TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 512.017 | Formula: C27H26ClNO5S
H donors: 1 H acceptors: 2 LogP: 7.26 Rotable bonds: 11
Rule of 5 violations (Lipinski): 2
SMILES: CCCc1cc(ccc1OCCCOc1cccc(c1)[C@H]1SC(=O)NC1=O)Oc1ccc(cc1)Cl
InChi: 1S/C27H26ClNO5S/c1-2-5-18-16-23(34-21-10-8-20(28)9-11-21)12-13-24(18)33-15-4-14-32-22-7-3-6-19(17-22)25-26(30)29-27(31)35-25/h3,6-13,16-17,25H,2,4-5,14-15H2,1H3,(H,29,30,31)/t25-/m1/s1
InChiKey: BSYLKYWBLKSLBJ-RUZDIDTESA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	peroxisome proliferator-activated receptor gamma	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	ecdysone induced protein 78C	peroxisome proliferator-activated receptor gamma	477 aa	447 aa	28.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus	Putative zinc finger protein	0.0084	0.021	0.5
Brugia malayi	protein kinase C II.	0.073	0.3179	0.3128
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0283	0.0075
Brugia malayi	TBC domain containing protein	0.0084	0.021	0.0137
Echinococcus multilocularis	FERM and pleckstrin domain containing protein	0.0084	0.021	0.0205
Echinococcus granulosus	Pleckstrin y	0.0084	0.021	0.0205
Onchocerca volvulus		0.0084	0.021	0.5
Brugia malayi	Hr1 repeat family protein	0.073	0.3179	0.3128
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.01	0.0283	0.0075
Brugia malayi	probable spectrin beta chain	0.0084	0.021	0.0137
Trichomonas vaginalis	AGC family protein kinase	0.0814	0.3565	0.3428
Brugia malayi	MAX-1A	0.0084	0.021	0.0137
Echinococcus multilocularis	nervana 2	0.14	0.6258	0.9308
Entamoeba histolytica	protein kinase, putative	0.01	0.0283	0.0075
Echinococcus granulosus	Pleckstrin y	0.0084	0.021	0.0205
Entamoeba histolytica	protein kinase, putative	0.01	0.0283	0.0075
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0432	0.1811	0.2615
Onchocerca volvulus	Putative neuronal RhoA GEF protein	0.0084	0.021	0.5
Brugia malayi	Plekhf2 protein	0.0084	0.021	0.0137
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.0084	0.021	0.0137
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0714	0.3106	0.2958
Loa Loa (eye worm)	hypothetical protein	0.0084	0.021	0.0137
Brugia malayi	Protein kinase domain containing protein	0.073	0.3179	0.3128
Echinococcus granulosus	protein kinase C gamma type	0.073	0.3179	0.4674
Echinococcus granulosus	collagen type iv alpha 3 binding protein	0.0084	0.021	0.0205
Entamoeba histolytica	PH domain containing protein kinase, putative	0.01	0.0283	0.0075
Leishmania major	protein kinase, putative	0.01	0.0283	1
Brugia malayi	Syntrophin-1	0.0084	0.021	0.0137
Trypanosoma brucei	rac serine-threonine kinase, putative	0.2214	1	1
Brugia malayi	PH domain containing protein	0.0084	0.021	0.0137
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.1416	0.6331	0.9406
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0283	0.0075
Schistosoma mansoni	serine/threonine protein kinase	0.073	0.3179	0.4674
Schistosoma mansoni	hypothetical protein	0.0084	0.021	0.0205
Plasmodium falciparum	phosphatidylinositol transfer protein, putative	0.0084	0.021	0.0218
Echinococcus multilocularis	collagen type iv alpha 3 binding protein	0.0084	0.021	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0084	0.021	0.0137
Giardia lamblia	Kinase, AGC PKA	0.1416	0.6331	0.5
Brugia malayi	PH domain containing protein	0.0084	0.021	0.0137
Schistosoma mansoni	serine/threonine kinase	0.073	0.3179	0.4674
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0084	0.021	0.0137
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0283	0.0075
Schistosoma mansoni	atypical protein kinase C	0.073	0.3179	0.4674
