0.0063 0.0179 0.3168
Echinococcus granulosus ecdysone induced protein 78C 0.0023 0.0032 0.0032
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0058 0.0161 0.3579
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0022 0.0028 0.0028
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.1014 0.3685 0.3685
Trichomonas vaginalis esterase, putative 0.0103 0.0324 0.6271
Echinococcus multilocularis geminin 0.0526 0.1885 0.1885
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0021 0.0023 0.0019
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0135 0.0444 0.0444
Leishmania major glycosyl hydrolase-like protein 0.0021 0.0023 0.0023
Trichomonas vaginalis D-aminoacylase, putative 0.0103 0.0324 0.6271
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0315 0.1106 0.1106
Loa Loa (eye worm) hypothetical protein 0.0023 0.0032 0.0032
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0023 0.0032 0.0032
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0037 0.008 0.008
Brugia malayi nuclear receptor NHR-88 0.0023 0.0032 0.0032
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0021 0.0023 0.0523
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0161 0.7359
Echinococcus granulosus dnaJ subfamily B 0.0901 0.3266 0.3266
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0056 0.0154 0.297
Loa Loa (eye worm) hypothetical protein 0.0103 0.0324 0.0324
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0001 0.0001
Plasmodium falciparum glutathione reductase 0.0015 0.0001 0.0032
Trypanosoma brucei importin beta-1 subunit, putative 0.002 0.0019 0.0019
Echinococcus granulosus FTZ F1 alpha 0.0023 0.0032 0.0032
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0135 0.0444 0.0444
Plasmodium vivax importin-beta 2, putative 0.002 0.0019 0.0599
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0022 0.0028 0.0028
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0023 0.0032 0.0032
Trichomonas vaginalis glutathione reductase, putative 0.0015 0.0001 0.0014
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0056 0.0154 0.297
Loa Loa (eye worm) hypothetical protein 0.0043 0.0104 0.0104
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0023 0.0032 0.0032
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0578 0.2075 0.2075
Brugia malayi beta-lactamase 0.0103 0.0324 0.0324
Schistosoma mansoni intermediate filament proteins 0.0044 0.0107 0.0107
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0103 0.0324 0.1369
Trichomonas vaginalis maltase-glucoamylase, putative 0.0056 0.0154 0.297
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0032 0.0032
Schistosoma mansoni cpg binding protein 0.0067 0.0192 0.0192
Entamoeba histolytica hypothetical protein 0.0023 0.0032 0.0717
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.2728 1 1
Mycobacterium ulcerans hypothetical protein 0.0103 0.0324 0.7199
Echinococcus granulosus neutral alpha glucosidase AB 0.0056 0.0154 0.0154
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0187 0.0635 0.0635
Entamoeba histolytica hypothetical protein 0.0023 0.0032 0.0717
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0043 0.0104 0.0438
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0001 0.0001
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0032 0.0032
Loa Loa (eye worm) fructose-1,6-bisphosphatase 0.2728 1 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0023 0.0032 0.0032
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0015 0.0001 0.0032
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0154 0.0154
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0001 0.0001
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0021 0.0023 0.0023
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0098 0.0307 0.1296
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0135 0.0444 0.0444
Brugia malayi Latrophilin receptor protein 2 0.0059 0.0164 0.0164
Entamoeba histolytica hypothetical protein 0.0023 0.0032 0.0717
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0023 0.0032 0.0032
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0001 0.0001
Echinococcus granulosus beta LACTamase domain containing family member 0.0103 0.0324 0.0324
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0023 0.0032 0.0032
Loa Loa (eye worm) transcription factor SMAD2 0.0087 0.0267 0.0267
Loa Loa (eye worm) CXXC zinc finger family protein 0.0063 0.0179 0.0179
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0058 0.0161 0.0681
Brugia malayi Glycosyl hydrolases family 31 protein 0.0021 0.0023 0.0023
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.026 0.0903 0.0903
Echinococcus multilocularis lysosomal alpha glucosidase 0.0254 0.0882 0.0882
Echinococcus granulosus importin subunit beta 1 0.002 0.0019 0.0019
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0059 0.0164 0.0164
