TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 534.691 | Formula: C34H38N4O2
H donors: 1 H acceptors: 2 LogP: 5.72 Rotable bonds: 7
Rule of 5 violations (Lipinski): 2
SMILES: O=C(c1ccccc1)N1CCC(CC1)(CCN1C2CCC1CC(C2)n1c(=O)[nH]c2c1cccc2)c1ccccc1
InChi: 1S/C34H38N4O2/c39-32(25-9-3-1-4-10-25)36-20-17-34(18-21-36,26-11-5-2-6-12-26)19-22-37-27-15-16-28(37)24-29(23-27)38-31-14-8-7-13-30(31)35-33(38)40/h1-14,27-29H,15-24H2,(H,35,40)
InChiKey: FUXFIESUNZUREI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	chemokine (C-C motif) receptor 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	methyltransferase protein 5	0.0096	0.0264	0.0264
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0136	0.0394	0.0635
Echinococcus multilocularis		0.0041	0.0085	0.0107
Loa Loa (eye worm)	sirtuin 4	0.0066	0.0167	0.0159
Trypanosoma cruzi	arginine N-methyltransferase, type I	0.0096	0.0264	0.1575
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0056	0.0048
Trypanosoma cruzi	Silent information regulator 2 related protein 3	0.0066	0.0167	0.0863
Echinococcus multilocularis	MAM	0.007	0.018	0.0225
Toxoplasma gondii	PA14 domain-containing protein	0.0032	0.0056	0.0959
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4)	0.0136	0.0394	1
Echinococcus multilocularis	discoidin domain containing receptor 2	0.0032	0.0056	0.0069
Chlamydia trachomatis	protoporphyrinogen oxidase	0.0041	0.0085	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0617	0.1951	0.3193
Toxoplasma gondii	subtilisin SUB1	0.0136	0.0394	0.7775
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0066	0.0167	0.0262
Giardia lamblia	Sirtuin type 2	0.0066	0.0167	0.0437
Loa Loa (eye worm)	hypothetical protein	0.007	0.018	0.0173
Onchocerca volvulus		0.0032	0.0056	0.0649
Plasmodium falciparum	protein arginine N-methyltransferase 1	0.0171	0.0505	1
Trichomonas vaginalis	conserved hypothetical protein	0.0617	0.1951	0.3193
Brugia malayi	proprotein convertase 2	0.196	0.6299	0.6296
Onchocerca volvulus		0.0077	0.02	0.2889
Schistosoma mansoni	hypothetical protein	0.0019	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.003	0.005	0.0042
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0449	0.1406	0.2297
Leishmania major	arginine N-methyltransferase, type III, putative;with=GeneDB:Tb927.7.5490	0.0096	0.0264	0.1575
Toxoplasma gondii	bicoid-interacting protein BIN3	0.0096	0.0264	0.5148
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0136	0.0394	0.0635
Schistosoma mansoni	hypothetical protein	0.0019	0.0014	0.0014
Mycobacterium leprae	PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3)	0.0136	0.0394	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0014	0.0006
Brugia malayi	Furin-like cysteine rich region family protein	0.025	0.0761	0.0753
Plasmodium vivax	subtilisin-like protease 2, putative	0.0136	0.0394	0.7568
Loa Loa (eye worm)	hypothetical protein	0.007	0.018	0.0173
Loa Loa (eye worm)	hypothetical protein	0.3103	1	1
Schistosoma mansoni	neuropilin (nrp) and tolloid (tll)-like	0.0019	0.0014	0.0014
Loa Loa (eye worm)	transcriptional regulator	0.0449	0.1406	0.1399
Trypanosoma brucei	protein arginine n-methyltransferase 7	0.0096	0.0264	0.078
Plasmodium falciparum	LCCL domain-containing protein	0.0032	0.0056	0.012
Brugia malayi	hypothetical protein	0.0019	0.0014	0.0006
Toxoplasma gondii	subtilisin SUB9	0.0136	0.0394	0.7775
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 1	0.0066	0.0167	0.0209
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0069	0.0177	0.1211
Mycobacterium ulcerans	Sir2-like regulatory protein	0.0066	0.0167	0.2647
Brugia malayi	Zinc metalloproteinase toh-2 precursor	0.0019	0.0014	0.0006
Mycobacterium ulcerans	membrane-anchored serine protease (mycosin), MycP4	0.0136	0.0394	1
Mycobacterium leprae	PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5)	0.0136	0.0394	1
Echinococcus multilocularis	Furin 1	0.0754	0.2392	0.299