Echinococcus granulosus	pdz domain containing protein	0.0084	0.021	0.0205
Brugia malayi	Dynamin	0.0084	0.021	0.0137
Echinococcus granulosus	protein kinase c iota type	0.073	0.3179	0.4674
Loa Loa (eye worm)	hypothetical protein	0.0084	0.021	0.0137
Loa Loa (eye worm)	hypothetical protein	0.0084	0.021	0.0137
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.073	0.3179	0.3128
Trichomonas vaginalis	AGC family protein kinase	0.2214	1	1
Schistosoma mansoni	serine/threonine protein kinase	0.073	0.3179	0.4674
Echinococcus multilocularis	Ras associated and pleckstrin y	0.0084	0.021	0.0205
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.073	0.3179	0.4674
Echinococcus granulosus	Rho GTPase activating protein 24	0.0084	0.021	0.0205
Trichomonas vaginalis	AGC family protein kinase	0.2214	1	1
Entamoeba histolytica	PH domain containing protein kinase, putative	0.15	0.6718	0.6647
Loa Loa (eye worm)	hypothetical protein	0.0084	0.021	0.0137
Schistosoma mansoni	syntrophin	0.0084	0.021	0.0205
Echinococcus multilocularis	Oxysterol binding protein 11	0.0084	0.021	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0084	0.021	0.0137
Echinococcus granulosus	serine:threonine protein kinase N2	0.073	0.3179	0.4674
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0084	0.021	0.0137
Loa Loa (eye worm)	cytohesin 3	0.0084	0.021	0.0137
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.01	0.0283	0.0075
Toxoplasma gondii	AGC kinase	0.213	0.9614	1
Echinococcus multilocularis	dynamin 1	0.0084	0.021	0.0205
Entamoeba histolytica	hypothetical protein	0.01	0.0283	0.0075
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0084	0.021	0.0137
Loa Loa (eye worm)	hypothetical protein	0.0084	0.021	0.0137
Loa Loa (eye worm)	hypothetical protein	0.0084	0.021	0.0137
Entamoeba histolytica	protein kinase, putative	0.01	0.0283	0.0075
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.01	0.0283	0.0113
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	0.1416	0.6331	1
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.01	0.0283	0.0075
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0283	0.0075
Schistosoma mansoni	serine/threonine-protein kinase	0.15	0.6718	1
Loa Loa (eye worm)	hypothetical protein	0.0084	0.021	0.0137
Echinococcus granulosus	arf GAP with coiled coil ANK repeat and PH	0.0084	0.021	0.0205
Toxoplasma gondii	phosphatidylinositol transfer protein	0.0084	0.021	0.0143
Brugia malayi	Cadps2 protein	0.0084	0.021	0.0137
Echinococcus granulosus	dynamin 1	0.0084	0.021	0.0205
Schistosoma mansoni	hypothetical protein	0.0084	0.021	0.0205
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0283	0.0075
Loa Loa (eye worm)	uncoordinated protein 104	0.0084	0.021	0.0137
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.01	0.0283	0.0075
Brugia malayi	PH domain containing protein	0.0084	0.021	0.0137
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.0084	0.021	0.0205
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0283	0.0075
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.01	0.0283	0.0113
Echinococcus multilocularis	cytohesin 1	0.0084	0.021	0.0205
Brugia malayi	Cytohesin 3	0.0084	0.021	0.0137
Trichomonas vaginalis	AGC family protein kinase	0.2214	1	1
Brugia malayi	PH domain containing protein	0.0084	0.021	0.0137
Plasmodium falciparum	oxysterol-binding protein, putative	0.0084	0.021	0.0218
Entamoeba histolytica	PH domain containing protein kinase, putative	0.15	0.6718	0.6647
Echinococcus granulosus	oxysterol binding protein 1	0.0084	0.021	0.0205
Toxoplasma gondii	AtPH1 family protein	0.0084	0.021	0.0143
