Detailed information for compound 1528159

Basic information

Technical information
  • TDR Targets ID: 1528159
  • Name: (1R,3aS,4S,7aS)-5-ethenyl-1,3a,4,7a-tetrameth yl-1,2,3,4,6,7-hexahydroinden-5-ol
  • MW: 222.366 | Formula: C15H26O
  • H donors: 1 H acceptors: 1 LogP: 4.28 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CC1(O)CC[C@@]2([C@@]([C@@H]1C)(C)CC[C@H]2C)C
  • InChi: 1S/C15H26O/c1-6-15(16)10-9-13(4)11(2)7-8-14(13,5)12(15)3/h6,11-12,16H,1,7-10H2,2-5H3/t11-,12+,13+,14+,15?/m1/s1
  • InChiKey: TUCSIUBDOHTKKQ-JFKAKTETSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (1R,3aS,4S,7aS)-1,3a,4,7a-tetramethyl-5-vinyl-1,2,3,4,6,7-hexahydroinden-5-ol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0053 0.0644 0.0636
Plasmodium vivax proteasome subunit beta type-3, putative 0.0053 0.0644 0.1489
Brugia malayi Cytochrome P450 family protein 0.0075 0.0949 0.1397
Loa Loa (eye worm) cytochrome P450 family protein 0.0075 0.0949 0.1395
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0095 0.1217 0.305
Brugia malayi 20S proteasome alpha5 subunit 0.0053 0.0644 0.0933
Echinococcus granulosus death domain containing protein 0.0052 0.0621 0.0613
Loa Loa (eye worm) proteasome subunit beta type 1 0.021 0.2806 0.4219
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.0019 0.0176 0.0157
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0053 0.0644 0.1489
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0053 0.0644 0.1771
Entamoeba histolytica proteasome subunit beta type 1, putative 0.021 0.2806 0.7599
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0053 0.0644 0.1489
Toxoplasma gondii proteasome subunit beta type 1, putative 0.021 0.2806 0.7637
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0053 0.0644 0.1489
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0019 0.0176 0.0483
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0053 0.0644 0.1489
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0053 0.0644 0.1489
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0095 0.1217 0.301
Brugia malayi Cytochrome P450 family protein 0.0026 0.0276 0.0373
Loa Loa (eye worm) hypothetical protein 0.0019 0.0176 0.0218
Loa Loa (eye worm) PAS-3 protein 0.0053 0.0644 0.0931
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0019 0.0176 0.0483
Echinococcus granulosus lysine specific demethylase 6a 0.0015 0.012 0.0112
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.0715 0.0708
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0018 0.0156 0.01
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0053 0.0644 0.1771
Echinococcus multilocularis deoxyribonuclease 1 2 0.0019 0.0176 0.0167
Brugia malayi exodeoxyribonuclease III family protein 0.0095 0.1217 0.1805
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0053 0.0644 0.1353
Echinococcus granulosus nuclear factor of activated T cells 5 0.0592 0.8048 0.8046
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0053 0.0644 0.1771
Giardia lamblia 20S proteasome alpha subunit 3 0.0053 0.0644 0.1353
Loa Loa (eye worm) CYP4Cod1 0.0026 0.0276 0.0371
Leishmania major proteasome beta 7 subunit, putative 0.0053 0.0644 0.1489
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0053 0.0644 0.0636
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0053 0.0644 0.1489
Giardia lamblia 20S proteasome alpha subunit 7 0.0053 0.0644 0.1353
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0019 0.0176 0.0157
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0053 0.0644 0.1353
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0271 0.3637 1
Schistosoma mansoni hypothetical protein 0.0052 0.0621 0.0613
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0019 0.0176 0.0157
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0052 0.0621 0.0895
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0053 0.0644 0.0636
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0053 0.0644 0.0636
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0053 0.0644 0.1353
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0095 0.1217 1
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0053 0.0644 0.1489
Brugia malayi follicle stimulating hormone receptor 0.0487 0.6605 1
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0053 0.0644 0.0636
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.013 0.1705 0.4507
Echinococcus granulosus traf and tnf receptor associated protein 0.0019 0.0176 0.0167
Toxoplasma gondii proteasome subunit beta type, putative 0.0271 0.3637 1
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0053 0.0644 0.1489
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0053 0.0644 0.0636
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0019 0.0176 0.0483
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0053 0.0644 0.1489
Trichomonas vaginalis ap endonuclease, putative 0.0095 0.1217 0.3347