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0066	0.0167	0.0262
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0136	0.0394	0.0635
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.0041	0.0085	0.0774
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0136	0.0394	0.0635
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0066	0.0167	0.0262
Toxoplasma gondii	subtilisin SUB12	0.0136	0.0394	0.7775
Loa Loa (eye worm)	bone morphogenetic protein 1b	0.0019	0.0014	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0014	0.0006
Onchocerca volvulus		0.0219	0.066	1
Giardia lamblia	High cysteine membrane protein Group 2	0.1143	0.3654	1
Echinococcus multilocularis	neuroendocrine convertase 2	0.196	0.6299	0.7872
Schistosoma mansoni	protein arginine N-methyltransferase 1	0.0171	0.0505	0.0505
Schistosoma mansoni	protein arginine N-methyltransferase 1	0.0171	0.0505	0.0505
Echinococcus multilocularis	protein arginine N methyltransferase 7	0.0096	0.0264	0.0329
Toxoplasma gondii	histone arginine methyltransferase PRMT1	0.0171	0.0505	1
Echinococcus granulosus	growth factor receptor bound protein 2	0.0123	0.0351	0.0351
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0056	0.0078
Echinococcus granulosus	neuropilin nrp and tolloid tll	0.0019	0.0014	0.0014
Toxoplasma gondii	subtilisin SUB5	0.0136	0.0394	0.7775
Echinococcus granulosus	cubilin	0.0019	0.0014	0.0014
Echinococcus multilocularis	neuropilin (nrp) and tolloid (tll)	0.0019	0.0014	0.0017
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0023	0.0027	0.0027
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0754	0.2392	0.3918
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0136	0.0394	0.0635
Trichomonas vaginalis	leucine-rich repeat protein, BspA family	0.0617	0.1951	0.3193
Trypanosoma cruzi	arginine N-methyltransferase, type III	0.0096	0.0264	0.1575
Plasmodium falciparum	protoporphyrinogen oxidase	0.0041	0.0085	0.0774
Schistosoma mansoni	discoidin domain receptor	0.0032	0.0056	0.0056
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0066	0.0167	0.0262
Trichomonas vaginalis	conserved hypothetical protein	0.0617	0.1951	0.3193
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0078	0.0204	0.0255
Leishmania major	UDP-galactopyranose mutase	0.0041	0.0085	0.0259
Brugia malayi	Protein arginine N-methyltransferase	0.0096	0.0264	0.0256
Schistosoma mansoni	growth factor receptor-bound protein	0.0123	0.0351	0.0351
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0136	0.0394	0.0635
Schistosoma mansoni	chromatin regulatory protein sir2	0.0066	0.0167	0.0167
Brugia malayi	Kelch motif family protein	0.0019	0.0014	0.0006
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0123	0.0351	0.0438
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0136	0.0394	0.0635
Trypanosoma cruzi	subtilisin peptidase	0.0136	0.0394	0.2538
Schistosoma mansoni	hypothetical protein	0.003	0.005	0.005
Schistosoma mansoni	chromatin regulatory protein sir2	0.0066	0.0167	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0394	0.0387
Trichomonas vaginalis	protein arginine N-methyltransferase, putative	0.0096	0.0264	0.042
Plasmodium vivax	hypothetical protein, conserved	0.0066	0.0167	0.2573
Echinococcus multilocularis	protein kinase c epsilon type	0.0085	0.0228	0.0285
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0449	0.1406	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0754	0.2392	0.3918
Toxoplasma gondii	subtilisin SUB2	0.0136	0.0394	0.7775
Onchocerca volvulus		0.003	0.005	0.0564
Trichomonas vaginalis	protein arginine N-methyltransferase, putative	0.0171	0.0505	0.0817
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0056	0.0078
Toxoplasma gondii	subtilisin SUB10	0.0136	0.0394	0.7775
Plasmodium vivax	LCCL domain-containing protein	0.0032	0.0056	0.012
Brugia malayi	NAD-dependent deacetylase SIRT1	0.0066	0.0167	0.0159
Toxoplasma gondii	histone deacetylase SIR2	0.0066	0.0167	0.3203
