TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 532.692 | Formula: C28H40N2O6S
H donors: 2 H acceptors: 4 LogP: 3.51 Rotable bonds: 10
Rule of 5 violations (Lipinski): 2
SMILES: CCOCCN(S(=O)(=O)c1c(C)cccc1C)C[C@H](CN1CCCC2(C1)CCc1c(O2)ccc(c1)O)O
InChi: 1S/C28H40N2O6S/c1-4-35-16-15-30(37(33,34)27-21(2)7-5-8-22(27)3)19-25(32)18-29-14-6-12-28(20-29)13-11-23-17-24(31)9-10-26(23)36-28/h5,7-10,17,25,31-32H,4,6,11-16,18-20H2,1-3H3/t25-,28?/m0/s1
InChiKey: KDVVGAZDAXSUBA-ALLRNTDFSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	v-akt murine thymoma viral oncogene homolog 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Plasmodium berghei	rac-beta serine/threonine protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	serine threonine protein kinase nrc	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	nervana 2	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma congolense	rac serine-threonine kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Candida albicans	protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	serine/threonine protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	ko:K04456 RAC serine/threonine-protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma cruzi	Protein kinase B	Get druggable targets OG5_126635	All targets in OG5_126635
Candida albicans	likely protein kinase similar to S. cerevisiae YPK2 (YMR104C)	Get druggable targets OG5_126635	All targets in OG5_126635
Giardia lamblia	Kinase, AGC PKA	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma cruzi	rac serine-threonine kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	nervana 2	Get druggable targets OG5_126635	All targets in OG5_126635
Brugia malayi	p70 ribosomal S6 kinase beta	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma mansoni	serine/threonine-protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	protein kinase 2, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	ko:K07390 monothiol glutaredoxin, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Loa Loa (eye worm)	AGC/AKT protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium knowlesi	RAC-beta serine/threonine protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	Glutaredoxin protein 5	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium yoelii	kinase Akt/PKB-related	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	nervana 2	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	Get druggable targets OG5_126635	All targets in OG5_126635
Neospora caninum	Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1), related	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	nervana 2	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	Glutaredoxin protein 5	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	PH domain containing protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma cruzi	rac serine-threonine kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma brucei gambiense	rac serine-threonine kinase, putative,protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	PH domain containing protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	ko:K08792 serum/glucocorticoid regulated kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Toxoplasma gondii	AGC kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma brucei	rac serine-threonine kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	RAC serine/threonine-protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	rac serine:threonine kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma mansoni	serine/threonine-protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	Sodium/potassium-transporting ATPase subunit beta-1, putative	Get druggable targets OG5_126635	All targets in OG5_126635

