Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | caspase 6, apoptosis-related cysteine peptidase | Starlite/ChEMBL | References |
Homo sapiens | caspase 1, apoptosis-related cysteine peptidase | Starlite/ChEMBL | References |
Homo sapiens | caspase 7, apoptosis-related cysteine peptidase | Starlite/ChEMBL | References |
Homo sapiens | caspase 3, apoptosis-related cysteine peptidase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Cell death protein 3 precursor | caspase 7, apoptosis-related cysteine peptidase | 303 aa | 256 aa | 37.1 % |
Echinococcus granulosus | caspase 8 | caspase 1, apoptosis-related cysteine peptidase | 383 aa | 312 aa | 26.6 % |
Brugia malayi | Cell death protein 3 precursor | caspase 3, apoptosis-related cysteine peptidase | 277 aa | 253 aa | 38.7 % |
Brugia malayi | Cell death protein 3 precursor | caspase 6, apoptosis-related cysteine peptidase | 293 aa | 270 aa | 34.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0712 | 1 | 1 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0712 | 1 | 1 |
Leishmania major | 0.0712 | 1 | 0.5 | |
Echinococcus granulosus | caspase | 0.0293 | 0.219 | 0.219 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0712 | 1 | 1 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0712 | 1 | 1 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0712 | 1 | 1 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0712 | 1 | 1 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0712 | 1 | 0.5 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0712 | 1 | 1 |
Echinococcus multilocularis | caspase | 0.0293 | 0.219 | 0.219 |
Echinococcus granulosus | caspase 3 apoptosis cysteine peptidase | 0.0293 | 0.219 | 0.219 |
Echinococcus multilocularis | caspase 3, apoptosis cysteine peptidase | 0.0293 | 0.219 | 0.219 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7.5 nM | Inhibition of human caspase 3 by fluorometric assay | ChEMBL. | 21441025 |
IC50 (binding) | = 26.5 nM | Inhibition of caspase 7 by fluorometric assay | ChEMBL. | 21441025 |
IC50 (binding) | = 770 nM | Inhibition of caspase 6 by fluorometric assay | ChEMBL. | 21441025 |
IC50 (binding) | = 3500 nM | Inhibition of caspase 1 by fluorometric assay | ChEMBL. | 21441025 |
IC50 (binding) | > 50000 nM | Inhibition of caspase 8 by fluorometric assay | ChEMBL. | 21441025 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.