Detailed information for compound 1528174

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 491.38 | Formula: C22H19F6NO5
  • H donors: 1 H acceptors: 2 LogP: 4.88 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCn1c2c3OCOc3c(c(c2c2c(c1=O)cccc2)OC)C(C(F)(F)F)(C(F)(F)F)O
  • InChi: 1S/C22H19F6NO5/c1-3-4-9-29-15-13(11-7-5-6-8-12(11)19(29)30)16(32-2)14(17-18(15)34-10-33-17)20(31,21(23,24)25)22(26,27)28/h5-8,31H,3-4,9-10H2,1-2H3
  • InChiKey: KHEUBNRTDWDQCM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis carbonic anhydrase 0.0273 0.3653 0.5086
Loa Loa (eye worm) hypothetical protein 0.0043 0.0389 0.0389
Entamoeba histolytica P-glycoprotein 6, putative 0.0027 0.0152 0.0104
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.005 0.0484 0.0625
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0083 0.0958 0.8593
Mycobacterium ulcerans aldehyde dehydrogenase 0.0046 0.0427 0.3155
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0029 0.0184 0.0184
Mycobacterium ulcerans component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD 0.0027 0.0152 0.1126
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0074 0.0074
Schistosoma mansoni lipoxygenase 0.003 0.0199 0.0277
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0029 0.0184 0.6372
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0306 0.1236
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0433 0.0603
Toxoplasma gondii exonuclease III APE 0.0029 0.0184 0.0089
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0039 0.0322 0.0322
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0424 0.0705
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0074 0.0103
Echinococcus granulosus ATP binding cassette sub family B 0.0027 0.0152 0.0212
Leishmania major agmatinase-like protein 0.0044 0.0403 0.0478
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0074 0.0103
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0043 0.0389 0.0685
Echinococcus granulosus multidrug resistance protein 1 0.0085 0.098 0.1364
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0216 0.2836 0.3949
Brugia malayi Calcitonin receptor-like protein seb-1 0.0039 0.0322 0.0568
Loa Loa (eye worm) hypothetical protein 0.003 0.0199 0.0199
Onchocerca volvulus 0.02 0.2612 0.921
Loa Loa (eye worm) hypothetical protein 0.003 0.0199 0.0199
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0424 0.0705
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0029 0.0184 0.0232
Entamoeba histolytica ABC transporter, putative 0.0027 0.0152 0.0104
Echinococcus granulosus mothers against decapentaplegic 5 0.0021 0.0069 0.0096
Onchocerca volvulus 0.0127 0.1571 0.554
Brugia malayi exodeoxyribonuclease III family protein 0.0029 0.0184 0.0324
Mycobacterium ulcerans carboxylesterase, LipT 0.0037 0.0296 0.2185
Brugia malayi ABC transporter transmembrane region family protein 0.0027 0.0152 0.0269
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0027 0.0152 0.0026
Loa Loa (eye worm) multidrug resistance protein 3 0.0085 0.098 0.098
Giardia lamblia Multidrug resistance-associated protein 1 0.0027 0.0152 0.1883
Brugia malayi ABC transporter 0.0027 0.0152 0.0269
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0424 0.0705
Schistosoma mansoni inositol monophosphatase 0.0037 0.0306 0.0427
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.005 0.0484 0.0674
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0074 0.0103
Loa Loa (eye worm) hypothetical protein 0.0216 0.2836 0.2836
Echinococcus granulosus RUN 0.003 0.0199 0.0277
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0306 0.2262
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0074 0.0131
Echinococcus granulosus carboxylesterase 5A 0.0217 0.2854 0.3974
Trypanosoma brucei p-glycoprotein 0.0027 0.0152 0.0224
Schistosoma mansoni hypothetical protein 0.0273 0.3653 0.5086
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0251 0.1183
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0139 0.1754 0.6186
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0037 0.0296 0.1657
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0029 0.0184 0.0082
Trypanosoma brucei DNA polymerase IV, putative 0.0046 0.0424 0.0705
Echinococcus multilocularis ATP binding cassette sub family B 0.0027 0.0152 0.0212
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0074 0.0131
Brugia malayi MH2 domain containing protein 0.0304 0.4081 0.7194
Echinococcus multilocularis lamin 0.002 0.0065 0.0091
Brugia malayi hypothetical protein 0.0127 0.1571 0.277
Echinococcus multilocularis ATP binding cassette sub family B 0.0084 0.0967 0.1346
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0097 0.0125
Loa Loa (eye worm) hypothetical protein 0.0021 0.0074 0.0074
Schistosoma mansoni neuroligin 3 (S09 family) 0.0037 0.0296 0.0412
Brugia malayi sodium-independent organic anion transporter family protein 0.0127 0.1571 0.277
Schistosoma mansoni hypothetical protein 0.003 0.0199 0.0277
Brugia malayi Intermediate filament tail domain containing protein 0.002 0.0065 0.0115
Schistosoma mansoni organic anion transporter 0.0127 0.1571 0.2188
Entamoeba histolytica P-glyco protein 6, putative 0.0085 0.098 0.6181
Echinococcus granulosus multidrug resistance protein 1 0.0085 0.098 0.1364