Brugia malayi	PH domain containing protein	0.0084	0.021	0.0137
Echinococcus multilocularis	oxysterol binding protein 9	0.0084	0.021	0.0205
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.1416	0.6331	0.9418
Echinococcus multilocularis	ras specific guanine nucleotide releasing factor	0.0084	0.021	0.0205
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0283	0.0075
Onchocerca volvulus		0.0084	0.021	0.5
Echinococcus multilocularis	nervana 2	0.14	0.6258	0.9308
Brugia malayi	Oxysterol binding protein	0.0084	0.021	0.0137
Entamoeba histolytica	PH domain containing protein kinase, putative	0.01	0.0283	0.0075
Schistosoma mansoni	zinc finger protein	0.0084	0.021	0.0205
Echinococcus multilocularis	actin binding protein anillin	0.0084	0.021	0.0205
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0283	0.0075
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.073	0.3179	0.4674
Echinococcus multilocularis	protein kinase c iota type	0.073	0.3179	0.4674
Schistosoma mansoni	hypothetical protein	0.0084	0.021	0.0205
Brugia malayi	hypothetical protein	0.0084	0.021	0.0137
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.01	0.0283	0.0113
Brugia malayi	Variant SH3 domain containing protein	0.0084	0.021	0.0137
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0283	0.0075
Echinococcus granulosus	nervana 2	0.14	0.6258	0.9308
Echinococcus granulosus	nervana 2	0.14	0.6258	0.9308
Echinococcus granulosus	cytohesin 1	0.0084	0.021	0.0205
Loa Loa (eye worm)	AGC/NDR protein kinase	0.073	0.3179	0.3128
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.073	0.3179	0.4674
Echinococcus granulosus	NDR protein kinase	0.073	0.3179	0.4674
Echinococcus granulosus	GRB2 associated binding protein 3	0.0084	0.021	0.0205
Echinococcus multilocularis	serine:threonine protein kinase N2	0.073	0.3179	0.4674
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0084	0.021	0.0218
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0283	0.0075
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0283	0.0075
Trypanosoma cruzi	NIMA-related kinase, putative	0.01	0.0283	0.0113
Entamoeba histolytica	protein kinase 2, putative	0.1416	0.6331	0.6253
Echinococcus granulosus	calcium dependent secretion activator 1	0.0084	0.021	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0084	0.021	0.0137
Echinococcus multilocularis	pdz domain containing protein	0.0084	0.021	0.0205
Echinococcus multilocularis	oxysterol binding protein 1	0.0084	0.021	0.0205
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0084	0.021	0.0205
Echinococcus multilocularis	GRB2 associated binding protein 3	0.0084	0.021	0.0205
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.01	0.0283	1
Onchocerca volvulus		0.0084	0.021	0.5
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.01	0.0283	0.012
Trichomonas vaginalis	AGC family protein kinase	0.2214	1	1
Echinococcus multilocularis	DCC interacting protein 13 beta	0.0084	0.021	0.0205
Onchocerca volvulus	Protein melted homolog	0.0084	0.021	0.5
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.073	0.3179	0.3128
Schistosoma mansoni	oxysterol-binding protein 1	0.0084	0.021	0.0205
Echinococcus multilocularis	Pleckstrin y	0.0084	0.021	0.0205
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.15	0.6718	1
Trichomonas vaginalis	AGC family protein kinase	0.2214	1	1
Echinococcus granulosus	serine threonine protein kinase nrc	0.1416	0.6331	0.9418
Trichomonas vaginalis	AGC family protein kinase	0.073	0.3179	0.3033
Loa Loa (eye worm)	hypothetical protein	0.0084	0.021	0.0137
Echinococcus multilocularis	pleckstrin y domain containing family A	0.0084	0.021	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0084	0.021	0.0137