Mycobacterium tuberculosis Conserved protein 0.0103 0.0324 0.1369
Brugia malayi Glycosyl hydrolases family 31 protein 0.0056 0.0154 0.0154
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0135 0.0444 0.0444
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0022 0.0028 0.0028
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0023 0.0032 0.0032
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0058 0.0161 0.0161
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0056 0.0154 0.3458
Schistosoma mansoni hypothetical protein 0.0059 0.0164 0.0164
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0006 0.0006
Trichomonas vaginalis mercuric reductase, putative 0.0015 0.0001 0.0014
Brugia malayi CXXC zinc finger family protein 0.0063 0.0179 0.0179
Mycobacterium tuberculosis Probable lipase LipD 0.0103 0.0324 0.1369
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0027 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0023 0.0032 0.0032
Entamoeba histolytica hypothetical protein 0.0016 0.0006 0.0124
Echinococcus multilocularis thioredoxin glutathione reductase 0.0043 0.0104 0.0104
Leishmania major trypanothione reductase 0.0043 0.0104 0.0104
Leishmania major mitochondrial DNA polymerase beta 0.026 0.0903 0.0903
Trypanosoma cruzi trypanothione reductase, putative 0.0015 0.0001 0.0001
Schistosoma mansoni alpha-glucosidase 0.0219 0.0751 0.0751
Trypanosoma cruzi trypanothione reductase, putative 0.0043 0.0104 0.0104
Mycobacterium ulcerans esterase/lipase LipP 0.0103 0.0324 0.7199
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0021 0.0021
Brugia malayi steroid hormone receptor 0.0023 0.0032 0.0032
Schistosoma mansoni cpg binding protein 0.0067 0.0192 0.0192
Echinococcus multilocularis isocitrate dehydrogenase 0.0022 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0021 0.0022 0.0022
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0023 0.0032 0.0032
Echinococcus multilocularis lamin dm0 0.0044 0.0107 0.0107
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0044 0.0107 0.0107
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0023 0.0032 0.0032
Toxoplasma gondii NADPH-glutathione reductase 0.0015 0.0001 0.0001
Trichomonas vaginalis alpha-glucosidase, putative 0.0056 0.0154 0.297
Plasmodium falciparum ataxin-2 like protein, putative 0.0074 0.0219 1
Mycobacterium leprae Probable lipase LipE 0.0103 0.0324 0.9264
Loa Loa (eye worm) MH2 domain-containing protein 0.0087 0.0267 0.0267
Trypanosoma cruzi hypothetical protein, conserved 0.0103 0.0324 0.0324
Onchocerca volvulus Bile acid receptor homolog 0.0023 0.0032 0.0197
Onchocerca volvulus 0.0103 0.0324 0.6103
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0023 0.0032 0.0032
Leishmania major hypothetical protein, conserved 0.0074 0.0219 0.0219
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0027 0.0044 0.0856
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0027 0.0044 0.0997
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.1014 0.3685 0.3685
Trichomonas vaginalis D-aminoacylase, putative 0.0103 0.0324 0.6271
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0058 0.0161 0.3638
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0022 0.0028 0.0028
Loa Loa (eye worm) cytochrome P450 family protein 0.0039 0.0089 0.0089
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0006 0.0006
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0023 0.0032 0.0032
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0022 0.0028 0.1271
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0024
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.002 0.0021 0.0021
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0135 0.0444 0.0444
Schistosoma mansoni lamin 0.0044 0.0107 0.0107
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0023 0.0032 0.0032
Brugia malayi hypothetical protein 0.0074 0.0219 0.0219
Brugia malayi beta-lactamase family protein 0.0103 0.0324 0.0324
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0021 0.0022 0.0022
Schistosoma mansoni inositol monophosphatase 0.0027 0.0044 0.0044
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0154 0.0154
Echinococcus granulosus snurportin 1 0.0213 0.0731 0.0731
Trypanosoma brucei mitochondrial DNA polymerase beta 0.026 0.0903 0.0903
Loa Loa (eye worm) glutathione reductase 0.0043 0.0104 0.0104
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0016 0.0006 0.0107
Onchocerca volvulus Protein ultraspiracle homolog 0.0023 0.0032 0.0197
Brugia malayi Pre-SET motif family protein 0.0021 0.0022 0.0022
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0059 0.0164 0.0164
Trypanosoma cruzi importin beta-1 subunit, putative 0.0016 0.0006 0.0006
Brugia malayi latrophilin 2 splice variant baaae 0.0128 0.0417 0.0417