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0306 0.0427
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0074 0.0103
Brugia malayi Trypsin family protein 0.0216 0.2836 0.5
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0273 0.3653 0.3653
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0043 0.0389 0.0675
Giardia lamblia DINP protein human, muc B family 0.0031 0.0209 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0037 0.0296 0.0412
Schistosoma mansoni multidrug resistance protein 0.0027 0.0152 0.0212
Brugia malayi glutathione reductase 0.0037 0.0294 0.0518
Loa Loa (eye worm) MH1 domain-containing protein 0.0021 0.0069 0.0069
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0306 0.0304
Brugia malayi intermediate filament protein 0.002 0.0065 0.0115
Toxoplasma gondii protease inhibitor PI2 0.0043 0.0389 0.0675
Trypanosoma cruzi DNA polymerase kappa, putative 0.0046 0.0424 0.0516
Trypanosoma cruzi DNA polymerase kappa, putative 0.0046 0.0424 0.0516
Schistosoma mansoni multidrug resistance protein 0.0027 0.0152 0.0212
Plasmodium vivax glutathione reductase, putative 0.0037 0.0294 0.1051
Loa Loa (eye worm) hypothetical protein 0.0217 0.2854 0.2854
Mycobacterium ulcerans hypothetical protein 0.0027 0.0163 0.1206
Leishmania major p-glycoprotein e 0.0027 0.0152 0.0026
Schistosoma mansoni single-minded 0.0037 0.0298 0.0415
Mycobacterium tuberculosis Carboxylesterase LipT 0.0037 0.0296 0.1657
Plasmodium vivax arginase, putative 0.0122 0.15 1
Brugia malayi nuclear receptor NHR-88 0.0021 0.0074 0.0131
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.005 0.0484 0.0812
Loa Loa (eye worm) hypothetical protein 0.0043 0.0389 0.0389
Onchocerca volvulus 0.0127 0.1571 0.554
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0085 0.098 0.416
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0074 0.0131
Brugia malayi latrophilin 2 splice variant baaae 0.0026 0.0149 0.0263
Schistosoma mansoni carbonic anhydrase-related 0.0273 0.3653 0.5086
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0306 0.0427
Brugia malayi MH1 domain containing protein 0.0021 0.0069 0.0122
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0074 0.0131
Brugia malayi MH2 domain containing protein 0.0021 0.0069 0.0122
Mycobacterium ulcerans aldehyde dehydrogenase 0.0046 0.0427 0.3155
Schistosoma mansoni aldehyde dehydrogenase 0.0046 0.0427 0.0595
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0074 0.0074
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0433 0.0603
Echinococcus granulosus single minded 2 0.0027 0.0162 0.0226
Onchocerca volvulus 0.0037 0.0296 0.1044
Mycobacterium ulcerans carbon monoxyde dehydrogenase small chain CoxS 0.0032 0.0231 0.1705
Echinococcus granulosus multidrug resistance protein 1 0.0059 0.0616 0.0858
Leishmania major trypanothione reductase 0.0037 0.0294 0.0282
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0074 0.0103
Brugia malayi ecdysteroid receptor 0.0021 0.0074 0.0131
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0074 0.0103
Leishmania major carbonic anhydrase-like protein 0.0416 0.5672 1
Loa Loa (eye worm) hypothetical protein 0.0127 0.1571 0.1571
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0027 0.0152 0.0026
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0074 0.0103
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0037 0.0296 0.0412
Echinococcus multilocularis acetylcholinesterase 0.0217 0.2854 0.3974
Onchocerca volvulus 0.0127 0.1571 0.554
Entamoeba histolytica P-glycoprotein-5 0.0085 0.098 0.6181
Loa Loa (eye worm) agrin synaptic family protein 0.0043 0.0389 0.0389
Loa Loa (eye worm) hypothetical protein 0.0021 0.0074 0.0074
Echinococcus multilocularis ATP binding cassette sub family B 0.0027 0.0152 0.0212
Schistosoma mansoni multidrug resistance protein 0.0026 0.0139 0.0194
Brugia malayi SPARC precursor 0.0043 0.0389 0.0685
Trichomonas vaginalis abcb9, putative 0.0085 0.098 0.416
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.005 0.0484 0.0484
Onchocerca volvulus 0.0216 0.2836 1
Onchocerca volvulus 0.003 0.0199 0.0702
Schistosoma mansoni ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7) 0.0027 0.0152 0.0212
Brugia malayi steroid hormone receptor 0.0021 0.0074 0.0131
Brugia malayi hypothetical protein 0.003 0.0199 0.0351
Echinococcus multilocularis expressed protein 0.0043 0.0389 0.0541
Toxoplasma gondii thioredoxin reductase 0.0037 0.0294 0.0404
Schistosoma mansoni multidrug resistance protein 0.0027 0.0152 0.0212
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0074 0.0103
Echinococcus multilocularis dna polymerase eta 0.0026 0.0138 0.0193
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0029 0.0184 0.1357
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0074 0.0103
Echinococcus multilocularis multidrug resistance protein 1 0.0085 0.098 0.1364
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0306 0.0827
Echinococcus granulosus geminin 0.0128 0.1594 0.222
Echinococcus granulosus para nitrobenzyl esterase 0.0037 0.0296 0.0412
Echinococcus granulosus carbonic anhydrase 0.0273 0.3653 0.5086
Schistosoma mansoni carbonic anhydrase-related 0.0273 0.3653 0.5086
Schistosoma mansoni hypothetical protein 0.0128 0.1594 0.222
