Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0092 | 1 | 1 |
Echinococcus granulosus | proteasome subunit beta type 6 | 0.0018 | 0.0241 | 0.0241 |
Echinococcus multilocularis | Proteasome, subunit alpha beta | 0.0018 | 0.0241 | 0.0241 |
Schistosoma mansoni | proteasome subunit alpha 1 (T01 family) | 0.0018 | 0.0241 | 0.0241 |
Echinococcus granulosus | 20S proteasome subunit alpha 6 | 0.0018 | 0.0241 | 0.0241 |
Loa Loa (eye worm) | proteasome subunit beta type 2 | 0.0044 | 0.3701 | 0.3701 |
Schistosoma mansoni | proteasome subunit alpha 3 (T01 family) | 0.0018 | 0.0241 | 0.0241 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0071 | 0.7291 | 0.7224 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0018 | 0.0241 | 0.0241 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0092 | 1 | 1 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0092 | 1 | 1 |
Plasmodium falciparum | proteasome subunit beta type-1, putative | 0.0071 | 0.7291 | 0.7224 |
Schistosoma mansoni | proteasome catalytic subunit 2 (T01 family) | 0.0018 | 0.0241 | 0.0241 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0092 | 1 | 1 |
Trypanosoma brucei | proteasome beta 6 subunit | 0.0071 | 0.7291 | 0.7224 |
Leishmania major | proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative | 0.0071 | 0.7291 | 0.7224 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0018 | 0.0241 | 0.0241 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0071 | 0.7291 | 0.7291 |
Loa Loa (eye worm) | proteasome subunit alpha type 7-1 | 0.0018 | 0.0241 | 0.0241 |
Brugia malayi | proteasome subunit beta type 2 | 0.0044 | 0.3701 | 0.3546 |
Schistosoma mansoni | proteasome catalytic subunit 1 (T01 family) | 0.0018 | 0.0241 | 0.0241 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0092 | 1 | 1 |
Loa Loa (eye worm) | proteasome subunit alpha type 6 | 0.0018 | 0.0241 | 0.0241 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0044 | 0.3701 | 0.3701 |
Onchocerca volvulus | Notchless protein homolog | 0.0018 | 0.0241 | 0.5 |
Echinococcus multilocularis | proteasome subunit beta type 7 | 0.0018 | 0.0241 | 0.0241 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0092 | 1 | 1 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0092 | 1 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0092 | 1 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0092 | 1 | 1 |
Toxoplasma gondii | proteasome subunit beta type 2, putative | 0.0044 | 0.3701 | 0.3546 |
Schistosoma mansoni | subfamily T1A non-peptidase homologue (T01 family) | 0.0018 | 0.0241 | 0.0241 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0071 | 0.7291 | 0.7291 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0092 | 1 | 1 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0092 | 1 | 1 |
Echinococcus multilocularis | 20S proteasome subunit alpha 6 | 0.0018 | 0.0241 | 0.0241 |
Loa Loa (eye worm) | proteasome subunit alpha type 3 | 0.0018 | 0.0241 | 0.0241 |
Echinococcus multilocularis | Proteasome subunit alpha type 7 | 0.0018 | 0.0241 | 0.0241 |
Loa Loa (eye worm) | PAS-3 protein | 0.0018 | 0.0241 | 0.0241 |
Echinococcus multilocularis | subfamily T1A non peptidase ue | 0.0018 | 0.0241 | 0.0241 |
Echinococcus granulosus | proteasome prosome macropain subunit alpha | 0.0018 | 0.0241 | 0.0241 |
Echinococcus multilocularis | proteasome subunit alpha type 2 | 0.0018 | 0.0241 | 0.0241 |
Entamoeba histolytica | probable proteasome subunit beta type 2, putative | 0.0044 | 0.3701 | 0.3546 |
Loa Loa (eye worm) | proteasome subunit beta type 1 | 0.0071 | 0.7291 | 0.7291 |
Schistosoma mansoni | proteasome subunit alpha 4 (T01 family) | 0.0018 | 0.0241 | 0.0241 |
Entamoeba histolytica | proteasome subunit beta type 1, putative | 0.0071 | 0.7291 | 0.7224 |
Mycobacterium ulcerans | proteasome PrcB | 0.0092 | 1 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-2, putative | 0.0044 | 0.3701 | 0.3546 |
Brugia malayi | proteasome subunit beta type 1 | 0.0071 | 0.7291 | 0.7224 |
Giardia lamblia | Proteasome subunit beta type 2 | 0.0044 | 0.3701 | 0.3546 |
Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.0082 | 0.8753 | 0.8753 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0092 | 1 | 1 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0071 | 0.7291 | 0.7224 |
Trypanosoma brucei | proteasome subunit beta type-2, putative | 0.0044 | 0.3701 | 0.3546 |
Schistosoma mansoni | proteasome subunit alpha 7 (T01 family) | 0.0018 | 0.0241 | 0.0241 |
