TDR Targets

Basic information

Technical information

TDR Targets ID: 1528148
Name: N-[6-[2-[[4-chloro-5-methyl-2-(2-methylaminoe thoxy)phenyl]carbamoylamino]ethyl]-1H-benzimi dazol-2-yl]acetamide
MW: 458.941 | Formula: C22H27ClN6O3
H donors: 5 H acceptors: 3 LogP: 2.49 Rotable bonds: 12
Rule of 5 violations (Lipinski): 1
SMILES: CNCCOc1cc(Cl)c(cc1NC(=O)NCCc1ccc2c(c1)[nH]c(n2)NC(=O)C)C
InChi: 1S/C22H27ClN6O3/c1-13-10-19(20(12-16(13)23)32-9-8-24-3)29-22(31)25-7-6-15-4-5-17-18(11-15)28-21(27-17)26-14(2)30/h4-5,10-12,24H,6-9H2,1-3H3,(H2,25,29,31)(H2,26,27,28,30)
InChiKey: YTELHSLAVCBEFZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[6-[2-[[[[4-chloro-5-methyl-2-(2-methylaminoethoxy)phenyl]amino]-oxomethyl]amino]ethyl]-1H-benzimidazol-2-yl]acetamide
N-[6-[2-[[4-chloro-5-methyl-2-(2-methylaminoethoxy)phenyl]carbamoylamino]ethyl]-1H-benzimidazol-2-yl]ethanamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	Raf-1 proto-oncogene, serine/threonine kinase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	raf serine:threonine protein kinase	Get druggable targets OG5_130459	All targets in OG5_130459
Loa Loa (eye worm)	raf kinase	Get druggable targets OG5_130459	All targets in OG5_130459
Brugia malayi	Raf kinase	Get druggable targets OG5_130459	All targets in OG5_130459
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_130459	All targets in OG5_130459
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	Get druggable targets OG5_130459	All targets in OG5_130459
Schistosoma japonicum	ko:K04365 B-Raf proto-oncogene serine/threonine-protein kinase, putative	Get druggable targets OG5_130459	All targets in OG5_130459
Echinococcus granulosus	raf serine:threonine protein kinase	Get druggable targets OG5_130459	All targets in OG5_130459

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	proteasome subunit beta type 1	0.0487	0.2452	0.7702
Schistosoma mansoni	ankyrin 23/unc44	0.0188	0.089	0.2796
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0123	0.0549	0.0549
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.004	0.0124
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0302	0.1483	0.1483
Trypanosoma cruzi	proteasome subunit alpha type-5, putative	0.0123	0.0549	0.1724
Brugia malayi	proteasome subunit beta type 3	0.0123	0.0549	0.1724
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0123	0.0549	0.1724
Giardia lamblia	Proteasome subunit beta type 4 precursor	0.0123	0.0549	0.1724
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0134	0.0605	0.1899
Brugia malayi	proteasome subunit alpha type 2	0.0123	0.0549	0.1724
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0302	0.1483	0.4659
Brugia malayi	Cathepsin L-like precursor	0.0026	0.004	0.0124
Echinococcus granulosus	proteasome subunit beta type 6	0.0123	0.0549	0.0549
Plasmodium falciparum	proteasome subunit alpha type-4, putative	0.0123	0.0549	0.1724
Plasmodium falciparum	proteasome subunit alpha type-5, putative	0.0123	0.0549	0.1724
Toxoplasma gondii	proteasome subunit alpha1, putative	0.0123	0.0549	0.1724
Brugia malayi	Cathepsin L-like precursor	0.0026	0.004	0.0124
Trypanosoma cruzi	proteasome subunit alpha type-5, putative	0.0123	0.0549	0.1724
Brugia malayi	MH2 domain containing protein	0.0116	0.0509	0.16
Trypanosoma cruzi	proteasome alpha 3 subunit, putative	0.0123	0.0549	0.1724
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0139	0.0634	0.1991
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0123	0.0549	0.1724
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.004	0.0124
Loa Loa (eye worm)	proteasome subunit alpha type 1	0.0123	0.0549	0.1724
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0134	0.0605	0.0605
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0123	0.0549	0.1724
Echinococcus granulosus	proteasome subunit alpha type 2	0.0123	0.0549	0.0549
Brugia malayi	Cathepsin L-like precursor	0.0026	0.004	0.0124
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0139	0.0634	0.1991
Entamoeba histolytica	hypothetical protein	0.0035	0.0087	0.0273