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0085 0.098 0.416
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0424 0.0705
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.005 0.0484 0.0625
Loa Loa (eye worm) ABC transporter 0.0027 0.0152 0.0152
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0074 0.0074
Brugia malayi Carboxylesterase family protein 0.0037 0.0296 0.0522
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.005 0.0484 0.0625
Schistosoma mansoni inositol monophosphatase 0.0037 0.0306 0.0427
Loa Loa (eye worm) hypothetical protein 0.0127 0.1571 0.1571
Trichomonas vaginalis xanthine dehydrogenase, putative 0.0168 0.2159 1
Echinococcus granulosus dna polymerase kappa 0.0046 0.0424 0.059
Echinococcus multilocularis carbonic anhydrase 0.0273 0.3653 0.5086
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0074 0.0131
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0127 0.1571 0.2188
Schistosoma mansoni agrin 0.0043 0.0389 0.0541
Trichomonas vaginalis ABC transporter, putative 0.0085 0.098 0.416
Onchocerca volvulus Putative organic anion transporter 0.0127 0.1571 0.554
Mycobacterium ulcerans DNA polymerase IV 0.0046 0.0424 0.3127
Schistosoma mansoni polycystin 1-related 0.003 0.0199 0.0277
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0127 0.1571 0.1571
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0085 0.098 0.416
Brugia malayi ABC transporter family protein 0.0027 0.0152 0.0269
Schistosoma mansoni ap endonuclease 0.0029 0.0184 0.0256
Echinococcus multilocularis carbonic anhydrase II 0.0416 0.5672 0.7899
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0416 0.5672 0.7899
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0085 0.098 0.2363
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0175 0.2261 0.2261
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0306 0.0304
Brugia malayi multidrug resistance related protein 1 0.0027 0.0152 0.0269
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0216 0.2836 0.3949
Brugia malayi Carboxylesterase family protein 0.0037 0.0296 0.0522
Echinococcus granulosus arginase 2 mitochondrial 0.0122 0.15 0.2088
Loa Loa (eye worm) hypothetical protein 0.0127 0.1571 0.1571
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0027 0.0152 0.1126
Loa Loa (eye worm) inositol-1 0.0037 0.0306 0.0306
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0074 0.0103
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0074 0.0261
Toxoplasma gondii transporter, major facilitator family protein 0.0127 0.1571 0.4053
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0074 0.0131
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0027 0.0152 0.0224
Echinococcus multilocularis arginase 2, mitochondrial 0.0122 0.15 0.2088
Brugia malayi prostaglandin transporter 0.0127 0.1571 0.277
Trichomonas vaginalis ap endonuclease, putative 0.0029 0.0184 0.022
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0027 0.0152 0.0152
Trypanosoma brucei agmatinase, putative 0.0044 0.0403 0.0668
Schistosoma mansoni multidrug resistance protein 0.0085 0.098 0.1364
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0085 0.098 0.416
Loa Loa (eye worm) hypothetical protein 0.0127 0.1571 0.1571
Trichomonas vaginalis ABC transporter, putative 0.0085 0.098 0.416
Brugia malayi Inositol-1 0.0037 0.0306 0.054
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0083 0.0958 0.8614
Schistosoma mansoni coup transcription factor 0.0021 0.0074 0.0103
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0029 0.0184 0.0478
Schistosoma mansoni acetylcholinesterase 0.0037 0.0296 0.0412
Mycobacterium tuberculosis Probable reductase 0.0083 0.0958 0.8614
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0416 0.5672 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0026 0.0138 0.0138
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0074 0.0103
Trichomonas vaginalis conserved hypothetical protein 0.0122 0.15 0.6733
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.005 0.0484 0.2542
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0059 0.0616 0.236
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0416 0.5672 0.5672
Echinococcus granulosus lamin dm0 0.002 0.0065 0.0091
Loa Loa (eye worm) MH2 domain-containing protein 0.0304 0.4081 0.4081
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0074 0.0131
Mycobacterium ulcerans carbon monoxyde dehydrogenase small chain CoxS 0.0032 0.0231 0.1705
Echinococcus multilocularis BC026374 protein (S09 family) 0.0037 0.0296 0.0412
Echinococcus multilocularis smad 0.0021 0.0069 0.0096
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0251 0.105
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.002 0.0065 0.0065
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0027 0.0152 0.1126
Schistosoma mansoni arginase 0.0122 0.15 0.2088
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0074 0.0103
Echinococcus multilocularis multidrug resistance protein 1 0.0085 0.098 0.1364
Onchocerca volvulus 0.002 0.0065 0.023
Schistosoma mansoni DNA polymerase eta 0.0026 0.0138 0.0193
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0424 0.0705
Onchocerca volvulus 0.0037 0.0296 0.1044
Trypanosoma cruzi MFS transporter, putative 0.0127 0.1571 0.2589
