TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 274.333 | Formula: C16H19FN2O
H donors: 1 H acceptors: 1 LogP: 2.72 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(F)ccc1c1cncc(c1)CNC(C)C
InChi: 1S/C16H19FN2O/c1-11(2)19-9-12-6-13(10-18-8-12)15-5-4-14(17)7-16(15)20-3/h4-8,10-11,19H,9H2,1-3H3
InChiKey: GVQRMCLPLPTJNW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Glutamate [NMDA] receptor subunit epsilon 2	Starlite/ChEMBL	References
Homo sapiens	potassium voltage-gated channel, subfamily H (eag-related), member 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	potassium voltage gated channel subfamily H	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma japonicum	ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma mansoni	glutamate receptor NMDA	Get druggable targets OG5_129290	All targets in OG5_129290
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma japonicum	ko:K05314 glutamate receptor, ionotropic, N-methyl-D-aspartate 2, invertebrate, putative	Get druggable targets OG5_129290	All targets in OG5_129290
Echinococcus multilocularis	potassium voltage gated channel subfamily H	Get druggable targets OG5_128858	All targets in OG5_128858
Loa Loa (eye worm)	voltage and ligand gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma japonicum	Potassium voltage-gated channel subfamily H member 2, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Echinococcus granulosus	glutamate NMDA receptor subunit	Get druggable targets OG5_129290	All targets in OG5_129290
Schistosoma mansoni	voltage-gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma japonicum	ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma mansoni	voltage-gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	Get druggable targets OG5_129290	All targets in OG5_129290

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.005	0.0414	0.0414
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0045	0.0361	0.0361
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.002	0.0111	0.0111
Echinococcus multilocularis	glutamate receptor 2	0.0014	0.0041	0.0041
Brugia malayi	RNA recognition motif domain containing protein	0.0272	0.2714	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0111	0.0409
Schistosoma mansoni	tar DNA-binding protein	0.0272	0.2714	1
Echinococcus granulosus	FTZ F1 alpha	0.002	0.0111	0.0111
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0034	0.025	0.1746
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.002	0.0111	0.0409
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0014	0.0041	0.0041
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.002	0.0111	0.0111
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0052	0.0435	0.0435
Brugia malayi	ecdysteroid receptor	0.002	0.0111	0.0409
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0116	0.1098	0.4044
Loa Loa (eye worm)	steroid hormone receptor	0.002	0.0111	0.0409
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.002	0.0111	0.0416
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0045	0.0361	0.1331
Loa Loa (eye worm)	hypothetical protein	0.0107	0.1009	0.3716
Schistosoma mansoni	glutamate receptor NMDA	0.0014	0.0041	0.0152
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0014	0.0041	0.0041
Echinococcus granulosus	glutamate NMDA receptor subunit	0.0076	0.0683	0.0683
Echinococcus granulosus	neuropeptide receptor A26	0.0977	1	1
Echinococcus multilocularis	voltage gated potassium channel	0.0013	0.0034	0.0034
Loa Loa (eye worm)	TAR-binding protein	0.0272	0.2714	1
Echinococcus granulosus	survival motor neuron protein 1	0.0267	0.2664	0.2664
Trichomonas vaginalis	alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative	0.0077	0.0699	0.2362
Echinococcus multilocularis	tar DNA binding protein	0.0272	0.2714	0.2714
Schistosoma mansoni	hypothetical protein	0.005	0.0414	0.1524
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.002	0.0111	0.0409
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0014	0.0041	0.0041
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0052	0.0435	0.1604
Schistosoma mansoni	survival motor neuron protein	0.0055	0.0464	0.1711
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0157	0.1521	0.5605
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.002	0.0111	0.0409
Schistosoma mansoni	nuclear hormone receptor	0.002	0.0111	0.0409
Schistosoma mansoni	apoferritin-2	0.0018	0.009	0.0332
Schistosoma mansoni	tar DNA-binding protein	0.0272	0.2714	1
Brugia malayi	Pre-SET motif family protein	0.0034	0.025	0.092
