Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | matrix metallopeptidase 12 (macrophage elastase) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | matrix metallopeptidase 12 (macrophage elastase) | 470 aa | 467 aa | 32.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hexokinase type II | 0.0779 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.0779 | 1 | 1 |
Entamoeba histolytica | hexokinase 2 | 0.0779 | 1 | 0.5 |
Onchocerca volvulus | 0.0779 | 1 | 1 | |
Loa Loa (eye worm) | hexokinase | 0.0241 | 0.248 | 0.248 |
Onchocerca volvulus | 0.0779 | 1 | 1 | |
Echinococcus granulosus | hexokinase type 2 | 0.0779 | 1 | 1 |
Leishmania major | hexokinase, putative | 0.0779 | 1 | 0.5 |
Leishmania major | hexokinase, putative | 0.0779 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0248 | 0.2573 | 0.2573 |
Echinococcus granulosus | hexokinase | 0.0779 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0779 | 1 | 1 |
Brugia malayi | hexokinase type II | 0.0248 | 0.2573 | 0.2573 |
Treponema pallidum | hexokinase (hxk) | 0.0779 | 1 | 0.5 |
Trypanosoma cruzi | hexokinase, putative | 0.0779 | 1 | 0.5 |
Brugia malayi | Hexokinase family protein | 0.0779 | 1 | 1 |
Plasmodium vivax | hexokinase, putative | 0.0779 | 1 | 0.5 |
Trypanosoma brucei | hexokinase | 0.0779 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0779 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.0779 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.0779 | 1 | 1 |
Entamoeba histolytica | hexokinase 1 | 0.0779 | 1 | 0.5 |
Brugia malayi | Hexokinase family protein | 0.0489 | 0.5942 | 0.5942 |
Loa Loa (eye worm) | hypothetical protein | 0.0248 | 0.2573 | 0.2573 |
Brugia malayi | Hexokinase family protein | 0.0241 | 0.248 | 0.248 |
Toxoplasma gondii | hexokinase | 0.0779 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0779 | 1 | 1 |
Schistosoma mansoni | hexokinase | 0.0779 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0779 | 1 | 1 |
Onchocerca volvulus | 0.0779 | 1 | 1 | |
Trypanosoma brucei | hexokinase | 0.0779 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0489 | 0.5942 | 0.5942 |
Echinococcus multilocularis | hexokinase type 2 | 0.0779 | 1 | 1 |
Plasmodium falciparum | hexokinase | 0.0779 | 1 | 0.5 |
Trypanosoma brucei | hexokinase, putative | 0.0779 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0532 | 0.6538 | 0.6538 |
Trypanosoma cruzi | hexokinase, putative | 0.0779 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 70 nM | Inhibition of MMP12 | ChEMBL. | 21344906 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.