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	proteasome subunit alpha type 5, putative	0.0089	0.1055	0.1728
Toxoplasma gondii	proteasome subunit alpha type 5-2, putative	0.0089	0.1055	0.1232
Schistosoma mansoni	serine/threonine-protein kinase	0.0028	0.0207	0.0334
Plasmodium falciparum	proteasome subunit beta type-5	0.045	0.6086	1
Trypanosoma cruzi	proteasome beta 3 subunit, putative	0.0089	0.1055	0.1492
Trypanosoma cruzi	proteasome alpha 1 subunit, putative	0.0089	0.1055	0.1492
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.008	0.0939	0.1537
Plasmodium vivax	proteasome subunit beta type-6, putative	0.0089	0.1055	0.1492
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.035	0.4689	0.7705
Echinococcus granulosus	subfamily T1A non peptidase ue	0.0089	0.1055	0.1051
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0089	0.1055	0.1733
Entamoeba histolytica	proteasome subunit beta type 1, putative	0.035	0.4689	0.7703
Echinococcus granulosus	nervana 2	0.0025	0.0169	0.0165
Toxoplasma gondii	proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative	0.0089	0.1055	0.1232
Schistosoma mansoni	proteasome catalytic subunit 3 (T01 family)	0.045	0.6086	1
Schistosoma mansoni	proteasome subunit beta 4 (T01 family)	0.0089	0.1055	0.1728
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0089	0.1055	0.1733
Loa Loa (eye worm)	proteasome subunit alpha type 7-1	0.0089	0.1055	0.1728
Giardia lamblia	Proteasome subunit beta type 9 precursor	0.0089	0.1055	0.1492
Wolbachia endosymbiont of Brugia malayi	ATP-dependent protease peptidase subunit	0.0089	0.1055	0.5
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0089	0.1055	0.1733
Loa Loa (eye worm)	proteasome subunit alpha type 3	0.0089	0.1055	0.1728
Plasmodium falciparum	proteasome subunit alpha type-6, putative	0.0089	0.1055	0.1492
Schistosoma mansoni	proteasome subunit alpha 6 (T01 family)	0.0089	0.1055	0.1728
Plasmodium falciparum	proteasome subunit beta type-7, putative	0.0089	0.1055	0.1492
Schistosoma mansoni	proteasome subunit alpha 3 (T01 family)	0.0089	0.1055	0.1728
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.045	0.6086	1
Giardia lamblia	20S proteasome alpha subunit 6	0.0089	0.1055	0.1492
Trypanosoma brucei	ATP-dependent protease subunit HslV	0.0089	0.1055	0.1179
Schistosoma mansoni	proteasome catalytic subunit 1 (T01 family)	0.0089	0.1055	0.1728
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0089	0.1055	0.1728
Toxoplasma gondii	20S proteasome subunit beta 7, putative	0.0089	0.1055	0.1232
Giardia lamblia	Proteasome subunit beta type 4 precursor	0.0089	0.1055	0.1492
Loa Loa (eye worm)	proteasome subunit alpha type 2	0.0089	0.1055	0.1728
Entamoeba histolytica	proteasome subunit alpha type 3, putative	0.0089	0.1055	0.1728
Entamoeba histolytica	proteasome subunit beta type 7-B precursor, putative	0.0089	0.1055	0.1728
Brugia malayi	proteasome subunit beta type 2	0.0217	0.2839	0.4661
Plasmodium falciparum	proteasome subunit alpha type-7, putative	0.0089	0.1055	0.1492
Giardia lamblia	20S proteasome alpha subunit 4	0.0089	0.1055	0.1492
Loa Loa (eye worm)	proteasome subunit beta type 1	0.035	0.4689	0.7703
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0025	0.0172	0.0169
Brugia malayi	Immunoglobulin I-set domain containing protein	0.008	0.0931	0.1525
Trypanosoma brucei	proteasome subunit beta type-5, putative	0.045	0.6086	1
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0089	0.1055	0.1492