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0139	0.0634	0.1991
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0188	0.089	0.089
Toxoplasma gondii	proteasome beta subunit	0.0123	0.0549	0.1724
Entamoeba histolytica	proteasome subunit alpha type 6, putative	0.0123	0.0549	0.1724
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0123	0.0549	0.1724
Leishmania major	proteasome alpha 7 subunit, putative	0.0123	0.0549	0.1724
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0123	0.0549	0.1724
Trypanosoma cruzi	proteasome subunit beta type-2, putative	0.0302	0.1483	0.4659
Onchocerca volvulus	Netrin receptor homolog	0.0188	0.089	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.004	0.0124
Entamoeba histolytica	proteasome subunit beta type 1, putative	0.0487	0.2452	0.7702
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0123	0.0549	0.1724
Plasmodium vivax	proteasome subunit beta type-3, putative	0.0123	0.0549	0.1724
Schistosoma mansoni	proteasome catalytic subunit 3 (T01 family)	0.0627	0.3183	1
Giardia lamblia	Cathepsin B precursor	0.005	0.0166	0.0523
Schistosoma mansoni	hypothetical protein	0.0035	0.0087	0.0273
Trypanosoma brucei	proteasome alpha 2 subunit, putative	0.0123	0.0549	0.1724
Loa Loa (eye worm)	PAS-3 protein	0.0123	0.0549	0.1724
Schistosoma mansoni	proteasome catalytic subunit 1 (T01 family)	0.0123	0.0549	0.1724
Plasmodium vivax	vivapain-2	0.0026	0.004	0.0124
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0087	0.0087
Giardia lamblia	Proteasome subunit beta type 2	0.0302	0.1483	0.4659
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.004	0.0124
Loa Loa (eye worm)	transcription factor SMAD2	0.0116	0.0509	0.16
Brugia malayi	proteasome subunit beta type 2	0.0302	0.1483	0.4659
Trypanosoma brucei	ATP-dependent protease subunit HslV	0.0123	0.0549	0.1724
Leishmania major	cathepsin L-like protease	0.0026	0.004	0.0124
Brugia malayi	Papain family cysteine protease containing protein	0.0026	0.004	0.0124
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.004	0.0124
Entamoeba histolytica	probable proteasome subunit beta type 2, putative	0.0302	0.1483	0.4659
Loa Loa (eye worm)	proteasome subunit alpha type 2	0.0123	0.0549	0.1724
Trypanosoma brucei	cysteine peptidase C (CPC)	0.005	0.0166	0.0523
Toxoplasma gondii	peptidase, T1 family protein	0.0123	0.0549	0.1724
Entamoeba histolytica	proteasome subunit alpha type 1, putative	0.0123	0.0549	0.1724
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.004	0.0124
Plasmodium falciparum	proteasome subunit alpha type-2, putative	0.0123	0.0549	0.1724
Onchocerca volvulus	Notchless protein homolog	0.0123	0.0549	0.5989
Trypanosoma cruzi	cysteine peptidase, putative	0.0026	0.004	0.0124
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0026	0.004	0.004
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0487	0.2452	0.7702
Plasmodium falciparum	ATP-dependent protease subunit ClpQ	0.0123	0.0549	0.1724
Leishmania major	cathepsin L-like protease	0.0026	0.004	0.0124
Plasmodium vivax	vivapain-2	0.0026	0.004	0.0124
Entamoeba histolytica	proteasome subunit alpha type 7, putative	0.0123	0.0549	0.1724
Giardia lamblia	Proteasome subunit beta type 5 precursor	0.0627	0.3183	1
Echinococcus multilocularis	integrin beta 2	0.0258	0.1254	0.1254
Mycobacterium tuberculosis	Proteasome alpha subunit PrcA; assembles with beta subunit PrcB.	0.0123	0.0549	0.1724
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0123	0.0549	0.1724
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.004	0.0124
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0302	0.1483	0.1483
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.004	0.0124
Echinococcus granulosus	proteasome subunit beta t family	0.0123	0.0549	0.0549
Echinococcus multilocularis	proteasome (prosome macropain) subunit beta type	0.0123	0.0549	0.0549
Leishmania major	cathepsin L-like protease	0.0026	0.004	0.0124
Plasmodium vivax	proteasome subunit alpha type-7, putative	0.0123	0.0549	0.1724
Trypanosoma cruzi	cysteine peptidase, putative	0.0026	0.004	0.0124
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.004	0.0124