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0053 0.0644 0.0636
Echinococcus granulosus cytochrome P450 2K1 0.0018 0.0156 0.0147
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0271 0.3637 1
Giardia lamblia Proteasome subunit beta type 1 0.021 0.2806 0.7599
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0053 0.0644 0.1489
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0156 0.01
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0053 0.0644 0.1353
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0053 0.0644 0.1353
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0053 0.0644 0.1771
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0772 0.1852
Brugia malayi jmjC domain containing protein 0.0058 0.0715 0.1042
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.03 0.0408
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0019 0.0176 0.022
Echinococcus multilocularis jumonji domain containing 1A 0.0015 0.012 0.0112
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0019 0.0176 0.022
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0053 0.0644 0.1489
Leishmania major proteasome alpha 1 subunit, putative 0.0053 0.0644 0.1489
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0053 0.0644 0.1489
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.0019 0.0176 0.0157
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0053 0.0644 0.1489
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0053 0.0644 0.1489
Plasmodium vivax proteasome subunit beta type-6, putative 0.0053 0.0644 0.1489
Schistosoma mansoni protein phosphatase 2C 0.0015 0.012 0.0112
Brugia malayi cytochrome P450 0.0018 0.0156 0.019
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.021 0.2806 0.7637
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0053 0.0644 0.1353
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0053 0.0644 0.1489
Echinococcus multilocularis phd:f box containing protein 0.0015 0.012 0.0112
Plasmodium vivax exodeoxyribonuclease III, putative 0.0019 0.0176 0.0157
Schistosoma mansoni hypothetical protein 0.0019 0.0176 0.0167
Echinococcus multilocularis 0.0018 0.0156 0.0147
Leishmania major proteasome alpha 1 subunit, putative 0.0053 0.0644 0.1489
Mycobacterium ulcerans proteasome PrcB 0.0271 0.3637 1
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0053 0.0644 0.1489
Schistosoma mansoni microtubule-associated protein tau 0.0734 1 1
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0053 0.0644 0.1489
Brugia malayi proteasome subunit alpha type 1 0.0053 0.0644 0.0933
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0053 0.0644 0.1489
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0276 0.0442
Schistosoma mansoni cript-related 0.0019 0.0176 0.0167
Plasmodium falciparum endonuclease/exonuclease/phosphatase family protein, putative 0.0019 0.0176 0.0157
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0271 0.3637 1
Trypanosoma brucei proteasome alpha 7 subunit 0.0053 0.0644 0.1489
Echinococcus granulosus cpg binding protein 0.003 0.0322 0.0314
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0053 0.0644 0.1771
Plasmodium vivax proteasome subunit beta type-4, putative 0.0053 0.0644 0.1489
Brugia malayi Uncoordinated protein 44 0.0052 0.0621 0.0897
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0053 0.0644 0.0636
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0053 0.0644 0.1489
Echinococcus granulosus JmjC domain containing protein 4 0.0015 0.012 0.0112
Echinococcus granulosus proteasome subunit beta t family 0.0053 0.0644 0.0636
Echinococcus granulosus phd:f box containing protein 0.0015 0.012 0.0112
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0053 0.0644 0.1489
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0053 0.0644 0.1489
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0053 0.0644 0.1489
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0053 0.0644 0.0636
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.021 0.2806 0.28
Schistosoma mansoni phd/f-box containing protein 0.0015 0.012 0.0112
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0052 0.0624 0.0616
Toxoplasma gondii proteasome subunit 0.0053 0.0644 0.1489
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0053 0.0644 0.1489
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0053 0.0644 0.0636
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.012 0.0134
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0053 0.0644 0.0636
Leishmania major endonuclease/exonuclease protein-like protein 0.0019 0.0176 0.0157
Brugia malayi proteasome subunit alpha type 2 0.0053 0.0644 0.0933
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0271 0.3637 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0032 0.0024
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0053 0.0644 0.1353