Echinococcus granulosus	proteasome subunit alpha type 2	0.0089	0.1055	0.1051
Echinococcus granulosus	proteasome subunit beta type 7	0.0089	0.1055	0.1051
Entamoeba histolytica	calcium-dependent protein kinase 2, putative	0.0089	0.1059	0.1734
Mycobacterium leprae	proteasome (beta subunit) PrcB	0.045	0.6086	1
Mycobacterium ulcerans	proteasome PrcB	0.045	0.6086	1
Plasmodium vivax	proteasome subunit alpha type-3, putative	0.0089	0.1055	0.1492
Trichomonas vaginalis	AGC family protein kinase	0.0013	0.0004	0.0006
Giardia lamblia	Proteasome subunit beta type 2	0.0217	0.2839	0.4509
Loa Loa (eye worm)	hypothetical protein	0.008	0.0939	0.1537
Trypanosoma cruzi	proteasome subunit alpha type-1, putative	0.0089	0.1055	0.1492
Trypanosoma cruzi	proteasome beta-1 subunit, putative	0.0089	0.1055	0.1492
Plasmodium vivax	proteasome subunit alpha type-4, putative	0.0089	0.1055	0.1492
Entamoeba histolytica	proteasome subunit beta type 3, putative	0.0089	0.1055	0.1728
Plasmodium falciparum	proteasome subunit alpha type-2, putative	0.0089	0.1055	0.1492
Echinococcus multilocularis	proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta	0.0089	0.1055	0.1051
Echinococcus granulosus	death domain containing protein	0.008	0.0931	0.0928
Trypanosoma cruzi	proteasome beta 3 subunit, putative	0.0089	0.1055	0.1492
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.008	0.0931	0.0928
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0089	0.1055	0.1051
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.035	0.4689	0.4687
Plasmodium vivax	proteasome subunit beta type-3, putative	0.0089	0.1055	0.1492
Schistosoma mansoni	ankyrin 23/unc44	0.008	0.0931	0.1525
Echinococcus granulosus	netrin receptor unc 5	0.008	0.0931	0.0928
Echinococcus granulosus	Ankyrin	0.008	0.0939	0.0935
Schistosoma mansoni	proteasome subunit alpha 4 (T01 family)	0.0089	0.1055	0.1728
Echinococcus granulosus	serine/threonine protein kinase	0.0028	0.0207	0.0203
Brugia malayi	Protein kinase domain containing protein	0.008	0.0935	0.1532
Plasmodium vivax	proteasome subunit beta type-4, putative	0.0089	0.1055	0.1492
Trypanosoma cruzi	proteasome alpha 3 subunit, putative	0.0089	0.1055	0.1492
Entamoeba histolytica	proteasome subunit beta type 5 precursor, putative	0.045	0.6086	1
Plasmodium vivax	proteasome subunit alpha type-7, putative	0.0089	0.1055	0.1492
Brugia malayi	proteasome subunit alpha type 2	0.0089	0.1055	0.1728
Trypanosoma brucei	proteasome subunit beta type-2, putative	0.0217	0.2839	0.4307
Entamoeba histolytica	proteasome subunit beta Type 4 precursor, putative	0.0089	0.1055	0.1728
Plasmodium vivax	proteasome subunit beta type-7, putative	0.0089	0.1055	0.1492
Echinococcus multilocularis	20S proteasome subunit alpha 6	0.0089	0.1055	0.1051
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0217	0.2839	0.2836
Echinococcus granulosus	proteasome subunit beta type 6	0.0089	0.1055	0.1051
Entamoeba histolytica	proteasome subunit beta type 6 precursor, putative	0.0089	0.1055	0.1728
Schistosoma mansoni	serine/threonine-protein kinase	0.0028	0.0207	0.0334
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0025	0.0169	0.0165
Plasmodium vivax	proteasome subunit beta type-1, putative	0.035	0.4689	0.7638
Echinococcus multilocularis	proteasome subunit alpha type 2	0.0089	0.1055	0.1051
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0382	0.0628
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.035	0.4689	0.4687
Leishmania major	proteasome beta 2 subunit, putative	0.0217	0.2839	0.3546
Schistosoma mansoni	proteasome subunit alpha 1 (T01 family)	0.0089	0.1055	0.1728