Leishmania major	hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B	0.0123	0.0549	0.1724
Schistosoma mansoni	serine/threonine protein kinase	0.0262	0.1274	0.4001
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0026	0.004	0.0124
Leishmania major	proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative)	0.0123	0.0549	0.1724
Giardia lamblia	20S proteasome alpha subunit 4	0.0123	0.0549	0.1724
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0134	0.0605	0.1899
Giardia lamblia	20S proteasome alpha subunit 5	0.0123	0.0549	0.1724
Plasmodium falciparum	proteasome subunit alpha type-3, putative	0.0123	0.0549	0.1724
Toxoplasma gondii	proteasome subunit alpha type, putative	0.0123	0.0549	0.1724
Loa Loa (eye worm)	proteasome subunit alpha type 7-1	0.0123	0.0549	0.1724
Entamoeba histolytica	hypothetical protein	0.0035	0.0087	0.0273
Trypanosoma cruzi	cysteine peptidase, putative	0.0026	0.004	0.0124
Echinococcus multilocularis	proteasome subunit beta type 7	0.0123	0.0549	0.0549
Echinococcus multilocularis	Proteasome, subunit alpha beta	0.0123	0.0549	0.0549
Leishmania major	cathepsin L-like protease	0.0026	0.004	0.0124
Entamoeba histolytica	proteasome subunit alpha type 4, putative	0.0123	0.0549	0.1724
Toxoplasma gondii	proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative	0.0123	0.0549	0.1724
Echinococcus granulosus	geminin	0.033	0.1629	0.1629
Giardia lamblia	Proteasome subunit beta type 9 precursor	0.0123	0.0549	0.1724
Schistosoma mansoni	proteasome subunit alpha 6 (T01 family)	0.0123	0.0549	0.1724
Trypanosoma cruzi	proteasome beta 3 subunit, putative	0.0123	0.0549	0.1724
Schistosoma mansoni	hypothetical protein	0.0188	0.089	0.2796
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.005	0.0166	0.0523
Leishmania major	proteasome alpha 3 subunit, putative	0.0123	0.0549	0.1724
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.004	0.0124
Leishmania major	cathepsin L-like protease	0.0026	0.004	0.0124
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0123	0.0549	0.1724
Trypanosoma cruzi	proteasome alpha 1 subunit, putative	0.0123	0.0549	0.1724
Trypanosoma cruzi	proteasome subunit alpha type-1, putative	0.0123	0.0549	0.1724
Toxoplasma gondii	proteasome subunit beta type 7 precursor, putative	0.0123	0.0549	0.1724
Loa Loa (eye worm)	cathepsin B	0.005	0.0166	0.0523
Schistosoma mansoni	proteasome subunit alpha 1 (T01 family)	0.0123	0.0549	0.1724
Schistosoma mansoni	cathepsin F (C01 family)	0.0026	0.004	0.0124
Mycobacterium ulcerans	proteasome PrcA	0.0123	0.0549	0.1724
Echinococcus granulosus	20S proteasome subunit alpha 6	0.0123	0.0549	0.0549
Echinococcus multilocularis	proteasome subunit alpha type 6	0.0123	0.0549	0.0549
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0123	0.0549	0.1724
Giardia lamblia	20S proteasome alpha subunit 3	0.0123	0.0549	0.1724
Brugia malayi	proteasome subunit alpha type 4	0.0123	0.0549	0.1724
Trypanosoma brucei	Proteasome subunit A N-terminal signature/Proteasome subunit, putative	0.0123	0.0549	0.1724
Brugia malayi	Proteasome A-type and B-type family protein	0.0627	0.3183	1
Schistosoma mansoni	proteasome subunit alpha 2 (T01 family)	0.0123	0.0549	0.1724
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0123	0.0549	0.1724
Brugia malayi	Kelch motif family protein	0.0055	0.0194	0.061
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.004	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0188	0.089	0.2796
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.004	0.0124
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0026	0.004	0.0124
Brugia malayi	proteasome subunit alpha type 6	0.0123	0.0549	0.1724
Loa Loa (eye worm)	cysteine protease	0.0026	0.004	0.0124
Brugia malayi	proteasome subunit alpha type 1	0.0123	0.0549	0.1724
Toxoplasma gondii	proteasome subunit beta type 2, putative	0.0302	0.1483	0.4659
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0123	0.0549	0.1724
Leishmania major	cathepsin L-like protease	0.0026	0.004	0.0124
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0134	0.0605	0.0605
