TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 439.895 | Formula: C22H22ClN5O3
H donors: 2 H acceptors: 3 LogP: 2.81 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: NC(=O)COc1ccccc1N1CCN(CC1)C(=O)c1[nH]nc(c1)c1ccc(cc1)Cl
InChi: 1S/C22H22ClN5O3/c23-16-7-5-15(6-8-16)17-13-18(26-25-17)22(30)28-11-9-27(10-12-28)19-3-1-2-4-20(19)31-14-21(24)29/h1-8,13H,9-12,14H2,(H2,24,29)(H,25,26)
InChiKey: XRKQSXRRQJSZEC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	tachykinin receptor 3	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	tachykinin peptides receptor 99D	Get druggable targets OG5_131969	All targets in OG5_131969
Echinococcus granulosus	tachykinin peptides receptor 99D	Get druggable targets OG5_131969	All targets in OG5_131969

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0165	0.0887	0.2633
Plasmodium vivax	proteasome subunit alpha type-2, putative	0.0119	0.0624	0.1715
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0119	0.0624	0.0624
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0291	0.1597	0.4742
Onchocerca volvulus	Netrin receptor homolog	0.0164	0.0882	1
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0291	0.1597	0.4653
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0119	0.0624	0.1715
Toxoplasma gondii	20S proteasome subunit beta 7, putative	0.0119	0.0624	0.1715
Echinococcus multilocularis	proteasome (prosome macropain) subunit beta type	0.0119	0.0624	0.0624
Toxoplasma gondii	proteasome subunit beta type 7 precursor, putative	0.0119	0.0624	0.1715
Brugia malayi	proteasome subunit alpha type 4	0.0119	0.0624	0.1854
Schistosoma mansoni	proteasome catalytic subunit 1 (T01 family)	0.0119	0.0624	0.1854
Trypanosoma cruzi	proteasome alpha 2 subunit, putative	0.0119	0.0624	0.1715
Toxoplasma gondii	proteasome subunit beta type, putative	0.0604	0.3368	1
Schistosoma mansoni	proteasome catalytic subunit 2 (T01 family)	0.0119	0.0624	0.1854
Giardia lamblia	Proteasome subunit beta type 9 precursor	0.0119	0.0624	0.1715
Toxoplasma gondii	peptidase, T1 family protein	0.0119	0.0624	0.1715
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0018	0.0056	0.0056
Trypanosoma cruzi	20S proteasome subunit	0.0291	0.1597	0.4653
Plasmodium falciparum	proteasome subunit beta type-1, putative	0.047	0.2606	0.77
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0119	0.0624	0.1715
Leishmania major	proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative	0.047	0.2606	0.77
Trypanosoma cruzi	proteasome beta 2 subunit, putative	0.0119	0.0624	0.1715
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0119	0.0624	0.1854
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0291	0.1597	0.4653
Echinococcus granulosus	Ankyrin	0.0165	0.0887	0.0887
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0119	0.0624	0.1715
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0119	0.0624	0.1715
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.047	0.2606	0.77
Toxoplasma gondii	proteasome subunit alpha type 5-2, putative	0.0119	0.0624	0.1715
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0119	0.0624	0.1854
Loa Loa (eye worm)	MH2 domain-containing protein	0.0121	0.0639	0.1896
Loa Loa (eye worm)	hypothetical protein	0.0033	0.014	0.0415
Echinococcus multilocularis	proteasome subunit alpha type 2	0.0119	0.0624	0.0624
Plasmodium vivax	proteasome subunit beta type-5, putative	0.0604	0.3368	1
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.047	0.2606	0.2606
Echinococcus multilocularis	GPCR, family 2	0.0015	0.004	0.004
Trypanosoma cruzi	proteasome beta 3 subunit, putative	0.0119	0.0624	0.1715
Loa Loa (eye worm)	20S proteasome alpha5 subunit	0.0119	0.0624	0.1854
Plasmodium vivax	proteasome subunit beta type-7, putative	0.0119	0.0624	0.1715
Leishmania major	hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B	0.0119	0.0624	0.1715
Mycobacterium leprae	proteasome (beta subunit) PrcB	0.0604	0.3368	1
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0119	0.0624	0.1715
Echinococcus granulosus	GPCR family 2	0.0015	0.004	0.004