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.002	0.0111	0.0409
Schistosoma mansoni	hypothetical protein	0.005	0.0414	0.1524
Brugia malayi	hypothetical protein	0.0267	0.2664	0.9815
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0014	0.0041	0.0041
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.002	0.0111	0.0409
Echinococcus multilocularis	Alpha N acetylgalactosaminidase	0.0116	0.1098	0.1098
Echinococcus granulosus	glutamate receptor 2	0.0014	0.0041	0.0041
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0011	0.0012	0.0012
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0013	0.0034	0.0126
Brugia malayi	Melibiase family protein	0.0077	0.0699	0.2575
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.002	0.0111	0.0111
Brugia malayi	Pre-SET motif family protein	0.0235	0.2333	0.8595
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0011	0.0012	0.0012
Echinococcus granulosus	geminin	0.0188	0.184	0.184
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.002	0.0111	0.0409
Echinococcus granulosus	ferritin	0.0018	0.009	0.009
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.002	0.0111	0.0111
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.002	0.0111	0.0409
Brugia malayi	latrophilin 2 splice variant baaae	0.0107	0.1009	0.3716
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0016	0.007	0.0259
Echinococcus multilocularis	muscleblind protein	0.0169	0.1646	0.1646
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.002	0.0111	0.0409
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.002	0.0111	0.0409
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.002	0.0111	0.0111
Brugia malayi	RNA binding protein	0.0272	0.2714	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0042	0.0331	0.0935
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0045	0.0361	0.0361
Brugia malayi	hypothetical protein	0.0011	0.0012	0.0044
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0898	0.9178	0.9178
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0116	0.1098	0.4044
Brugia malayi	TAR-binding protein	0.0272	0.2714	1
Schistosoma mansoni	voltage-gated potassium channel	0.0013	0.0034	0.0126
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0052	0.0435	0.0435
Brugia malayi	hypothetical protein	0.0011	0.0012	0.0044
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0116	0.1098	0.4044
Echinococcus granulosus	histone lysine methyltransferase setb	0.0034	0.025	0.025
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0052	0.0435	0.0435
Echinococcus multilocularis	Glycoside hydrolase, family 27	0.0116	0.1098	0.1098
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0011	0.0012	0.0044
Schistosoma mansoni	hypothetical protein	0.005	0.0414	0.1524
Schistosoma mansoni	hypothetical protein	0.005	0.0414	0.1524
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0034	0.025	0.025
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.002	0.0111	0.0111
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	0.0076	0.0683	0.0683
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0077	0.0699	0.2575
Mycobacterium leprae	PROBABLE BACTERIOFERRITIN BFRA	0.0018	0.009	0.5
Loa Loa (eye worm)	latrophilin receptor protein 2	0.005	0.0414	0.1524
Plasmodium vivax	SET domain protein, putative	0.0034	0.025	0.5
Brugia malayi	photoreceptor-specific nuclear receptor	0.002	0.0111	0.0409
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0013	0.0034	0.0034
Echinococcus granulosus	muscleblind protein	0.0169	0.1646	0.1646
Onchocerca volvulus		0.0034	0.025	0.0936
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.005	0.0414	0.0414
Echinococcus granulosus	Alpha N acetylgalactosaminidase	0.0116	0.1098	0.1098
Loa Loa (eye worm)	hypothetical protein	0.002	0.0111	0.0409
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.002	0.0111	0.0409
Schistosoma mansoni	thyroid hormone receptor	0.002	0.0111	0.0409
Schistosoma mansoni	voltage-gated potassium channel	0.0049	0.0404	0.1487
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0052	0.0435	0.1604
Chlamydia trachomatis	glutamine binding protein	0.0023	0.0139	0.5
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.002	0.0111	0.0409
Echinococcus granulosus	voltage gated potassium channel	0.0013	0.0034	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0034	0.025	0.092
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.005	0.0414	0.0414
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.002	0.0111	0.0409
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.002	0.0111	0.0409
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0034	0.025	0.092