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.213	0.9614	0.9611
Echinococcus multilocularis	arf GAP with coiled coil, ANK repeat and PH	0.0084	0.021	0.0205
Schistosoma mansoni	serine/threonine protein kinase	0.073	0.3179	0.4674
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.01	0.0283	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0084	0.021	0.0137
Entamoeba histolytica	protein kinase, putative	0.2214	1	1
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.073	0.3179	0.3128
Toxoplasma gondii	hypothetical protein	0.0084	0.021	0.0143
Entamoeba histolytica	protein kinase, putative	0.01	0.0283	0.0075
Toxoplasma gondii	protein kinase domain-containing protein	0.01	0.0283	0.022
Leishmania major	protein kinase, putative	0.01	0.0283	1
Schistosoma mansoni	phosphoinositol 4-phosphate adaptor protein	0.0084	0.021	0.0205
Echinococcus granulosus	Arf GAP and Pleckstrin domain containing protein	0.0084	0.021	0.0205
Loa Loa (eye worm)	Plekhf2 protein	0.0084	0.021	0.0137
Echinococcus multilocularis	Pleckstrin y	0.0084	0.021	0.0205
Entamoeba histolytica	protein kinase, putative	0.01	0.0283	0.0075
Schistosoma mansoni	zinc finger protein	0.0084	0.021	0.0205
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.01	0.0283	0.0113
Entamoeba histolytica	p21-activated kinase	0.01	0.0283	0.0075
Brugia malayi	Variant SH3 domain containing protein	0.0084	0.021	0.0137
Trypanosoma brucei	protein kinase, putative	0.01	0.0283	0.0075
Brugia malayi	PH domain containing protein	0.0084	0.021	0.0137
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0283	0.0075
Entamoeba histolytica	PH domain containing protein kinase, putative	0.01	0.0283	0.0075
Echinococcus granulosus	oxysterol binding protein 9	0.0084	0.021	0.0205
Loa Loa (eye worm)	AGC/PKN protein kinase	0.073	0.3179	0.3128
Schistosoma mansoni	vav2	0.0084	0.021	0.0205
Plasmodium falciparum	calcium-dependent protein kinase 7	0.01	0.0283	0.0335
Onchocerca volvulus		0.0084	0.021	0.5
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.073	0.3179	0.4674
Schistosoma mansoni	serine/threonine protein kinase	0.073	0.3179	0.4674
Trichomonas vaginalis	AGC family protein kinase	0.073	0.3179	0.3033
Echinococcus multilocularis	serine:threonine protein kinase 38	0.073	0.3179	0.4674
Toxoplasma gondii	hypothetical protein	0.0084	0.021	0.0143
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.073	0.3179	0.4674
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.01	0.0283	0.0113
Schistosoma mansoni	rhogef and pleckstrin domain protein	0.0084	0.021	0.0205
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0084	0.021	0.0218
Loa Loa (eye worm)	syntrophin-1	0.0084	0.021	0.0137
Echinococcus granulosus	Pleckstrin domain containing protein family B	0.0084	0.021	0.0205
Echinococcus multilocularis	serine threonine protein kinase	0.073	0.3179	0.4674
Trichomonas vaginalis	AGC family protein kinase	0.2214	1	1
Loa Loa (eye worm)	rho-GTPase-activating	0.0084	0.021	0.0137
Onchocerca volvulus	Abnormal cell migration protein 10 homolog	0.0084	0.021	0.5
Trichomonas vaginalis	AGC family protein kinase	0.2214	1	1
Leishmania major	serine/threonine-protein kinase a, putative	0.01	0.0283	1
Echinococcus multilocularis	oxysterol binding protein 3	0.0084	0.021	0.0205
Schistosoma mansoni	hypothetical protein	0.0084	0.021	0.0205
Echinococcus multilocularis	beta 1 syntrophin	0.0084	0.021	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0084	0.021	0.0137
Echinococcus granulosus	FERM and pleckstrin domain containing protein	0.0084	0.021	0.0205