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0015	0.004	0.0117
Schistosoma mansoni	hypothetical protein	0.0346	0.1907	0.5663
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.047	0.2606	0.2606
Plasmodium falciparum	proteasome subunit alpha type-5, putative	0.0119	0.0624	0.1715
Plasmodium vivax	proteasome subunit beta type-3, putative	0.0119	0.0624	0.1715
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0604	0.3368	1
Brugia malayi	Proteasome A-type and B-type family protein	0.0119	0.0624	0.1854
Schistosoma mansoni	proteasome subunit alpha 2 (T01 family)	0.0119	0.0624	0.1854
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.0468	0.139
Toxoplasma gondii	proteasome subunit beta type 1, putative	0.047	0.2606	0.77
Entamoeba histolytica	proteasome subunit beta type 5 precursor, putative	0.0604	0.3368	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0121	0.0639	0.1896
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0291	0.1597	0.1597
Schistosoma mansoni	proteasome subunit beta 1 (T01 family)	0.047	0.2606	0.7738
Brugia malayi	Proteasome subunit alpha type 1	0.0119	0.0624	0.1854
Leishmania major	proteasome beta 2 subunit, putative	0.0119	0.0624	0.1715
Trypanosoma brucei	proteasome alpha 3 subunit, putative	0.0119	0.0624	0.1715
Echinococcus granulosus	netrin receptor unc 5	0.0164	0.0882	0.0882
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0164	0.0882	0.0882
Giardia lamblia	Proteasome subunit beta type 4 precursor	0.0119	0.0624	0.1715
Giardia lamblia	Proteasome subunit beta type 7 precursor	0.0119	0.0624	0.1715
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0831	0.4648	0.4648
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.0226	0.0671
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0119	0.0624	0.1715
Plasmodium falciparum	proteasome subunit beta type-4	0.0119	0.0624	0.1715
Entamoeba histolytica	proteasome subunit alpha type 7, putative	0.0119	0.0624	0.1715
Schistosoma mansoni	proteasome subunit alpha 4 (T01 family)	0.0119	0.0624	0.1854
Echinococcus granulosus	proteasome subunit beta t family	0.0119	0.0624	0.0624
Giardia lamblia	Proteasome subunit beta type 3	0.0119	0.0624	0.1715
Trypanosoma brucei	proteasome alpha 7 subunit, putative	0.0119	0.0624	0.1715
Leishmania major	proteasome alpha 2 subunit, putative	0.0119	0.0624	0.1715
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0119	0.0624	0.1715
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0119	0.0624	0.1715
Schistosoma mansoni	proteasome catalytic subunit 3 (T01 family)	0.0604	0.3368	1
Giardia lamblia	20S proteasome alpha subunit 1	0.0119	0.0624	0.1715
Echinococcus multilocularis	20S proteasome subunit alpha 6	0.0119	0.0624	0.0624
Echinococcus multilocularis	netrin receptor unc 5	0.0164	0.0882	0.0882
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0604	0.3368	1
Echinococcus granulosus	proteasome subunit alpha type 6	0.0119	0.0624	0.0624
Plasmodium falciparum	proteasome subunit beta type-6, putative	0.0119	0.0624	0.1715
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0604	0.3368	1
Leishmania major	proteasome alpha 1 subunit, putative	0.0119	0.0624	0.1715
Toxoplasma gondii	proteasome beta subunit	0.0119	0.0624	0.1715
Schistosoma mansoni	proteasome subunit alpha 1 (T01 family)	0.0119	0.0624	0.1854
Plasmodium falciparum	ATP-dependent protease subunit ClpQ	0.0119	0.0624	0.1715
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0164	0.0882	0.262
Trypanosoma cruzi	proteasome beta 7 subunit, putative	0.0119	0.0624	0.1715
Plasmodium vivax	ATP-dependent protease subunit ClpQ, putative	0.0119	0.0624	0.1715
Mycobacterium tuberculosis	Proteasome beta subunit PrcB; assembles with alpha subunit PrcA.	0.0604	0.3368	1
Schistosoma mansoni	hypothetical protein	0.0015	0.004	0.0117
Plasmodium vivax	proteasome subunit alpha type-7, putative	0.0119	0.0624	0.1715
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0119	0.0624	0.1715
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0119	0.0624	0.1715
Echinococcus granulosus	death domain containing protein	0.0164	0.0882	0.0882
