Detailed information for compound 1528160

Basic information

Technical information
  • TDR Targets ID: 1528160
  • Name: [1-(phenylmethyl)indol-3-yl]methanol
  • MW: 237.296 | Formula: C16H15NO
  • H donors: 1 H acceptors: 1 LogP: 2.71 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCc1cn(c2c1cccc2)Cc1ccccc1
  • InChi: 1S/C16H15NO/c18-12-14-11-17(10-13-6-2-1-3-7-13)16-9-5-4-8-15(14)16/h1-9,11,18H,10,12H2
  • InChiKey: DXCRDLUQTDLMKZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [1-(phenylmethyl)-3-indolyl]methanol
  • [1-(benzyl)indol-3-yl]methanol
  • Maybridge1_006370
  • NCI60_040365
  • Oprea1_329464
  • 1H-Indole-3-methanol, 1-(phenylmethyl)-
  • N-Benzyl-indole-3-carbinol
  • NSC716807

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia 20S proteasome alpha subunit 7 0.012 0.0774 0.1843
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.012 0.0774 0.1843
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.012 0.0774 0.1843
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.012 0.0774 0.5
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.012 0.0774 0.1843
Brugia malayi proteasome subunit alpha type 6 0.012 0.0774 0.1843
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.012 0.0774 0.0773
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.012 0.0774 0.1843
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.012 0.0774 0.0773
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.012 0.0774 0.1843
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.012 0.0774 0.1843
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0295 0.1987 0.1987
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.012 0.0774 0.1843
Echinococcus granulosus Ankyrin 0.0131 0.0845 0.0845
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0476 0.3246 0.7735
Echinococcus granulosus Proteasome subunit alpha type 7 0.012 0.0774 0.0773
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.012 0.0774 0.1843
Loa Loa (eye worm) hypothetical protein 0.0176 0.116 0.2765
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0295 0.1987 0.1987
Giardia lamblia 20S proteasome alpha subunit 2 0.012 0.0774 0.1843
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0613 0.4196 1
Brugia malayi Proteasome A-type and B-type family protein 0.012 0.0774 0.1843
Trypanosoma brucei proteasome beta 6 subunit 0.0476 0.3246 0.7735
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.012 0.0774 0.1843
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.012 0.0774 0.1843
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.012 0.0774 0.1843
Trypanosoma cruzi 20S proteasome subunit 0.0295 0.1987 0.4735
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.012 0.0774 0.1843
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.012 0.0774 0.1843
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.012 0.0774 0.1843
Echinococcus granulosus proteasome subunit beta type 7 0.012 0.0774 0.0773
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.012 0.0774 0.1843
Entamoeba histolytica proteasome subunit beta type 3, putative 0.012 0.0774 0.1843
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.012 0.0774 0.1843
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.012 0.0774 0.1843
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.012 0.0774 0.1843
Brugia malayi proteasome subunit beta type 3 0.012 0.0774 0.1843
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.013 0.084 0.2001
Plasmodium vivax proteasome subunit alpha type-5, putative 0.012 0.0774 0.1843
Echinococcus multilocularis Proteasome subunit alpha type 7 0.012 0.0774 0.0773
Loa Loa (eye worm) hypothetical protein 0.0131 0.0845 0.2014
Trypanosoma brucei proteasome alpha 7 subunit 0.012 0.0774 0.1843
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0613 0.4196 1
Brugia malayi Death domain containing protein 0.013 0.084 0.2001
Echinococcus multilocularis Proteasome, subunit alpha beta 0.012 0.0774 0.0773
Giardia lamblia 20S proteasome alpha subunit 3 0.012 0.0774 0.1843
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0476 0.3246 0.7735
Giardia lamblia Proteasome subunit beta type 9 precursor 0.012 0.0774 0.1843
Giardia lamblia 20S proteasome alpha subunit 4 0.012 0.0774 0.1843
Giardia lamblia Proteasome subunit beta type 2 0.0295 0.1987 0.4735
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.012 0.0774 0.1843
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.012 0.0774 0.1843
Plasmodium vivax proteasome subunit alpha type-3, putative 0.012 0.0774 0.1843
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.012 0.0774 0.1843
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0295 0.1987 0.4735
Brugia malayi Proteasome A-type and B-type family protein 0.012 0.0774 0.1843
Plasmodium falciparum proteasome subunit beta type-7, putative 0.012 0.0774 0.1843
Leishmania major proteasome alpha 7 subunit, putative 0.012 0.0774 0.1843
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.012 0.0774 0.1843
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.012 0.0774 0.1843
Toxoplasma gondii proteasome subunit alpha1, putative 0.012 0.0774 0.1843
