Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | thymidylate synthase | 0.0106 | 0.2501 | 0.2501 |
Schistosoma mansoni | tyrosine kinase | 0.0157 | 0.451 | 0.451 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0158 | 0.4576 | 0.4576 |
Schistosoma mansoni | tyrosine kinase | 0.0157 | 0.451 | 0.451 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0094 | 0.2024 | 0.2024 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.009 | 0.1841 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0094 | 0.2024 | 0.2024 |
Brugia malayi | hypothetical protein | 0.005 | 0.0287 | 0.0287 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.1841 | 0.1841 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.009 | 0.1841 | 0.1841 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0158 | 0.4576 | 0.4576 |
Onchocerca volvulus | 0.0106 | 0.2501 | 1 | |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0295 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0158 | 0.4576 | 0.4576 |
Loa Loa (eye worm) | norepinephrine transporter | 0.009 | 0.1841 | 0.1841 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0149 | 0.4223 | 0.5 |
Loa Loa (eye worm) | serotonin transporter b | 0.009 | 0.1841 | 0.1841 |
Schistosoma mansoni | tyrosine kinase | 0.0094 | 0.2024 | 0.2024 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.4937 | 0.4937 |
Trichomonas vaginalis | conserved hypothetical protein | 0.005 | 0.0287 | 0.5 |
Echinococcus multilocularis | serotonin transporter | 0.009 | 0.1841 | 0.1841 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0295 | 1 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.005 | 0.0287 | 0.1148 |
Schistosoma mansoni | tyrosine kinase | 0.0158 | 0.4576 | 0.4576 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.4937 | 0.4937 |
Echinococcus multilocularis | geminin | 0.0167 | 0.4937 | 0.4937 |
Echinococcus granulosus | geminin | 0.0167 | 0.4937 | 0.4937 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0295 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0094 | 0.2024 | 0.2024 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0158 | 0.4576 | 0.4576 |
Echinococcus multilocularis | insulin receptor | 0.0094 | 0.2024 | 0.2024 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0106 | 0.2501 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0106 | 0.2501 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0106 | 0.2501 | 0.2501 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.1841 | 0.1841 |
Echinococcus granulosus | serotonin transporter | 0.009 | 0.1841 | 0.1841 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.009 | 0.1841 | 0.1841 |
Echinococcus granulosus | thymidylate synthase | 0.0106 | 0.2501 | 0.2501 |
Echinococcus multilocularis | thymidylate synthase | 0.0106 | 0.2501 | 0.2501 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0149 | 0.4223 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.1841 | 0.1841 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.009 | 0.1841 | 0.1841 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0149 | 0.4223 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0149 | 0.4223 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0149 | 0.4223 | 0.5 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0094 | 0.2024 | 0.2024 |
Brugia malayi | thymidylate synthase | 0.0106 | 0.2501 | 0.2501 |
Mycobacterium ulcerans | thymidylate synthase | 0.0106 | 0.2501 | 1 |
Echinococcus multilocularis | 0.0091 | 0.1906 | 0.1906 | |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0094 | 0.2024 | 0.2024 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.009 | 0.1841 | 0.1841 |
Echinococcus granulosus | insulin receptor | 0.0094 | 0.2024 | 0.2024 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0149 | 0.4223 | 0.5 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0295 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0157 | 0.451 | 0.451 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 5.6 uM | Cytotoxicity against human HL60 cells | ChEMBL. | 21439821 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 21439821 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.