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0273 0.3653 0.6439
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0029 0.0184 0.0334
Loa Loa (eye worm) hypothetical protein 0.0026 0.0149 0.0149
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0084 0.0961 0.1338
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0085 0.098 0.416
Entamoeba histolytica multidrug resistance protein, putative 0.0027 0.0152 0.0104
Loa Loa (eye worm) carbonic anhydrase 3 0.0416 0.5672 0.5672
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0074 0.0103
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0083 0.0958 0.8614
Echinococcus granulosus Smad4 0.0021 0.0069 0.0096
Entamoeba histolytica P-glycoprotein-2 0.0085 0.098 0.6181
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0039 0.0322 0.0568
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0433 0.0433
Onchocerca volvulus Putative organic anion transporter 0.0127 0.1571 0.554
Schistosoma mansoni smad 0.0021 0.0069 0.0096
Loa Loa (eye worm) hypothetical protein 0.0028 0.0174 0.0174
Onchocerca volvulus 0.002 0.0065 0.023
Echinococcus multilocularis acetylcholinesterase 0.0217 0.2854 0.3974
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0026 0.0138 0.0193
Leishmania major arginase 0.0122 0.15 0.246
Entamoeba histolytica hypothetical protein 0.0027 0.0152 0.0104
Plasmodium falciparum arginase 0.0122 0.15 0.3849
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0306 0.0827
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0217 0.2854 0.2854
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0433 0.0603
Mycobacterium ulcerans carbon monoxyde dehydrogenase medium chain CoxM 0.0057 0.0581 0.4286
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxM_2 0.0057 0.0581 0.4286
Schistosoma mansoni multidrug resistance protein 0.0027 0.0152 0.0212
Onchocerca volvulus Putative organic anion transporter 0.0127 0.1571 0.554
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0027 0.0152 0.0065
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0026 0.0138 0.0193
Entamoeba histolytica P-glycoprotein-1 0.0085 0.098 0.6181
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0097 0.0125
Giardia lamblia MRP-like ABC transporter 0.0027 0.0152 0.1883
Echinococcus multilocularis tumor protein p63 0.0256 0.3402 0.4737
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0085 0.098 0.2363
Brugia malayi Carboxylesterase family protein 0.0217 0.2854 0.5032
Echinococcus multilocularis carbonic anhydrase 0.0273 0.3653 0.5086
Loa Loa (eye worm) Smad1 0.0021 0.0069 0.0069
Entamoeba histolytica P-glycoprotein 6, putative 0.0027 0.0152 0.0104
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0273 0.3653 0.6439
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0127 0.1571 0.2188
Onchocerca volvulus 0.0085 0.098 0.3454
Treponema pallidum quinoline 2-oxidoreductase 0.0027 0.0154 0.6682
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0031 0.0209 0.0744
Giardia lamblia Multidrug resistance-associated protein 1 0.0027 0.0152 0.1883
Schistosoma mansoni cellular tumor antigen P53 0.0037 0.0307 0.0427
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0433 0.0603
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0085 0.098 0.416
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0074 0.0103
Echinococcus multilocularis 0.0122 0.15 0.2088
Schistosoma mansoni smad1 5 8 and 0.0021 0.0069 0.0096
Brugia malayi ABC transporter family protein 0.0085 0.098 0.1727
Trypanosoma brucei carbonic anhydrase-like protein 0.0416 0.5672 1
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0085 0.098 0.416
Echinococcus granulosus dna polymerase eta 0.0026 0.0138 0.0193
Schistosoma mansoni gliotactin 0.0037 0.0296 0.0412
Brugia malayi ABC transporter transmembrane region family protein 0.0026 0.0139 0.0246
Echinococcus granulosus multidrug resistance associated protein 7 0.0027 0.0152 0.0212
Loa Loa (eye worm) acetylcholinesterase 1 0.0217 0.2854 0.2854
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0043 0.0389 0.0685
Trichomonas vaginalis abcb9, putative 0.0085 0.098 0.416
Loa Loa (eye worm) hypothetical protein 0.0139 0.1754 0.1754
Schistosoma mansoni lipoxygenase 0.0084 0.0961 0.1338
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0085 0.098 0.1364
Brugia malayi sodium-independent organic anion transporter family protein 0.0127 0.1571 0.277
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0416 0.5672 1
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0085 0.098 0.8842
Trichomonas vaginalis DNA polymerase eta, putative 0.0046 0.0424 0.1407
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0029 0.0184 0.0082
Schistosoma mansoni smad1 5 8 and 0.0021 0.0069 0.0096
Loa Loa (eye worm) hypothetical protein 0.0039 0.0322 0.0322
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0074 0.0103
Mycobacterium ulcerans drugs-transport transmembrane ATP-binding protein ABC transporter 0.0027 0.0152 0.1126
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0043 0.0389 0.0675
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0074 0.0131
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0097 0.0125
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0306 0.0497