Giardia lamblia 20S proteasome alpha subunit 1 0.012 0.0774 0.1843
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.012 0.0774 0.1843
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.012 0.0774 0.1843
Plasmodium falciparum proteasome subunit beta type-6, putative 0.012 0.0774 0.1843
Plasmodium vivax proteasome subunit alpha type-1, putative 0.012 0.0774 0.1843
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0613 0.4196 1
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.012 0.0774 0.0773
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.012 0.0774 0.1843
Giardia lamblia Proteasome subunit beta type 4 precursor 0.012 0.0774 0.1843
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.012 0.0774 0.1843
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.012 0.0774 0.1843
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.012 0.0774 0.1843
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.012 0.0774 0.0773
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.012 0.0774 0.1843
Plasmodium vivax proteasome subunit alpha type-6, putative 0.012 0.0774 0.1843
Leishmania major proteasome alpha 2 subunit, putative 0.012 0.0774 0.1843
Brugia malayi proteasome subunit alpha type 2 0.012 0.0774 0.1843
Toxoplasma gondii peptidase, T1 family protein 0.012 0.0774 0.1843
Loa Loa (eye worm) proteasome subunit beta type 2 0.0295 0.1987 0.4735
Trypanosoma brucei proteasome beta 2 subunit, putative 0.012 0.0774 0.1843
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.012 0.0774 0.1843
Echinococcus multilocularis nuclear factor of activated T cells 5 0.1447 1 1
Brugia malayi Uncoordinated protein 44 0.013 0.084 0.2001
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.012 0.0774 0.1843
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.012 0.0774 0.1843
Leishmania major proteasome alpha 3 subunit, putative 0.012 0.0774 0.1843
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0295 0.1987 0.4735
Plasmodium vivax proteasome subunit beta type-6, putative 0.012 0.0774 0.1843
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.012 0.0774 0.1843
Trypanosoma brucei proteasome beta 7 subunit 0.012 0.0774 0.1843
Giardia lamblia 20S proteasome alpha subunit 6 0.012 0.0774 0.1843
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0295 0.1987 0.4735
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0295 0.1987 0.4735
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.012 0.0774 0.1843
Brugia malayi Protein kinase domain containing protein 0.013 0.084 0.2001
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.012 0.0774 0.1843
Loa Loa (eye worm) proteasome subunit alpha type 2 0.012 0.0774 0.1843
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.012 0.0774 0.1843
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.012 0.0774 0.1843
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.012 0.0774 0.1843
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.012 0.0774 0.1843
Loa Loa (eye worm) hypothetical protein 0.013 0.084 0.2001
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.012 0.0774 0.1843
Brugia malayi Proteasome A-type and B-type family protein 0.0613 0.4196 1
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.012 0.0774 0.1843
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.012 0.0774 0.1843
Onchocerca volvulus 0.0176 0.116 1
Loa Loa (eye worm) PAS-3 protein 0.012 0.0774 0.1843
Brugia malayi proteasome subunit alpha type 4 0.012 0.0774 0.1843
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0613 0.4196 1
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.012 0.0774 0.1843
Brugia malayi Proteasome subunit alpha type 1 0.012 0.0774 0.1843
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0295 0.1987 0.4735
Brugia malayi 20S proteasome alpha5 subunit 0.012 0.0774 0.1843
Toxoplasma gondii proteasome subunit 0.012 0.0774 0.1843
Brugia malayi proteasome subunit beta type 2 0.0295 0.1987 0.4735
Giardia lamblia 20S proteasome alpha subunit 5 0.012 0.0774 0.1843
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.012 0.0774 0.1843
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.012 0.0774 0.1843
Trypanosoma brucei proteasome beta-1 subunit, putative 0.012 0.0774 0.1843
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.012 0.0774 0.1843
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.012 0.0774 0.1843
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.012 0.0774 0.1843
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.012 0.0774 0.1843
Plasmodium vivax proteasome subunit beta type-3, putative 0.012 0.0774 0.1843
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.012 0.0774 0.1843
Echinococcus multilocularis proteasome subunit beta type 7 0.012 0.0774 0.0773
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0613 0.4196 1
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.012 0.0774 0.1843
Echinococcus multilocularis proteasome subunit alpha type 6 0.012 0.0774 0.0773
Loa Loa (eye worm) proteasome subunit alpha type 3 0.012 0.0774 0.1843
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.012 0.0774 0.1843