Brugia malayi	protein kinase C II.	0.0085	0.0228	0.022
Plasmodium vivax	NAD-dependent deacetylase, putative	0.0066	0.0167	0.2573
Echinococcus multilocularis	epidermal growth factor receptor	0.025	0.0761	0.095
Trichomonas vaginalis	conserved hypothetical protein	0.0617	0.1951	0.3193
Trypanosoma brucei	subtilisin peptidase	0.0136	0.0394	0.1834
Entamoeba histolytica	arginine N-methyltransferase protein, putative	0.0267	0.0816	0.5779
Toxoplasma gondii	subtilisin SUB6	0.0136	0.0394	0.7775
Schistosoma mansoni	furin-1 (S08 family)	0.1343	0.4301	0.4301
Echinococcus granulosus	discoidin domain containing receptor 2	0.0032	0.0056	0.0056
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0136	0.0394	0.0635
Brugia malayi	Angiotensin-converting enzyme family protein	0.0606	0.1914	0.1907
Plasmodium falciparum	transcriptional regulatory protein sir2b	0.0066	0.0167	0.2573
Trichomonas vaginalis	conserved hypothetical protein	0.0136	0.0394	0.0635
Loa Loa (eye worm)	proprotein convertase 2	0.0754	0.2392	0.2386
Echinococcus granulosus	peptidase s8 s53 subtilisin kexin sedolisin	0.0136	0.0394	0.0394
Schistosoma mansoni	protein arginine n-methyltransferase	0.0096	0.0264	0.0264
Schistosoma mansoni	chromatin regulatory protein sir2	0.0449	0.1406	0.1406
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0449	0.1406	1
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0066	0.0167	0.1139
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0042	0.0034
Trypanosoma cruzi	Silent information regulator 2 related protein 1	0.0449	0.1406	1
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.0136	0.0394	0.0394
Toxoplasma gondii	F5/8 type C domain-containing protein	0.0032	0.0056	0.0959
Brugia malayi	hypothetical protein	0.0041	0.0085	0.0077
Echinococcus granulosus	tissue type plasminogen activator	0.003	0.005	0.005
Plasmodium vivax	LCCL domain-containing protein	0.0032	0.0056	0.012
Schistosoma mansoni	site-1 peptidase (S08 family)	0.0136	0.0394	0.0394
Brugia malayi	Hypothetical subtilase-type proteinase F21H12.6 in chromosome II	0.0136	0.0394	0.0387
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0136	0.0394	0.0635
Echinococcus granulosus	SWI:SNF complex subunit SMARCC2	0.0017	0.0008	0.0008
Schistosoma mansoni	hypothetical protein	0.0096	0.0264	0.0264
Echinococcus multilocularis	histone arginine methyltransferase CARMER	0.0096	0.0264	0.0329
Loa Loa (eye worm)	TK/EGFR protein kinase	0.025	0.0761	0.0753
Loa Loa (eye worm)	endoprotease bli-4	0.3103	1	1
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 3	0.0449	0.1406	0.1757
Brugia malayi	Calcium binding EGF domain containing protein	0.0028	0.0042	0.0034
Mycobacterium tuberculosis	Possible oxidoreductase	0.0041	0.0085	0.0877
Entamoeba histolytica	NAD-dependent deacetylase 1, putative	0.0066	0.0167	0.1139
Entamoeba histolytica	hypothetical protein	0.0267	0.0816	0.5779
Brugia malayi	amine oxidase, flavin-containing family protein	0.0058	0.014	0.0133
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0041	0.0085	0.0877
Loa Loa (eye worm)	DPY-31 protein	0.0019	0.0014	0.0006
Echinococcus multilocularis	proprotein convertase subtilisin:kexin type 5	0.1897	0.6093	0.7615
Schistosoma mansoni	chromatin regulatory protein sir2	0.0066	0.0167	0.0167
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0041	0.0085	0.0774
Toxoplasma gondii	subtilisin SUB4	0.0136	0.0394	0.7775
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0056	0.0078
Onchocerca volvulus		0.007	0.018	0.258
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0123	0.0351	0.0343
Echinococcus multilocularis	discoidin domain receptor	0.0032	0.0056	0.0069
Brugia malayi	neuroendocrine convertase 1 precursor	0.196	0.6299	0.6296
Schistosoma mansoni	discoidin domain receptor	0.0032	0.0056	0.0056
Brugia malayi	CUB domain containing protein	0.0019	0.0014	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0014	0.0006