Echinococcus multilocularis	proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta	0.0123	0.0549	0.0549
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0188	0.089	0.2796
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.004	0.0124
Plasmodium vivax	proteasome subunit alpha type-6, putative	0.0123	0.0549	0.1724
Echinococcus multilocularis	Ankyrin	0.0189	0.0894	0.0894
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.1929	1	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.005	0.0166	0.0523
Leishmania major	proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative	0.0487	0.2452	0.7702
Plasmodium vivax	proteasome subunit beta type-6, putative	0.0123	0.0549	0.1724
Plasmodium falciparum	proteasome subunit beta type-6, putative	0.0123	0.0549	0.1724
Plasmodium falciparum	proteasome subunit beta type-3, putative	0.0123	0.0549	0.1724
Plasmodium falciparum	proteasome subunit beta type-7, putative	0.0123	0.0549	0.1724
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.004	0.0124
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0026	0.004	0.004
Plasmodium vivax	proteasome subunit beta type-5, putative	0.0627	0.3183	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.004	0.0124
Entamoeba histolytica	proteasome subunit alpha type 3, putative	0.0123	0.0549	0.1724
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0026	0.004	0.0124
Echinococcus granulosus	proteasome prosome macropain	0.0627	0.3183	0.3183
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0134	0.0605	0.1899
Trypanosoma cruzi	ATP-dependent protease subunit HslV, putative	0.0123	0.0549	0.1724
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0302	0.1483	0.4659
Loa Loa (eye worm)	hypothetical protein	0.0026	0.004	0.0124
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0189	0.0894	0.2809
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0123	0.0549	0.0549
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0123	0.0549	0.1724
Entamoeba histolytica	proteasome subunit alpha type 3, putative	0.0123	0.0549	0.1724
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0123	0.0549	0.0549
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0194	0.061
Giardia lamblia	20S proteasome alpha subunit 6	0.0123	0.0549	0.1724
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0026	0.004	0.0124
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.004	0.0124
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0123	0.0549	0.1724
Brugia malayi	Cathepsin L-like precursor	0.0026	0.004	0.0124
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0134	0.0605	0.1899
Loa Loa (eye worm)	hypothetical protein	0.0189	0.0894	0.2809
Trypanosoma cruzi	proteasome alpha 2 subunit, putative	0.0123	0.0549	0.1724
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.004	0.0124
Echinococcus multilocularis	geminin	0.033	0.1629	0.1629
Loa Loa (eye worm)	proteasome subunit beta type 2	0.0302	0.1483	0.4659
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0123	0.0549	0.1724
Loa Loa (eye worm)	proteasome subunit alpha type 3	0.0123	0.0549	0.1724
Trypanosoma brucei	proteasome beta-1 subunit, putative	0.0123	0.0549	0.1724
Entamoeba histolytica	calcium-dependent protein kinase 2, putative	0.0123	0.0549	0.1724
Brugia malayi	Cathepsin L-like precursor	0.0026	0.004	0.0124
Brugia malayi	Proteasome subunit alpha type 7-1	0.0123	0.0549	0.1724
Toxoplasma gondii	proteasome subunit	0.0123	0.0549	0.1724
Loa Loa (eye worm)	kelch domain-containing protein family protein	0.0055	0.0194	0.061
Entamoeba histolytica	proteasome subunit alpha type 5, putative	0.0123	0.0549	0.1724
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0123	0.0549	0.1724
Plasmodium vivax	proteasome subunit alpha type-5, putative	0.0123	0.0549	0.1724
Plasmodium falciparum	proteasome subunit beta type-2, putative	0.0302	0.1483	0.4659
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0134	0.0605	0.1899
Plasmodium vivax	proteasome subunit beta type-7, putative	0.0123	0.0549	0.1724
Plasmodium vivax	proteasome subunit alpha type-2, putative	0.0123	0.0549	0.1724