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0085 0.098 0.416
Loa Loa (eye worm) hypothetical protein 0.0084 0.0967 0.0967
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0037 0.0296 0.1657
Brugia malayi MH2 domain containing protein 0.0021 0.0069 0.0122
Echinococcus multilocularis lipoxygenase domain containing protein 0.003 0.0199 0.0277
Onchocerca volvulus 0.003 0.0199 0.0702
Trypanosoma cruzi arginase, putative 0.0044 0.0403 0.0478
Loa Loa (eye worm) hypothetical protein 0.0026 0.0138 0.0138
Echinococcus granulosus acetylcholinesterase 0.0217 0.2854 0.3974
Echinococcus granulosus tumor protein p63 0.0256 0.3402 0.4737
Brugia malayi hypothetical protein 0.0127 0.1571 0.277
Mycobacterium tuberculosis Probable oxidoreductase 0.0093 0.109 1
Loa Loa (eye worm) hypothetical protein 0.0123 0.1527 0.1527
Loa Loa (eye worm) hypothetical protein 0.0021 0.0074 0.0074
Brugia malayi Carboxylesterase family protein 0.0037 0.0296 0.0522
Echinococcus multilocularis multidrug resistance associated protein 7 0.0027 0.0152 0.0212
Echinococcus multilocularis ATP binding cassette sub family B 0.0027 0.0152 0.0212
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0043 0.0389 0.0685
Brugia malayi multidrug resistance protein 3 0.0085 0.098 0.1727
Trypanosoma cruzi ABC transporter, mitochondrial, putative 0.0027 0.0152 0.0026
Echinococcus multilocularis neuroligin 0.0037 0.0296 0.0412
Loa Loa (eye worm) hypothetical protein 0.0127 0.1571 0.1571
Loa Loa (eye worm) hypothetical protein 0.0085 0.098 0.098
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0084 0.0967 0.1346
Echinococcus granulosus multidrug resistance protein 1 0.0085 0.098 0.1364
Schistosoma mansoni intermediate filament proteins 0.002 0.0065 0.0091
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0306 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0074 0.0103
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0085 0.098 0.416
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0043 0.0389 0.0675
Brugia malayi ImpB/MucB/SamB family protein 0.0026 0.0138 0.0244
Onchocerca volvulus 0.0037 0.0296 0.1044
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0273 0.3653 0.6439
Onchocerca volvulus 0.0021 0.0074 0.0261
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0174 0.0262
Loa Loa (eye worm) hypoxia-induced factor 1 0.0114 0.1392 0.1392
Echinococcus granulosus microtubule associated protein 2 0.0522 0.7181 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0029 0.0184 0.2032
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0074 0.0103
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.005 0.0484 0.0674
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0027 0.0152 0.0152
Loa Loa (eye worm) hypothetical protein 0.0037 0.0296 0.0296
Loa Loa (eye worm) hypothetical protein 0.0037 0.0307 0.0307
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0029 0.0184 0.0089
Leishmania major p-glycoprotein 0.0085 0.098 0.152
Trypanosoma cruzi arginase, putative 0.0044 0.0403 0.0478
Loa Loa (eye worm) hypothetical protein 0.0127 0.1571 0.1571
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0085 0.098 0.416
Echinococcus granulosus ATP binding cassette sub family B 0.0027 0.0152 0.0212
Toxoplasma gondii hypothetical protein 0.0273 0.3653 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0074 0.0131
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0085 0.098 0.416
Echinococcus granulosus smad 0.0021 0.0069 0.0096
Entamoeba histolytica ATP-binding cassette protein, putative 0.0027 0.0152 0.0104
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (medium chain) 0.0057 0.0581 0.4648
Entamoeba histolytica P-glycoprotein-2 0.0085 0.098 0.6181
Schistosoma mansoni lamin 0.002 0.0065 0.0091
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0085 0.098 0.416
Trichomonas vaginalis abcb9, putative 0.0085 0.098 0.416
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0294 0.0409
Echinococcus granulosus 3'partial|arginase 2 mitochondrial 0.0122 0.15 0.2088
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0083 0.0958 0.8614
Loa Loa (eye worm) hypothetical protein 0.0037 0.0296 0.0296
Brugia malayi secreted modular calcium-binding protein 1 0.0043 0.0389 0.0685
Schistosoma mansoni organic anion transporter 0.0127 0.1571 0.2188
Leishmania major pentamidine resistance protein 1 0.0027 0.0152 0.0026
Schistosoma mansoni aryl hydrocarbon receptor 0.0037 0.0298 0.0415
Plasmodium falciparum carbonic anhydrase 0.0273 0.3653 1
Echinococcus multilocularis carboxylesterase 5A 0.0217 0.2854 0.3974
Brugia malayi N-terminal motif family protein 0.0139 0.1754 0.3093
Leishmania major ATP-binding cassette protein subfamily B, member 1, putative 0.0027 0.0152 0.0026
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0424 0.0705
Brugia malayi PAS domain containing protein 0.0037 0.0298 0.0525
Brugia malayi ABC transporter 0.0026 0.0139 0.0246
Echinococcus granulosus agrin 0.0043 0.0389 0.0541
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0085 0.098 0.1364
Loa Loa (eye worm) hypothetical protein 0.0037 0.0296 0.0296
Brugia malayi hypothetical protein 0.0037 0.0296 0.0522
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0085 0.098 0.416
