TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 294.301 | Formula: C18H14O4
H donors: 0 H acceptors: 2 LogP: 3.34 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccccc1c1cc2cc(C=O)cc(c2oc1=O)C
InChi: 1S/C18H14O4/c1-11-7-12(10-19)8-13-9-15(18(20)22-17(11)13)14-5-3-4-6-16(14)21-2/h3-10H,1-2H3
InChiKey: BDXMXQFJHFYMJC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	PAS-3 protein	0.0086	0.028	0.0922
Leishmania major	cathepsin L-like protease	0.0076	0.02	0.065
Echinococcus granulosus	Proteasome subunit alpha type 7	0.0086	0.028	0.0277
Echinococcus multilocularis	proteasome subunit beta type 6	0.0086	0.028	0.0117
Schistosoma mansoni	proteasome subunit alpha 7 (T01 family)	0.0086	0.028	0.0782
Plasmodium falciparum	proteasome subunit alpha type-7, putative	0.0086	0.028	0.0915
Echinococcus granulosus	Proteasome subunit alpha beta	0.0086	0.028	0.0277
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0086	0.028	0.0912
Trypanosoma cruzi	proteasome alpha 1 subunit, putative	0.0086	0.028	0.0915
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0801	0.2636
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0086	0.028	0.0915
Leishmania major	proteasome beta 3 subunit, putative	0.0086	0.028	0.0915
Plasmodium falciparum	proteasome subunit beta type-6, putative	0.0086	0.028	0.0915
Trypanosoma cruzi	20S proteasome subunit	0.0211	0.1257	0.4136
Leishmania major	proteasome alpha 1 subunit, putative	0.0086	0.028	0.0915
Echinococcus multilocularis	20S proteasome subunit alpha 6	0.0086	0.028	0.0117
Plasmodium falciparum	proteasome subunit alpha type-1, putative	0.0086	0.028	0.0915
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0076	0.02	0.0647
Leishmania major	hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B	0.0086	0.028	0.0915
Loa Loa (eye worm)	hypothetical protein	0.0076	0.02	0.0658
Trypanosoma brucei	Proteasome subunit A N-terminal signature/Proteasome subunit, putative	0.0086	0.028	0.0915
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0086	0.028	0.0782
Brugia malayi	Cathepsin L-like precursor	0.0076	0.02	0.0658
Plasmodium falciparum	proteasome subunit beta type-4	0.0086	0.028	0.0915
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0211	0.1257	0.3547
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0003	0.0011
Brugia malayi	Cathepsin L-like precursor	0.0051	0.0003	0.0011
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0086	0.028	0.0117
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0167	0.0915	0.3008
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0086	0.028	0.0915
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0086	0.028	0.0912
Schistosoma mansoni	proteasome catalytic subunit 1 (T01 family)	0.0086	0.028	0.0782
Entamoeba histolytica	proteasome subunit alpha type 4, putative	0.0086	0.028	0.0912
Trypanosoma cruzi	cysteine peptidase, putative	0.0167	0.0915	0.3008
Brugia malayi	Cathepsin L-like precursor	0.0051	0.0003	0.0011
Echinococcus multilocularis	proteasome subunit alpha type 6	0.0086	0.028	0.0117
Leishmania major	proteasome beta 5 subunit, putative	0.0438	0.3036	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0167	0.0915	0.3008
Echinococcus granulosus	proteasome subunit alpha type 2	0.0086	0.028	0.0277
Brugia malayi	Proteasome subunit alpha type 1	0.0086	0.028	0.0922
Entamoeba histolytica	hypothetical protein	0.0071	0.0165	0.0532
Loa Loa (eye worm)	ctsf protein	0.0076	0.02	0.0658
Schistosoma mansoni	proteasome subunit beta 1 (T01 family)	0.034	0.2271	0.6414
Brugia malayi	proteasome subunit alpha type 3	0.0086	0.028	0.0922
Entamoeba histolytica	proteasome subunit alpha type 7, putative	0.0086	0.028	0.0912
Onchocerca volvulus		0.0076	0.02	0.2463
Echinococcus multilocularis	netrin receptor unc 5	0.0136	0.0669	0.0512
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0136	0.0669	0.0512