Schistosoma mansoni | proteasome subunit beta 4 (T01 family) | 0.0018 | 0.0241 | 0.0241 |
Echinococcus multilocularis | Proteasome subunit alpha type 7 | 0.0018 | 0.0241 | 0.0241 |
Echinococcus multilocularis | Proteasome subunit alpha type 7 | 0.0018 | 0.0241 | 0.0241 |
Loa Loa (eye worm) | 20S proteasome alpha5 subunit | 0.0018 | 0.0241 | 0.0241 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0044 | 0.3701 | 0.3546 |
Schistosoma mansoni | proteasome subunit beta 1 (T01 family) | 0.0071 | 0.7291 | 0.7291 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0092 | 1 | 1 |
Echinococcus granulosus | Proteasome subunit alpha beta | 0.0018 | 0.0241 | 0.0241 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0018 | 0.0241 | 0.0241 |
Echinococcus multilocularis | proteasome subunit beta type 6 | 0.0018 | 0.0241 | 0.0241 |
Echinococcus multilocularis | proteasome (prosome macropain) subunit beta type | 0.0018 | 0.0241 | 0.0241 |
Plasmodium vivax | proteasome subunit beta type-1, putative | 0.0071 | 0.7291 | 0.7224 |
Echinococcus multilocularis | proteasome (prosome macropain) subunit alpha | 0.0018 | 0.0241 | 0.0241 |
Plasmodium vivax | proteasome subunit beta type-2, putative | 0.0044 | 0.3701 | 0.3546 |
Echinococcus granulosus | Proteasome subunit alpha type 7 | 0.0018 | 0.0241 | 0.0241 |
Echinococcus granulosus | proteasome prosome macropain subunit beta type | 0.0018 | 0.0241 | 0.0241 |
Schistosoma mansoni | proteasome subunit alpha 2 (T01 family) | 0.0018 | 0.0241 | 0.0241 |
Trypanosoma cruzi | 20S proteasome subunit | 0.0044 | 0.3701 | 0.3546 |
Loa Loa (eye worm) | proteasome subunit alpha type 2 | 0.0018 | 0.0241 | 0.0241 |
Echinococcus multilocularis | proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta | 0.0018 | 0.0241 | 0.0241 |
Schistosoma mansoni | subfamily T1A non-peptidase homologue (T01 family) | 0.0018 | 0.0241 | 0.0241 |
Schistosoma mansoni | subfamily T1A non-peptidase homologue (T01 family) | 0.0018 | 0.0241 | 0.0241 |
Echinococcus granulosus | subfamily T1A non peptidase ue | 0.0018 | 0.0241 | 0.0241 |
Echinococcus granulosus | proteasome subunit alpha type 6 | 0.0018 | 0.0241 | 0.0241 |
Toxoplasma gondii | proteasome subunit beta type 1, putative | 0.0071 | 0.7291 | 0.7224 |
Leishmania major | proteasome beta 2 subunit, putative | 0.0044 | 0.3701 | 0.3546 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0092 | 1 | 1 |
Echinococcus granulosus | proteasome prosome macropain | 0.0092 | 1 | 1 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0044 | 0.3701 | 0.3701 |
Echinococcus granulosus | proteasome subunit alpha type 2 | 0.0018 | 0.0241 | 0.0241 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0018 | 0.0241 | 0.0241 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0044 | 0.3701 | 0.3546 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0044 | 0.3701 | 0.3701 |
Plasmodium falciparum | proteasome subunit beta type-2, putative | 0.0044 | 0.3701 | 0.3546 |
Loa Loa (eye worm) | proteasome subunit beta type 3 | 0.0018 | 0.0241 | 0.0241 |
Loa Loa (eye worm) | proteasome subunit alpha type 1 | 0.0018 | 0.0241 | 0.0241 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0082 | 0.8753 | 0.8753 |
Schistosoma mansoni | proteasome subunit alpha 6 (T01 family) | 0.0018 | 0.0241 | 0.0241 |
Echinococcus granulosus | proteasome subunit beta t family | 0.0018 | 0.0241 | 0.0241 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0092 | 1 | 1 |
Echinococcus granulosus | proteasome subunit beta type 7 | 0.0018 | 0.0241 | 0.0241 |
Giardia lamblia | Proteasome subunit beta type 1 | 0.0071 | 0.7291 | 0.7224 |
Schistosoma mansoni | proteasome subunit beta 3 (T01 family) | 0.0018 | 0.0241 | 0.0241 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent protease peptidase subunit | 0.0018 | 0.0241 | 0.5 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0044 | 0.3701 | 0.3701 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0071 | 0.7291 | 0.7224 |
Schistosoma mansoni | proteasome subunit beta 3 (T01 family) | 0.0018 | 0.0241 | 0.0241 |
Echinococcus multilocularis | proteasome subunit alpha type 6 | 0.0018 | 0.0241 | 0.0241 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 71.4 % | Antidepressant activity in Swiss albino mouse assessed as decrease in immobility duration at 0.5 mg/kg, ip administered 30 mins prior to test measured after 30 mins by tail suspension test (Rvb = 79.9%) | ChEMBL. | 21377878 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.