Echinococcus granulosus multidrug resistance associated protein 1 0.0027 0.0152 0.0212
Brugia malayi multidrug Resistance Protein family member (mrp-5), putative 0.0027 0.0152 0.0269
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0043 0.0389 0.0685
Loa Loa (eye worm) hypothetical protein 0.0026 0.0139 0.0139
Mycobacterium ulcerans aldehyde dehydrogenase 0.0046 0.0427 0.3155
Trypanosoma brucei ABC transporter of the mitochondrion, putative 0.0027 0.0152 0.0224
Echinococcus multilocularis Smad4 0.0021 0.0069 0.0096
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0074 0.0131
Brugia malayi sodium-independent organic anion transporter family protein 0.0127 0.1571 0.277
Echinococcus granulosus follistatin 0.0043 0.0389 0.0541
Echinococcus multilocularis agrin 0.0043 0.0389 0.0541
Trichomonas vaginalis ABC transporter, putative 0.0085 0.098 0.416
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0029 0.0184 0.0256
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0046 0.0424 0.1407
Echinococcus multilocularis mothers against decapentaplegic 5 0.0021 0.0069 0.0096
Loa Loa (eye worm) hypothetical protein 0.0021 0.0074 0.0074
Schistosoma mansoni terminal deoxycytidyl transferase 0.0026 0.0138 0.0193
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0029 0.0184 0.0082
Trichomonas vaginalis spcc417.12 protein, putative 0.0037 0.0296 0.0775
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0433 0.0603
Echinococcus granulosus carbonic anhydrase II 0.0416 0.5672 0.7899
Entamoeba histolytica ATP-binding cassette protein, putative 0.0027 0.0152 0.0104
Echinococcus granulosus neuroligin 0.0037 0.0296 0.0412
Mycobacterium ulcerans carbon monoxide dehydrogenase 0.0111 0.1355 1
Loa Loa (eye worm) carboxylesterase 0.0217 0.2854 0.2854
Echinococcus multilocularis RUN 0.003 0.0199 0.0277
Schistosoma mansoni Smad4 0.0021 0.0069 0.0096
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0074 0.0074
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0093 0.109 1
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0074 0.0103
Mycobacterium tuberculosis Probable dehydrogenase 0.0083 0.0958 0.8614
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0416 0.5672 1
Echinococcus multilocularis ATP binding cassette sub family B 0.0027 0.0152 0.0212
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0085 0.098 0.416
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 0.0079 0.09 0.6641
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0294 0.1637
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0046 0.0427 0.0523
Loa Loa (eye worm) hypothetical protein 0.0043 0.0389 0.0389
Trypanosoma brucei DNA polymerase IV, putative 0.0046 0.0424 0.0705
Echinococcus granulosus lipoxygenase domain containing protein 0.003 0.0199 0.0277
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0085 0.098 0.1364
Brugia malayi ABC transporter family protein 0.0027 0.0152 0.0269
Echinococcus granulosus carbonic anhydrase 0.0273 0.3653 0.5086
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0424 0.0705
Entamoeba histolytica P-glycoprotein 5, putative 0.0026 0.0139 0.0008
Treponema pallidum exodeoxyribonuclease (exoA) 0.0029 0.0184 1
Brugia malayi hypothetical protein 0.0123 0.1527 0.2693
Trichomonas vaginalis aldehyde oxidase, putative 0.0168 0.2159 1
Echinococcus multilocularis lamin dm0 0.002 0.0065 0.0091
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0021 0.0069 0.0096
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0046 0.0427 0.3039
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0353 0.0579
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0424 0.0705
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0085 0.098 0.416
Trypanosoma cruzi agmatinase, putative 0.0044 0.0403 0.0478
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0026 0.0138 0.0193
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0294 0.0409
Loa Loa (eye worm) hypothetical protein 0.0021 0.0074 0.0074
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0021 0.0069 0.0096
Brugia malayi Carboxylesterase family protein 0.0037 0.0296 0.0522
Echinococcus granulosus carbonic anhydrase 0.0273 0.3653 0.5086
Loa Loa (eye worm) transcription factor SMAD2 0.0304 0.4081 0.4081
Echinococcus multilocularis lipoxygenase domain containing protein 0.003 0.0199 0.0277
Onchocerca volvulus 0.0127 0.1571 0.554
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0074 0.0074
Schistosoma mansoni multidrug resistance protein 0.0027 0.0152 0.0212
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0027 0.0152 0.0026
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0074 0.0103
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0433 0.0763
Brugia malayi Carboxylesterase family protein 0.0217 0.2854 0.5032
Trypanosoma brucei unspecified product 0.0041 0.0353 0.0579
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0074 0.0103
Schistosoma mansoni hypothetical protein 0.0026 0.0149 0.0208
Echinococcus granulosus Solute carrier organic anion transporter family 0.0127 0.1571 0.2188
Echinococcus granulosus lamin 0.002 0.0065 0.0091
Echinococcus multilocularis 0.0027 0.0152 0.0212
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0037 0.0296 0.0412
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0416 0.5672 0.7899
