Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | insulin-like growth factor 1 receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | cathepsin CPL | 0.0167 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0158 | 0.9044 | 0.9044 |
Echinococcus multilocularis | cathepsin L | 0.0086 | 0.1609 | 0.1497 |
Leishmania major | cathepsin L-like protease | 0.0167 | 1 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0167 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0167 | 1 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0167 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0167 | 1 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0167 | 1 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0167 | 1 | 1 |
Onchocerca volvulus | 0.0167 | 1 | 1 | |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0167 | 1 | 1 |
Echinococcus granulosus | cathepsin L | 0.0086 | 0.1609 | 0.1497 |
Echinococcus multilocularis | cysteine protease | 0.0167 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0167 | 1 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0167 | 1 | 1 |
Onchocerca volvulus | 0.0167 | 1 | 1 | |
Leishmania major | cathepsin L-like protease | 0.0167 | 1 | 0.5 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0086 | 0.1609 | 0.1609 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0167 | 1 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0167 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0167 | 1 | 1 |
Onchocerca volvulus | 0.0167 | 1 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0167 | 1 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0167 | 1 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0167 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0167 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0167 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0167 | 1 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0167 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0072 | 0.0132 | 0.0132 |
Echinococcus multilocularis | cysteine protease | 0.0167 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0112 | 0.4279 | 0.3182 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.0086 | 0.1609 | 0.1497 |
Loa Loa (eye worm) | ctsf protein | 0.0167 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0167 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0167 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0167 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0167 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0167 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0072 | 0.0132 | 0.0132 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0167 | 1 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0112 | 0.4279 | 0.4279 |
Echinococcus granulosus | insulin receptor | 0.0158 | 0.9044 | 0.9032 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0167 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0167 | 1 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0167 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0167 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0167 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0167 | 1 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0086 | 0.1609 | 0.1497 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0086 | 0.1609 | 0.1497 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0167 | 1 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0167 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0167 | 1 | 1 |
Echinococcus granulosus | cysteine protease | 0.0086 | 0.1609 | 0.1497 |
Brugia malayi | Cathepsin L-like precursor | 0.0167 | 1 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0112 | 0.4279 | 0.4203 |
Onchocerca volvulus | 0.0167 | 1 | 1 | |
Leishmania major | cathepsin L-like protease | 0.0167 | 1 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0167 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0167 | 1 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0167 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0167 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0167 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0167 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0158 | 0.9044 | 0.9044 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0167 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0167 | 1 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0167 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.4279 | 0.4203 |
Leishmania major | cathepsin L-like protease | 0.0167 | 1 | 0.5 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0167 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0167 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0167 | 1 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0167 | 1 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0086 | 0.1609 | 0.1609 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0167 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0167 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1607 | 0.1495 |
Onchocerca volvulus | 0.0167 | 1 | 1 | |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0167 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0167 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0167 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0167 | 1 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0167 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0167 | 1 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.0112 | 0.4279 | 0.4203 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0158 | 0.9044 | 0.9032 |
Plasmodium vivax | vivapain-2 | 0.0167 | 1 | 1 |
Echinococcus multilocularis | insulin receptor | 0.0158 | 0.9044 | 0.9032 |
Brugia malayi | cathepsin L-like precursor | 0.0112 | 0.4279 | 0.4203 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0112 | 0.4279 | 0.3182 |
Brugia malayi | Protein kinase domain containing protein | 0.0087 | 0.1739 | 0.1629 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0112 | 0.4279 | 0.4203 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0167 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0158 | 0.9044 | 0.9032 |
Schistosoma mansoni | tyrosine kinase | 0.0072 | 0.0132 | 0.0132 |
Onchocerca volvulus | 0.0167 | 1 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0112 | 0.4279 | 0.4203 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0167 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0112 | 0.4279 | 0.3182 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0167 | 1 | 1 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0158 | 0.9044 | 0.9032 |
Leishmania major | cysteine peptidase A (CPA) | 0.0167 | 1 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0167 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0167 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0167 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0167 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0167 | 1 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0086 | 0.1609 | 0.1609 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0167 | 1 | 1 |
Onchocerca volvulus | 0.0167 | 1 | 1 | |
Plasmodium vivax | vivapain-2 | 0.0167 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0112 | 0.4279 | 0.3182 |
Brugia malayi | Cathepsin L-like precursor | 0.0167 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.4279 | 0.4203 |
Onchocerca volvulus | Cathepsin F homolog | 0.0167 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0167 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0167 | 1 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0167 | 1 | 1 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0158 | 0.9044 | 0.9032 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0167 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0167 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0167 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.4279 | 0.4203 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.