Detailed information for compound 1528157

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 439.895 | Formula: C22H22ClN5O3
  • H donors: 2 H acceptors: 3 LogP: 2.81 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=O)COc1ccccc1N1CCN(CC1)C(=O)c1[nH]nc(c1)c1ccc(cc1)Cl
  • InChi: 1S/C22H22ClN5O3/c23-16-7-5-15(6-8-16)17-13-18(26-25-17)22(30)28-11-9-27(10-12-28)19-3-1-2-4-20(19)31-14-21(24)29/h1-8,13H,9-12,14H2,(H2,24,29)(H,25,26)
  • InChiKey: XRKQSXRRQJSZEC-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tachykinin receptor 3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis tachykinin peptides receptor 99D Get druggable targets OG5_131969 All targets in OG5_131969
Echinococcus granulosus tachykinin peptides receptor 99D Get druggable targets OG5_131969 All targets in OG5_131969

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Leishmania major proteasome alpha 7 subunit, putative 0.0119 0.0624 0.1715
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0291 0.1597 0.1597
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0119 0.0624 0.1715
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0119 0.0624 0.1715
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0119 0.0624 0.1715
Brugia malayi Latrophilin receptor protein 2 0.0015 0.004 0.0117
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0119 0.0624 0.1715
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0119 0.0624 0.1715
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0119 0.0624 0.1854
Echinococcus granulosus Ankyrin 0.0165 0.0887 0.0887
Leishmania major proteasome alpha 1 subunit, putative 0.0119 0.0624 0.1715
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0119 0.0624 0.0624
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0119 0.0624 0.1715
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0119 0.0624 0.1715
Echinococcus granulosus proteasome prosome macropain 0.0604 0.3368 0.3368
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0119 0.0624 0.1715
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0119 0.0624 0.1715
Giardia lamblia 20S proteasome alpha subunit 4 0.0119 0.0624 0.1715
Giardia lamblia 20S proteasome alpha subunit 2 0.0119 0.0624 0.1715
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0119 0.0624 0.1854
Giardia lamblia Proteasome subunit beta type 2 0.0291 0.1597 0.4653
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0119 0.0624 0.1715
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0119 0.0624 0.1854
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0604 0.3368 1
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0119 0.0624 0.1715
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.047 0.2606 0.77
Echinococcus multilocularis proteasome subunit alpha type 2 0.0119 0.0624 0.0624
Brugia malayi Proteasome A-type and B-type family protein 0.0119 0.0624 0.1854
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0604 0.3368 1
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0119 0.0624 0.1715
Brugia malayi Protein kinase domain containing protein 0.0164 0.0882 0.262
Leishmania major proteasome beta 3 subunit, putative 0.0119 0.0624 0.1715
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0119 0.0624 0.1854
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0119 0.0624 0.1715
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0119 0.0624 0.1715
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0119 0.0624 0.1854
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0604 0.3368 1
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0604 0.3368 1
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0119 0.0624 0.1715
Leishmania major proteasome alpha 7 subunit, putative 0.0119 0.0624 0.1715
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0119 0.0624 0.1715
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0119 0.0624 0.1715
Echinococcus granulosus netrin receptor unc 5 0.0164 0.0882 0.0882
Loa Loa (eye worm) hypothetical protein 0.0033 0.014 0.0415
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.0639 0.1896
Brugia malayi proteasome subunit alpha type 4 0.0119 0.0624 0.1854
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0119 0.0624 0.1715
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0119 0.0624 0.0624
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0119 0.0624 0.1715
Brugia malayi Proteasome A-type and B-type family protein 0.0119 0.0624 0.1854
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0119 0.0624 0.1715
Leishmania major proteasome beta 5 subunit, putative 0.0604 0.3368 1
Schistosoma mansoni hypothetical protein 0.0015 0.004 0.0117
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0119 0.0624 0.1715
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0119 0.0624 0.0624
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0119 0.0624 0.1854
Giardia lamblia Proteasome subunit beta type 1 0.047 0.2606 0.77
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0119 0.0624 0.1715
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0119 0.0624 0.1715
Plasmodium vivax proteasome subunit beta type-2, putative 0.0291 0.1597 0.4653
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0468 0.139
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0831 0.4648 0.4648
Plasmodium vivax proteasome subunit beta type-6, putative 0.0119 0.0624 0.1715
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0468 0.139
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0056 0.0167
Echinococcus granulosus proteasome prosome macropain subunit beta 0.047 0.2606 0.2606
Toxoplasma gondii proteasome subunit alpha1, putative 0.0119 0.0624 0.1715
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0119 0.0624 0.1715