Brugia malayi	Cathepsin L-like precursor	0.0076	0.02	0.0658
Brugia malayi	Death domain containing protein	0.0136	0.0669	0.2203
Leishmania major	proteasome beta-1 subunit, putative	0.0086	0.028	0.0915
Entamoeba histolytica	proteasome subunit beta Type 4 precursor, putative	0.0086	0.028	0.0912
Entamoeba histolytica	proteasome subunit alpha type 5, putative	0.0086	0.028	0.0912
Trypanosoma cruzi	proteasome subunit beta type-2, putative	0.0211	0.1257	0.4136
Toxoplasma gondii	cathepsin CPL	0.0076	0.02	0.065
Plasmodium falciparum	proteasome subunit beta type-2, putative	0.0211	0.1257	0.4136
Brugia malayi	Cathepsin L-like precursor	0.0076	0.02	0.0658
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0076	0.02	0.0647
Plasmodium vivax	proteasome subunit alpha type-5, putative	0.0086	0.028	0.0915
Schistosoma mansoni	proteasome subunit alpha 1 (T01 family)	0.0086	0.028	0.0782
Onchocerca volvulus		0.0076	0.02	0.2463
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0076	0.02	0.065
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0076	0.02	0.065
Plasmodium falciparum	proteasome subunit beta type-5	0.0438	0.3036	1
Toxoplasma gondii	proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative	0.0086	0.028	0.0915
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0086	0.028	0.0782
Leishmania major	proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative	0.034	0.2271	0.7478
Plasmodium vivax	proteasome subunit beta type-2, putative	0.0211	0.1257	0.4136
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0142	0.0719	0.236
Trypanosoma cruzi	proteasome beta 3 subunit, putative	0.0086	0.028	0.0915
Trypanosoma cruzi	proteasome subunit alpha type-5, putative	0.0086	0.028	0.0915
Schistosoma mansoni	proteasome subunit alpha 2 (T01 family)	0.0086	0.028	0.0782
Brugia malayi	proteasome subunit beta type 2	0.0211	0.1257	0.4141
Echinococcus multilocularis	proteasome subunit beta type 7	0.0086	0.028	0.0117
Echinococcus granulosus	proteasome subunit beta t family	0.0086	0.028	0.0277
Echinococcus multilocularis	proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta	0.0086	0.028	0.0117
Entamoeba histolytica	proteasome subunit alpha type 3, putative	0.0086	0.028	0.0912
Loa Loa (eye worm)	cysteine protease	0.0076	0.02	0.0658
Brugia malayi	proteasome subunit alpha type 2	0.0086	0.028	0.0922
Trypanosoma cruzi	cysteine peptidase, putative	0.0167	0.0915	0.3008
Entamoeba histolytica	cysteine proteinase, putative	0.0076	0.02	0.0647
Loa Loa (eye worm)	20S proteasome alpha5 subunit	0.0086	0.028	0.0922
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0669	0.2203
Loa Loa (eye worm)	proteasome subunit beta type 1	0.034	0.2271	0.748
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0086	0.028	0.0912
Echinococcus granulosus	proteasome prosome macropain subunit beta type	0.0086	0.028	0.0277
Onchocerca volvulus	Netrin receptor homolog	0.0136	0.0669	0.8347
Plasmodium vivax	vivapain-2	0.0076	0.02	0.065
Plasmodium vivax	proteasome subunit beta type-7, putative	0.0086	0.028	0.0915
Plasmodium vivax	proteasome subunit alpha type-3, putative	0.0086	0.028	0.0915
Echinococcus multilocularis	proteasome subunit alpha type 2	0.0086	0.028	0.0117
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0076	0.02	0.0035
Schistosoma mansoni	proteasome subunit alpha 6 (T01 family)	0.0086	0.028	0.0782
Echinococcus granulosus	proteasome subunit alpha type 6	0.0086	0.028	0.0277
Echinococcus multilocularis	subfamily T1A non peptidase ue	0.0086	0.028	0.0117
Echinococcus granulosus	cathepsin l1	0.0076	0.02	0.0196
Echinococcus multilocularis	cathepsin L cysteine protease	0.0076	0.02	0.0035
Brugia malayi	proteasome subunit beta type 3	0.0086	0.028	0.0922
Entamoeba histolytica	hypothetical protein	0.0071	0.0165	0.0532
Brugia malayi	Proteasome A-type and B-type family protein	0.0086	0.028	0.0922
Entamoeba histolytica	proteasome subunit alpha type 4, putative	0.0086	0.028	0.0912