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.01	0.0283	0.0113
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	0.1416	0.6331	1
Schistosoma mansoni	rho gtpase activating protein	0.0084	0.021	0.0205
Schistosoma mansoni	dynamin	0.0084	0.021	0.0205
Echinococcus granulosus	ras specific guanine nucleotide releasing factor	0.0084	0.021	0.0205
Onchocerca volvulus		0.0084	0.021	0.5
Brugia malayi	PH domain containing protein	0.0084	0.021	0.0137
Loa Loa (eye worm)	PH domain-containing protein	0.0084	0.021	0.0137
Entamoeba histolytica	hypothetical protein	0.01	0.0283	0.0075
Leishmania major	folate/biopterin transporter, putative	0.01	0.0283	1
Schistosoma mansoni	oxysterol-binding protein 1	0.0084	0.021	0.0205
Echinococcus multilocularis	rac serine:threonine kinase	0.15	0.6718	1
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0283	0.0075
Echinococcus multilocularis	Rho GTPase activating protein 24	0.0084	0.021	0.0205
Brugia malayi	p70 ribosomal S6 kinase beta	0.213	0.9614	0.9611
Brugia malayi	Protein kinase domain containing protein	0.073	0.3179	0.3128
Echinococcus granulosus	Glutaredoxin protein 5	0.14	0.6258	0.9308
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0084	0.021	0.0205
Echinococcus granulosus	myotubularin protein 13	0.0084	0.021	0.0205
Schistosoma mansoni	serine/threonine protein kinase	0.073	0.3179	0.4674
Brugia malayi	PH domain containing protein	0.0084	0.021	0.0137
Loa Loa (eye worm)	AGC/AKT protein kinase	0.2214	1	1
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0283	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0084	0.021	0.0137
Echinococcus multilocularis	myotubularin protein 13	0.0084	0.021	0.0205
Trypanosoma cruzi	NIMA-related kinase, putative	0.01	0.0283	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0084	0.021	0.0137
Echinococcus granulosus	Protein kinase C brain isozyme	0.073	0.3179	0.4674
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.073	0.3179	0.4674
Schistosoma mansoni	serine/threonine-protein kinase	0.15	0.6718	1
Brugia malayi	PH domain containing protein	0.0084	0.021	0.0137
Loa Loa (eye worm)	hypothetical protein	0.073	0.3179	0.3128
Schistosoma mansoni	goodpasture antigen-binding protein	0.0084	0.021	0.0205
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.14	0.6258	0.9308
Echinococcus multilocularis	Pleckstrin y	0.0084	0.021	0.0205
Echinococcus multilocularis	Arf GAP and Pleckstrin domain containing protein	0.0084	0.021	0.0205
Schistosoma mansoni	hypothetical protein	0.0084	0.021	0.0205
Echinococcus granulosus	pleckstrin y domain containing family A	0.0084	0.021	0.0205
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0283	0.0075
Schistosoma mansoni	growth factor receptor-bound protein	0.0084	0.021	0.0205
Schistosoma mansoni	serine/threonine protein kinase	0.073	0.3179	0.4674
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.01	0.0283	0.022
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0283	0.0075
Echinococcus multilocularis	Glutaredoxin protein 5	0.14	0.6258	0.9308
Schistosoma mansoni	myotubularin-related protein	0.0084	0.021	0.0205
Entamoeba histolytica	PH domain containing protein kinase, putative	0.01	0.0283	0.0075
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.073	0.3179	0.3128
Schistosoma mansoni	dynamin	0.0084	0.021	0.0205
Toxoplasma gondii	Oxysterol-binding protein	0.0084	0.021	0.0143
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.01	0.0283	0.0075
Echinococcus granulosus	type II inositol 34 bisphosphate 4 phosphatase	0.0084	0.021	0.0205
Schistosoma mansoni	goodpasture antigen-binding protein	0.0084	0.021	0.0205