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0164 0.0882 0.0882
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0119 0.0624 0.1715
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0291 0.1597 0.4653
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0119 0.0624 0.1715
Brugia malayi proteasome subunit alpha type 3 0.0119 0.0624 0.1854
Echinococcus granulosus geminin 0.0346 0.1907 0.1907
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.0639 0.1896
Giardia lamblia 20S proteasome alpha subunit 3 0.0119 0.0624 0.1715
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0291 0.1597 0.4653
Echinococcus granulosus GPCR family 2 0.0015 0.004 0.004
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0468 0.0468
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0119 0.0624 0.1715
Loa Loa (eye worm) hypothetical protein 0.0164 0.0882 0.262
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0119 0.0624 0.1715
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0119 0.0624 0.1854
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0468 0.0468
Leishmania major proteasome alpha 1 subunit, putative 0.0119 0.0624 0.1715
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0119 0.0624 0.1715
Mycobacterium ulcerans proteasome PrcB 0.0604 0.3368 1
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0604 0.3368 1
Plasmodium vivax proteasome subunit beta type-7, putative 0.0119 0.0624 0.1715
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0291 0.1597 0.4653
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0119 0.0624 0.0624
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0119 0.0624 0.1715
Trypanosoma brucei proteasome beta 7 subunit 0.0119 0.0624 0.1715
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0604 0.3368 1
Echinococcus multilocularis netrin receptor unc 5 0.0164 0.0882 0.0882
Plasmodium vivax proteasome subunit beta type-3, putative 0.0119 0.0624 0.1715
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.004 0.0117
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0119 0.0624 0.1715
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0119 0.0624 0.1715
Loa Loa (eye worm) hypothetical protein 0.0165 0.0887 0.2633
Plasmodium falciparum proteasome subunit beta type-1, putative 0.047 0.2606 0.77
Echinococcus granulosus proteasome subunit alpha type 6 0.0119 0.0624 0.0624
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0119 0.0624 0.1715
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0119 0.0624 0.1715
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0291 0.1597 0.4653
Toxoplasma gondii proteasome subunit beta type 1, putative 0.047 0.2606 0.77
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0119 0.0624 0.1715
Onchocerca volvulus Netrin receptor homolog 0.0164 0.0882 1
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0119 0.0624 0.1715
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0119 0.0624 0.1715
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0291 0.1597 0.4742
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0119 0.0624 0.1715
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0056 0.0167
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0119 0.0624 0.1715
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0119 0.0624 0.1715
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0119 0.0624 0.0624
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0226 0.0671
Brugia malayi MH2 domain containing protein 0.0121 0.0639 0.1896
Brugia malayi proteasome subunit beta type 1 0.047 0.2606 0.7738
Brugia malayi Proteasome subunit alpha type 1 0.0119 0.0624 0.1854
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0119 0.0624 0.1854
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0119 0.0624 0.1715
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0119 0.0624 0.1715
Entamoeba histolytica proteasome subunit beta type 1, putative 0.047 0.2606 0.77
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0119 0.0624 0.1715
Brugia malayi Proteasome subunit alpha type 7-1 0.0119 0.0624 0.1854
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0119 0.0624 0.1715
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0119 0.0624 0.1715
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0164 0.0882 0.0882
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0226 0.0671
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0119 0.0624 0.1715
Echinococcus granulosus proteasome subunit beta type 6 0.0119 0.0624 0.0624
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0119 0.0624 0.1854
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0291 0.1597 0.4653
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0119 0.0624 0.1715
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0119 0.0624 0.1715
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0604 0.3368 1
Plasmodium vivax proteasome subunit beta type-5, putative 0.0604 0.3368 1
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.047 0.2606 0.2606
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0119 0.0624 0.1715
Brugia malayi 20S proteasome alpha5 subunit 0.0119 0.0624 0.1854
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0119 0.0624 0.1715
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.004 0.004
Echinococcus multilocularis proteasome subunit beta type 6 0.0119 0.0624 0.0624
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0119 0.0624 0.1854
Giardia lamblia Proteasome subunit beta type 3 0.0119 0.0624 0.1715
Schistosoma mansoni netrin receptor unc5 0.0164 0.0882 0.262
Echinococcus multilocularis geminin 0.0346 0.1907 0.1907
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0119 0.0624 0.1715
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0056 0.0056
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0119 0.0624 0.1715
