Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Anandamide amidohydrolase | Starlite/ChEMBL | References |
Homo sapiens | fatty acid amide hydrolase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | fatty acid amide hydrolase 1 | Anandamide amidohydrolase | 579 aa | 470 aa | 28.7 % |
Leishmania major | hypothetical protein, conserved | fatty acid amide hydrolase | 579 aa | 471 aa | 26.5 % |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | Anandamide amidohydrolase | 579 aa | 470 aa | 28.3 % |
Onchocerca volvulus | Anandamide amidohydrolase | 579 aa | 539 aa | 34.7 % | |
Schistosoma japonicum | Fatty-acid amide hydrolase 1, putative | Anandamide amidohydrolase | 579 aa | 499 aa | 24.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0246 | 0.6939 | 0.6939 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0106 | 0.1896 | 0.1896 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0057 | 0.0132 | 0.5 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0106 | 0.1896 | 0.1896 |
Schistosoma mansoni | hypothetical protein | 0.0188 | 0.4856 | 0.4856 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0168 | 0.413 | 0.5389 |
Brugia malayi | thymidylate synthase | 0.0119 | 0.2381 | 0.2381 |
Brugia malayi | hypothetical protein | 0.0057 | 0.0132 | 0.0132 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0246 | 0.6939 | 0.6939 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0101 | 0.1711 | 0.1711 |
Echinococcus multilocularis | insulin receptor | 0.0106 | 0.1896 | 0.1896 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.1711 | 0.1711 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0101 | 0.1711 | 0.1711 |
Echinococcus multilocularis | thymidylate synthase | 0.0119 | 0.2381 | 0.2381 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0168 | 0.413 | 0.5 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0178 | 0.449 | 0.449 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.1711 | 0.1711 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0331 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0188 | 0.4856 | 0.4856 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0246 | 0.6939 | 0.6939 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0168 | 0.413 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0222 | 0.6067 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0106 | 0.1896 | 0.1896 |
Mycobacterium ulcerans | thymidylate synthase | 0.0119 | 0.2381 | 1 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0101 | 0.1711 | 0.1711 |
Schistosoma mansoni | tyrosine kinase | 0.0178 | 0.449 | 0.449 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0222 | 0.6067 | 1 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0106 | 0.1896 | 0.1896 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0105 | 0.1866 | 0.2922 |
Schistosoma mansoni | tyrosine kinase | 0.0106 | 0.1896 | 0.1896 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0101 | 0.1711 | 0.1711 |
Brugia malayi | Protein kinase domain containing protein | 0.0106 | 0.1896 | 0.1896 |
Echinococcus granulosus | thymidylate synthase | 0.0119 | 0.2381 | 0.2381 |
Schistosoma mansoni | amidase | 0.0246 | 0.6939 | 0.6939 |
Schistosoma mansoni | tyrosine kinase | 0.0176 | 0.4422 | 0.4422 |
Echinococcus multilocularis | serotonin transporter | 0.0101 | 0.1711 | 0.1711 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0101 | 0.1711 | 0.1711 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0119 | 0.2381 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0117 | 0.2292 | 0.9606 |
Echinococcus granulosus | geminin | 0.0188 | 0.4856 | 0.4856 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0222 | 0.6067 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0246 | 0.6939 | 0.6939 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0119 | 0.2381 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0119 | 0.2381 | 0.2381 |
Echinococcus granulosus | serotonin transporter | 0.0101 | 0.1711 | 0.1711 |
Schistosoma mansoni | tyrosine kinase | 0.0331 | 1 | 1 |
Loa Loa (eye worm) | serotonin transporter b | 0.0101 | 0.1711 | 0.1711 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.6939 | 0.6939 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0331 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0176 | 0.4422 | 0.4422 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0178 | 0.449 | 0.449 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0101 | 0.1711 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0168 | 0.413 | 0.6736 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0331 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.1711 | 0.1711 |
Schistosoma mansoni | tyrosine kinase | 0.0176 | 0.4422 | 0.4422 |
Echinococcus granulosus | insulin receptor | 0.0106 | 0.1896 | 0.1896 |
Schistosoma mansoni | tyrosine kinase | 0.0178 | 0.449 | 0.449 |
Brugia malayi | amidase | 0.0246 | 0.6939 | 0.6939 |
Onchocerca volvulus | 0.0119 | 0.2381 | 1 | |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0246 | 0.6939 | 0.6939 |
Loa Loa (eye worm) | thymidylate synthase | 0.0119 | 0.2381 | 0.2381 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0222 | 0.6067 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0168 | 0.413 | 0.5389 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0178 | 0.449 | 0.449 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0168 | 0.413 | 0.5 |
Echinococcus multilocularis | geminin | 0.0188 | 0.4856 | 0.4856 |
Onchocerca volvulus | 0.0101 | 0.1711 | 0.7187 | |
Echinococcus multilocularis | 0.0103 | 0.1777 | 0.1777 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.02 uM | Inhibition of human FAAH assessed as hydrolysis of anandamido-amino-methyl-cumarin | ChEMBL. | 21392988 |
IC50 (binding) | > 10 uM | Inhibition of rat FAAH assessed as hydrolysis of anandamido-amino-methyl-cumarin | ChEMBL. | 21392988 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.