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0014	0.0041	0.0041
Schistosoma mansoni	coup transcription factor	0.002	0.0111	0.0409
Brugia malayi	Nuclear hormone receptor-like 1	0.002	0.0111	0.0409
Echinococcus multilocularis	muscleblind protein 1	0.0169	0.1646	0.1646
Echinococcus granulosus	expressed protein	0.0018	0.009	0.009
Wolbachia endosymbiont of Brugia malayi	bacterioferritin/cytochrome b1	0.0018	0.009	0.5
Onchocerca volvulus	Protein ultraspiracle homolog	0.002	0.0111	0.0416
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.002	0.0111	0.0111
Schistosoma mansoni	RAR-like nuclear receptor	0.002	0.0111	0.0409
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0042	0.0331	0.0935
Chlamydia trachomatis	arginine ABC transporter substrate-binding protein ArtJ	0.0023	0.0139	0.5
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0034	0.025	0.025
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0077	0.0699	0.2575
Schistosoma mansoni	ferritin	0.0018	0.009	0.0332
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0699	0.2575
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0034	0.0126
Schistosoma mansoni	ferritin light chain	0.0018	0.009	0.0332
Echinococcus multilocularis	FTZ F1 alpha	0.002	0.0111	0.0111
Schistosoma mansoni	tar DNA-binding protein	0.0272	0.2714	1
Schistosoma mansoni	voltage-gated potassium channel	0.0049	0.0404	0.1487
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0011	0.0012	0.0044
Echinococcus granulosus	GPCR family 2	0.005	0.0414	0.0414
Schistosoma mansoni	ferritin light chain	0.0018	0.009	0.0332
Echinococcus multilocularis	thyroid hormone receptor alpha	0.002	0.0111	0.0111
Schistosoma mansoni	tar DNA-binding protein	0.0272	0.2714	1
Echinococcus granulosus	tar DNA binding protein	0.0272	0.2714	0.2714
Schistosoma mansoni	hypothetical protein	0.0188	0.184	0.6778
Schistosoma mansoni	apoferritin-2	0.0018	0.009	0.0332
Loa Loa (eye worm)	hypothetical protein	0.005	0.0414	0.1524
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.0012	0.0044
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.025	0.092
Brugia malayi	nuclear hormone receptor	0.002	0.0111	0.0409
Schistosoma mansoni	ferritin	0.0018	0.009	0.0332
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0235	0.2333	0.8595
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0012	0.0044
Brugia malayi	nuclear receptor NHR-88	0.002	0.0111	0.0409
Echinococcus multilocularis	survival motor neuron protein 1	0.0267	0.2664	0.2664
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.002	0.0111	0.0409
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.002	0.0111	0.0409
Echinococcus multilocularis	neuropeptide receptor A26	0.0977	1	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.0435	0.1604
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.002	0.0111	0.0409
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.002	0.0111	0.0409
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.002	0.0111	0.0111
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.0435	0.1604
Schistosoma mansoni	glutamate receptor NMDA	0.0076	0.0683	0.2515
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0301	0.1107
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.025	0.092
Schistosoma mansoni	thyroid hormone receptor	0.002	0.0111	0.0409
Loa Loa (eye worm)	hypothetical protein	0.002	0.0111	0.0409
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0272	0.2714	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0111	0.0409
Loa Loa (eye worm)	hypothetical protein	0.002	0.0111	0.0409
Toxoplasma gondii	melibiase subfamily protein	0.0116	0.1098	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.002	0.0111	0.0111
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.002	0.0111	0.0409
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.002	0.0111	0.0409
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.002	0.0111	0.0409
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.002	0.0111	0.0409
Schistosoma mansoni	hypothetical protein	0.0188	0.184	0.6778
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.005	0.0414	0.0414
Onchocerca volvulus		0.0055	0.0464	0.1741
Brugia malayi	Latrophilin receptor protein 2	0.005	0.0414	0.1524
Schistosoma mansoni	hypothetical protein	0.0055	0.0464	0.1711
Brugia malayi	Steroid receptor seven-up type 2	0.002	0.0111	0.0409
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0013	0.0034	0.0034
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.005	0.0414	0.1524
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.0012	0.0044