Echinococcus granulosus	serine:threonine protein kinase N2	0.0069	0.0177	0.0177
Echinococcus multilocularis	protein arginine N methyltransferase 8	0.0171	0.0505	0.0631
Loa Loa (eye worm)	hypothetical protein	0.007	0.018	0.0173
Trypanosoma brucei	Protein arginine N-methyltransferase 1 catalytic subunit	0.0267	0.0816	0.5237
Echinococcus multilocularis	nuclear receptor 2C2 associated protein	0.0032	0.0056	0.0069
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0016	0.0004	0.0005
Trichomonas vaginalis	hypothetical protein	0.0617	0.1951	0.3193
Echinococcus multilocularis	discoidin domain containing receptor 2	0.0032	0.0056	0.0069
Trichomonas vaginalis	proprotein convertase subtilisin/kexin type, putative	0.0617	0.1951	0.3193
Brugia malayi	CUB domain containing protein	0.0019	0.0014	0.0006
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.1897	0.6093	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0136	0.0394	0.0635
Echinococcus multilocularis	protein arginine methyltransferase	0.0171	0.0505	0.0631
Mycobacterium tuberculosis	Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5)	0.0136	0.0394	1
Plasmodium vivax	protein arginine N-methyltransferase 1, putative	0.0171	0.0505	1
Trichomonas vaginalis	conserved hypothetical protein	0.0136	0.0394	0.0635
Trichomonas vaginalis	beta-hexosaminidase B, putative	0.0032	0.0056	0.0078
Loa Loa (eye worm)	CUB domain-containing protein	0.0019	0.0014	0.0006
Loa Loa (eye worm)	CUB domain-containing protein	0.0019	0.0014	0.0006
Leishmania major	silent information regulator 2, putative	0.0449	0.1406	1
Schistosoma mansoni	hypothetical protein	0.0019	0.0014	0.0014
Loa Loa (eye worm)	zinc metalloproteinase toh-2	0.0019	0.0014	0.0006
Trichomonas vaginalis	protein arginine N-methyltransferase, putative	0.0096	0.0264	0.042
Echinococcus granulosus	protein arginine N methyltransferase 8	0.0171	0.0505	0.0505
Echinococcus granulosus	Tolloid protein 1	0.0019	0.0014	0.0014
Toxoplasma gondii	histone arginine methyltransferase PRMT4/CARM1	0.0096	0.0264	0.5148
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0056	0.0078
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0056	0.0078
Loa Loa (eye worm)	TK/ALK protein kinase	0.007	0.018	0.0173
Trichomonas vaginalis	protein arginine N-methyltransferase, putative	0.0171	0.0505	0.0817
Toxoplasma gondii	histone lysine-specific demethylase LSD1/BHC110/KDMA1A	0.0041	0.0085	0.1557
Brugia malayi	CUB domain containing protein	0.0019	0.0014	0.0006
Schistosoma mansoni	hypothetical protein	0.007	0.018	0.018
Echinococcus granulosus	protein arginine methyltransferase	0.0171	0.0505	0.0505
Schistosoma mansoni	serine/threonine protein kinase	0.0016	0.0004	0.0004
Onchocerca volvulus		0.0032	0.0056	0.0649
Trichomonas vaginalis	neuroendocrine convertase 2 precursor, putative	0.0617	0.1951	0.3193
Echinococcus granulosus	furin	0.3103	1	1
Brugia malayi	Carm1-pending protein	0.0096	0.0264	0.0256
Loa Loa (eye worm)	hypothetical protein	0.0058	0.014	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0054	0.0047
Echinococcus multilocularis	cubilin	0.0019	0.0014	0.0017
Trypanosoma cruzi	Silent information regulator 2 related protein 3	0.0066	0.0167	0.0863
Echinococcus multilocularis	protoporphyrinogen oxidase	0.0041	0.0085	0.0107
Trypanosoma brucei	Silent information regulator 2 related protein 1	0.0449	0.1406	1
Schistosoma mansoni	chromatin regulatory protein sir2	0.0449	0.1406	0.1406
Echinococcus multilocularis	Tolloid protein 1	0.0019	0.0014	0.0017
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0041	0.0085	0.0259
Trichomonas vaginalis	conserved hypothetical protein	0.0617	0.1951	0.3193
Echinococcus granulosus	NAD dependent deacetylase sirtuin 7	0.0066	0.0167	0.0167
Schistosoma mansoni	hypothetical protein	0.0019	0.0014	0.0014
Schistosoma mansoni	septate junction protein	0.004	0.0084	0.0084
Schistosoma mansoni	hypothetical protein	0.007	0.018	0.018
