Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0104 | 0.2279 | 1 | |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0147 | 0.4052 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0147 | 0.4052 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0092 | 0.1788 | 0.0224 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0147 | 0.4052 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0147 | 0.4052 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0104 | 0.2279 | 0.0808 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0092 | 0.1788 | 0.0224 |
Echinococcus multilocularis | 0.009 | 0.1667 | 0.0079 | |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0104 | 0.2279 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0092 | 0.1788 | 0.0224 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0147 | 0.4052 | 0.5 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0289 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0154 | 0.4348 | 0.3271 |
Echinococcus multilocularis | thymidylate synthase | 0.0104 | 0.2279 | 0.0808 |
Brugia malayi | Protein kinase domain containing protein | 0.0092 | 0.1788 | 0.1788 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0155 | 0.4416 | 0.3352 |
Loa Loa (eye worm) | thymidylate synthase | 0.0104 | 0.2279 | 0.0808 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0104 | 0.2279 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0088 | 0.16 | 0.16 |
Mycobacterium ulcerans | thymidylate synthase | 0.0104 | 0.2279 | 0.5 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0088 | 0.16 | 0.5 |
Echinococcus granulosus | insulin receptor | 0.0092 | 0.1788 | 0.0224 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0147 | 0.4052 | 0.5 |
Echinococcus granulosus | geminin | 0.0164 | 0.4788 | 0.3795 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0289 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0155 | 0.4416 | 0.3352 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0092 | 0.1788 | 0.0224 |
Schistosoma mansoni | tyrosine kinase | 0.0289 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.4788 | 0.3795 |
Echinococcus multilocularis | geminin | 0.0164 | 0.4788 | 0.3795 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.4788 | 0.3795 |
Schistosoma mansoni | tyrosine kinase | 0.0154 | 0.4348 | 0.3271 |
Echinococcus granulosus | thymidylate synthase | 0.0104 | 0.2279 | 0.0808 |
Schistosoma mansoni | tyrosine kinase | 0.0155 | 0.4416 | 0.3352 |
Echinococcus multilocularis | insulin receptor | 0.0092 | 0.1788 | 0.0224 |
Schistosoma mansoni | tyrosine kinase | 0.0154 | 0.4348 | 0.3271 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0092 | 0.1788 | 0.0224 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0155 | 0.4416 | 0.3352 |
Trichomonas vaginalis | conserved hypothetical protein | 0.005 | 0 | 0.5 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0289 | 1 | 1 |
Brugia malayi | thymidylate synthase | 0.0104 | 0.2279 | 0.2279 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0155 | 0.4416 | 0.3352 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.