Detailed information for compound 1528154

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 532.692 | Formula: C28H40N2O6S
  • H donors: 2 H acceptors: 4 LogP: 3.51 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCOCCN(S(=O)(=O)c1c(C)cccc1C)C[C@H](CN1CCCC2(C1)CCc1c(O2)ccc(c1)O)O
  • InChi: 1S/C28H40N2O6S/c1-4-35-16-15-30(37(33,34)27-21(2)7-5-8-22(27)3)19-25(32)18-29-14-6-12-28(20-29)13-11-23-17-24(31)9-10-26(23)36-28/h5,7-10,17,25,31-32H,4,6,11-16,18-20H2,1-3H3/t25-,28?/m0/s1
  • InChiKey: KDVVGAZDAXSUBA-ALLRNTDFSA-N  

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens v-akt murine thymoma viral oncogene homolog 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Neospora caninum Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1), related Get druggable targets OG5_126635 All targets in OG5_126635
Toxoplasma gondii AGC kinase Get druggable targets OG5_126635 All targets in OG5_126635
Giardia lamblia Kinase, AGC PKA Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium yoelii kinase Akt/PKB-related Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus serine threonine protein kinase nrc Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma cruzi rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma mansoni serine/threonine-protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium vivax rac-beta serine/threonine protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma mansoni serine/threonine-protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma cruzi Protein kinase B Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium falciparum RAC-beta serine/threonine protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus Glutaredoxin protein 5 Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Loa Loa (eye worm) AGC/RSK/P70 protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum RAC serine/threonine-protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus calcium:calmodulin dependent protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Candida albicans likely protein kinase similar to S. cerevisiae YPK2 (YMR104C) Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma brucei gambiense rac serine-threonine kinase, putative,protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Brugia malayi p70 ribosomal S6 kinase beta Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum ko:K07390 monothiol glutaredoxin, putative Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum ko:K08792 serum/glucocorticoid regulated kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis Glutaredoxin protein 5 Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis rac serine:threonine kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus serine/threonine protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium knowlesi RAC-beta serine/threonine protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Loa Loa (eye worm) AGC/AKT protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Candida albicans protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus sodium:potassium dependent atpase beta subunit Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium berghei rac-beta serine/threonine protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica protein kinase 2, putative Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum Sodium/potassium-transporting ATPase subunit beta-1, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma brucei rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma congolense rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum ko:K04456 RAC serine/threonine-protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma cruzi rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0089 0.1055 0.1492
Giardia lamblia 20S proteasome alpha subunit 1 0.0089 0.1055 0.1492
Entamoeba histolytica protein kinase 2, putative 0.0025 0.0172 0.0277
Plasmodium vivax proteasome subunit beta type-7, putative 0.0089 0.1055 0.1492
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0089 0.1055 0.1492
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0089 0.1055 0.1492
Onchocerca volvulus Notchless protein homolog 0.0089 0.1055 1
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0089 0.1055 0.1492
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0089 0.1055 0.1728
Echinococcus multilocularis rac serine:threonine kinase 0.0028 0.0207 0.0203
Echinococcus granulosus proteasome subunit beta type 7 0.0089 0.1055 0.1051
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0089 0.1055 0.1492
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0089 0.1055 0.1492
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0089 0.1055 0.1733
Brugia malayi proteasome subunit beta type 2 0.0217 0.2839 0.4661
Echinococcus multilocularis nervana 2 0.0025 0.0169 0.0165
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0089 0.1055 0.1492
Echinococcus granulosus proteasome prosome macropain 0.045 0.6086 0.6084
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.045 0.6086 1
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.035 0.4689 0.7703
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0089 0.1055 0.1733
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0089 0.1055 0.1492
Plasmodium vivax proteasome subunit beta type-4, putative 0.0089 0.1055 0.1492
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0089 0.1055 0.1492
Brugia malayi proteasome subunit alpha type 4 0.0089 0.1055 0.1728
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0089 0.1055 0.1733
Brugia malayi Death domain containing protein 0.008 0.0931 0.1525
Brugia malayi 20S proteasome alpha5 subunit 0.0089 0.1055 0.1728
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0089 0.1055 0.1492
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0217 0.2839 0.4664
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0089 0.1055 0.1232
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0089 0.1055 0.1728
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.008 0.0931 0.1525