Giardia lamblia	Proteasome subunit beta type 1	0.047	0.2606	0.77
Trypanosoma cruzi	hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B	0.0119	0.0624	0.1715
Brugia malayi	proteasome subunit beta type 1	0.047	0.2606	0.7738
Schistosoma mansoni	hypothetical protein	0.0015	0.004	0.0117
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0119	0.0624	0.1715
Brugia malayi	proteasome subunit beta type 3	0.0119	0.0624	0.1854
Plasmodium vivax	proteasome subunit alpha type-4, putative	0.0119	0.0624	0.1715
Leishmania major	proteasome beta 7 subunit, putative	0.0119	0.0624	0.1715
Leishmania major	proteasome beta 5 subunit, putative	0.0604	0.3368	1
Plasmodium vivax	proteasome subunit alpha type-6, putative	0.0119	0.0624	0.1715
Entamoeba histolytica	calcium-dependent protein kinase 2, putative	0.0119	0.0624	0.1715
Giardia lamblia	20S proteasome alpha subunit 7	0.0119	0.0624	0.1715
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0018	0.0056	0.5
Entamoeba histolytica	proteasome subunit alpha type 2-A, putative	0.0119	0.0624	0.1715
Leishmania major	proteasome alpha 1 subunit, putative	0.0119	0.0624	0.1715
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0119	0.0624	0.0624
Leishmania major	proteasome beta 3 subunit, putative	0.0119	0.0624	0.1715
Brugia malayi	Proteasome subunit alpha type 7-1	0.0119	0.0624	0.1854
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0119	0.0624	0.1715
Toxoplasma gondii	proteasome subunit alpha1, putative	0.0119	0.0624	0.1715
Brugia malayi	exodeoxyribonuclease III family protein	0.0018	0.0056	0.0167
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0119	0.0624	0.1715
Loa Loa (eye worm)	hypothetical protein	0.0164	0.0882	0.262
Echinococcus multilocularis	geminin	0.0346	0.1907	0.1907
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0091	0.0468	0.0468
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.047	0.2606	0.77
Entamoeba histolytica	proteasome subunit alpha type 3, putative	0.0119	0.0624	0.1715
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0119	0.0624	0.1854
Entamoeba histolytica	proteasome subunit alpha type 4, putative	0.0119	0.0624	0.1715
Entamoeba histolytica	proteasome subunit alpha type 4, putative	0.0119	0.0624	0.1715
Plasmodium falciparum	proteasome subunit beta type-5	0.0604	0.3368	1
Leishmania major	proteasome beta 2 subunit, putative	0.0291	0.1597	0.4653
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0091	0.0468	0.0468
Giardia lamblia	Proteasome subunit beta type 5 precursor	0.0604	0.3368	1
Brugia malayi	Proteasome A-type and B-type family protein	0.0119	0.0624	0.1854
Leishmania major	proteasome alpha 7 subunit, putative	0.0119	0.0624	0.1715
Schistosoma mansoni	hypothetical protein	0.0164	0.0882	0.262
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0226	0.0671
Echinococcus multilocularis	Proteasome, subunit alpha beta	0.0119	0.0624	0.0624
Leishmania major	proteasome beta-1 subunit, putative	0.0119	0.0624	0.1715
Trypanosoma brucei	proteasome subunit beta type-5, putative	0.0604	0.3368	1
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0119	0.0624	0.1715
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0119	0.0624	0.1715
Toxoplasma gondii	proteasome subunit alpha type 1, putative	0.0119	0.0624	0.1715
Trypanosoma cruzi	proteasome subunit alpha type-5, putative	0.0119	0.0624	0.1715
Brugia malayi	Uncoordinated protein 44	0.0164	0.0882	0.262
Trypanosoma cruzi	proteasome alpha 3 subunit, putative	0.0119	0.0624	0.1715
Echinococcus granulosus	tachykinin peptides receptor 99D	0.036	0.1987	0.1987
Echinococcus multilocularis	Ankyrin	0.0165	0.0887	0.0887
Trypanosoma brucei	proteasome alpha 7 subunit	0.0119	0.0624	0.1715
Toxoplasma gondii	proteasome subunit alpha type, putative	0.0119	0.0624	0.1715
Loa Loa (eye worm)	proteasome subunit alpha type 3	0.0119	0.0624	0.1854
Trypanosoma cruzi	ATP-dependent protease subunit HslV, putative	0.0119	0.0624	0.1715
Trypanosoma cruzi	proteasome subunit alpha type-5, putative	0.0119	0.0624	0.1715
Brugia malayi	Proteasome A-type and B-type family protein	0.0119	0.0624	0.1854