Loa Loa (eye worm)	oxysterol binding protein	0.0084	0.021	0.0137
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0283	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0084	0.021	0.0137
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.01	0.0283	0.0113
Plasmodium falciparum	acylated pleckstrin-homology domain-containing protein, putative	0.0084	0.021	0.0218
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0283	0.0075
Entamoeba histolytica	protein kinase, putative	0.073	0.3179	0.3033
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0084	0.021	0.0137
Loa Loa (eye worm)	hypothetical protein	0.0084	0.021	0.0137
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0084	0.021	0.0205
Entamoeba histolytica	protein kinase, putative	0.213	0.9614	0.9605
Trichomonas vaginalis	AGC family protein kinase	0.073	0.3179	0.3033
Onchocerca volvulus		0.0084	0.021	0.5
Entamoeba histolytica	protein kinase, putative	0.2214	1	1
Trypanosoma cruzi	Protein kinase B	0.15	0.6718	1
Brugia malayi	Pleckstrin Homology Domain	0.0084	0.021	0.0137
Schistosoma mansoni	centaurin alpha	0.0084	0.021	0.0205
Echinococcus granulosus	beta 1 syntrophin	0.0084	0.021	0.0205
Schistosoma mansoni	serine/threonine protein kinase	0.073	0.3179	0.4674
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0283	0.0075
Trichomonas vaginalis	AGC family protein kinase	0.01	0.0283	0.0075
Echinococcus multilocularis	protein kinase c epsilon type	0.073	0.3179	0.4674
Brugia malayi	Uncoordinated protein 104	0.0084	0.021	0.0137
Echinococcus multilocularis	type II inositol 3,4 bisphosphate 4 phosphatase	0.0084	0.021	0.0205
Echinococcus granulosus	serine/threonine protein kinase	0.15	0.6718	1
Echinococcus granulosus	Pleckstrin y	0.0084	0.021	0.0205
Echinococcus multilocularis	serine:threonine protein kinase N2	0.073	0.3179	0.4674
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.01	0.0283	1
Echinococcus granulosus	protein kinase c epsilon type	0.073	0.3179	0.4674
Plasmodium falciparum	PH domain-containing protein, putative	0.0084	0.021	0.0218
Echinococcus granulosus	oxysterol binding protein 3	0.0084	0.021	0.0205
Onchocerca volvulus	outspread protein homolog	0.0084	0.021	0.5
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.1416	0.6331	0.9418
Echinococcus multilocularis	calcium dependent secretion activator 1	0.0084	0.021	0.0205
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.01	0.0283	0.0075
Brugia malayi	Dynamin	0.0084	0.021	0.0137
Mycobacterium ulcerans	hypothetical protein	0.0038	0	0.5
Onchocerca volvulus		0.0084	0.021	0.5
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.073	0.3179	0.4674
Brugia malayi	Oxysterol-binding protein	0.0084	0.021	0.0137
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0084	0.021	0.0137
Entamoeba histolytica	hypothetical protein	0.0394	0.1632	0.1453
Brugia malayi	GTPase-activator protein for Ras-like GTPase containing protein	0.0084	0.021	0.0137
Echinococcus granulosus	Oxysterol binding protein 11	0.0084	0.021	0.0205
Echinococcus granulosus	DCC interacting protein 13 beta	0.0084	0.021	0.0205
Echinococcus multilocularis	Pleckstrin domain containing protein, family B	0.0084	0.021	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0084	0.021	0.0137
Loa Loa (eye worm)	hypothetical protein	0.0084	0.021	0.0137
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.14	0.6258	0.9308

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 73 nM	Displacement of radio-labeled full agonist from PPARgamma receptor	ChEMBL.	21482446

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1783046

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1527595