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0076	0.02	0.0647
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0086	0.028	0.0912
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.034	0.2271	0.7477
Plasmodium vivax	ATP-dependent protease subunit ClpQ, putative	0.0086	0.028	0.0915
Plasmodium vivax	proteasome subunit alpha type-4, putative	0.0086	0.028	0.0915
Trypanosoma brucei	ATP-dependent protease subunit HslV	0.0086	0.028	0.0915
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0211	0.1257	0.4134
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0086	0.028	0.0782
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0086	0.028	0.0915
Loa Loa (eye worm)	proteasome subunit alpha type 1	0.0086	0.028	0.0922
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0167	0.0915	0.3008
Trypanosoma cruzi	proteasome subunit alpha type-1, putative	0.0086	0.028	0.0915
Giardia lamblia	Proteasome subunit beta type 2	0.0211	0.1257	0.3546
Echinococcus granulosus	proteasome prosome macropain subunit alpha	0.0086	0.028	0.0277
Schistosoma mansoni	hypothetical protein	0.0502	0.3539	1
Loa Loa (eye worm)	proteasome subunit alpha type 6	0.0086	0.028	0.0922
Schistosoma mansoni	transcription factor LCR-F1	0.0071	0.0165	0.0457
Echinococcus multilocularis	geminin	0.0502	0.3539	0.3431
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0076	0.02	0.0647
Plasmodium vivax	proteasome subunit beta type-3, putative	0.0086	0.028	0.0915
Echinococcus granulosus	subfamily T1A non peptidase ue	0.0086	0.028	0.0277
Loa Loa (eye worm)	proteasome subunit alpha type 2	0.0086	0.028	0.0922
Entamoeba histolytica	probable proteasome subunit beta type 2, putative	0.0211	0.1257	0.4134
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.034	0.2271	0.7478
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0167	0.0915	0.3008
Trypanosoma cruzi	proteasome alpha 3 subunit, putative	0.0086	0.028	0.0915
Trypanosoma brucei	proteasome alpha 7 subunit, putative	0.0086	0.028	0.0915
Schistosoma mansoni	hypothetical protein	0.0071	0.0165	0.0457
Plasmodium falciparum	proteasome subunit beta type-3, putative	0.0086	0.028	0.0915
Trypanosoma cruzi	proteasome beta 3 subunit, putative	0.0086	0.028	0.0915
Plasmodium falciparum	proteasome subunit alpha type-4, putative	0.0086	0.028	0.0915
Loa Loa (eye worm)	fibroinase	0.0076	0.02	0.0658
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0086	0.028	0.0912
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0136	0.0673	0.1894
Schistosoma mansoni	cathepsin F (C01 family)	0.0076	0.02	0.0555
Toxoplasma gondii	proteasome subunit alpha type, putative	0.0086	0.028	0.0915
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0086	0.028	0.0912
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0076	0.02	0.0658
Schistosoma mansoni	proteasome subunit alpha 3 (T01 family)	0.0086	0.028	0.0782
Plasmodium falciparum	proteasome subunit beta type-1, putative	0.034	0.2271	0.7478
Leishmania major	cathepsin L-like protease	0.0076	0.02	0.065
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.1327	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0167	0.0915	0.3008
Leishmania major	proteasome beta 7 subunit, putative	0.0086	0.028	0.0915
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0673	0.2216
Loa Loa (eye worm)	proteasome subunit alpha type 7-1	0.0086	0.028	0.0922
Trypanosoma brucei	proteasome alpha 3 subunit, putative	0.0086	0.028	0.0915
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0076	0.02	0.0647
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0086	0.028	0.0117
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0211	0.1257	0.3547
Trypanosoma cruzi	proteasome alpha 2 subunit, putative	0.0086	0.028	0.0915
Echinococcus multilocularis	cathepsin L cysteine protease	0.0076	0.02	0.0035
Onchocerca volvulus		0.0076	0.02	0.2463