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.0226	0.0671
Plasmodium vivax	proteasome subunit beta type-1, putative	0.047	0.2606	0.77
Giardia lamblia	20S proteasome alpha subunit 5	0.0119	0.0624	0.1715
Plasmodium vivax	proteasome subunit alpha type-3, putative	0.0119	0.0624	0.1715
Loa Loa (eye worm)	PAS-3 protein	0.0119	0.0624	0.1854
Schistosoma mansoni	ap endonuclease	0.0018	0.0056	0.0167
Leishmania major	proteasome alpha 3 subunit, putative	0.0119	0.0624	0.1715
Entamoeba histolytica	proteasome subunit beta type 1, putative	0.047	0.2606	0.77
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.1779	1	1
Schistosoma mansoni	ankyrin 23/unc44	0.0164	0.0882	0.262
Schistosoma mansoni	proteasome subunit alpha 3 (T01 family)	0.0119	0.0624	0.1854
Trypanosoma brucei	proteasome alpha 1 subunit, putative	0.0119	0.0624	0.1715
Plasmodium falciparum	proteasome subunit alpha type-3, putative	0.0119	0.0624	0.1715
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0119	0.0624	0.1715
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0119	0.0624	0.1854
Trypanosoma cruzi	proteasome subunit beta type-2, putative	0.0291	0.1597	0.4653
Brugia malayi	proteasome subunit alpha type 3	0.0119	0.0624	0.1854
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.0226	0.0671
Brugia malayi	MH2 domain containing protein	0.0121	0.0639	0.1896
Brugia malayi	Latrophilin receptor protein 2	0.0015	0.004	0.0117
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0119	0.0624	0.1854
Echinococcus granulosus	Proteasome subunit alpha beta	0.0119	0.0624	0.0624
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0604	0.3368	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0091	0.0468	0.0468
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.0468	0.139
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0119	0.0624	0.1854
Echinococcus granulosus	proteasome subunit alpha type 2	0.0119	0.0624	0.0624
Entamoeba histolytica	proteasome subunit alpha type 5, putative	0.0119	0.0624	0.1715
Echinococcus multilocularis	proteasome subunit beta type 7	0.0119	0.0624	0.0624
Trypanosoma brucei	proteasome beta 7 subunit	0.0119	0.0624	0.1715
Entamoeba histolytica	proteasome subunit alpha type 1, putative	0.0119	0.0624	0.1715
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0015	0.004	0.004
Schistosoma mansoni	ap endonuclease	0.0018	0.0056	0.0167
Trypanosoma cruzi	proteasome beta-1 subunit, putative	0.0119	0.0624	0.1715
Loa Loa (eye worm)	proteasome subunit alpha type 6	0.0119	0.0624	0.1854
Plasmodium falciparum	proteasome subunit alpha type-7, putative	0.0119	0.0624	0.1715
Echinococcus granulosus	proteasome subunit beta type 6	0.0119	0.0624	0.0624
Loa Loa (eye worm)	hypothetical protein	0.0015	0.004	0.0117
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0119	0.0624	0.1854
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.036	0.1987	0.1987
Schistosoma mansoni	proteasome subunit alpha 6 (T01 family)	0.0119	0.0624	0.1854
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0119	0.0624	0.1854
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0119	0.0624	0.1715
Trypanosoma cruzi	proteasome subunit alpha type-1, putative	0.0119	0.0624	0.1715
Brugia malayi	proteasome subunit beta type 2	0.0291	0.1597	0.4742
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0119	0.0624	0.0624
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0119	0.0624	0.1715
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0015	0.004	0.004
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.014	0.0415
Plasmodium vivax	proteasome subunit alpha type-1, putative	0.0119	0.0624	0.1715
Trypanosoma cruzi	proteasome alpha 3 subunit, putative	0.0119	0.0624	0.1715
Loa Loa (eye worm)	proteasome subunit alpha type 2	0.0119	0.0624	0.1854
Loa Loa (eye worm)	proteasome subunit alpha type 1	0.0119	0.0624	0.1854
Echinococcus multilocularis	proteasome subunit alpha type 6	0.0119	0.0624	0.0624
Echinococcus granulosus	geminin	0.0346	0.1907	0.1907
Toxoplasma gondii	proteasome subunit beta type 2, putative	0.0291	0.1597	0.4653