Loa Loa (eye worm)	subtilase	0.0136	0.0394	0.0387
Toxoplasma gondii	subtilisin SUB7	0.0136	0.0394	0.7775
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0754	0.2392	0.3918
Echinococcus granulosus	protein arginine N methyltransferase 7	0.0096	0.0264	0.0264
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0754	0.2392	0.3918
Plasmodium vivax	hypothetical protein, conserved	0.0041	0.0085	0.0774
Echinococcus granulosus	membrane bound transcription factor site 1	0.0136	0.0394	0.0394
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0136	0.0394	0.0635
Trypanosoma cruzi	protein arginine n-methyltransferase 7	0.0096	0.0264	0.1575
Trypanosoma cruzi	arginine N-methyltransferase, putative	0.0267	0.0816	0.5648
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.0155	0.0455	0.2988
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0754	0.2392	0.3918
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0085	0.0077
Echinococcus multilocularis	chromatin regulatory protein sir2	0.0449	0.1406	0.1757
Loa Loa (eye worm)	DEAH box polypeptide 35	0.0031	0.0054	0.0047
Echinococcus granulosus	CUB	0.0019	0.0014	0.0014
Toxoplasma gondii	histone deacetylase SIR2-like	0.0066	0.0167	0.3203
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0056	0.0078
Echinococcus granulosus	discoidin domain receptor	0.0032	0.0056	0.0056
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0056	0.0078
Trichomonas vaginalis	conserved hypothetical protein	0.0617	0.1951	0.3193
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0056	0.0048
Echinococcus granulosus	discoidin domain containing receptor 2	0.0032	0.0056	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0014	0.0006
Mycobacterium tuberculosis	Transcriptional regulatory protein	0.0066	0.0167	0.3293
Brugia malayi	Probable ATP-dependent helicase DHX35	0.0031	0.0054	0.0047
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0056	0.0078
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0136	0.0394	0.0635
Schistosoma mansoni	growth factor receptor-bound protein	0.0123	0.0351	0.0351
Echinococcus granulosus	MAM	0.007	0.018	0.018
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.3103	1	1
Brugia malayi	celfurPC protein	0.2486	0.8002	0.8
Echinococcus multilocularis	CUB	0.0019	0.0014	0.0017
Brugia malayi	hypothetical protein	0.007	0.018	0.0173
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0041	0.0085	0.0085
Trichomonas vaginalis	alpha-L-fucosidase, putative	0.0032	0.0056	0.0078
Echinococcus granulosus	neuroendocrine convertase 2	0.196	0.6299	0.6299
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0056	0.0078
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0056	0.0078
Toxoplasma gondii	subtilisin SUB8	0.0136	0.0394	0.7775
Schistosoma mansoni	site-1 peptidase (S08 family)	0.0136	0.0394	0.0394
Echinococcus multilocularis	cubilin	0.0019	0.0014	0.0017
Mycobacterium leprae	Possible secreted protease	0.0136	0.0394	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0116	0.0109
Echinococcus granulosus	Protein kinase C brain isozyme	0.0016	0.0004	0.0004
Echinococcus granulosus	discoidin domain containing receptor 2	0.0032	0.0056	0.0056
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0136	0.0394	0.0635
Brugia malayi	Kringle domain containing protein	0.003	0.005	0.0042
Giardia lamblia	Hypothetical protein	0.0449	0.1406	0.3834
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0014	0.0006
Trichomonas vaginalis	conserved hypothetical protein	0.0617	0.1951	0.3193
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0014	0.0009
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0023	0.0027	0.0027
Echinococcus granulosus	chromatin regulatory protein sir2	0.0449	0.1406	0.1406
Brugia malayi	Subtilase family protein	0.0136	0.0394	0.0387
Echinococcus granulosus	NAD dependent deacetylase sirtuin 1	0.0066	0.0167	0.0167