Plasmodium vivax	proteasome subunit alpha type-2, putative	0.0086	0.028	0.0915
Plasmodium falciparum	proteasome subunit alpha type-5, putative	0.0086	0.028	0.0915
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0086	0.028	0.0915
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0086	0.028	0.0782
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0076	0.02	0.0196
Entamoeba histolytica	proteasome subunit alpha type 1, putative	0.0086	0.028	0.0912
Brugia malayi	Proteasome A-type and B-type family protein	0.0438	0.3036	1
Echinococcus multilocularis	cysteine protease	0.0076	0.02	0.0035
Plasmodium vivax	proteasome subunit beta type-4, putative	0.0086	0.028	0.0915
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0086	0.028	0.0912
Echinococcus multilocularis	proteasome (prosome macropain) subunit alpha	0.0086	0.028	0.0117
Schistosoma mansoni	proteasome catalytic subunit 2 (T01 family)	0.0086	0.028	0.0782
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0086	0.028	0.0922
Plasmodium falciparum	proteasome subunit alpha type-6, putative	0.0086	0.028	0.0915
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0076	0.02	0.0647
Trypanosoma brucei	proteasome beta-1 subunit, putative	0.0086	0.028	0.0915
Entamoeba histolytica	cysteine proteinase, putative	0.0076	0.02	0.0647
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0438	0.3036	1
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0211	0.1257	0.1254
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0076	0.02	0.0035
Entamoeba histolytica	proteasome subunit beta type 5 precursor, putative	0.0438	0.3036	1
Trypanosoma cruzi	proteasome alpha 3 subunit, putative	0.0086	0.028	0.0915
Leishmania major	proteasome alpha 1 subunit, putative	0.0086	0.028	0.0915
Brugia malayi	hypothetical protein	0.0153	0.0801	0.2636
Onchocerca volvulus	Cathepsin F homolog	0.0076	0.02	0.2463
Echinococcus multilocularis	Ankyrin	0.0136	0.0673	0.0517
Echinococcus granulosus	proteasome subunit beta type 7	0.0086	0.028	0.0277
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0438	0.3036	1
Toxoplasma gondii	proteasome subunit beta type 2, putative	0.0211	0.1257	0.4136
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0167	0.0915	0.3008
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0438	0.3036	1
Plasmodium vivax	proteasome subunit alpha type-1, putative	0.0086	0.028	0.0915
Echinococcus multilocularis	proteasome (prosome macropain) subunit beta type	0.0086	0.028	0.0117
Trypanosoma brucei	proteasome beta 2 subunit, putative	0.0086	0.028	0.0915
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0076	0.02	0.0647
Entamoeba histolytica	proteasome subunit alpha type 7, putative	0.0086	0.028	0.0912
Leishmania major	proteasome beta 2 subunit, putative	0.0086	0.028	0.0915
Toxoplasma gondii	20S proteasome subunit beta 7, putative	0.0086	0.028	0.0915
Trypanosoma cruzi	cysteine peptidase, putative	0.0076	0.02	0.065
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0076	0.02	0.0647
Trypanosoma cruzi	proteasome alpha 1 subunit, putative	0.0086	0.028	0.0915
Trypanosoma cruzi	ATP-dependent protease subunit HslV, putative	0.0086	0.028	0.0915
Onchocerca volvulus		0.0076	0.02	0.2463
Brugia malayi	proteasome subunit beta type 1	0.034	0.2271	0.748
Schistosoma mansoni	hypothetical protein	0.0136	0.0669	0.1882
Brugia malayi	hypothetical protein	0.0071	0.0165	0.0543
Brugia malayi	proteasome subunit alpha type 4	0.0086	0.028	0.0922
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0086	0.028	0.0912
Wolbachia endosymbiont of Brugia malayi	ATP-dependent protease peptidase subunit	0.0086	0.028	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0076	0.02	0.0647
Entamoeba histolytica	proteasome subunit alpha type 5, putative	0.0086	0.028	0.0912
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0167	0.0915	0.3008
