Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | estrogen receptor 1 | Starlite/ChEMBL | References |
Homo sapiens | estrogen receptor 2 (ER beta) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | estrogen receptor 2 (ER beta) | 495 aa | 418 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.003 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.003 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.003 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.003 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.003 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.003 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.003 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.003 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.003 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.003 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.003 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.003 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.003 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.003 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.003 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.003 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.003 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.003 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.003 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.003 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.003 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.003 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.003 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.003 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.003 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.003 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.003 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.003 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.003 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.003 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.003 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.003 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.003 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.003 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.003 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.003 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.003 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.003 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.003 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.003 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.003 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.003 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.003 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.003 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.003 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.003 | 0.5 | 0.5 |
Onchocerca volvulus | 0.003 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.003 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.003 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.003 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.003 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.003 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.003 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.003 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.003 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.003 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.003 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.003 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.003 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.003 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.003 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.003 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Antagonism (functional) | = 89 % | Anti-estrogen effects in rat (uterine weight) following 1 mg/kg s.c. | ChEMBL. | 15125925 |
Antagonism (functional) | = 89 % | Anti-estrogen effects in rat (uterine weight) following 1 mg/kg s.c. | ChEMBL. | 15125925 |
CL (ADMET) | = 41 ml min-1 kg-1 | Plasma clearance of the compund in female SpragueDawley rats | ChEMBL. | 15125925 |
Estrogenic effect (functional) | = -2 % | Intrinsic estrogenic activity in rat (uterine weight) following 1 mg/kg s.c. | ChEMBL. | 15125925 |
Estrogenic effect (functional) | = -2 % | Intrinsic estrogenic activity in rat (uterine weight) following 1 mg/kg s.c. | ChEMBL. | 15125925 |
F (ADMET) | = 4.4 % | Bioavailability in rat (Sprague-Dawley) (female) | ChEMBL. | 15125925 |
IC50 (binding) | = 0.5 nM | Displacement of [3H]-17-beta-estradiol from full length human estrogen receptor alpha | ChEMBL. | 15125925 |
IC50 (binding) | = 0.5 nM | Displacement of [3H]-17-beta-estradiol from full length human estrogen receptor alpha | ChEMBL. | 15125925 |
IC50 (functional) | = 6.1 nM | Potency in cellular transactivation assay utilizing HEK-293 cells stably co-transfected with human estrogen receptor alpha and the alkaline phosphatase reporter gene. | ChEMBL. | 15125925 |
IC50 (functional) | = 6.1 nM | Potency in cellular transactivation assay utilizing HEK-293 cells stably co-transfected with human estrogen receptor alpha and the alkaline phosphatase reporter gene. | ChEMBL. | 15125925 |
IC50 (binding) | = 13 nM | Displacement of [3H]-17-beta-estradiol from full length human estrogen receptor beta | ChEMBL. | 15125925 |
IC50 (binding) | = 13 nM | Displacement of [3H]-17-beta-estradiol from full length human estrogen receptor beta | ChEMBL. | 15125925 |
IC50 (functional) | = 516.1 nM | Potency in cellular transactivation assay utilizing HEK-293 cells stably co-transfected with human estrogen receptor beta and the alkaline phosphatase reporter gene | ChEMBL. | 15125925 |
IC50 (functional) | = 516.1 nM | Potency in cellular transactivation assay utilizing HEK-293 cells stably co-transfected with human estrogen receptor beta and the alkaline phosphatase reporter gene | ChEMBL. | 15125925 |
T1/2 (ADMET) | = 5.9 hr | Half life period of the compound in female SpragueDawley rats | ChEMBL. | 15125925 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.