Mycobacterium tuberculosis Probable exported protein 0.0019 0.0176 0.0057
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0095 0.1217 0.312
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0053 0.0644 0.1489
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0095 0.1217 0.312
Plasmodium falciparum DNase I-like protein, putative 0.0019 0.0176 0.0157
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0053 0.0644 0.1489
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0018 0.0156 0.01
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0053 0.0644 0.0931
Toxoplasma gondii cytochrome p450 superfamily protein 0.0018 0.0156 0.01
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0156 0.01
Brugia malayi Protein kinase domain containing protein 0.0052 0.0621 0.0897
Giardia lamblia 20S proteasome alpha subunit 5 0.0053 0.0644 0.1353
Giardia lamblia Proteasome subunit beta type 2 0.013 0.1705 0.4419
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0053 0.0644 0.1489
Trypanosoma cruzi mitochondrial protein 99, putative 0.0019 0.0176 0.0157
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.013 0.1705 0.1698
Toxoplasma gondii proteasome subunit alpha type, putative 0.0053 0.0644 0.1489
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0019 0.0176 0.0218
Brugia malayi proteasome subunit alpha type 6 0.0053 0.0644 0.0933
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.012 0.0134
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0053 0.0644 0.1489
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.0019 0.0176 0.0157
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0053 0.0644 0.0636
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0019 0.0176 0.0157
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0271 0.3637 1
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0053 0.0644 0.1771
Leishmania major hypothetical protein, conserved 0.0019 0.0176 0.0157
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0095 0.1217 0.121
Leishmania major proteasome alpha 3 subunit, putative 0.0053 0.0644 0.1489
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0019 0.0176 0.0157
Giardia lamblia 20S proteasome alpha subunit 2 0.0053 0.0644 0.1353
Echinococcus granulosus dnaJ subfamily B 0.0402 0.5441 0.5437
Schistosoma mansoni ap endonuclease 0.0095 0.1217 0.121
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0772 0.177
Toxoplasma gondii proteasome beta subunit 0.0053 0.0644 0.1489
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0019 0.0176 0.0157
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0019 0.0176 0.0483
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0053 0.0644 0.1353
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0276 0.0371
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0053 0.0644 0.0636
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0053 0.0644 0.1353
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.013 0.1705 0.1698
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0053 0.0644 0.1489
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0053 0.0644 0.0636
Brugia malayi proteasome subunit alpha type 4 0.0053 0.0644 0.0933
Schistosoma mansoni phosphatidylserine receptor 0.0015 0.012 0.0112
Trypanosoma brucei proteasome subunit beta type-2, putative 0.013 0.1705 0.4507
Echinococcus multilocularis dnaJ subfamily B 0.0402 0.5441 0.5437
Trichomonas vaginalis Phospholipase C precursor, putative 0.0019 0.0176 0.0483
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0271 0.3637 1
Leishmania major hypothetical protein, conserved 0.0019 0.0176 0.0157
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0053 0.0644 0.0636
Leishmania major proteasome alpha 7 subunit, putative 0.0053 0.0644 0.1489
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0176 0.0157
Brugia malayi Proteasome subunit alpha type 1 0.0053 0.0644 0.0933
Leishmania major cytochrome p450-like protein 0.0018 0.0156 0.01
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0772 0.1852
Schistosoma mansoni nocturnin 0.0019 0.0176 0.0167
Plasmodium falciparum exodeoxyribonuclease III, putative 0.0019 0.0176 0.0157
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0053 0.0644 0.1353
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0053 0.0644 0.1489
Leishmania major RNA-editing complex protein MP100, putative 0.0019 0.0176 0.0157
Loa Loa (eye worm) hypothetical protein 0.0015 0.012 0.0134
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0053 0.0644 0.0636
Echinococcus granulosus proteasome prosome macropain 0.0271 0.3637 0.3631
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.0693 0.0685
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0053 0.0644 0.0636
Giardia lamblia 20S proteasome alpha subunit 4 0.0053 0.0644 0.1353
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0015 0.012 0.0112