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0164	0.0882	0.262
Brugia malayi	proteasome subunit alpha type 6	0.0119	0.0624	0.1854
Leishmania major	proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative)	0.0119	0.0624	0.1715
Loa Loa (eye worm)	proteasome subunit beta type 3	0.0119	0.0624	0.1854
Toxoplasma gondii	proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative	0.0119	0.0624	0.1715
Trypanosoma brucei	proteasome subunit alpha type-5, putative	0.0119	0.0624	0.1715
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0015	0.004	0.004
Plasmodium falciparum	proteasome subunit beta type-7, putative	0.0119	0.0624	0.1715
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0119	0.0624	0.1715
Mycobacterium tuberculosis	Proteasome alpha subunit PrcA; assembles with beta subunit PrcB.	0.0119	0.0624	0.1715
Brugia malayi	Death domain containing protein	0.0164	0.0882	0.262
Giardia lamblia	Proteasome subunit beta type 2	0.0291	0.1597	0.4653
Toxoplasma gondii	proteasome subunit	0.0119	0.0624	0.1715
Entamoeba histolytica	proteasome subunit beta type 6 precursor, putative	0.0119	0.0624	0.1715
Brugia malayi	Proteasome A-type and B-type family protein	0.0604	0.3368	1
Trypanosoma brucei	ATP-dependent protease subunit HslV	0.0119	0.0624	0.1715
Mycobacterium ulcerans	proteasome PrcB	0.0604	0.3368	1
Schistosoma mansoni	proteasome subunit beta 4 (T01 family)	0.0119	0.0624	0.1854
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0015	0.004	0.004
Entamoeba histolytica	probable proteasome subunit beta type 2, putative	0.0291	0.1597	0.4653
Trypanosoma brucei	proteasome subunit beta type-2, putative	0.0291	0.1597	0.4653
Echinococcus granulosus	20S proteasome subunit alpha 6	0.0119	0.0624	0.0624
Entamoeba histolytica	proteasome subunit beta type 3, putative	0.0119	0.0624	0.1715
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.0468	0.139
Echinococcus granulosus	proteasome prosome macropain	0.0604	0.3368	0.3368
Loa Loa (eye worm)	proteasome subunit beta type 1	0.047	0.2606	0.7738
Echinococcus granulosus	proteasome subunit beta type 7	0.0119	0.0624	0.0624
Schistosoma mansoni	proteasome subunit alpha 7 (T01 family)	0.0119	0.0624	0.1854
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0291	0.1597	0.4742
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0164	0.0882	0.0882
Brugia malayi	proteasome subunit alpha type 2	0.0119	0.0624	0.1854
Wolbachia endosymbiont of Brugia malayi	ATP-dependent protease peptidase subunit	0.0119	0.0624	1
Plasmodium vivax	proteasome subunit beta type-6, putative	0.0119	0.0624	0.1715
Trypanosoma brucei	proteasome beta 3 subunit, putative	0.0119	0.0624	0.1715
Schistosoma mansoni	hypothetical protein	0.0015	0.004	0.0117
Giardia lamblia	20S proteasome alpha subunit 3	0.0119	0.0624	0.1715
Giardia lamblia	20S proteasome alpha subunit 4	0.0119	0.0624	0.1715
Giardia lamblia	20S proteasome alpha subunit 6	0.0119	0.0624	0.1715
Entamoeba histolytica	proteasome subunit beta Type 4 precursor, putative	0.0119	0.0624	0.1715
Trypanosoma brucei	proteasome beta 2 subunit, putative	0.0119	0.0624	0.1715
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0119	0.0624	0.1715
Echinococcus multilocularis	subfamily T1A non peptidase ue	0.0119	0.0624	0.0624
Echinococcus multilocularis	proteasome (prosome macropain) subunit alpha	0.0119	0.0624	0.0624
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0119	0.0624	0.1715
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0015	0.004	0.0117
Trypanosoma cruzi	proteasome beta-1 subunit, putative	0.0119	0.0624	0.1715
Trypanosoma cruzi	proteasome beta 3 subunit, putative	0.0119	0.0624	0.1715
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0091	0.0468	0.0468
Schistosoma mansoni	hypothetical protein	0.0015	0.004	0.0117
Echinococcus granulosus	proteasome prosome macropain subunit beta type	0.0119	0.0624	0.0624
Entamoeba histolytica	proteasome subunit alpha type 7, putative	0.0119	0.0624	0.1715
Loa Loa (eye worm)	proteasome subunit beta type 2	0.0291	0.1597	0.4742