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0085 0.098 0.1364
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0085 0.098 0.416
Onchocerca volvulus 0.0037 0.0296 0.1044
Loa Loa (eye worm) hypothetical protein 0.0027 0.0152 0.0152
Brugia malayi Doublecortin family protein 0.003 0.0199 0.0351
Plasmodium falciparum thioredoxin reductase 0.0037 0.0294 0.0404
Loa Loa (eye worm) intermediate filament protein 0.002 0.0065 0.0065
Entamoeba histolytica P-glycoprotein 5, putative 0.0085 0.098 0.6181
Echinococcus granulosus acetylcholinesterase 0.0217 0.2854 0.3974
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0027 0.0152 0.0026
Trichomonas vaginalis Arginase, putative 0.0122 0.15 0.6733
Onchocerca volvulus 0.0037 0.0296 0.1044
Trichomonas vaginalis ap endonuclease, putative 0.0029 0.0184 0.022
Brugia malayi bHLH-PAS transcription factor 0.0027 0.0162 0.0286
Schistosoma mansoni aldehyde dehydrogenase 0.0046 0.0427 0.0595
Echinococcus granulosus ATP binding cassette sub family B 0.0026 0.0139 0.0194
Loa Loa (eye worm) glutathione reductase 0.0037 0.0294 0.0294
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0074 0.0131
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0029 0.0184 0.0256
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0416 0.5672 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0037 0.0296 0.0412
Trypanosoma brucei DNA polymerase eta, putative 0.0026 0.0138 0.0199
Schistosoma mansoni multidrug resistance protein 0.0085 0.098 0.1364
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0085 0.098 0.1364
Brugia malayi ABC transporter family protein 0.0027 0.0152 0.0269
Leishmania major ATP-binding cassette protein subfamily C, member 8, putative 0.0027 0.0152 0.0026
Brugia malayi MH1 domain containing protein 0.0021 0.0069 0.0122
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0043 0.0389 0.0389
Plasmodium vivax multidomain scavenger receptor, putative 0.003 0.0199 0.0345
Brugia malayi nuclear hormone receptor 0.0021 0.0074 0.0131
Brugia malayi follicle stimulating hormone receptor 0.0175 0.2261 0.3987
Loa Loa (eye worm) hypothetical protein 0.0021 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0127 0.1571 0.1571
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0433 0.0603
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0294 0.0294
Brugia malayi hypothetical protein 0.003 0.0199 0.0351
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0074 0.0103
Brugia malayi polk-prov protein 0.0028 0.0174 0.0306
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0074 0.0131
Echinococcus granulosus lipoxygenase domain containing protein 0.003 0.0199 0.0277
Loa Loa (eye worm) hypothetical protein 0.0043 0.0389 0.0389
Loa Loa (eye worm) hypothetical protein 0.002 0.006 0.006
Entamoeba histolytica P-glycoprotein-2, putative 0.0085 0.098 0.6181
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0085 0.098 0.416
Plasmodium falciparum glutathione reductase 0.0037 0.0294 0.0404
Schistosoma mansoni microtubule-associated protein tau 0.0522 0.7181 1
Brugia malayi hypoxia-induced factor 1 0.0114 0.1392 0.2453
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0084 0.0961 0.1338
Mycobacterium tuberculosis Iron-regulated transporter IrtA 0.0027 0.0152 0.0149
Trypanosoma brucei multidrug resistance protein E 0.0027 0.0152 0.0224
Echinococcus multilocularis microtubule associated protein 2 0.0522 0.7181 1
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0074 0.0261
Trypanosoma brucei trypanothione reductase 0.0037 0.0294 0.0475
Brugia malayi ABC transporter transmembrane region family protein 0.0027 0.0152 0.0269
Loa Loa (eye worm) hypothetical protein 0.002 0.0065 0.0065
Leishmania major ABC-thiol transporter 0.0027 0.0152 0.0026
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0074 0.0131
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0027 0.0152 0.0026
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0085 0.098 0.1364
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0273 0.3653 0.6439
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (large chain) 0.0079 0.09 0.8001
Schistosoma mansoni ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6) 0.0026 0.0139 0.0194
Echinococcus granulosus multidrug resistance protein 1 0.0059 0.0616 0.0858
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.005 0.0484 0.0674
Loa Loa (eye worm) hypothetical protein 0.0026 0.0139 0.0139
Entamoeba histolytica ATP-binding cassette protein, putative 0.0027 0.0152 0.0104
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0083 0.0958 0.8614
Echinococcus multilocularis multidrug resistance protein 1 0.0059 0.0616 0.0858
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0074 0.0074
Loa Loa (eye worm) ABC transporter 0.0027 0.0152 0.0152
Loa Loa (eye worm) hypothetical protein 0.0273 0.3653 0.3653
Echinococcus multilocularis transfer RNA-Lys 0.0027 0.0162 0.0226
Treponema pallidum hypothetical protein 0.0027 0.0163 0.7696
Loa Loa (eye worm) hypothetical protein 0.0085 0.098 0.098
Plasmodium vivax multidrug resistance protein 1, putative 0.0085 0.098 0.6141
Plasmodium falciparum multidrug resistance protein 1 0.0085 0.098 0.2363
Echinococcus multilocularis transcription factor Dp 1 0.0029 0.0186 0.0259