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0033 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0021 0.0023 0.0023
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0001 0.0001
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0135 0.0444 0.8589
Loa Loa (eye worm) steroid hormone receptor 0.0023 0.0032 0.0032
Leishmania major 0.2728 1 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0023 0.0032 0.0032
Trichomonas vaginalis sucrase-isomaltase, putative 0.0056 0.0154 0.297
Trichomonas vaginalis alpha-glucosidase, putative 0.0021 0.0023 0.0449
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0032 0.0032
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0024 0.0034 0.0141
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0022 0.0028 0.0028
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0023 0.0032 0.0032
Trypanosoma cruzi hypothetical protein, conserved 0.0103 0.0324 0.0324
Schistosoma mansoni alpha-glucosidase 0.0219 0.0751 0.0751
Trypanosoma cruzi PAB1-binding protein , putative 0.0074 0.0219 0.0219
Loa Loa (eye worm) hypothetical protein 0.0023 0.0032 0.0032
Trypanosoma brucei hypothetical protein, conserved 0.0103 0.0324 0.0324
Loa Loa (eye worm) latrophilin receptor protein 2 0.0059 0.0164 0.0164
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0021 0.0024 0.0024
Plasmodium vivax SET domain protein, putative 0.0021 0.0022 0.0687
Schistosoma mansoni ap endonuclease 0.0058 0.0161 0.0161
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0023 0.0032 0.0032
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0135 0.0444 0.0444
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0103 0.0324 0.1369
Plasmodium vivax hypothetical protein, conserved 0.0103 0.0324 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0656 0.2362 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0032 0.0032
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0315 0.1106 0.1106
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0027 0.0044 0.0044
Plasmodium vivax thioredoxin reductase, putative 0.0043 0.0104 0.3213
Trichomonas vaginalis alpha-glucosidase, putative 0.0021 0.0023 0.0449
Brugia malayi MH2 domain containing protein 0.0087 0.0267 0.0267
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0032 0.0032
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0021 0.0022 0.0022
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0135 0.0444 0.0444
Trichomonas vaginalis alpha-glucosidase, putative 0.0056 0.0154 0.297
Toxoplasma gondii isocitrate dehydrogenase 0.0022 0.0028 0.0028
Mycobacterium ulcerans hypothetical protein 0.0137 0.045 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0103 0.0324 0.0324
Mycobacterium ulcerans lipase LipD 0.0103 0.0324 0.7199
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0058 0.0161 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0022 0.0028 0.0028
Schistosoma mansoni hypothetical protein 0.0059 0.0164 0.0164
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0016 0.0006 0.0107
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0056 0.0154 0.0154
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0098 0.0307 0.1296
Plasmodium vivax glutathione reductase, putative 0.0043 0.0104 0.3213
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0027 0.0044 0.0856
Onchocerca volvulus 0.0103 0.0324 0.6103
Toxoplasma gondii isocitrate dehydrogenase 0.0022 0.0028 0.0028
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0023 0.0032 0.0032
Brugia malayi Inositol-1 0.0027 0.0044 0.0044
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0015 0.0001 0.0022
Plasmodium vivax ataxin-2 like protein, putative 0.0074 0.0219 0.6771
Echinococcus granulosus histone lysine methyltransferase setb 0.0021 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.0059 0.0164 0.0164
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0006 0.0006
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0135 0.0444 0.8589
Echinococcus multilocularis lysosomal alpha glucosidase 0.0254 0.0882 0.0882
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0161 0.3124
Brugia malayi Cytochrome P450 family protein 0.0039 0.0089 0.0089
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.011 0.011
Mycobacterium tuberculosis Conserved hypothetical protein 0.0137 0.045 0.1902
Echinococcus granulosus intermediate filament protein 0.0044 0.0107 0.0107
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0023 0.0032 0.0032
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0315 0.1106 0.1106
Trypanosoma cruzi PAB1-binding protein , putative 0.0074 0.0219 0.0219
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0123 0.0399 0.0399
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0023 0.0032 0.0032
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0021 0.0024 0.0024