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0089 0.1055 0.1492
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0217 0.2839 0.2836
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0089 0.1055 0.1492
Brugia malayi proteasome subunit alpha type 6 0.0089 0.1055 0.1728
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0089 0.1055 0.1051
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0089 0.1055 0.1733
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0089 0.1055 0.1492
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0089 0.1055 0.1492
Plasmodium vivax proteasome subunit beta type-2, putative 0.0217 0.2839 0.4509
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0089 0.1055 0.1728
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0089 0.1055 0.1232
Brugia malayi Proteasome A-type and B-type family protein 0.0089 0.1055 0.1728
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.008 0.0931 0.0928
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0089 0.1055 0.1179
Brugia malayi Protein kinase domain containing protein 0.004 0.0382 0.0622
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0089 0.1055 0.1051
Entamoeba histolytica proteasome subunit beta type 1, putative 0.035 0.4689 0.7703
Brugia malayi proteasome subunit beta type 1 0.035 0.4689 0.7703
Echinococcus granulosus netrin receptor unc 5 0.008 0.0931 0.0928
Toxoplasma gondii heat shock protein hslv, putative 0.0089 0.1055 0.1232
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0089 0.1055 0.1728
Schistosoma mansoni netrin receptor unc5 0.008 0.0931 0.1525
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0089 0.1055 0.1733
Echinococcus granulosus proteasome subunit beta type 6 0.0089 0.1055 0.1051
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.045 0.6086 1
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0089 0.1055 0.1051
Brugia malayi proteasome subunit alpha type 2 0.0089 0.1055 0.1728
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0217 0.2839 0.4509
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0089 0.1055 0.1492
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0089 0.1055 0.1728
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0089 0.1055 0.1728
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.035 0.4689 0.4687
Brugia malayi p70 ribosomal S6 kinase beta 0.0038 0.0348 0.0566
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0089 0.1055 0.1232
Trichomonas vaginalis AGC family protein kinase 0.004 0.0382 0.0628
Brugia malayi proteasome subunit alpha type 3 0.0089 0.1055 0.1728
Entamoeba histolytica protein kinase, putative 0.0038 0.0348 0.0566
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0089 0.1055 0.1492
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0004 0.0006
Loa Loa (eye worm) PAS-3 protein 0.0089 0.1055 0.1728
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0089 0.1055 0.1728
Brugia malayi Uncoordinated protein 44 0.008 0.0931 0.1525
Toxoplasma gondii proteasome subunit beta type, putative 0.045 0.6086 1
Plasmodium vivax proteasome subunit beta type-5, putative 0.045 0.6086 1
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0089 0.1055 0.1728
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0089 0.1055 0.1733
Echinococcus granulosus nervana 2 0.0025 0.0169 0.0165
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0089 0.1055 0.1492
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0217 0.2839 0.4341
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0089 0.1055 0.1728
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0089 0.1055 0.1728
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0217 0.2839 0.4661
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0089 0.1055 0.1051
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0089 0.1055 0.1051
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0089 0.1055 0.1492
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0089 0.1055 0.1492
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0004 0.0006
Echinococcus granulosus proteasome subunit alpha type 6 0.0089 0.1055 0.1051
Trypanosoma brucei proteasome beta 6 subunit 0.035 0.4689 0.7551
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0089 0.1055 0.1728
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0089 0.1055 0.1728
Giardia lamblia 20S proteasome alpha subunit 3 0.0089 0.1055 0.1492
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0089 0.1055 0.1179
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.035 0.4689 0.7705
Loa Loa (eye worm) AGC/AKT protein kinase 0.004 0.0382 0.0622
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0025 0.0172 0.0169
Brugia malayi Proteasome A-type and B-type family protein 0.045 0.6086 1
Loa Loa (eye worm) proteasome subunit beta type 2 0.0217 0.2839 0.4661
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.045 0.6086 1
Giardia lamblia 20S proteasome alpha subunit 5 0.0089 0.1055 0.1492
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0089 0.1055 0.1492
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0089 0.1055 0.1733
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0089 0.1055 0.1492
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0089 0.1055 0.1492
Echinococcus granulosus Proteasome subunit alpha type 7 0.0089 0.1055 0.1051
Echinococcus granulosus proteasome subunit beta t family 0.0089 0.1055 0.1051
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0089 0.1055 0.1492
Brugia malayi Protein kinase domain containing protein 0.008 0.0935 0.1532
Brugia malayi proteasome subunit alpha type 1 0.0089 0.1055 0.1728
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0089 0.1055 0.1728
Echinococcus multilocularis Ankyrin 0.008 0.0939 0.0935
Echinococcus multilocularis proteasome subunit beta type 7 0.0089 0.1055 0.1051
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0089 0.1055 0.1179
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0089 0.1055 0.1492