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.035	0.4689	0.7638
Loa Loa (eye worm)	PAS-3 protein	0.0089	0.1055	0.1728
Echinococcus multilocularis	nervana 2	0.0025	0.0169	0.0165
Brugia malayi	Proteasome subunit alpha type 7-1	0.0089	0.1055	0.1728
Trypanosoma brucei	proteasome subunit alpha type-5, putative	0.0089	0.1055	0.1179
Echinococcus granulosus	Proteasome subunit alpha type 7	0.0089	0.1055	0.1051
Echinococcus multilocularis	netrin receptor unc 5	0.008	0.0931	0.0928
Entamoeba histolytica	proteasome subunit alpha type 5, putative	0.0089	0.1055	0.1728
Echinococcus multilocularis	proteasome (prosome macropain) subunit alpha	0.0089	0.1055	0.1051
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0089	0.1055	0.1733
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0089	0.1055	0.1728
Plasmodium falciparum	proteasome subunit alpha type-5, putative	0.0089	0.1055	0.1492
Leishmania major	proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative	0.035	0.4689	0.7224
Schistosoma mansoni	netrin receptor unc5	0.008	0.0931	0.1525
Schistosoma mansoni	proteasome subunit beta 1 (T01 family)	0.035	0.4689	0.7703
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.045	0.6086	1
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0217	0.2839	0.4664
Loa Loa (eye worm)	AGC/AKT protein kinase	0.004	0.0382	0.0622
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.008	0.0931	0.0928
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.035	0.4689	0.7638
Brugia malayi	proteasome subunit beta type 1	0.035	0.4689	0.7703
Schistosoma mansoni	proteasome subunit alpha 2 (T01 family)	0.0089	0.1055	0.1728
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.045	0.6086	1
Entamoeba histolytica	proteasome subunit alpha type 1, putative	0.0089	0.1055	0.1728
Trypanosoma brucei	proteasome beta 7 subunit	0.0089	0.1055	0.1179
Echinococcus multilocularis	Proteasome, subunit alpha beta	0.0089	0.1055	0.1051
Leishmania major	proteasome beta 5 subunit, putative	0.045	0.6086	1
Brugia malayi	Proteasome A-type and B-type family protein	0.0089	0.1055	0.1728
Toxoplasma gondii	proteasome subunit alpha type 1, putative	0.0089	0.1055	0.1232
Trypanosoma brucei	proteasome beta 6 subunit	0.035	0.4689	0.7551
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0382	0.0628
Toxoplasma gondii	proteasome subunit alpha1, putative	0.0089	0.1055	0.1232
Loa Loa (eye worm)	proteasome subunit beta type 3	0.0089	0.1055	0.1728
Plasmodium falciparum	proteasome subunit alpha type-1, putative	0.0089	0.1055	0.1492
Brugia malayi	Proteasome subunit alpha type 1	0.0089	0.1055	0.1728
Echinococcus granulosus	Glutaredoxin protein 5	0.0025	0.0169	0.0165
Echinococcus granulosus	proteasome prosome macropain subunit beta type	0.0089	0.1055	0.1051
Echinococcus granulosus	proteasome subunit beta t family	0.0089	0.1055	0.1051
Brugia malayi	Proteasome A-type and B-type family protein	0.045	0.6086	1
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0089	0.1055	0.1733
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0089	0.1055	0.1051
Trypanosoma cruzi	proteasome alpha 2 subunit, putative	0.0089	0.1055	0.1492
Toxoplasma gondii	proteasome subunit beta type, putative	0.045	0.6086	1
Brugia malayi	p70 ribosomal S6 kinase beta	0.0038	0.0348	0.0566
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0089	0.1055	0.1051
Plasmodium falciparum	ATP-dependent protease subunit ClpQ	0.0089	0.1055	0.1492
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0089	0.1055	0.1733
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0038	0.0348	0.0566
Schistosoma mansoni	proteasome catalytic subunit 2 (T01 family)	0.0089	0.1055	0.1728