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0019 0.0176 0.0167
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0053 0.0644 0.1489
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0053 0.0644 0.0931
Schistosoma mansoni ap endonuclease 0.0095 0.1217 0.121
Schistosoma mansoni cpg binding protein 0.0028 0.03 0.0292
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0053 0.0644 0.0636
Schistosoma mansoni jumonji domain containing protein 0.0015 0.012 0.0112
Echinococcus multilocularis lysine specific demethylase 6a 0.0015 0.012 0.0112
Giardia lamblia 20S proteasome alpha subunit 1 0.0053 0.0644 0.1353
Echinococcus granulosus proteasome subunit alpha type 2 0.0053 0.0644 0.0636
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0019 0.0176 0.0157
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0095 0.1217 0.312
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0019 0.0176 0.0483
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0053 0.0644 0.1353
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.0693 0.0685
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0772 0.0764
Leishmania major cytochrome p450-like protein 0.0026 0.0276 0.0442
Brugia malayi Proteasome A-type and B-type family protein 0.0053 0.0644 0.0933
Echinococcus multilocularis proteasome subunit alpha type 6 0.0053 0.0644 0.0636
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0019 0.0176 0.0218
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.021 0.2806 0.7715
Echinococcus granulosus proteasome subunit alpha type 6 0.0053 0.0644 0.0636
Brugia malayi proteasome subunit beta type 3 0.0053 0.0644 0.0933
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0019 0.0176 0.0157
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0053 0.0644 0.1489
Echinococcus granulosus lysine specific demethylase 5A 0.0058 0.0715 0.0708
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0053 0.0644 0.1403
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0019 0.0176 0.0167
Trypanosoma brucei proteasome beta 6 subunit 0.021 0.2806 0.7637
Echinococcus granulosus neutral sphingomyelinase 0.0019 0.0176 0.0167
Schistosoma mansoni synaptojanin 0.0019 0.0176 0.0167
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0592 0.8048 0.8046
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0053 0.0644 0.1489
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0019 0.0176 0.0157
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0772 0.0764
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0052 0.0621 0.0613
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0053 0.0644 0.0636
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0772 0.0764
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0053 0.0644 0.0931
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0648 0.1499
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.0715 0.0708
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0095 0.1217 0.312
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0019 0.0176 0.0167
Trypanosoma cruzi 20S proteasome subunit 0.013 0.1705 0.4507
Brugia malayi Proteasome subunit alpha type 7-1 0.0053 0.0644 0.0933
Schistosoma mansoni hypothetical protein 0.0018 0.0156 0.0147
Brugia malayi Cytochrome P450 family protein 0.0026 0.0276 0.0373
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0019 0.0176 0.0157
Echinococcus granulosus proteasome prosome macropain subunit beta 0.021 0.2806 0.28
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0019 0.0176 0.0157
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0053 0.0644 0.1771
Mycobacterium ulcerans proteasome PrcA 0.0053 0.0644 0.1403
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0019 0.0176 0.0157
Schistosoma mansoni cpg binding protein 0.003 0.0322 0.0314
Plasmodium vivax proteasome subunit beta type-2, putative 0.013 0.1705 0.4507
Brugia malayi jmjC domain containing protein 0.0015 0.012 0.0137
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.013 0.1705 0.4688
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0053 0.0644 0.1489
Brugia malayi Cytochrome P450 family protein 0.0018 0.0156 0.019
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0053 0.0644 0.1771
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0053 0.0644 0.1353
Leishmania major proteasome beta 2 subunit, putative 0.0053 0.0644 0.1489
Leishmania major proteasome beta 5 subunit, putative 0.0271 0.3637 1
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.021 0.2806 0.7637
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0053 0.0644 0.1353
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0487 0.6605 1
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0271 0.3637 0.3631
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0053 0.0644 0.1489
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0019 0.0176 0.022
Onchocerca volvulus Netrin receptor homolog 0.0052 0.0621 0.9501
