Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | retinoid X receptor, beta | Starlite/ChEMBL | No references |
Homo sapiens | retinoic acid receptor, gamma | Starlite/ChEMBL | References |
Homo sapiens | retinoid X receptor, gamma | Starlite/ChEMBL | No references |
Homo sapiens | retinoic acid receptor, alpha | Starlite/ChEMBL | References |
Homo sapiens | retinoic acid receptor, beta | Starlite/ChEMBL | References |
Homo sapiens | retinoid X receptor, alpha | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | ecdysteroid receptor | retinoid X receptor, alpha | 435 aa | 352 aa | 23.9 % |
Brugia malayi | ecdysteroid receptor | retinoid X receptor, gamma | 340 aa | 338 aa | 24.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | retinoic acid receptor RXR | 0.0507 | 0.1767 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0507 | 0.1767 | 0.5 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.047 | 0.0849 | 0.5 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0802 | 0.9083 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0802 | 0.9083 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0769 | 0.8263 | 0.9098 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | Agonist activity for retinoic acid receptor RAR alpha in transcriptional activation assay; NA means not active (EC50>10e4 nM) | ChEMBL. | No reference | |
EC50 (functional) | 0 | Agonist activity for retinoic acid receptor RAR alpha in transcriptional activation assay; NA means not active (EC50>10e4 nM) | ChEMBL. | No reference |
EC50 (binding) | > 0.001 nM | Transcriptional activation of Retinoic acid receptor RAR alpha | ChEMBL. | 7636843 |
EC50 (binding) | > 0.001 nM | Transcriptional activation of Retinoic acid receptor RAR beta | ChEMBL. | 7636843 |
EC50 (binding) | > 0.001 nM | Transcriptional activation of Retinoic acid receptor RAR gamma | ChEMBL. | 7636843 |
EC50 (binding) | > 0.001 nM | Transcriptional activation of Retinoic acid receptor RAR alpha | ChEMBL. | 7636843 |
EC50 (binding) | > 0.001 nM | Transcriptional activation of Retinoic acid receptor RAR beta | ChEMBL. | 7636843 |
EC50 (binding) | > 0.001 nM | Transcriptional activation of Retinoic acid receptor RAR gamma | ChEMBL. | 7636843 |
EC50 (functional) | = 20 nM | Transglutaminase activity in HL-60 cdm-1 cells | ChEMBL. | 7636843 |
EC50 (functional) | = 20 nM | Transglutaminase activity in HL-60 cdm-1 cells | ChEMBL. | 7636843 |
EC50 (functional) | = 105 nM | Agonist activity for retinoic acid receptor RXR gamma in transcriptional activation assay | ChEMBL. | No reference |
EC50 (functional) | = 105 nM | Agonist activity for retinoic acid receptor RXR gamma in transcriptional activation assay | ChEMBL. | No reference |
EC50 (functional) | = 180 nM | Agonist activity for retinoic acid receptor RXR beta in transcriptional activation assay | ChEMBL. | No reference |
EC50 (functional) | = 180 nM | Agonist activity for retinoic acid receptor RXR beta in transcriptional activation assay | ChEMBL. | No reference |
EC50 (binding) | = 201 nM | Transcriptional activation of Retinoid X receptor RXR alpha | ChEMBL. | 7636843 |
EC50 (binding) | = 201 nM | Transcriptional activation of Retinoid X receptor RXR alpha | ChEMBL. | 7636843 |
EC50 (functional) | = 215 nM | Agonist activity for retinoic acid receptor RXR alpha in transcriptional activation assay | ChEMBL. | No reference |
EC50 (functional) | = 215 nM | Agonist activity for retinoic acid receptor RXR alpha in transcriptional activation assay | ChEMBL. | No reference |
EC50 (functional) | = 979 nM | Agonist activity for retinoic acid receptor RAR gamma in transcriptional activation assay | ChEMBL. | No reference |
EC50 (functional) | = 979 nM | Agonist activity for retinoic acid receptor RAR gamma in transcriptional activation assay | ChEMBL. | No reference |
EC50 (functional) | = 1990 nM | Agonist activity for retinoic acid receptor RAR beta in transcriptional activation assay | ChEMBL. | No reference |
EC50 (functional) | = 1990 nM | Agonist activity for retinoic acid receptor RAR beta in transcriptional activation assay | ChEMBL. | No reference |
IC50 (functional) | = 63 nM | In vitro inhibition of chondrogenesis in mouse embryo limb bud cells | ChEMBL. | 7636843 |
IC50 (functional) | = 63 nM | In vitro inhibition of chondrogenesis in mouse embryo limb bud cells | ChEMBL. | 7636843 |
IC80 (functional) | > 300 nM | Inhibition of tumor-promoter-induced ornithine decarboxylase in TPA-treated female hairless mice | ChEMBL. | 7636843 |
IC80 (functional) | > 300 nM | Inhibition of tumor-promoter-induced ornithine decarboxylase in TPA-treated female hairless mice | ChEMBL. | 7636843 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 7636843 | |
Mus musculus | ChEMBL23 | 7636843 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.