Toxoplasma gondii proteasome subunit alpha type, putative 0.0089 0.1055 0.1232
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0089 0.1055 0.1179
Brugia malayi Immunoglobulin I-set domain containing protein 0.008 0.0931 0.1525
Schistosoma mansoni serine/threonine-protein kinase 0.0028 0.0207 0.0334
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0089 0.1055 0.1728
Plasmodium falciparum proteasome subunit beta type-5 0.045 0.6086 1
Mycobacterium ulcerans proteasome PrcB 0.045 0.6086 1
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0089 0.1055 0.1492
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0089 0.1055 0.1733
Echinococcus multilocularis proteasome subunit beta type 6 0.0089 0.1055 0.1051
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0089 0.1055 0.1728
Plasmodium vivax proteasome subunit beta type-3, putative 0.0089 0.1055 0.1492
Trichomonas vaginalis AGC family protein kinase 0.004 0.0382 0.0628
Echinococcus granulosus Ankyrin 0.008 0.0939 0.0935
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.045 0.6086 1
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0089 0.1055 0.1179
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0089 0.1055 0.1492
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.035 0.4689 0.7224
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.035 0.4689 0.7638
Brugia malayi Proteasome subunit alpha type 7-1 0.0089 0.1055 0.1728
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0089 0.1055 0.1728
Giardia lamblia 20S proteasome alpha subunit 7 0.0089 0.1055 0.1492
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.008 0.0939 0.1537
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0089 0.1055 0.1728
Trichomonas vaginalis AGC family protein kinase 0.004 0.0382 0.0628
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0089 0.1055 0.1728
Loa Loa (eye worm) hypothetical protein 0.008 0.0939 0.1537
Echinococcus granulosus death domain containing protein 0.008 0.0931 0.0928
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.045 0.6086 1
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0089 0.1055 0.1492
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0089 0.1055 0.1733
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0089 0.1055 0.1728
Schistosoma mansoni serine/threonine-protein kinase 0.0028 0.0207 0.0334
Entamoeba histolytica protein kinase, putative 0.004 0.0382 0.0622
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0089 0.1055 0.1492
Echinococcus multilocularis proteasome subunit alpha type 2 0.0089 0.1055 0.1051
Entamoeba histolytica PH domain containing protein kinase, putative 0.0028 0.0207 0.0334
Echinococcus granulosus Proteasome subunit alpha beta 0.0089 0.1055 0.1051
Brugia malayi proteasome subunit beta type 3 0.0089 0.1055 0.1728
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0217 0.2839 0.4307
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0089 0.1055 0.1728
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0089 0.1055 0.1733
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0089 0.1055 0.1492
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0089 0.1055 0.1492
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0217 0.2839 0.4664
Plasmodium falciparum proteasome subunit beta type-4 0.0089 0.1055 0.1492
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0089 0.1055 0.1728
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0089 0.1055 0.1051
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0089 0.1059 0.1734
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0089 0.1055 0.1728
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0089 0.1055 0.1733
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0089 0.1055 0.1728
Giardia lamblia Proteasome subunit beta type 5 precursor 0.045 0.6086 1
Giardia lamblia Proteasome subunit beta type 2 0.0217 0.2839 0.4509
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0089 0.1055 0.1733
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0089 0.1055 0.1728
Echinococcus granulosus serine threonine protein kinase nrc 0.0025 0.0172 0.0169
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0089 0.1055 0.1179
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0089 0.1055 0.1051
Mycobacterium leprae proteasome (beta subunit) PrcB 0.045 0.6086 1
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0089 0.1055 0.1728
Toxoplasma gondii proteasome subunit beta type 1, putative 0.035 0.4689 0.7566
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0038 0.0348 0.0566
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0089 0.1055 0.1051
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0732 1 1
Echinococcus granulosus serine/threonine protein kinase 0.0028 0.0207 0.0203
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0028 0.0207 0.0058
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0089 0.1055 0.1728
Echinococcus multilocularis netrin receptor unc 5 0.008 0.0931 0.0928
Echinococcus multilocularis nervana 2 0.0025 0.0169 0.0165
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0089 0.1055 0.1728
Giardia lamblia Proteasome subunit beta type 1 0.035 0.4689 0.7638
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0089 0.1055 0.1728
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0089 0.1055 0.1232
Trypanosoma brucei proteasome alpha 7 subunit 0.0089 0.1055 0.1179
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0089 0.1055 0.1728
Brugia malayi Proteasome A-type and B-type family protein 0.0089 0.1055 0.1728
Entamoeba histolytica protein kinase, putative 0.004 0.0382 0.0622
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0089 0.1055 0.1728
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0089 0.1055 0.1232
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0089 0.1055 0.1728
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0025 0.0169 0.0165
Giardia lamblia Proteasome subunit beta type 3 0.0089 0.1055 0.1492
Toxoplasma gondii proteasome subunit 0.0089 0.1055 0.1232