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0053 0.0644 0.0636
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0018 0.0156 0.01
Leishmania major pantothenate kinase subunit, putative 0.0019 0.0176 0.0157
Loa Loa (eye worm) proteasome subunit beta type 2 0.013 0.1705 0.2545
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0019 0.0176 0.0157
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0019 0.0176 0.0167
Toxoplasma gondii peptidase, T1 family protein 0.0053 0.0644 0.1489
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0053 0.0644 0.0931
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0053 0.0644 0.1489
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0053 0.0644 0.1353
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0095 0.1217 0.312
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0019 0.0176 0.0483
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.021 0.2806 0.28
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0053 0.0644 0.0931
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0053 0.0644 0.1489
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0053 0.0644 0.1489
Brugia malayi Proteasome A-type and B-type family protein 0.0271 0.3637 0.5484
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0053 0.0644 0.1353
Loa Loa (eye worm) hypothetical protein 0.0019 0.0176 0.0218
Schistosoma mansoni netrin receptor unc5 0.0052 0.0621 0.0613
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0772 0.177
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0019 0.0176 0.0167
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0019 0.0176 0.022
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0053 0.0644 0.0931
Plasmodium falciparum proteasome subunit beta type-2, putative 0.013 0.1705 0.4507
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0053 0.0644 0.1489
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0019 0.0176 0.0157
Leishmania major proteasome beta-1 subunit, putative 0.0053 0.0644 0.1489
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0271 0.3637 0.5483
Trypanosoma brucei cytochrome P450, putative 0.0026 0.0276 0.0442
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0053 0.0644 0.1489
Toxoplasma gondii proteasome subunit alpha1, putative 0.0053 0.0644 0.1489
Trypanosoma cruzi mitochondrial protein 99, putative 0.0019 0.0176 0.0157
Leishmania major proteasome beta 3 subunit, putative 0.0053 0.0644 0.1489
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0019 0.0176 0.0218
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0053 0.0644 0.0636
Brugia malayi proteasome subunit beta type 1 0.021 0.2806 0.4221
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0019 0.0176 0.0157
Brugia malayi Proteasome A-type and B-type family protein 0.0053 0.0644 0.0933
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0053 0.0644 0.0636
Loa Loa (eye worm) hypothetical protein 0.0015 0.012 0.0134
Brugia malayi Proteasome A-type and B-type family protein 0.0053 0.0644 0.0933
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0053 0.0644 0.0636
Loa Loa (eye worm) hypothetical protein 0.0052 0.0621 0.0895
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0053 0.0644 0.1771
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.012 0.0134
Echinococcus multilocularis cpg binding protein 0.003 0.0322 0.0314
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0053 0.0644 0.1489
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.021 0.2806 0.7637
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0053 0.0644 0.0636
Giardia lamblia Proteasome subunit beta type 3 0.0053 0.0644 0.1353
Toxoplasma gondii heat shock protein hslv, putative 0.0053 0.0644 0.1489
Schistosoma mansoni ankyrin 23/unc44 0.0052 0.0621 0.0613
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0019 0.0176 0.0157
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0019 0.0176 0.0157
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0053 0.0644 0.1489
Plasmodium vivax proteasome subunit beta type-1, putative 0.021 0.2806 0.7637
Trypanosoma brucei proteasome beta 7 subunit 0.0053 0.0644 0.1489
Leishmania major proteasome beta 2 subunit, putative 0.013 0.1705 0.4507
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0053 0.0644 0.1489
Schistosoma mansoni carbon catabolite repressor protein 0.0019 0.0176 0.0167
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0026 0.0276 0.0345
Leishmania major inositol phosphosphingolipid phospholipase C-Like 0.0019 0.0176 0.0157
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0053 0.0644 0.1489
Echinococcus granulosus Ankyrin 0.0052 0.0624 0.0616
Brugia malayi jmjC domain containing protein 0.0015 0.012 0.0137
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0019 0.0176 0.0218
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0019 0.0176 0.0157