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0119 0.0624 0.1854
Toxoplasma gondii proteasome subunit alpha type, putative 0.0119 0.0624 0.1715
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0119 0.0624 0.1854
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0119 0.0624 0.1715
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0119 0.0624 0.1715
Schistosoma mansoni hypothetical protein 0.0164 0.0882 0.262
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0119 0.0624 0.0624
Echinococcus granulosus subfamily T1A non peptidase ue 0.0119 0.0624 0.0624
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0119 0.0624 0.1715
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0119 0.0624 0.1715
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.014 0.0415
Echinococcus granulosus Proteasome subunit alpha beta 0.0119 0.0624 0.0624
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0119 0.0624 0.0624
Plasmodium vivax proteasome subunit beta type-4, putative 0.0119 0.0624 0.1715
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0119 0.0624 0.0624
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0119 0.0624 0.1715
Brugia malayi proteasome subunit alpha type 1 0.0119 0.0624 0.1854
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0119 0.0624 1
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0119 0.0624 0.1715
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0119 0.0624 0.1854
Echinococcus multilocularis tachykinin peptides receptor 99D 0.036 0.1987 0.1987
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0119 0.0624 0.1715
Leishmania major proteasome beta-1 subunit, putative 0.0119 0.0624 0.1715
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0119 0.0624 0.1715
Toxoplasma gondii proteasome beta subunit 0.0119 0.0624 0.1715
Mycobacterium ulcerans proteasome PrcA 0.0119 0.0624 0.1715
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.004 0.004
Brugia malayi proteasome subunit beta type 2 0.0291 0.1597 0.4742
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0119 0.0624 0.1715
Toxoplasma gondii heat shock protein hslv, putative 0.0119 0.0624 0.1715
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0119 0.0624 0.1715
Schistosoma mansoni ap endonuclease 0.0018 0.0056 0.0167
Echinococcus granulosus death domain containing protein 0.0164 0.0882 0.0882
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0119 0.0624 0.1854
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0119 0.0624 0.1715
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0468 0.139
Trypanosoma brucei proteasome alpha 7 subunit 0.0119 0.0624 0.1715
Giardia lamblia 20S proteasome alpha subunit 7 0.0119 0.0624 0.1715
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0119 0.0624 0.1854
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0291 0.1597 0.4653
Schistosoma mansoni hypothetical protein 0.0033 0.014 0.0415
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.047 0.2606 0.77
Leishmania major proteasome beta 2 subunit, putative 0.0119 0.0624 0.1715
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0468 0.139
Loa Loa (eye worm) proteasome subunit beta type 1 0.047 0.2606 0.7738
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0119 0.0624 0.0624
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0119 0.0624 0.1715
Plasmodium falciparum proteasome subunit beta type-4 0.0119 0.0624 0.1715
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0119 0.0624 0.0624
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.004 0.0117
Schistosoma mansoni ap endonuclease 0.0018 0.0056 0.0167
Loa Loa (eye worm) proteasome subunit beta type 3 0.0119 0.0624 0.1854
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0468 0.0468
Schistosoma mansoni hypothetical protein 0.0346 0.1907 0.5663
Echinococcus multilocularis proteasome subunit alpha type 6 0.0119 0.0624 0.0624
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0119 0.0624 0.1715
Loa Loa (eye worm) proteasome subunit beta type 2 0.0291 0.1597 0.4742
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0119 0.0624 0.1854
Brugia malayi Death domain containing protein 0.0164 0.0882 0.262
Brugia malayi Uncoordinated protein 44 0.0164 0.0882 0.262
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0119 0.0624 0.0624
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0119 0.0624 0.1715
Schistosoma mansoni hypothetical protein 0.0015 0.004 0.0117
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0056 0.5
Echinococcus multilocularis GPCR, family 2 0.0015 0.004 0.004
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0119 0.0624 0.1715
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.047 0.2606 0.77
Plasmodium vivax proteasome subunit beta type-1, putative 0.047 0.2606 0.77
Echinococcus granulosus Proteasome subunit alpha type 7 0.0119 0.0624 0.0624
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0119 0.0624 0.1715
Leishmania major proteasome alpha 3 subunit, putative 0.0119 0.0624 0.1715
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0119 0.0624 0.1715
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0119 0.0624 0.1715
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0119 0.0624 0.1715
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0119 0.0624 0.1854
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0604 0.3368 1
Leishmania major proteasome beta 7 subunit, putative 0.0119 0.0624 0.1715
Leishmania major proteasome alpha 2 subunit, putative 0.0119 0.0624 0.1715
Giardia lamblia 20S proteasome alpha subunit 1 0.0119 0.0624 0.1715
Echinococcus multilocularis proteasome (prosome, macropain) 0.0604 0.3368 0.3368
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0119 0.0624 0.1715