Trypanosoma cruzi	hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B	0.0086	0.028	0.0915
Entamoeba histolytica	hypothetical protein	0.0071	0.0165	0.0532
Leishmania major	cysteine peptidase A (CPA)	0.0076	0.02	0.065
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0076	0.02	0.0647
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0086	0.028	0.0915
Giardia lamblia	Proteasome subunit beta type 1	0.034	0.2271	0.7224
Trypanosoma cruzi	cruzipain precursor, putative	0.0167	0.0915	0.3008
Plasmodium falciparum	ATP-dependent protease subunit ClpQ	0.0086	0.028	0.0915
Trypanosoma cruzi	proteasome beta-1 subunit, putative	0.0086	0.028	0.0915
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0086	0.028	0.0912
Plasmodium vivax	proteasome subunit beta type-5, putative	0.0438	0.3036	1
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0086	0.028	0.0915
Plasmodium vivax	vivapain-2	0.0076	0.02	0.065
Toxoplasma gondii	proteasome subunit alpha type 5-2, putative	0.0086	0.028	0.0915
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0086	0.028	0.0117
Brugia malayi	Protein kinase domain containing protein	0.0136	0.0669	0.2203
Leishmania major	cathepsin L-like protease	0.0167	0.0915	0.3008
Mycobacterium ulcerans	proteasome PrcB	0.0438	0.3036	1
Toxoplasma gondii	peptidase, T1 family protein	0.0086	0.028	0.0915
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0076	0.02	0.0647
Entamoeba histolytica	proteasome subunit beta type 1, putative	0.034	0.2271	0.7477
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0076	0.02	0.065
Echinococcus granulosus	20S proteasome subunit alpha 6	0.0086	0.028	0.0277
Brugia malayi	Cathepsin L-like precursor	0.0076	0.02	0.0658
Mycobacterium tuberculosis	Proteasome beta subunit PrcB; assembles with alpha subunit PrcA.	0.0438	0.3036	1
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0086	0.028	0.0782
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0076	0.02	0.0647
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0086	0.028	0.0915
Leishmania major	proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative)	0.0086	0.028	0.0915
Leishmania major	proteasome alpha 2 subunit, putative	0.0086	0.028	0.0915
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0167	0.0915	0.3008
Brugia malayi	hypothetical protein	0.0051	0.0002	0.0008
Leishmania major	proteasome alpha 3 subunit, putative	0.0086	0.028	0.0915
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0076	0.02	0.0647
Entamoeba histolytica	proteasome subunit beta type 3, putative	0.0086	0.028	0.0912
Trypanosoma cruzi	proteasome subunit alpha type-5, putative	0.0086	0.028	0.0915
Entamoeba histolytica	cysteine protease, putative	0.0076	0.02	0.0647
Echinococcus granulosus	death domain containing protein	0.0136	0.0669	0.0666
Leishmania major	proteasome alpha 7 subunit, putative	0.0086	0.028	0.0915
Onchocerca volvulus		0.0076	0.02	0.2463
Plasmodium falciparum	proteasome subunit alpha type-3, putative	0.0086	0.028	0.0915
Brugia malayi	Cathepsin L-like precursor	0.0076	0.02	0.0658
Entamoeba histolytica	hypothetical protein	0.0071	0.0165	0.0532
Entamoeba histolytica	proteasome subunit beta type 6 precursor, putative	0.0086	0.028	0.0912
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0071	0.0165	0.0162
Brugia malayi	proteasome subunit alpha type 1	0.0086	0.028	0.0922
Plasmodium falciparum	proteasome subunit alpha type-2, putative	0.0086	0.028	0.0915
Entamoeba histolytica	calcium-dependent protein kinase 2, putative	0.0086	0.028	0.0912
Echinococcus granulosus	proteasome prosome macropain	0.0438	0.3036	0.3034
Trypanosoma cruzi	proteasome beta-1 subunit, putative	0.0086	0.028	0.0915
Trypanosoma brucei	proteasome alpha 1 subunit, putative	0.0086	0.028	0.0915
Echinococcus granulosus	Ankyrin	0.0136	0.0673	0.067
Trypanosoma brucei	proteasome beta 3 subunit, putative	0.0086	0.028	0.0915
Onchocerca volvulus	Cathepsin L homolog	0.0076	0.02	0.2463