Loa Loa (eye worm)	integrin beta-2	0.0352	0.1748	0.549
Entamoeba histolytica	proteasome subunit alpha type 4, putative	0.0123	0.0549	0.1724
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.004	0.0124
Brugia malayi	Cathepsin L-like precursor	0.0026	0.004	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0026	0.004	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0026	0.004	0.0124
Giardia lamblia	Proteasome subunit beta type 7 precursor	0.0123	0.0549	0.1724
Toxoplasma gondii	heat shock protein hslv, putative	0.0123	0.0549	0.1724
Trypanosoma brucei	proteasome alpha 7 subunit, putative	0.0123	0.0549	0.1724
Trypanosoma cruzi	cysteine peptidase, putative	0.0026	0.004	0.0124
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.005	0.0166	0.0523
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0634	0.1991
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0123	0.0549	0.1724
Echinococcus granulosus	proteasome prosome macropain subunit alpha	0.0123	0.0549	0.0549
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0123	0.0549	0.1724
Leishmania major	cathepsin L-like protease	0.0026	0.004	0.0124
Schistosoma mansoni	proteasome subunit alpha 4 (T01 family)	0.0123	0.0549	0.1724
Toxoplasma gondii	proteasome subunit alpha type 1, putative	0.0123	0.0549	0.1724
Schistosoma mansoni	proteasome subunit beta 4 (T01 family)	0.0123	0.0549	0.1724
Echinococcus multilocularis	cathepsin b	0.0139	0.0634	0.0634
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0123	0.0549	0.1724
Leishmania major	proteasome beta 3 subunit, putative	0.0123	0.0549	0.1724
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.004	0.0124
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0627	0.3183	1
Schistosoma mansoni	proteasome catalytic subunit 2 (T01 family)	0.0123	0.0549	0.1724
Giardia lamblia	20S proteasome alpha subunit 2	0.0123	0.0549	0.1724
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.004	0.0124
Trypanosoma brucei	proteasome alpha 1 subunit, putative	0.0123	0.0549	0.1724
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.004	0.0124
Entamoeba histolytica	proteasome subunit beta type 7-B precursor, putative	0.0123	0.0549	0.1724
Toxoplasma gondii	proteasome subunit alpha type 5-2, putative	0.0123	0.0549	0.1724
Schistosoma mansoni	proteasome subunit beta 1 (T01 family)	0.0487	0.2452	0.7702
Echinococcus multilocularis	cathepsin L cysteine protease	0.0026	0.004	0.004
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0123	0.0549	0.1724
Giardia lamblia	Proteasome subunit beta type 1	0.0487	0.2452	0.7702
Brugia malayi	Protein kinase domain containing protein	0.0188	0.089	0.2796
Brugia malayi	cathepsin L-like precursor	0.0026	0.004	0.0124
Entamoeba histolytica	cysteine proteinase, putative	0.0026	0.004	0.0124
Echinococcus granulosus	cathepsin b	0.0139	0.0634	0.0634
Echinococcus granulosus	proteasome subunit alpha type 6	0.0123	0.0549	0.0549
Leishmania major	cathepsin L-like protease	0.0026	0.004	0.0124
Loa Loa (eye worm)	MH2 domain-containing protein	0.0116	0.0509	0.16
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0123	0.0549	0.1724
Leishmania major	proteasome beta 2 subunit, putative	0.0123	0.0549	0.1724
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0627	0.3183	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.004	0.0124
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0026	0.004	0.004
Brugia malayi	proteasome subunit alpha type 3	0.0123	0.0549	0.1724
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.004	0.0124
Echinococcus granulosus	integrin beta 2	0.0258	0.1254	0.1254
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0123	0.0549	0.1724
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0123	0.0549	0.1724
Trypanosoma brucei	proteasome subunit alpha type-5, putative	0.0123	0.0549	0.1724
Entamoeba histolytica	cysteine proteinase, putative	0.0026	0.004	0.0124
Plasmodium vivax	proteasome subunit alpha type-4, putative	0.0123	0.0549	0.1724
Giardia lamblia	Cathepsin B precursor	0.005	0.0166	0.0523