Plasmodium vivax	proteasome subunit alpha type-5, putative	0.0089	0.1055	0.1492
Mycobacterium tuberculosis	Proteasome beta subunit PrcB; assembles with alpha subunit PrcA.	0.045	0.6086	1
Giardia lamblia	20S proteasome alpha subunit 3	0.0089	0.1055	0.1492
Echinococcus multilocularis	subfamily T1A non peptidase ue	0.0089	0.1055	0.1051
Plasmodium falciparum	proteasome subunit beta type-1, putative	0.035	0.4689	0.7638
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0382	0.0628
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0028	0.0207	0.0058
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.045	0.6086	1
Schistosoma mansoni	hypothetical protein	0.008	0.0931	0.1525
Toxoplasma gondii	proteasome subunit beta type 7 precursor, putative	0.0089	0.1055	0.1232
Echinococcus granulosus	proteasome subunit alpha type 6	0.0089	0.1055	0.1051
Plasmodium vivax	proteasome subunit beta type-2, putative	0.0217	0.2839	0.4509
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0217	0.2839	0.2836
Entamoeba histolytica	proteasome subunit alpha type 4, putative	0.0089	0.1055	0.1728
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0089	0.1055	0.1728
Trichomonas vaginalis	AGC family protein kinase	0.0013	0.0004	0.0006
Echinococcus multilocularis	Glutaredoxin protein 5	0.0025	0.0169	0.0165
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0089	0.1055	0.1733
Loa Loa (eye worm)	proteasome subunit alpha type 1	0.0089	0.1055	0.1728
Trypanosoma cruzi	ATP-dependent protease subunit HslV, putative	0.0089	0.1055	0.1492
Giardia lamblia	Proteasome subunit beta type 7 precursor	0.0089	0.1055	0.1492
Entamoeba histolytica	proteasome subunit alpha type 7, putative	0.0089	0.1055	0.1728
Plasmodium falciparum	proteasome subunit beta type-4	0.0089	0.1055	0.1492
Plasmodium vivax	ATP-dependent protease subunit ClpQ, putative	0.0089	0.1055	0.1492
Echinococcus granulosus	proteasome prosome macropain subunit alpha	0.0089	0.1055	0.1051
Entamoeba histolytica	protein kinase, putative	0.004	0.0382	0.0622
Echinococcus granulosus	nervana 2	0.0025	0.0169	0.0165
Trypanosoma cruzi	proteasome subunit alpha type-5, putative	0.0089	0.1055	0.1492
Trypanosoma cruzi	proteasome alpha 1 subunit, putative	0.0089	0.1055	0.1492
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0382	0.0628
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0382	0.0628
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0089	0.1055	0.1733
Echinococcus multilocularis	proteasome (prosome macropain) subunit beta type	0.0089	0.1055	0.1051
Brugia malayi	Death domain containing protein	0.008	0.0931	0.1525
Toxoplasma gondii	proteasome subunit beta type 1, putative	0.035	0.4689	0.7566
Echinococcus multilocularis	proteasome subunit beta type 6	0.0089	0.1055	0.1051
Brugia malayi	Proteasome A-type and B-type family protein	0.0089	0.1055	0.1728
Plasmodium falciparum	proteasome subunit beta type-3, putative	0.0089	0.1055	0.1492
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0089	0.1055	0.1492
Toxoplasma gondii	proteasome subunit alpha type, putative	0.0089	0.1055	0.1232
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0089	0.1055	0.1733
Plasmodium vivax	proteasome subunit alpha type-1, putative	0.0089	0.1055	0.1492
Trypanosoma cruzi	proteasome subunit beta type-2, putative	0.0217	0.2839	0.4509
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0025	0.0169	0.0165
Brugia malayi	proteasome subunit alpha type 1	0.0089	0.1055	0.1728
Trypanosoma cruzi	proteasome beta 2 subunit, putative	0.0089	0.1055	0.1492
Onchocerca volvulus	Notchless protein homolog	0.0089	0.1055	1