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0014	0.0041	0.0041
Schistosoma mansoni	voltage-gated potassium channel	0.0013	0.0034	0.0126
Echinococcus multilocularis	nmda type glutamate receptor	0.0032	0.0231	0.0231
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0116	0.1098	0.4044
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.002	0.0111	0.0111
Schistosoma mansoni	ferritin	0.0018	0.009	0.0332
Loa Loa (eye worm)	RNA binding protein	0.0272	0.2714	1
Loa Loa (eye worm)	hypothetical protein	0.0169	0.1646	0.6066
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.002	0.0111	0.0111
Schistosoma mansoni	tar DNA-binding protein	0.0272	0.2714	1
Trichomonas vaginalis	set domain proteins, putative	0.0268	0.2669	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0157	0.1521	0.5605
Echinococcus multilocularis	GPCR, family 2	0.005	0.0414	0.0414
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0055	0.0464	0.1711
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.0435	0.1604
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0014	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.002	0.0111	0.0409
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.002	0.0111	0.0409
Onchocerca volvulus	Bile acid receptor homolog	0.002	0.0111	0.0416
Onchocerca volvulus		0.002	0.0111	0.0416
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein (hisJ)	0.0023	0.0139	1
Echinococcus granulosus	ecdysone induced protein 78C	0.002	0.0111	0.0111
Schistosoma mansoni	ferritin	0.0018	0.009	0.0332
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0012	0.0044
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 3	0.0032	0.0231	0.0231
Schistosoma mansoni	retinoic acid receptor RXR	0.002	0.0111	0.0409
Brugia malayi	Muscleblind-like protein	0.0169	0.1646	0.6066
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein	0.0023	0.0139	1
Echinococcus multilocularis	geminin	0.0188	0.184	0.184
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.002	0.0111	0.0409
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0012	0.0044
Loa Loa (eye worm)	hypothetical protein	0.002	0.0111	0.0409
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.025	0.092
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0045	0.0361	0.1331
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0012	0.0044
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0052	0.0435	0.0435
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0157	0.1521	0.5605
Onchocerca volvulus		0.0268	0.2669	1
Brugia malayi	nuclear receptor RXR	0.0011	0.0012	0.0044
Brugia malayi	steroid hormone receptor	0.002	0.0111	0.0409
Mycobacterium tuberculosis	Probable glutamine-binding lipoprotein GlnH (GLNBP)	0.0023	0.0139	1
Echinococcus multilocularis	ferritin	0.0018	0.009	0.009
Echinococcus multilocularis	neuropeptide s receptor	0.0977	1	1
Mycobacterium ulcerans	glutamine-binding lipoprotein GlnH	0.0023	0.0139	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.002	0.0111	0.0111
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.002	0.0111	0.0409
Schistosoma mansoni	steroid hormone receptor ad4bp	0.002	0.0111	0.0409
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.002	0.0111	0.0111
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0011	0.0012	0.0044
Schistosoma mansoni	hypothetical protein	0.0107	0.1009	0.3716
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0033	0.0237	0.0237
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0014	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0267	0.2664	0.9815
Echinococcus multilocularis	expressed protein	0.0018	0.009	0.009
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.002	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0157	0.1521	0.5605
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.002	0.0111	0.0409
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.002	0.0111	0.0409
Loa Loa (eye worm)	hypothetical protein	0.0169	0.1646	0.6066
Echinococcus granulosus	nmda type glutamate receptor	0.0032	0.0231	0.0231
Loa Loa (eye worm)	hypothetical protein	0.002	0.0111	0.0409
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0012	0.0044

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 6.67 uM	Inhibition of human ERG expressed in CHOK1 cells electrophysiology study	ChEMBL.	21524576
Ki (binding)	= 266 nM	Displacement of [3H]CP101606 from NR2B in rat brain minus cerebellum membrane	ChEMBL.	21524576

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1779008

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1526197