Echinococcus multilocularis	proteasome (prosome, macropain)	0.0627	0.3183	0.3183
Loa Loa (eye worm)	20S proteasome alpha5 subunit	0.0123	0.0549	0.1724
Schistosoma mansoni	cathepsin F (C01 family)	0.0026	0.004	0.0124
Leishmania major	proteasome alpha 2 subunit, putative	0.0123	0.0549	0.1724
Echinococcus granulosus	death domain containing protein	0.0188	0.089	0.089
Toxoplasma gondii	proteasome subunit beta type 1, putative	0.0487	0.2452	0.7702
Brugia malayi	Proteasome A-type and B-type family protein	0.0123	0.0549	0.1724
Trypanosoma cruzi	proteasome beta 2 subunit, putative	0.0123	0.0549	0.1724
Trypanosoma cruzi	proteasome alpha 1 subunit, putative	0.0123	0.0549	0.1724
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0026	0.004	0.0124
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0087	0.0273
Entamoeba histolytica	cysteine protease, putative	0.0026	0.004	0.0124
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.004	0.0124
Trypanosoma cruzi	proteasome alpha 3 subunit, putative	0.0123	0.0549	0.1724
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0123	0.0549	0.1724
Giardia lamblia	Proteasome subunit beta type 3	0.0123	0.0549	0.1724
Echinococcus granulosus	raf serine:threonine protein kinase	0.0262	0.1274	0.1274
Giardia lamblia	20S proteasome alpha subunit 1	0.0123	0.0549	0.1724
Brugia malayi	Integrin beta pat-3 precursor	0.0352	0.1748	0.549
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0123	0.0549	0.1724
Echinococcus granulosus	cathepsin l1	0.0026	0.004	0.004
Entamoeba histolytica	hypothetical protein	0.0035	0.0087	0.0273
Brugia malayi	Cathepsin L-like precursor	0.0026	0.004	0.0124
Echinococcus granulosus	Ankyrin	0.0189	0.0894	0.0894
Trypanosoma cruzi	proteasome beta 3 subunit, putative	0.0123	0.0549	0.1724
Entamoeba histolytica	proteasome subunit alpha type 2-A, putative	0.0123	0.0549	0.1724
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0026	0.004	0.0124
Trypanosoma cruzi	proteasome beta 7 subunit, putative	0.0123	0.0549	0.1724
Entamoeba histolytica	proteasome subunit alpha type 5, putative	0.0123	0.0549	0.1724
Trypanosoma brucei	proteasome subunit beta type-5, putative	0.0627	0.3183	1
Brugia malayi	Proteasome subunit alpha type 1	0.0123	0.0549	0.1724
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0123	0.0549	0.1724
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0139	0.0634	0.1991
Brugia malayi	Uncoordinated protein 44	0.0188	0.089	0.2796
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0123	0.0549	0.1724
Mycobacterium ulcerans	proteasome PrcB	0.0627	0.3183	1
Brugia malayi	Proteasome A-type and B-type family protein	0.0123	0.0549	0.1724
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.004	0.0124
Brugia malayi	20S proteasome alpha5 subunit	0.0123	0.0549	0.1724
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0302	0.1483	0.4659
Plasmodium falciparum	proteasome subunit beta type-5	0.0627	0.3183	1
Echinococcus granulosus	subfamily T1A non peptidase ue	0.0123	0.0549	0.0549
Echinococcus granulosus	proteasome prosome macropain subunit beta type	0.0123	0.0549	0.0549
Leishmania major	cysteine peptidase A (CPA)	0.0026	0.004	0.0124
Entamoeba histolytica	proteasome subunit beta type 6 precursor, putative	0.0123	0.0549	0.1724
Echinococcus granulosus	Proteasome subunit alpha type 7	0.0123	0.0549	0.0549
Trypanosoma brucei	proteasome beta 6 subunit	0.0487	0.2452	0.7702
Trypanosoma brucei	proteasome beta 7 subunit	0.0123	0.0549	0.1724
Schistosoma mansoni	hypothetical protein	0.033	0.1629	0.5117
Schistosoma mansoni	integrin beta subunit	0.0203	0.0965	0.303
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.004	0.0124
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.004	0.0124
Toxoplasma gondii	proteasome subunit beta type, putative	0.0627	0.3183	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.004	0.0124
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0134	0.0605	0.0605
Wolbachia endosymbiont of Brugia malayi	ATP-dependent protease peptidase subunit	0.0123	0.0549	1
Entamoeba histolytica	proteasome subunit beta type 3, putative	0.0123	0.0549	0.1724