Plasmodium vivax	proteasome subunit beta type-4, putative	0.0119	0.0624	0.1715
Echinococcus multilocularis	proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta	0.0119	0.0624	0.0624
Plasmodium vivax	proteasome subunit alpha type-5, putative	0.0119	0.0624	0.1715
Trypanosoma brucei	proteasome beta-1 subunit, putative	0.0119	0.0624	0.1715
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0018	0.0056	0.0167
Brugia malayi	20S proteasome alpha5 subunit	0.0119	0.0624	0.1854
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0291	0.1597	0.1597
Giardia lamblia	20S proteasome alpha subunit 2	0.0119	0.0624	0.1715
Plasmodium falciparum	proteasome subunit alpha type-2, putative	0.0119	0.0624	0.1715
Trypanosoma brucei	proteasome beta 6 subunit	0.047	0.2606	0.77
Schistosoma mansoni	netrin receptor unc5	0.0164	0.0882	0.262
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0119	0.0624	0.1854
Echinococcus granulosus	subfamily T1A non peptidase ue	0.0119	0.0624	0.0624
Trypanosoma cruzi	proteasome alpha 1 subunit, putative	0.0119	0.0624	0.1715
Schistosoma mansoni	hypothetical protein	0.0346	0.1907	0.5663
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0091	0.0468	0.139
Trypanosoma brucei	proteasome alpha 2 subunit, putative	0.0119	0.0624	0.1715
Plasmodium falciparum	proteasome subunit alpha type-1, putative	0.0119	0.0624	0.1715
Echinococcus multilocularis	proteasome subunit beta type 6	0.0119	0.0624	0.0624
Plasmodium falciparum	proteasome subunit alpha type-6, putative	0.0119	0.0624	0.1715
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0091	0.0468	0.139
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0119	0.0624	0.1715
Echinococcus granulosus	Proteasome subunit alpha type 7	0.0119	0.0624	0.0624
Plasmodium falciparum	proteasome subunit beta type-3, putative	0.0119	0.0624	0.1715
Brugia malayi	proteasome subunit alpha type 1	0.0119	0.0624	0.1854
Loa Loa (eye worm)	proteasome subunit alpha type 7-1	0.0119	0.0624	0.1854
Trypanosoma cruzi	proteasome alpha 1 subunit, putative	0.0119	0.0624	0.1715
Loa Loa (eye worm)	hypothetical protein	0.0165	0.0887	0.2633
Leishmania major	proteasome alpha 7 subunit, putative	0.0119	0.0624	0.1715
Plasmodium falciparum	proteasome subunit alpha type-4, putative	0.0119	0.0624	0.1715
Echinococcus granulosus	proteasome prosome macropain subunit alpha	0.0119	0.0624	0.0624
Plasmodium falciparum	proteasome subunit beta type-2, putative	0.0291	0.1597	0.4653
Entamoeba histolytica	proteasome subunit beta type 7-B precursor, putative	0.0119	0.0624	0.1715
Echinococcus multilocularis	proteasome (prosome, macropain)	0.0604	0.3368	0.3368
Brugia malayi	Protein kinase domain containing protein	0.0164	0.0882	0.262
Entamoeba histolytica	proteasome subunit alpha type 3, putative	0.0119	0.0624	0.1715
Trypanosoma cruzi	proteasome alpha 2 subunit, putative	0.0119	0.0624	0.1715
Schistosoma mansoni	hypothetical protein	0.0033	0.014	0.0415
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.047	0.2606	0.77
Entamoeba histolytica	proteasome subunit alpha type 6, putative	0.0119	0.0624	0.1715
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0018	0.0056	0.0056
Mycobacterium ulcerans	proteasome PrcA	0.0119	0.0624	0.1715
Entamoeba histolytica	proteasome subunit alpha type 5, putative	0.0119	0.0624	0.1715
Trypanosoma brucei	Proteasome subunit A N-terminal signature/Proteasome subunit, putative	0.0119	0.0624	0.1715
Plasmodium vivax	proteasome subunit beta type-2, putative	0.0291	0.1597	0.4653
Toxoplasma gondii	heat shock protein hslv, putative	0.0119	0.0624	0.1715

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 80 nM	Antagonist activity at human recombinant NK3 receptor expressed in CHO cells assessed as inhibition of NKB-induced increase of intracellular calcium level by aequorin bioluminescence assay	ChEMBL.	21376585
Ki (binding)	= 240 nM	Displacement [3H]SB-222200 from of human recombinant NK3 receptor expressed in CHO cells	ChEMBL.	21376585

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1760333

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1528157