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.0019 0.0176 0.0157
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0772 0.0764
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0095 0.1217 0.312
Echinococcus granulosus netrin receptor unc 5 0.0052 0.0621 0.0613
Echinococcus multilocularis proteasome subunit alpha type 2 0.0053 0.0644 0.0636
Schistosoma mansoni jumonji domain containing protein 0.0057 0.0693 0.0685
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0053 0.0644 0.0931
Echinococcus granulosus subfamily T1A non peptidase ue 0.0053 0.0644 0.0636
Schistosoma mansoni cytochrome P450 0.0018 0.0156 0.0147
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0053 0.0644 0.1489
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0176 0.0157
Echinococcus granulosus proteasome subunit beta type 6 0.0053 0.0644 0.0636
Brugia malayi jmjC domain containing protein 0.0015 0.012 0.0137
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0053 0.0644 0.0636
Treponema pallidum exodeoxyribonuclease (exoA) 0.0095 0.1217 1
Schistosoma mansoni cpg binding protein 0.003 0.0322 0.0314
Echinococcus multilocularis proteasome subunit beta type 6 0.0053 0.0644 0.0636
Echinococcus multilocularis traf and tnf receptor associated protein 0.0019 0.0176 0.0167
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0019 0.0176 0.0157
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0053 0.0644 0.1489
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0053 0.0644 0.1353
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0053 0.0644 0.1771
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0276 0.0442
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0053 0.0644 0.1489
Schistosoma mansoni neutral sphingomyelinase 0.0019 0.0176 0.0167
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0053 0.0644 0.0931
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0053 0.0644 0.1771
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0053 0.0644 0.1353
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0019 0.0176 0.0157
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0053 0.0644 0.1489
Loa Loa (eye worm) hypothetical protein 0.0052 0.0624 0.0901
Echinococcus multilocularis neutral sphingomyelinase 0.0019 0.0176 0.0167
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0019 0.0176 0.0218
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0053 0.0644 0.1489
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0019 0.0176 0.0218
Plasmodium falciparum proteasome subunit beta type-5 0.0271 0.3637 1
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0019 0.0176 0.0483
Brugia malayi jmjC domain containing protein 0.0015 0.012 0.0137
Plasmodium falciparum proteasome subunit beta type-1, putative 0.021 0.2806 0.7637
Brugia malayi CXXC zinc finger family protein 0.0028 0.03 0.041
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0095 0.1217 0.305
Echinococcus multilocularis netrin receptor unc 5 0.0052 0.0621 0.0613
Echinococcus granulosus synaptojanin 1 0.0019 0.0176 0.0167
Brugia malayi Death domain containing protein 0.0052 0.0621 0.0897
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0053 0.0644 0.1489
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0053 0.0644 0.1489
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.0143 0.0134
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0271 0.3637 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0032 0.0000096378
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0053 0.0644 0.1489
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0053 0.0644 0.1353
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0019 0.0176 0.022
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0271 0.3637 1
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0053 0.0644 0.1489
Toxoplasma gondii proteasome subunit beta type 2, putative 0.013 0.1705 0.4507
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0053 0.0644 0.1489
Echinococcus multilocularis microtubule associated protein 2 0.0734 1 1
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0053 0.0644 0.1489
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0772 0.177
Loa Loa (eye worm) hypothetical protein 0.0015 0.012 0.0134
Echinococcus granulosus jumonji domain containing 1A 0.0015 0.012 0.0112
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.0019 0.0176 0.0157
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0019 0.0176 0.0157
Trypanosoma brucei RNA editing exonuclease 2 0.0019 0.0176 0.0157
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0019 0.0176 0.0483
Loa Loa (eye worm) hypothetical protein 0.0019 0.0176 0.0218
Echinococcus multilocularis proteasome subunit beta type 7 0.0053 0.0644 0.0636
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.0019 0.0176 0.0157
Echinococcus multilocularis proteasome (prosome, macropain) 0.0271 0.3637 0.3631