Entamoeba histolytica	probable proteasome subunit beta type 2, putative	0.0217	0.2839	0.4661
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0089	0.1055	0.1728
Echinococcus multilocularis	Ankyrin	0.008	0.0939	0.0935
Entamoeba histolytica	protein kinase 2, putative	0.0025	0.0172	0.0277
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0089	0.1055	0.1733
Trypanosoma brucei	proteasome alpha 3 subunit, putative	0.0089	0.1055	0.1179
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0089	0.1055	0.1728
Trypanosoma brucei	proteasome alpha 7 subunit, putative	0.0089	0.1055	0.1179
Brugia malayi	proteasome subunit alpha type 4	0.0089	0.1055	0.1728
Entamoeba histolytica	protein kinase, putative	0.0038	0.0348	0.0566
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0025	0.0172	0.0169
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0089	0.1055	0.1492
Plasmodium vivax	proteasome subunit alpha type-6, putative	0.0089	0.1055	0.1492
Echinococcus multilocularis	proteasome (prosome, macropain)	0.045	0.6086	0.6084
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0089	0.1055	0.1728
Echinococcus multilocularis	proteasome subunit beta type 7	0.0089	0.1055	0.1051
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0089	0.1055	0.1728
Giardia lamblia	Proteasome subunit beta type 1	0.035	0.4689	0.7638
Brugia malayi	proteasome subunit alpha type 3	0.0089	0.1055	0.1728
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0382	0.0628
Toxoplasma gondii	heat shock protein hslv, putative	0.0089	0.1055	0.1232
Entamoeba histolytica	proteasome subunit alpha type 3, putative	0.0089	0.1055	0.1728
Entamoeba histolytica	proteasome subunit alpha type 6, putative	0.0089	0.1055	0.1728
Giardia lamblia	Proteasome subunit beta type 3	0.0089	0.1055	0.1492
Toxoplasma gondii	proteasome beta subunit	0.0089	0.1055	0.1232
Toxoplasma gondii	proteasome subunit	0.0089	0.1055	0.1232
Trypanosoma cruzi	hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B	0.0089	0.1055	0.1492
Loa Loa (eye worm)	proteasome subunit beta type 2	0.0217	0.2839	0.4661
Giardia lamblia	20S proteasome alpha subunit 5	0.0089	0.1055	0.1492
Trypanosoma brucei	proteasome alpha 2 subunit, putative	0.0089	0.1055	0.1179
Entamoeba histolytica	protein kinase, putative	0.004	0.0382	0.0622
Brugia malayi	Proteasome A-type and B-type family protein	0.0089	0.1055	0.1728
Loa Loa (eye worm)	20S proteasome alpha5 subunit	0.0089	0.1055	0.1728
Trypanosoma cruzi	proteasome alpha 2 subunit, putative	0.0089	0.1055	0.1492
Plasmodium falciparum	proteasome subunit beta type-2, putative	0.0217	0.2839	0.4509
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0217	0.2839	0.4664
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0382	0.0628
Trypanosoma brucei	proteasome alpha 1 subunit, putative	0.0089	0.1055	0.1179
Echinococcus granulosus	Proteasome subunit alpha beta	0.0089	0.1055	0.1051
Echinococcus multilocularis	nervana 2	0.0025	0.0169	0.0165
Echinococcus multilocularis	proteasome subunit alpha type 6	0.0089	0.1055	0.1051
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0732	1	1
Echinococcus granulosus	serine threonine protein kinase nrc	0.0025	0.0172	0.0169
Echinococcus granulosus	20S proteasome subunit alpha 6	0.0089	0.1055	0.1051
Brugia malayi	proteasome subunit beta type 3	0.0089	0.1055	0.1728
Giardia lamblia	20S proteasome alpha subunit 7	0.0089	0.1055	0.1492
Trypanosoma cruzi	proteasome alpha 3 subunit, putative	0.0089	0.1055	0.1492
Giardia lamblia	20S proteasome alpha subunit 2	0.0089	0.1055	0.1492
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0089	0.1055	0.1492
Trichomonas vaginalis	AGC family protein kinase	0.0013	0.0004	0.0006