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0119 0.0624 0.1715
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0468 0.0468
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0119 0.0624 0.1715
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0119 0.0624 0.1854
Toxoplasma gondii proteasome subunit beta type, putative 0.0604 0.3368 1
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0119 0.0624 0.1715
Toxoplasma gondii proteasome subunit 0.0119 0.0624 0.1715
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.004 0.004
Schistosoma mansoni ankyrin 23/unc44 0.0164 0.0882 0.262
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0119 0.0624 0.1715
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0119 0.0624 0.1715
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0119 0.0624 0.1715
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0604 0.3368 1
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.047 0.2606 0.7738
Brugia malayi Immunoglobulin I-set domain containing protein 0.0164 0.0882 0.262
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0604 0.3368 1
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0119 0.0624 0.1715
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0119 0.0624 0.1715
Brugia malayi proteasome subunit beta type 3 0.0119 0.0624 0.1854
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0119 0.0624 0.1854
Brugia malayi proteasome subunit alpha type 2 0.0119 0.0624 0.1854
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0291 0.1597 0.4653
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0119 0.0624 0.0624
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0468 0.139
Brugia malayi Proteasome A-type and B-type family protein 0.0119 0.0624 0.1854
Echinococcus granulosus proteasome subunit beta type 7 0.0119 0.0624 0.0624
Schistosoma mansoni hypothetical protein 0.0015 0.004 0.0117
Trypanosoma cruzi 20S proteasome subunit 0.0291 0.1597 0.4653
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0164 0.0882 0.262
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.047 0.2606 0.77
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0119 0.0624 0.1715
Loa Loa (eye worm) hypothetical protein 0.0015 0.004 0.0117
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0119 0.0624 0.1854
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0119 0.0624 0.1715
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0119 0.0624 0.1715
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0056 0.0056
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0119 0.0624 0.1715
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0226 0.0671
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0119 0.0624 0.1854
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0119 0.0624 0.1715
Echinococcus multilocularis Ankyrin 0.0165 0.0887 0.0887
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0119 0.0624 0.1715
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0119 0.0624 0.1715
Echinococcus granulosus proteasome subunit beta t family 0.0119 0.0624 0.0624
Trypanosoma brucei proteasome beta 6 subunit 0.047 0.2606 0.77
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0119 0.0624 0.1715
Loa Loa (eye worm) PAS-3 protein 0.0119 0.0624 0.1854
Plasmodium falciparum proteasome subunit beta type-5 0.0604 0.3368 1
Giardia lamblia 20S proteasome alpha subunit 5 0.0119 0.0624 0.1715
Echinococcus multilocularis nuclear factor of activated T cells 5 0.1779 1 1
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0119 0.0624 0.1854
Loa Loa (eye worm) hypothetical protein 0.0048 0.0226 0.0671
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.004 0.004
Echinococcus granulosus tachykinin peptides receptor 99D 0.036 0.1987 0.1987
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0119 0.0624 0.1715
Brugia malayi Proteasome A-type and B-type family protein 0.0604 0.3368 1
Brugia malayi proteasome subunit alpha type 6 0.0119 0.0624 0.1854
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0119 0.0624 0.1854
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0119 0.0624 0.1715
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0119 0.0624 0.1715
Schistosoma mansoni hypothetical protein 0.0346 0.1907 0.5663
Giardia lamblia 20S proteasome alpha subunit 6 0.0119 0.0624 0.1715
Toxoplasma gondii peptidase, T1 family protein 0.0119 0.0624 0.1715
Leishmania major proteasome beta 2 subunit, putative 0.0291 0.1597 0.4653
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0291 0.1597 0.1597
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0119 0.0624 0.1715
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0165 0.0887 0.2633
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0119 0.0624 0.1854
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0119 0.0624 0.1715
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0291 0.1597 0.4742
Echinococcus multilocularis proteasome subunit beta type 7 0.0119 0.0624 0.0624
Schistosoma mansoni hypothetical protein 0.0015 0.004 0.0117
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0119 0.0624 0.1715
Echinococcus granulosus proteasome subunit alpha type 2 0.0119 0.0624 0.0624
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0119 0.0624 0.1715

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 80 nM Antagonist activity at human recombinant NK3 receptor expressed in CHO cells assessed as inhibition of NKB-induced increase of intracellular calcium level by aequorin bioluminescence assay ChEMBL. 21376585
Ki (binding) = 240 nM Displacement [3H]SB-222200 from of human recombinant NK3 receptor expressed in CHO cells ChEMBL. 21376585

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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