Brugia malayi Immunoglobulin I-set domain containing protein 0.0052 0.0621 0.0897
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0095 0.1217 0.301
Loa Loa (eye worm) hypothetical protein 0.0019 0.0176 0.0218
Leishmania major hypothetical protein, conserved 0.0019 0.0176 0.0157
Trichomonas vaginalis ap endonuclease, putative 0.0095 0.1217 0.3347
Brugia malayi proteasome subunit beta type 2 0.013 0.1705 0.2547
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0019 0.0176 0.0157
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0053 0.0644 0.1489
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0053 0.0644 0.1353
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0053 0.0644 0.1489
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0053 0.0644 0.1771
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0019 0.0176 0.022
Brugia malayi proteasome subunit alpha type 3 0.0053 0.0644 0.0933
Brugia malayi CCR4 0.0019 0.0176 0.022
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0053 0.0644 0.1489
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0176 0.0157
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0772 0.177
Plasmodium vivax proteasome subunit beta type-7, putative 0.0053 0.0644 0.1489
Echinococcus multilocularis synaptojanin 1 0.0019 0.0176 0.0167
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.0693 0.0685
Leishmania major proteasome alpha 7 subunit, putative 0.0053 0.0644 0.1489
Echinococcus granulosus proteasome subunit beta type 7 0.0053 0.0644 0.0636
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0053 0.0644 0.1489
Brugia malayi jmjC domain containing protein 0.0057 0.0693 0.1008
Onchocerca volvulus 0.0028 0.03 0.2663
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0032 0.0024
Echinococcus granulosus proteasome prosome macropain subunit beta 0.013 0.1705 0.1698
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0019 0.0176 0.0167
Giardia lamblia 20S proteasome alpha subunit 6 0.0053 0.0644 0.1353
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.013 0.1705 0.4419
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0019 0.0176 0.022
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0053 0.0644 0.1489
Leishmania major cytochrome p450-like protein 0.0018 0.0156 0.01
Toxoplasma gondii exonuclease III APE 0.0095 0.1217 0.312
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0053 0.0644 0.1489
Mycobacterium leprae probable proteasome (alpha subunit) PrcA 0.0053 0.0644 0.1403
Schistosoma mansoni synaptojanin 0.0019 0.0176 0.0167
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0053 0.0644 0.0931
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.013 0.1705 0.4688
Plasmodium vivax proteasome subunit beta type-5, putative 0.0271 0.3637 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0095 0.1217 0.121
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0715 0.1039
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.0019 0.0176 0.0157
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0019 0.0176 0.0167
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0095 0.1217 0.1803
Onchocerca volvulus Notchless protein homolog 0.0053 0.0644 1
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.013 0.1705 0.1698
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0053 0.0644 0.1489
Leishmania major inositol/phosphatidylinositol phosphatase, putative 0.0019 0.0176 0.0157
Plasmodium falciparum proteasome subunit beta type-4 0.0053 0.0644 0.1489
Loa Loa (eye worm) cytochrome P450 0.0018 0.0156 0.0188
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0019 0.0176 0.022
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0053 0.0644 0.0636
Echinococcus multilocularis Ankyrin 0.0052 0.0624 0.0616
Loa Loa (eye worm) proteasome subunit beta type 3 0.0053 0.0644 0.0931
Leishmania major proteasome alpha 2 subunit, putative 0.0053 0.0644 0.1489
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0053 0.0644 0.1489
Echinococcus granulosus Proteasome subunit alpha type 7 0.0053 0.0644 0.0636
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0019 0.0176 0.022
Schistosoma mansoni hypothetical protein 0.0402 0.5441 0.5437
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0736 0.0728
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0276 0.0371
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0053 0.0644 0.0636
Echinococcus granulosus Proteasome subunit alpha beta 0.0053 0.0644 0.0636
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0053 0.0644 0.1489
Echinococcus multilocularis JmjC domain containing protein 4 0.0015 0.012 0.0112
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.0143 0.0134
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0052 0.0621 0.0613

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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