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.012 0.0774 0.1843
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.012 0.0774 0.1843
Loa Loa (eye worm) proteasome subunit alpha type 6 0.012 0.0774 0.1843
Plasmodium vivax proteasome subunit alpha type-2, putative 0.012 0.0774 0.1843
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.012 0.0774 0.1843
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.012 0.0774 0.1843
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0613 0.4196 1
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.012 0.0774 0.1843
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.012 0.0774 0.1843
Brugia malayi Proteasome A-type and B-type family protein 0.012 0.0774 0.1843
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.012 0.0774 0.1843
Plasmodium vivax proteasome subunit alpha type-7, putative 0.012 0.0774 0.1843
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.013 0.084 0.084
Plasmodium vivax proteasome subunit beta type-7, putative 0.012 0.0774 0.1843
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.012 0.0774 0.1843
Plasmodium falciparum proteasome subunit beta type-5 0.0613 0.4196 1
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.012 0.0774 0.1843
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.012 0.0774 0.1843
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0476 0.3246 0.7735
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.012 0.0774 0.1843
Brugia malayi Immunoglobulin I-set domain containing protein 0.013 0.084 0.2001
Brugia malayi proteasome subunit beta type 1 0.0476 0.3246 0.7735
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.012 0.0774 0.1843
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.012 0.0774 0.1843
Onchocerca volvulus Netrin receptor homolog 0.013 0.084 0.1716
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.012 0.0774 0.1843
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.012 0.0774 0.1843
Leishmania major proteasome beta 2 subunit, putative 0.0295 0.1987 0.4735
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.012 0.0774 0.1843
Leishmania major proteasome beta 7 subunit, putative 0.012 0.0774 0.1843
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.013 0.084 0.084
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.012 0.0774 0.1843
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.012 0.0774 0.1843
Brugia malayi proteasome subunit alpha type 3 0.012 0.0774 0.1843
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.012 0.0774 0.1843
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.012 0.0774 0.1843
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0476 0.3246 0.7735
Echinococcus granulosus proteasome subunit alpha type 6 0.012 0.0774 0.0773
Trypanosoma brucei ATP-dependent protease subunit HslV 0.012 0.0774 0.1843
Plasmodium vivax proteasome subunit beta type-2, putative 0.0295 0.1987 0.4735
Schistosoma mansoni netrin receptor unc5 0.013 0.084 0.2001
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.012 0.0774 0.1843
Leishmania major proteasome alpha 1 subunit, putative 0.012 0.0774 0.1843
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0476 0.3246 0.7735
Echinococcus multilocularis Proteasome subunit alpha type 7 0.012 0.0774 0.0773
Echinococcus multilocularis Proteasome subunit alpha type 7 0.012 0.0774 0.0773
Toxoplasma gondii proteasome subunit beta type, putative 0.0613 0.4196 1
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0131 0.0845 0.2014
Plasmodium vivax proteasome subunit alpha type-4, putative 0.012 0.0774 0.1843
Echinococcus granulosus proteasome prosome macropain 0.0613 0.4196 0.4196
Brugia malayi proteasome subunit alpha type 1 0.012 0.0774 0.1843
Mycobacterium ulcerans proteasome PrcB 0.0613 0.4196 1
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.012 0.0774 0.1843
Echinococcus granulosus subfamily T1A non peptidase ue 0.012 0.0774 0.0773
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.012 0.0774 0.0773
Echinococcus granulosus netrin receptor unc 5 0.013 0.084 0.084
Brugia malayi hypothetical protein 0.0176 0.116 0.2765
Echinococcus granulosus proteasome subunit beta t family 0.012 0.0774 0.0773
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0476 0.3246 0.7735
Leishmania major proteasome alpha 1 subunit, putative 0.012 0.0774 0.1843
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.012 0.0774 0.1843
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.012 0.0774 0.1843
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.012 0.0774 0.1843
Toxoplasma gondii proteasome subunit alpha type, putative 0.012 0.0774 0.1843
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0613 0.4196 1
Loa Loa (eye worm) proteasome subunit beta type 1 0.0476 0.3246 0.7735
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.012 0.0774 0.1843
Loa Loa (eye worm) proteasome subunit beta type 3 0.012 0.0774 0.1843
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.012 0.0774 0.1843
Giardia lamblia Proteasome subunit beta type 1 0.0476 0.3246 0.7735
Schistosoma mansoni ankyrin 23/unc44 0.013 0.084 0.2001