Toxoplasma gondii	cathepsin B	0.005	0.0166	0.0523
Trypanosoma cruzi	proteasome beta-1 subunit, putative	0.0123	0.0549	0.1724
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0487	0.2452	0.7702
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0627	0.3183	1
Echinococcus multilocularis	subfamily T1A non peptidase ue	0.0123	0.0549	0.0549
Trypanosoma brucei	proteasome beta 2 subunit, putative	0.0123	0.0549	0.1724
Trypanosoma cruzi	proteasome alpha 2 subunit, putative	0.0123	0.0549	0.1724
Giardia lamblia	20S proteasome alpha subunit 7	0.0123	0.0549	0.1724
Schistosoma mansoni	netrin receptor unc5	0.0188	0.089	0.2796
Loa Loa (eye worm)	proteasome subunit beta type 1	0.0487	0.2452	0.7702
Echinococcus multilocularis	cathepsin b	0.0139	0.0634	0.0634
Plasmodium vivax	proteasome subunit alpha type-3, putative	0.0123	0.0549	0.1724
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0262	0.1274	0.1274
Toxoplasma gondii	cathepsin CPL	0.0026	0.004	0.0124
Trypanosoma cruzi	20S proteasome subunit	0.0302	0.1483	0.4659
Echinococcus granulosus	cathepsin l1	0.0026	0.004	0.004
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0026	0.004	0.0124
Entamoeba histolytica	cysteine proteinase, putative	0.0026	0.004	0.0124
Plasmodium falciparum	proteasome subunit beta type-4	0.0123	0.0549	0.1724
Plasmodium vivax	proteasome subunit beta type-4, putative	0.0123	0.0549	0.1724
Loa Loa (eye worm)	ctsf protein	0.0026	0.004	0.0124
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0487	0.2452	0.2452
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0018	0	0.5
Echinococcus multilocularis	proteasome (prosome macropain) subunit alpha	0.0123	0.0549	0.0549
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.004	0.0124
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0487	0.2452	0.2452
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0302	0.1483	0.4659
Trypanosoma cruzi	proteasome beta-1 subunit, putative	0.0123	0.0549	0.1724
Trypanosoma brucei	proteasome alpha 3 subunit, putative	0.0123	0.0549	0.1724
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.004	0.0124
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.004	0.0124
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0148	0.0681	0.2139
Schistosoma mansoni	proteasome subunit alpha 7 (T01 family)	0.0123	0.0549	0.1724
Entamoeba histolytica	proteasome subunit beta type 5 precursor, putative	0.0627	0.3183	1
Leishmania major	proteasome alpha 1 subunit, putative	0.0123	0.0549	0.1724
Plasmodium falciparum	proteasome subunit alpha type-7, putative	0.0123	0.0549	0.1724
Trypanosoma cruzi	hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B	0.0123	0.0549	0.1724
Leishmania major	proteasome beta-1 subunit, putative	0.0123	0.0549	0.1724
Loa Loa (eye worm)	proteasome subunit alpha type 6	0.0123	0.0549	0.1724
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0123	0.0549	0.1724
Echinococcus granulosus	proteasome subunit beta type 7	0.0123	0.0549	0.0549
Plasmodium vivax	proteasome subunit beta type-2, putative	0.0302	0.1483	0.4659
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0188	0.089	0.089
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.004	0.0124
Trypanosoma brucei	proteasome subunit beta type-2, putative	0.0302	0.1483	0.4659
Echinococcus multilocularis	20S proteasome subunit alpha 6	0.0123	0.0549	0.0549
Leishmania major	proteasome beta 7 subunit, putative	0.0123	0.0549	0.1724
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.004	0.0124
Loa Loa (eye worm)	raf kinase	0.026	0.1267	0.398
Plasmodium vivax	proteasome subunit alpha type-1, putative	0.0123	0.0549	0.1724
Leishmania major	proteasome beta 5 subunit, putative	0.0627	0.3183	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.004	0.0124
Brugia malayi	Raf kinase	0.0253	0.1226	0.3851
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.004	0.0124
Entamoeba histolytica	hypothetical protein	0.0035	0.0087	0.0273
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0123	0.0549	0.1724
Brugia malayi	cathepsin B-like cysteine proteinase	0.0139	0.0634	0.1991