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0449	0.1406	0.2297
Brugia malayi	Membrane-bound transcription factor site-1 protease precursor	0.0136	0.0394	0.0387
Trichomonas vaginalis	conserved hypothetical protein	0.0617	0.1951	0.3193
Loa Loa (eye worm)	angiotensin-converting enzyme family protein	0.0606	0.1914	0.1907
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 6	0.0066	0.0167	0.0209
Toxoplasma gondii	F5/8 type C domain-containing protein	0.0032	0.0056	0.0959
Echinococcus granulosus	protein kinase c epsilon type	0.0085	0.0228	0.0228
Plasmodium vivax	subtilisin-like serine protease, putative	0.0136	0.0394	0.7568
Echinococcus granulosus	cubilin	0.0019	0.0014	0.0014
Schistosoma mansoni	protein arginine N-methyltransferase 1	0.0171	0.0505	0.0505
Mycobacterium tuberculosis	Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like)	0.0136	0.0394	1
Brugia malayi	astacin protease protein 30	0.0019	0.0014	0.0006
Onchocerca volvulus		0.007	0.018	0.258
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3)	0.0136	0.0394	1
Echinococcus granulosus	NAD dependent deacetylase sirtuin 6	0.0066	0.0167	0.0167
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 7	0.0066	0.0167	0.0209
Schistosoma mansoni	matrix metallopeptidase-9 (M10 family)	0.0071	0.0182	0.0182
Loa Loa (eye worm)	protein arginine N-methyltransferase	0.0096	0.0264	0.0256
Toxoplasma gondii	F5/8 type C domain-containing protein	0.0032	0.0056	0.0959
Toxoplasma gondii	kringle domain-containing protein	0.003	0.005	0.0849
Loa Loa (eye worm)	hypothetical protein	0.0267	0.0816	0.0809
Loa Loa (eye worm)	hypothetical protein	0.1207	0.3859	0.3854
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0136	0.0394	0.0635
Schistosoma mansoni	serine/threonine protein kinase	0.0085	0.0228	0.0228
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0167	0.0159
Brugia malayi	SWIRM domain containing protein	0.0219	0.066	0.0653
Schistosoma mansoni	neuropilin (nrp) and tolloid (tll)-like	0.0019	0.0014	0.0014
Plasmodium falciparum	subtilisin-like protease 1	0.0136	0.0394	0.7568
Plasmodium falciparum	subtilisin-like protease 3	0.0136	0.0394	0.7568
Trypanosoma cruzi	arginine N-methyltransferase, putative	0.0267	0.0816	0.5648
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.0041	0.0085	0.0774
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.0041	0.0085	0.0085
Echinococcus granulosus	Furin 1	0.0754	0.2392	0.2392
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0066	0.0167	0.0262
Loa Loa (eye worm)	transcriptional regulator	0.0066	0.0167	0.0159
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0754	0.2392	0.3918
Brugia malayi	hypothetical protein	0.0267	0.0816	0.0809
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.0041	0.0085	0.0774
Brugia malayi	transcriptional regulator, Sir2 family protein	0.0066	0.0167	0.0159
Onchocerca volvulus	Putative cubilin	0.0028	0.0042	0.0436
Mycobacterium ulcerans	NAD-dependent deacetylase	0.0066	0.0167	0.2647
Schistosoma mansoni	amine oxidase	0.0041	0.0085	0.0085
Toxoplasma gondii	histone arginine methyltransferase PRMT3	0.0096	0.0264	0.5148
Trypanosoma cruzi	arginine N-methyltransferase, type I	0.0096	0.0264	0.1575
Echinococcus multilocularis	membrane bound transcription factor site 1	0.0136	0.0394	0.0493
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0014	0.0006
Trichomonas vaginalis	alpha-L-fucosidase, putative	0.0032	0.0056	0.0078
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0066	0.0167	0.0262
Loa Loa (eye worm)	hypothetical protein	0.0201	0.0605	0.0598
Toxoplasma gondii	subtilisin SUB11	0.0136	0.0394	0.7775
Leishmania major	arginine N-methyltransferase, type I	0.0096	0.0264	0.1575
Leishmania major	subtilisin-like serine peptidase	0.0136	0.0394	0.2538
Echinococcus multilocularis	Coagulation factor 5 8 type, C terminal	0.0032	0.0056	0.0069
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0136	0.0394	0.0635