Leishmania major proteasome alpha 7 subunit, putative 0.012 0.0774 0.1843
Trypanosoma brucei proteasome beta 3 subunit, putative 0.012 0.0774 0.1843
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0295 0.1987 0.4735
Echinococcus multilocularis proteasome subunit beta type 6 0.012 0.0774 0.0773
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0295 0.1987 0.4735
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.012 0.0774 0.1843
Echinococcus granulosus death domain containing protein 0.013 0.084 0.084
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.012 0.0774 0.1843
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.012 0.0774 0.1843
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.012 0.0774 0.1843
Giardia lamblia Proteasome subunit beta type 3 0.012 0.0774 0.1843
Leishmania major proteasome beta 2 subunit, putative 0.012 0.0774 0.1843
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0613 0.4196 1
Echinococcus granulosus 20S proteasome subunit alpha 6 0.012 0.0774 0.0773
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.012 0.0774 0.1843
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0476 0.3246 0.3246
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0295 0.1987 0.4735
Leishmania major proteasome beta-1 subunit, putative 0.012 0.0774 0.1843
Echinococcus multilocularis proteasome subunit alpha type 2 0.012 0.0774 0.0773
Toxoplasma gondii proteasome beta subunit 0.012 0.0774 0.1843
Plasmodium vivax proteasome subunit beta type-1, putative 0.0476 0.3246 0.7735
Echinococcus multilocularis netrin receptor unc 5 0.013 0.084 0.084
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.012 0.0774 0.1843
Leishmania major proteasome beta 5 subunit, putative 0.0613 0.4196 1
Echinococcus granulosus proteasome subunit alpha type 2 0.012 0.0774 0.0773
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.012 0.0774 0.0773
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.012 0.0774 0.1843
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.012 0.0774 0.1843
Plasmodium falciparum proteasome subunit beta type-3, putative 0.012 0.0774 0.1843
Loa Loa (eye worm) proteasome subunit alpha type 1 0.012 0.0774 0.1843
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.012 0.0774 0.1843
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.012 0.0774 0.1843
Echinococcus granulosus proteasome subunit beta type 6 0.012 0.0774 0.0773
Echinococcus multilocularis subfamily T1A non peptidase ue 0.012 0.0774 0.0773
Plasmodium falciparum proteasome subunit beta type-4 0.012 0.0774 0.1843
Giardia lamblia Proteasome subunit beta type 7 precursor 0.012 0.0774 0.1843
Echinococcus multilocularis proteasome (prosome, macropain) 0.0613 0.4196 0.4196
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.012 0.0774 0.1843
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0613 0.4196 1
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.012 0.0774 0.1843
Schistosoma mansoni hypothetical protein 0.013 0.084 0.2001
Brugia malayi Proteasome subunit alpha type 7-1 0.012 0.0774 0.1843
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0295 0.1987 0.4735
Plasmodium vivax proteasome subunit beta type-5, putative 0.0613 0.4196 1
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0476 0.3246 0.7735
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.012 0.0774 0.1843
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.012 0.0774 0.1843
Toxoplasma gondii heat shock protein hslv, putative 0.012 0.0774 0.1843
Plasmodium vivax proteasome subunit beta type-4, putative 0.012 0.0774 0.1843
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.012 0.0774 0.1843
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0613 0.4196 1
Echinococcus multilocularis Ankyrin 0.0131 0.0845 0.0845
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0476 0.3246 0.3246
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0476 0.3246 0.7735
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.012 0.0774 0.1843
Leishmania major proteasome beta 3 subunit, putative 0.012 0.0774 0.1843
Echinococcus granulosus Proteasome subunit alpha beta 0.012 0.0774 0.0773

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -5.263 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.259 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.229 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.842 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.666 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.59 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.585 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.552 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.462 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.448 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.057 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) = 0.112 uM Cytotoxicity against human H460 cells assessed as cell viability after 3 days by sulforhodamine B assay ChEMBL. 21443218

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 21443218

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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