Brugia malayi	hypothetical protein	0.0035	0.0087	0.0273
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0123	0.0549	0.1724
Loa Loa (eye worm)	hypothetical protein	0.0026	0.004	0.0124
Mycobacterium leprae	proteasome (beta subunit) PrcB	0.0627	0.3183	1
Echinococcus granulosus	Proteasome subunit alpha beta	0.0123	0.0549	0.0549
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0123	0.0549	0.1724
Entamoeba histolytica	proteasome subunit alpha type 7, putative	0.0123	0.0549	0.1724
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0134	0.0605	0.0605
Plasmodium falciparum	proteasome subunit alpha type-1, putative	0.0123	0.0549	0.1724
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0026	0.004	0.0124
Giardia lamblia	Cathepsin B precursor	0.005	0.0166	0.0523
Plasmodium falciparum	proteasome subunit alpha type-6, putative	0.0123	0.0549	0.1724
Schistosoma mansoni	proteasome subunit alpha 3 (T01 family)	0.0123	0.0549	0.1724
Echinococcus multilocularis	proteasome subunit alpha type 2	0.0123	0.0549	0.0549
Entamoeba histolytica	proteasome subunit beta Type 4 precursor, putative	0.0123	0.0549	0.1724
Trypanosoma brucei	proteasome beta 3 subunit, putative	0.0123	0.0549	0.1724
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0026	0.004	0.0124
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0792	0.4048	0.4048
Echinococcus granulosus	cathepsin b	0.0139	0.0634	0.0634
Trypanosoma cruzi	cruzipain precursor, putative	0.0026	0.004	0.0124
Echinococcus multilocularis	cysteine protease	0.0026	0.004	0.004
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0139	0.0634	0.1991
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0188	0.089	0.2796
Brugia malayi	Death domain containing protein	0.0188	0.089	0.2796
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0123	0.0549	0.1724
Echinococcus granulosus	netrin receptor unc 5	0.0188	0.089	0.089
Leishmania major	proteasome alpha 1 subunit, putative	0.0123	0.0549	0.1724
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0487	0.2452	0.7702
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.005	0.0166	0.0523
Echinococcus multilocularis	netrin receptor unc 5	0.0188	0.089	0.089
Plasmodium falciparum	proteasome subunit beta type-1, putative	0.0487	0.2452	0.7702
Leishmania major	proteasome beta 2 subunit, putative	0.0302	0.1483	0.4659
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0627	0.3183	1
Trypanosoma brucei	proteasome alpha 7 subunit	0.0123	0.0549	0.1724
Echinococcus multilocularis	cysteine protease	0.0026	0.004	0.004
Plasmodium vivax	ATP-dependent protease subunit ClpQ, putative	0.0123	0.0549	0.1724
Brugia malayi	Proteasome A-type and B-type family protein	0.0123	0.0549	0.1724
Mycobacterium tuberculosis	Proteasome beta subunit PrcB; assembles with alpha subunit PrcA.	0.0627	0.3183	1
Echinococcus multilocularis	proteasome subunit beta type 6	0.0123	0.0549	0.0549
Loa Loa (eye worm)	proteasome subunit beta type 3	0.0123	0.0549	0.1724
Loa Loa (eye worm)	fibroinase	0.0026	0.004	0.0124
Plasmodium vivax	proteasome subunit beta type-1, putative	0.0487	0.2452	0.7702
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0026	0.004	0.004
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.004	0.0124
Schistosoma mansoni	hypothetical protein	0.033	0.1629	0.5117
Toxoplasma gondii	20S proteasome subunit beta 7, putative	0.0123	0.0549	0.1724
Brugia malayi	hypothetical protein	0.0055	0.0194	0.061
Brugia malayi	Cathepsin L-like precursor	0.0026	0.004	0.0124
Echinococcus multilocularis	cathepsin L cysteine protease	0.0026	0.004	0.004
Schistosoma mansoni	cathepsin F (C01 family)	0.0026	0.004	0.0124
Leishmania major	proteasome alpha 7 subunit, putative	0.0123	0.0549	0.1724
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0087	0.0087

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.49 uM	Inhibition of human cRAF using [gamma-33P-ATP] as a substrate by scintillation counting	ChEMBL.	21420298

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1760640

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1528148