Entamoeba histolytica	proteasome subunit beta type 7-B precursor, putative	0.0086	0.028	0.0912
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0086	0.028	0.0922
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0076	0.02	0.0647
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.034	0.2271	0.2269
Toxoplasma gondii	proteasome subunit	0.0086	0.028	0.0915
Plasmodium falciparum	proteasome subunit beta type-7, putative	0.0086	0.028	0.0915
Schistosoma mansoni	hypothetical protein	0.0502	0.3539	1
Onchocerca volvulus	Notchless protein homolog	0.0086	0.028	0.3469
Toxoplasma gondii	proteasome subunit beta type 7 precursor, putative	0.0086	0.028	0.0915
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0051	0.0003	0.0011
Onchocerca volvulus	Cathepsin L homolog	0.0076	0.02	0.2463
Trypanosoma cruzi	cysteine peptidase, putative	0.0167	0.0915	0.3008
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.034	0.2271	0.7478
Schistosoma mansoni	netrin receptor unc5	0.0136	0.0669	0.1882
Mycobacterium leprae	proteasome (beta subunit) PrcB	0.0438	0.3036	1
Leishmania major	cathepsin L-like protease	0.0076	0.02	0.065
Toxoplasma gondii	proteasome subunit beta type, putative	0.0438	0.3036	1
Trypanosoma cruzi	proteasome beta 7 subunit, putative	0.0086	0.028	0.0915
Schistosoma mansoni	ankyrin 23/unc44	0.0136	0.0669	0.1882
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0086	0.028	0.0912
Brugia malayi	Cathepsin L-like precursor	0.0076	0.02	0.0658
Plasmodium vivax	proteasome subunit alpha type-6, putative	0.0086	0.028	0.0915
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0076	0.02	0.0647
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0076	0.02	0.0647
Schistosoma mansoni	cathepsin F (C01 family)	0.0076	0.02	0.0555
Onchocerca volvulus		0.0076	0.02	0.2463
Trypanosoma brucei	proteasome subunit beta type-2, putative	0.0211	0.1257	0.4136
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0076	0.02	0.0647
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0076	0.02	0.0647
Schistosoma mansoni	proteasome subunit alpha 4 (T01 family)	0.0086	0.028	0.0782
Trypanosoma brucei	proteasome subunit alpha type-5, putative	0.0086	0.028	0.0915
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0086	0.028	0.0912
Entamoeba histolytica	proteasome subunit alpha type 6, putative	0.0086	0.028	0.0912
Schistosoma mansoni	proteasome catalytic subunit 3 (T01 family)	0.0438	0.3036	0.8579
Leishmania major	cathepsin L-like protease	0.0076	0.02	0.065
Toxoplasma gondii	proteasome subunit alpha1, putative	0.0086	0.028	0.0915
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0086	0.028	0.0915
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0136	0.0669	0.0666
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0086	0.028	0.0782
Leishmania major	cathepsin L-like protease	0.0076	0.02	0.065
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0003	0.0011
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0167	0.0915	0.3008
Schistosoma mansoni	proteasome subunit beta 4 (T01 family)	0.0086	0.028	0.0782
Giardia lamblia	Proteasome subunit beta type 5 precursor	0.0438	0.3036	1
Onchocerca volvulus		0.0153	0.0801	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0167	0.0915	0.3008
Echinococcus granulosus	netrin receptor unc 5	0.0136	0.0669	0.0666
Brugia malayi	Uncoordinated protein 44	0.0136	0.0669	0.2203
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0076	0.02	0.0647
Echinococcus granulosus	geminin	0.0502	0.3539	0.3537
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0076	0.02	0.0647
Onchocerca volvulus		0.0076	0.02	0.2463
Loa Loa (eye worm)	proteasome subunit beta type 3	0.0086	0.028	0.0922
Trypanosoma brucei	proteasome beta 7 subunit	0.0086	0.028	0.0915
Trypanosoma brucei	proteasome alpha 2 subunit, putative	0.0086	0.028	0.0915