Entamoeba histolytica	hypothetical protein, conserved	0.0066	0.0167	0.1139
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0066	0.0167	0.0262
Entamoeba histolytica	arginine N-methyltransferase 1, putative	0.0096	0.0264	0.183
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0136	0.0394	0.0635
Trichomonas vaginalis	hypothetical protein	0.0032	0.0056	0.0078
Brugia malayi	Nematode astacin protease protein 30	0.0019	0.0014	0.0006
Brugia malayi	Protein kinase domain containing protein	0.0032	0.0056	0.0048
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0136	0.0394	0.0635
Plasmodium falciparum	transcriptional regulatory protein sir2a	0.0066	0.0167	0.2573
Toxoplasma gondii	histone lysine-specific demethylase	0.0041	0.0085	0.1557
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0136	0.0394	0.0635
Brugia malayi	Protein kinase domain containing protein	0.007	0.018	0.0173
Trichomonas vaginalis	conserved hypothetical protein	0.0617	0.1951	0.3193
Trypanosoma brucei	serine peptidase, clan SB, family S8-like protein	0.0155	0.0455	0.2326
Echinococcus granulosus	epidermal growth factor receptor	0.025	0.0761	0.0761
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0201	0.0605	0.0756
Trichomonas vaginalis	conserved hypothetical protein	0.0136	0.0394	0.0635
Schistosoma mansoni	subfamily S8B non-peptidase homologue (S08 family)	0.0754	0.2392	0.2392
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0056	0.0078
Giardia lamblia	Furin precursor putative serine protease	0.0617	0.1951	0.533
Echinococcus granulosus	proprotein convertase subtilisin:kexin type 5	0.1897	0.6093	0.6093
Brugia malayi	transcriptional regulator, Sir2 family protein	0.0449	0.1406	0.1399
Schistosoma mansoni	subfamily M12A unassigned peptidase (M12 family)	0.0019	0.0014	0.0014
Leishmania major	NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe	0.0066	0.0167	0.0863
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0136	0.0394	0.0635
Leishmania major	sir2-family protein-like protein	0.0066	0.0167	0.0863
Schistosoma mansoni	tyrosine kinase	0.025	0.0761	0.0761
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0056	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0219	0.066	0.0653
Schistosoma mansoni	amine oxidase	0.0041	0.0085	0.0085
Schistosoma mansoni	chromatin regulatory protein sir2	0.0449	0.1406	0.1406
Schistosoma mansoni	tripeptidyl-peptidase II (S08 family)	0.0136	0.0394	0.0394
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0066	0.0167	0.0262
Echinococcus granulosus	Coagulation factor 5 8 type C terminal	0.0032	0.0056	0.0056
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0136	0.0394	0.0635
Loa Loa (eye worm)	transcriptional regulator	0.0066	0.0167	0.0159
Echinococcus multilocularis	Peptidase S8 S53, subtilisin kexin sedolisin	0.0136	0.0394	0.0493
Trichomonas vaginalis	protein arginine N-methyltransferase, putative	0.0171	0.0505	0.0817
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0085	0.0077
Mycobacterium leprae	PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)	0.0041	0.0085	0.0877
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0066	0.0167	0.0262
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0201	0.0605	0.0605
Plasmodium vivax	hypothetical protein, conserved	0.0041	0.0085	0.0774
Loa Loa (eye worm)	hypothetical protein	0.0201	0.0605	0.0598
Trichomonas vaginalis	conserved hypothetical protein	0.0617	0.1951	0.3193
Echinococcus granulosus	histone arginine methyltransferase CARMER	0.0096	0.0264	0.0264
Loa Loa (eye worm)	TK/ROR protein kinase	0.003	0.005	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0014	0.0006
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0056	0.0078
Brugia malayi	Lectin C-type domain containing protein	0.0019	0.0014	0.0006
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0136	0.0394	0.0635
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.0155	0.0455	0.2988