Trichomonas vaginalis	AGC family protein kinase	0.0015	0.0038	0.0063
Echinococcus granulosus	proteasome prosome macropain	0.045	0.6086	0.6084
Giardia lamblia	20S proteasome alpha subunit 1	0.0089	0.1055	0.1492
Trypanosoma brucei	proteasome beta 3 subunit, putative	0.0089	0.1055	0.1179
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.008	0.0931	0.1525
Brugia malayi	Protein kinase domain containing protein	0.004	0.0382	0.0622
Trypanosoma brucei	Proteasome subunit A N-terminal signature/Proteasome subunit, putative	0.0089	0.1055	0.1179
Toxoplasma gondii	peptidase, T1 family protein	0.0089	0.1055	0.1232
Echinococcus multilocularis	rac serine:threonine kinase	0.0028	0.0207	0.0203
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0028	0.0207	0.0334
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0217	0.2839	0.4661
Trypanosoma cruzi	Protein kinase B	0.0028	0.0207	0.0058
Trypanosoma cruzi	20S proteasome subunit	0.0217	0.2839	0.4509
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0089	0.1055	0.1733
Plasmodium falciparum	proteasome subunit beta type-6, putative	0.0089	0.1055	0.1492
Plasmodium vivax	proteasome subunit alpha type-2, putative	0.0089	0.1055	0.1492
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0089	0.1055	0.1728
Trypanosoma brucei	proteasome alpha 7 subunit	0.0089	0.1055	0.1179
Plasmodium falciparum	proteasome subunit alpha type-4, putative	0.0089	0.1055	0.1492
Trypanosoma cruzi	proteasome beta 7 subunit, putative	0.0089	0.1055	0.1492
Trypanosoma cruzi	proteasome beta-1 subunit, putative	0.0089	0.1055	0.1492
Loa Loa (eye worm)	proteasome subunit alpha type 6	0.0089	0.1055	0.1728
Brugia malayi	proteasome subunit alpha type 6	0.0089	0.1055	0.1728
Plasmodium falciparum	proteasome subunit alpha type-3, putative	0.0089	0.1055	0.1492
Schistosoma mansoni	proteasome subunit alpha 7 (T01 family)	0.0089	0.1055	0.1728
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0217	0.2839	0.4661
Toxoplasma gondii	proteasome subunit beta type 2, putative	0.0217	0.2839	0.4341
Trypanosoma brucei	proteasome beta-1 subunit, putative	0.0089	0.1055	0.1179
Trypanosoma cruzi	proteasome subunit alpha type-5, putative	0.0089	0.1055	0.1492
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0089	0.1055	0.1728
Entamoeba histolytica	proteasome subunit alpha type 7, putative	0.0089	0.1055	0.1728
Trypanosoma brucei	proteasome beta 2 subunit, putative	0.0089	0.1055	0.1179
Giardia lamblia	Proteasome subunit beta type 5 precursor	0.045	0.6086	1
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0089	0.1055	0.1733
Loa Loa (eye worm)	hypothetical protein	0.008	0.0931	0.1525
Entamoeba histolytica	proteasome subunit alpha type 2-A, putative	0.0089	0.1055	0.1728
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0028	0.0207	0.0334
Plasmodium vivax	proteasome subunit beta type-5, putative	0.045	0.6086	1
Brugia malayi	Uncoordinated protein 44	0.008	0.0931	0.1525
Brugia malayi	20S proteasome alpha5 subunit	0.0089	0.1055	0.1728
Entamoeba histolytica	proteasome subunit alpha type 4, putative	0.0089	0.1055	0.1728

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.04 uM	Inhibition of AKT1 by IMAP assay	ChEMBL.	21392984
IC50 (binding)	= 2.6 uM	Inhibition of AKT1 in human LNCaP cells assessed as PRAS40 phosphorylation at Thr246 after 1.5 hrs	ChEMBL.	21392984
Inhibition (binding)		Inhibition of AKT2 by IMAP assay	ChEMBL.	21392984
Inhibition (binding)		Inhibition of AKT3 by IMAP assay	ChEMBL.	21392984

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1761085

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1528154