Toxoplasma gondii	heat shock protein hslv, putative	0.0086	0.028	0.0915
Brugia malayi	Papain family cysteine protease containing protein	0.0076	0.02	0.0658
Brugia malayi	cathepsin L-like precursor	0.0051	0.0003	0.0011
Plasmodium vivax	proteasome subunit alpha type-7, putative	0.0086	0.028	0.0915
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0136	0.0669	0.2203
Brugia malayi	Proteasome A-type and B-type family protein	0.0086	0.028	0.0922
Echinococcus multilocularis	cysteine protease	0.0076	0.02	0.0035
Loa Loa (eye worm)	proteasome subunit beta type 2	0.0211	0.1257	0.4141
Toxoplasma gondii	proteasome subunit beta type 1, putative	0.034	0.2271	0.7478
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0076	0.02	0.0647
Entamoeba histolytica	proteasome subunit alpha type 2-A, putative	0.0086	0.028	0.0912
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.034	0.2271	0.2142
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0076	0.02	0.0647
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0086	0.028	0.0915
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0086	0.028	0.0915
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0167	0.0915	0.3008
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0076	0.02	0.0647
Leishmania major	proteasome alpha 7 subunit, putative	0.0086	0.028	0.0915
Leishmania major	proteasome beta 2 subunit, putative	0.0211	0.1257	0.4136
Loa Loa (eye worm)	proteasome subunit alpha type 3	0.0086	0.028	0.0922
Leishmania major	cathepsin L-like protease	0.0167	0.0915	0.3008
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0002	0.0008
Trypanosoma brucei	proteasome alpha 7 subunit	0.0086	0.028	0.0915
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0211	0.1257	0.1111
Brugia malayi	proteasome subunit alpha type 6	0.0086	0.028	0.0922
Echinococcus granulosus	proteasome subunit beta type 6	0.0086	0.028	0.0277
Trypanosoma cruzi	proteasome beta 2 subunit, putative	0.0086	0.028	0.0915
Toxoplasma gondii	proteasome subunit alpha type 1, putative	0.0086	0.028	0.0915
Trypanosoma cruzi	proteasome alpha 2 subunit, putative	0.0086	0.028	0.0915
Brugia malayi	20S proteasome alpha5 subunit	0.0086	0.028	0.0922
Echinococcus multilocularis	proteasome (prosome, macropain)	0.0438	0.3036	0.292
Trypanosoma brucei	proteasome subunit beta type-5, putative	0.0438	0.3036	1
Plasmodium vivax	proteasome subunit beta type-1, putative	0.034	0.2271	0.7478
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0076	0.02	0.0196
Brugia malayi	Proteasome subunit alpha type 7-1	0.0086	0.028	0.0922
Entamoeba histolytica	proteasome subunit alpha type 3, putative	0.0086	0.028	0.0912
Toxoplasma gondii	proteasome beta subunit	0.0086	0.028	0.0915
Echinococcus multilocularis	Proteasome, subunit alpha beta	0.0086	0.028	0.0117
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0438	0.3036	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0003	0.0011
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0076	0.02	0.0647
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0211	0.1257	0.4134
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0076	0.02	0.0647
Leishmania major	cathepsin L-like protease	0.0167	0.0915	0.3008
Plasmodium vivax	proteasome subunit beta type-6, putative	0.0086	0.028	0.0915
Trypanosoma cruzi	major cysteine proteinase, putative	0.0105	0.0431	0.1411
Trypanosoma brucei	proteasome beta 6 subunit	0.034	0.2271	0.7478
Brugia malayi	Proteasome A-type and B-type family protein	0.0086	0.028	0.0922
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0086	0.028	0.0912
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0136	0.0669	0.2203
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0076	0.02	0.0658
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0086	0.028	0.0922

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1760706

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1528151