Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | acetylcholinesterase | 0.2835 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0747 | 0.2106 | 0.2106 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0479 | 0.1092 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0479 | 0.1092 | 0.1092 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0479 | 0.1092 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0479 | 0.1092 | 0.1092 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0479 | 0.1092 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.0138 | 0.0138 |
Loa Loa (eye worm) | hypothetical protein | 0.0479 | 0.1092 | 0.1092 |
Loa Loa (eye worm) | hypothetical protein | 0.0479 | 0.1092 | 0.1092 |
Schistosoma mansoni | tyrosine kinase | 0.1221 | 0.3899 | 0.3899 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.2835 | 1 | 1 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0479 | 0.1092 | 0.0967 |
Echinococcus multilocularis | acetylcholinesterase | 0.2835 | 1 | 1 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0747 | 0.2106 | 0.2106 |
Loa Loa (eye worm) | hypothetical protein | 0.0479 | 0.1092 | 0.1092 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0479 | 0.1092 | 0.5 |
Echinococcus granulosus | insulin receptor | 0.0747 | 0.2106 | 0.2106 |
Loa Loa (eye worm) | carboxylesterase | 0.2835 | 1 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.2311 | 0.8017 | 0.7989 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0479 | 0.1092 | 0.1092 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0479 | 0.1092 | 0.1092 |
Brugia malayi | Protein kinase domain containing protein | 0.0747 | 0.2106 | 0.1138 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0747 | 0.2106 | 0.2106 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0479 | 0.1092 | 0.0967 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.2189 | 0.7557 | 1 |
Echinococcus granulosus | neuroligin | 0.0479 | 0.1092 | 0.1092 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0479 | 0.1092 | 0.0967 |
Loa Loa (eye worm) | hypothetical protein | 0.0479 | 0.1092 | 0.1092 |
Echinococcus granulosus | epidermal growth factor receptor | 0.2311 | 0.8017 | 0.8017 |
Schistosoma mansoni | tyrosine kinase | 0.2311 | 0.8017 | 0.8017 |
Schistosoma mansoni | tyrosine kinase | 0.0747 | 0.2106 | 0.2106 |
Schistosoma mansoni | tyrosine kinase | 0.1247 | 0.3998 | 0.3998 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.1247 | 0.3998 | 0.3998 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0479 | 0.1092 | 0.1092 |
Onchocerca volvulus | 0.2126 | 0.732 | 0.9634 | |
Echinococcus granulosus | carboxylesterase 5A | 0.2835 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.1221 | 0.3899 | 0.3899 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.2835 | 1 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.2342 | 0.8137 | 0.7909 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0479 | 0.1092 | 0.1092 |
Loa Loa (eye worm) | hypothetical protein | 0.2835 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0479 | 0.1092 | 0.1092 |
Echinococcus multilocularis | carboxylesterase 5A | 0.2835 | 1 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0479 | 0.1092 | 0.1092 |
Schistosoma mansoni | acetylcholinesterase | 0.0479 | 0.1092 | 0.1092 |
Schistosoma mansoni | tyrosine kinase | 0.1247 | 0.3998 | 0.3998 |
Loa Loa (eye worm) | hypothetical protein | 0.0479 | 0.1092 | 0.1092 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.2342 | 0.8137 | 0.8137 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.2311 | 0.8017 | 0.7774 |
Echinococcus multilocularis | 0.0711 | 0.197 | 0.1857 | |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0479 | 0.1092 | 0.1092 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.0138 | 0.0138 |
Schistosoma mansoni | gliotactin | 0.0479 | 0.1092 | 0.1092 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0479 | 0.1092 | 0.5 |
Echinococcus granulosus | roundabout 2 | 0.0227 | 0.0138 | 0.0138 |
Loa Loa (eye worm) | hypothetical protein | 0.2835 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.2835 | 1 | 1 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.2311 | 0.8017 | 0.8017 |
Echinococcus multilocularis | insulin receptor | 0.0747 | 0.2106 | 0.1996 |
Echinococcus granulosus | acetylcholinesterase | 0.2835 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.2835 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0479 | 0.1092 | 0.5 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0747 | 0.2106 | 0.1996 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.1247 | 0.3998 | 0.3914 |
Echinococcus granulosus | epidermal growth factor receptor | 0.1247 | 0.3998 | 0.3998 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0479 | 0.1092 | 0.1092 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0479 | 0.1092 | 0.1092 |
Loa Loa (eye worm) | hypothetical protein | 0.0479 | 0.1092 | 0.1092 |
Echinococcus multilocularis | neuroligin | 0.0479 | 0.1092 | 0.0967 |
Schistosoma mansoni | tyrosine kinase | 0.1221 | 0.3899 | 0.3899 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 1 ug ml-1 | Antimicrobial activity against tetracycline-susceptible Escherichia coli isolate 107 by CLSI dilution method | ChEMBL. | 21500832 |
MIC (functional) | = 8 ug ml-1 | Antimicrobial activity against tetracycline-resistant Escherichia coli isolate 155 harboring tetA gene by CLSI dilution method | ChEMBL. | 21500832 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.