Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.2071 | 0 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.2404 | 0.1523 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.4098 | 0.9282 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.2404 | 0.1523 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.2404 | 0.1523 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
clogP | = 3.09 | Calculated partition coefficient (clogP) (relative to BAY K 8644) | ChEMBL. | 8151623 |
CMR (ADMET) | = 7.6 | CMR value (relative to BAY K 8644) | ChEMBL. | 8151623 |
EC50 (functional) | = 0.27 | Effective concentration required for force of contraction relative to BAY K 8644 | ChEMBL. | 8151623 |
EC50 (functional) | = 4.3 uM | Tested for the increase in [Ca2+] uptake into rat pituitary growth hormone3 (GH3) cells | ChEMBL. | 7692047 |
EC50 (functional) | = 4.84 uM | Tested for the force increase in guinea pig atria | ChEMBL. | 7692047 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.