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0089 0.1055 0.1492
Trichomonas vaginalis AGC family protein kinase 0.004 0.0382 0.0628
Leishmania major proteasome beta 2 subunit, putative 0.0217 0.2839 0.3546
Toxoplasma gondii proteasome subunit alpha1, putative 0.0089 0.1055 0.1232
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0089 0.1055 0.1492
Echinococcus multilocularis proteasome subunit alpha type 6 0.0089 0.1055 0.1051
Loa Loa (eye worm) proteasome subunit beta type 3 0.0089 0.1055 0.1728
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0089 0.1055 0.1051
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.045 0.6086 1
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.035 0.4689 0.7638
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0089 0.1055 0.1728
Leishmania major proteasome beta 5 subunit, putative 0.045 0.6086 1
Trypanosoma cruzi Protein kinase B 0.0028 0.0207 0.0058
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0025 0.0172 0.0169
Trypanosoma brucei proteasome beta 7 subunit 0.0089 0.1055 0.1179
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.045 0.6086 1
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0089 0.1055 0.1728
Loa Loa (eye worm) hypothetical protein 0.008 0.0931 0.1525
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0089 0.1055 0.1728
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0089 0.1055 0.1492
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0089 0.1055 0.1492
Trichomonas vaginalis AGC family protein kinase 0.004 0.0382 0.0628
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0089 0.1055 0.1492
Echinococcus granulosus nervana 2 0.0025 0.0169 0.0165
Giardia lamblia 20S proteasome alpha subunit 6 0.0089 0.1055 0.1492
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0089 0.1055 0.1051
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0089 0.1055 0.1728
Echinococcus multilocularis proteasome (prosome, macropain) 0.045 0.6086 0.6084
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0089 0.1055 0.1179
Trichomonas vaginalis AGC family protein kinase 0.004 0.0382 0.0628
Trypanosoma brucei proteasome subunit beta type-5, putative 0.045 0.6086 1
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0089 0.1055 0.1179
Giardia lamblia 20S proteasome alpha subunit 4 0.0089 0.1055 0.1492
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0089 0.1055 0.1179
Plasmodium vivax proteasome subunit beta type-1, putative 0.035 0.4689 0.7638
Echinococcus granulosus proteasome prosome macropain subunit beta 0.035 0.4689 0.4687
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0089 0.1055 0.1728
Trichomonas vaginalis AGC family protein kinase 0.004 0.0382 0.0628
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0089 0.1055 0.1728
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0217 0.2839 0.4509
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0089 0.1055 0.1492
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0089 0.1055 0.1051
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0089 0.1055 0.1492
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0089 0.1055 0.1492
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0217 0.2839 0.4661
Trichomonas vaginalis AGC family protein kinase 0.0015 0.0038 0.0063
Echinococcus multilocularis Glutaredoxin protein 5 0.0025 0.0169 0.0165
Toxoplasma gondii peptidase, T1 family protein 0.0089 0.1055 0.1232
Brugia malayi Proteasome subunit alpha type 1 0.0089 0.1055 0.1728
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0004 0.0006
Plasmodium falciparum proteasome subunit beta type-1, putative 0.035 0.4689 0.7638
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0089 0.1055 0.1492
Echinococcus granulosus subfamily T1A non peptidase ue 0.0089 0.1055 0.1051
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0025 0.0169 0.0165
Schistosoma mansoni ankyrin 23/unc44 0.008 0.0931 0.1525
Loa Loa (eye worm) proteasome subunit beta type 1 0.035 0.4689 0.7703
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0089 0.1055 0.1051
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0089 0.1055 0.1492
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0089 0.1055 0.1728
Echinococcus granulosus Glutaredoxin protein 5 0.0025 0.0169 0.0165
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0217 0.2839 0.2836
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0089 0.1055 0.1179
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0217 0.2839 0.4661
Echinococcus granulosus proteasome subunit alpha type 2 0.0089 0.1055 0.1051
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.008 0.0931 0.0928
Giardia lamblia 20S proteasome alpha subunit 2 0.0089 0.1055 0.1492
Plasmodium vivax proteasome subunit beta type-6, putative 0.0089 0.1055 0.1492
Brugia malayi Proteasome A-type and B-type family protein 0.0089 0.1055 0.1728
Toxoplasma gondii proteasome beta subunit 0.0089 0.1055 0.1232
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0089 0.1055 0.1492
Trypanosoma cruzi 20S proteasome subunit 0.0217 0.2839 0.4509
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0089 0.1055 0.1492
Entamoeba histolytica PH domain containing protein kinase, putative 0.0028 0.0207 0.0334
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0089 0.1055 0.5
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0089 0.1055 0.1492
Schistosoma mansoni hypothetical protein 0.008 0.0931 0.1525
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0089 0.1055 0.1728

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.04 uM Inhibition of AKT1 by IMAP assay ChEMBL. 21392984
IC50 (binding) = 2.6 uM Inhibition of AKT1 in human LNCaP cells assessed as PRAS40 phosphorylation at Thr246 after 1.5 hrs ChEMBL. 21392984
Inhibition (binding) Inhibition of AKT2 by IMAP assay ChEMBL. 21392984
Inhibition (binding) Inhibition of AKT3 by IMAP assay ChEMBL. 21392984

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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