Trypanosoma cruzi	Silent information regulator 2 related protein 1	0.0449	0.1406	1
Echinococcus multilocularis	SWI:SNF complex subunit SMARCC2	0.0017	0.0008	0.001
Mycobacterium ulcerans	proline rich membrane-anchored mycosin MycP5	0.0136	0.0394	1
Echinococcus granulosus	NAD dependent deacetylase sirtuin 3	0.0449	0.1406	0.1406
Brugia malayi	Protein kinase domain containing protein	0.003	0.005	0.0042
Brugia malayi	Nematode astacin protease protein 30	0.0019	0.0014	0.0006
Brugia malayi	Suppressor of lurcher protein 1 precursor	0.0019	0.0014	0.0006
Echinococcus multilocularis	discoidin domain containing receptor 2	0.0032	0.0056	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0014	0.0006
Plasmodium vivax	subtilisin-like protease 1	0.0136	0.0394	0.7568
Brugia malayi	CUB domain containing protein	0.0019	0.0014	0.0006
Schistosoma mansoni	hypothetical protein	0.0617	0.1951	0.1951
Echinococcus multilocularis	tissue type plasminogen activator	0.003	0.005	0.0063
Trichomonas vaginalis	conserved hypothetical protein	0.0136	0.0394	0.0635
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0014	0.0006
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0041	0.0085	0.0259
Trypanosoma cruzi	serine peptidase, clan SB, family S8-like protein	0.0136	0.0394	0.2538
Mycobacterium ulcerans	membrane-anchored mycosin MycP3	0.0136	0.0394	1
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0056	0.0078
Schistosoma mansoni	serine/threonine protein kinase	0.0016	0.0004	0.0004
Onchocerca volvulus		0.0136	0.0394	0.5885
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0136	0.0394	0.0635
Loa Loa (eye worm)	kelch domain-containing protein family protein	0.0019	0.0014	0.0006
Plasmodium falciparum	LCCL domain-containing protein	0.0032	0.0056	0.012
Leishmania major	arginine N-methyltransferase-like protein	0.0171	0.0505	0.3354
Loa Loa (eye worm)	Carm1-pending protein	0.0096	0.0264	0.0256
Giardia lamblia	Transcriptional regulator, Sir2 family	0.0066	0.0167	0.0437
Giardia lamblia	NAD-dependent histone deacetylase Sir2	0.0066	0.0167	0.0437
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0136	0.0394	0.0635
Loa Loa (eye worm)	lectin C-type domain-containing protein	0.0019	0.0014	0.0006
Schistosoma mansoni	dock	0.0032	0.0056	0.0056
Brugia malayi	Sex muscle abnormal protein 5	0.0123	0.0351	0.0343
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0201	0.0605	0.0605
Schistosoma mansoni	hypothetical protein	0.0032	0.0056	0.0056
Echinococcus multilocularis		0.2486	0.8002	1
Trichomonas vaginalis	protein arginine N-methyltransferase, putative	0.0096	0.0264	0.042
Plasmodium falciparum	subtilisin-like protease 2	0.0136	0.0394	0.7568
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0136	0.0394	0.0635
Brugia malayi	zinc metalloproteinase toh-2 precursor	0.0019	0.0014	0.0006
Brugia malayi	transcriptional regulator, Sir2 family protein	0.0066	0.0167	0.0159
Trichomonas vaginalis	conserved hypothetical protein	0.0617	0.1951	0.3193
Schistosoma mansoni	SWI/SNF complex-related	0.0017	0.0008	0.0008
Brugia malayi	CUB domain containing protein	0.0019	0.0014	0.0006
Schistosoma mansoni	btb and poz domain-containing protein	0.0032	0.0056	0.0056
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.1897	0.6093	1
Trichomonas vaginalis	conserved hypothetical protein	0.0136	0.0394	0.0635
Schistosoma mansoni	chromatin regulatory protein sir2	0.0066	0.0167	0.0167
Schistosoma mansoni	hypothetical protein	0.0019	0.0014	0.0014
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0085	0.0228	0.022
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0056	0.0078

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	> 5.5	Displacement of 125I-MIP-1beta from human CCR5 receptor after 4 hrs by scintillation counting	ChEMBL.	21539377

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1784394

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1526616