Toxoplasma gondii ABC1 family protein 0.0103 0.0324 0.0324
Mycobacterium tuberculosis Probable hydrolase 0.0103 0.0324 0.1369
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0103 0.0324 0.0324
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0058 0.0161 0.0161
Plasmodium falciparum importin beta, putative 0.002 0.0019 0.0885
Treponema pallidum exodeoxyribonuclease (exoA) 0.0058 0.0161 1
Loa Loa (eye worm) hypothetical protein 0.0187 0.0635 0.0635
Brugia malayi Thioredoxin reductase 0.0043 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0023 0.0032 0.0032
Schistosoma mansoni hypothetical protein 0.0033 0.0069 0.0069
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0022 0.0022
Trypanosoma brucei importin beta-1 subunit, putative 0.002 0.0019 0.0019
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0022 0.0028 0.0028
Brugia malayi beta-lactamase family protein 0.0103 0.0324 0.0324
Toxoplasma gondii HEAT repeat-containing protein 0.002 0.0019 0.0019
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0098 0.0307 0.8714
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0001 0.0001
Onchocerca volvulus 0.0044 0.0107 0.1715
Schistosoma mansoni lamin 0.0044 0.0107 0.0107
Echinococcus multilocularis ecdysone induced protein 78C 0.0023 0.0032 0.0032
Echinococcus multilocularis beta LACTamase domain containing family member 0.0103 0.0324 0.0324
Echinococcus multilocularis FTZ F1 alpha 0.0023 0.0032 0.0032
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0108 0.0343 0.0343
Mycobacterium leprae conserved hypothetical protein 0.0103 0.0324 0.9264
Mycobacterium tuberculosis Probable reductase 0.0098 0.0307 0.1296
Mycobacterium tuberculosis Probable esterase LipL 0.0103 0.0324 0.1369
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0109 0.0347 0.1467
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0021 0.0022 0.0022
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0059 0.0164 0.0164
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0058 0.0161 0.0161
Schistosoma mansoni hypothetical protein 0.0128 0.0417 0.0417
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0023 0.0032 0.0032
Plasmodium falciparum thioredoxin reductase 0.0043 0.0104 0.4745
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0315 0.1106 0.1106
Toxoplasma gondii hypothetical protein 0.0042 0.01 0.01
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0023 0.0032 0.0032
Schistosoma mansoni hypothetical protein 0.0901 0.3266 0.3266
Schistosoma mansoni coup transcription factor 0.0023 0.0032 0.0032
Brugia malayi intermediate filament protein 0.0044 0.0107 0.0107
Schistosoma mansoni alpha glucosidase 0.0056 0.0154 0.0154
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0135 0.0444 1
Echinococcus granulosus lysosomal alpha glucosidase 0.0254 0.0882 0.0882
Trypanosoma brucei glycosyl hydrolase-like protein 0.0021 0.0023 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0032 0.0032
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0032 0.0032
Echinococcus multilocularis snurportin 1 0.0213 0.0731 0.0731
Trichomonas vaginalis alpha-glucosidase, putative 0.0021 0.0023 0.0449
Trichomonas vaginalis set domain proteins, putative 0.0155 0.0517 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0032 0.0032
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0015 0.0001 0.0001
Onchocerca volvulus 0.0103 0.0324 0.6103
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0027 0.0044 0.0044
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0037 0.008 0.008

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) Agonist activity at human delta opioid receptor expressed CHO cells assessed as inhibition of [35S]-GTP[gammaS] binding at 10 uM ChEMBL. 24635568
Activity (functional) Antagonist activity at human delta opioid receptor expressed CHO cells assessed as inhibition of [35S]-GTP[gammaS] binding at 10 uM ChEMBL. 24635568
Ke (functional) = 194 nM Antagonist activity at human kappa opioid receptor expressed in CHO cells assessed as inhibition of U69,593 stimulated [35S]GTPgammaS binding ChEMBL. 21116435
Ke (functional) = 194 nM Antagonist activity at human kappa opioid receptor expressed CHO cells assessed as inhibition of [35S]-GTP[gammaS] binding ChEMBL. 24635568
Ke (functional) = 508 nM Antagonist activity at human mu opioid receptor expressed in CHO cells assessed as inhibition of DAMGO stimulated [35S]GTPgammaS binding ChEMBL. 21116435
Ke (binding) = 508 nM Antagonist activity at human mu opioid receptor expressed CHO cells assessed as inhibition of [35S]-GTP[gammaS] binding ChEMBL. 24635568
Ke (functional) > 10 uM Antagonist activity at human delta opioid receptor expressed in CHO cells assessed as inhibition of DPDPE stimulated [35S]GTPgammaS binding ChEMBL. 21116435

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.