Schistosoma mansoni loxhd1 0.003 0.0199 0.0277
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0074 0.0103
Echinococcus multilocularis dna polymerase kappa 0.0046 0.0424 0.059
Loa Loa (eye worm) MH2 domain-containing protein 0.0021 0.0069 0.0069
Brugia malayi Thioredoxin reductase 0.0037 0.0294 0.0518
Loa Loa (eye worm) hypothetical protein 0.0037 0.0296 0.0296
Echinococcus multilocularis para nitrobenzyl esterase 0.0037 0.0296 0.0412
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0085 0.098 0.416
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.0079 0.09 0.6641
Schistosoma mansoni hypothetical protein 0.0128 0.1594 0.222
Schistosoma mansoni follistatin 0.0043 0.0389 0.0541
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0085 0.098 0.5
Echinococcus multilocularis musashi 0.002 0.0065 0.0091
Loa Loa (eye worm) carboxylesterase 0.0037 0.0296 0.0296
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0085 0.098 0.098
Loa Loa (eye worm) hypothetical protein 0.0216 0.2836 0.2836
Leishmania major DNA polymerase kappa, putative 0.0031 0.0209 0.0128
Trypanosoma cruzi DNA polymerase kappa, putative 0.0046 0.0424 0.0516
Leishmania major ATP-binding cassette protein subfamily B, member 3, putative 0.0027 0.0152 0.0026
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0294 0.0282
Brugia malayi ImpB/MucB/SamB family protein 0.0026 0.0138 0.0244
Entamoeba histolytica Arginase, putative 0.0122 0.15 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0029 0.0184 0.028
Plasmodium falciparum LCCL domain-containing protein 0.003 0.0199 0.0133
Schistosoma mansoni BC026374 protein (S09 family) 0.0037 0.0296 0.0412
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0085 0.098 0.416
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0046 0.0427 0.0595
Echinococcus multilocularis Polycystic kidney disease protein 0.003 0.0199 0.0277
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0306 0.0304
Onchocerca volvulus 0.0037 0.0307 0.1081
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0074 0.0103
Brugia malayi P-glycoprotein-like protein 0.0027 0.0152 0.0269
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0085 0.098 0.1364
Schistosoma mansoni rab6-interacting 0.003 0.0199 0.0277
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0424 0.0705
Onchocerca volvulus 0.0043 0.0389 0.1371
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0294 0.1051
Schistosoma mansoni lamin 0.002 0.0065 0.0091
Trypanosoma brucei ABC transporter, mitochondrial, putative 0.0027 0.0152 0.0224
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0074 0.0103
Mycobacterium ulcerans putative regulatory protein 0.0027 0.0162 0.1198
Trichomonas vaginalis conserved hypothetical protein 0.0122 0.15 0.6733
Trypanosoma cruzi DNA polymerase kappa, putative 0.0046 0.0424 0.0516
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0037 0.0296 0.0775
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0306 0.0827
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0074 0.0261
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0074 0.0103
Echinococcus granulosus transcription factor Dp 1 0.0029 0.0186 0.0259
Trypanosoma cruzi agmatinase, putative 0.0044 0.0403 0.0478
Entamoeba histolytica P-glycoprotein-2, putative 0.0026 0.0139 0.0008
Mycobacterium tuberculosis Probable drugs-transport transmembrane ATP-binding protein ABC transporter 0.0027 0.0152 0.0149
Loa Loa (eye worm) hypothetical protein 0.0021 0.0074 0.0074
Brugia malayi Cytochrome P450 family protein 0.0037 0.0299 0.0528
Schistosoma mansoni smdr2 0.0085 0.098 0.1364
Trichomonas vaginalis taga, putative 0.0085 0.098 0.416
Schistosoma mansoni rab6-interacting 0.003 0.0199 0.0277
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0085 0.098 0.416
Entamoeba histolytica ATP-binding cassette protein, putative 0.0027 0.0152 0.0104
Schistosoma mansoni smdr1 0.0027 0.0152 0.0212
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (small chain) 0.0032 0.0231 0.0974
Loa Loa (eye worm) hypothetical protein 0.0037 0.0296 0.0296
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.005 0.0482 0.3561
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.005 0.0484 0.0854
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0027 0.0152 0.0026
Echinococcus granulosus intermediate filament protein 0.002 0.0065 0.0091
Brugia malayi Smad1 0.0021 0.0069 0.0122
Schistosoma mansoni smad1 5 8 and 0.0021 0.0069 0.0096
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0027 0.0152 0.1126
Onchocerca volvulus 0.0127 0.1571 0.554
Schistosoma mansoni carbonic anhydrase 0.0273 0.3653 0.5086
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0093 0.109 1
Echinococcus multilocularis geminin 0.0128 0.1594 0.222
Trypanosoma cruzi multidrug resistance protein E, putative 0.0027 0.0152 0.0026
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0433 0.0603
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0074 0.0103
Toxoplasma gondii aldehyde dehydrogenase 0.0046 0.0427 0.0786
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0127 0.1571 0.2188
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0074 0.0103
Echinococcus multilocularis multidrug resistance associated protein 1 0.0027 0.0152 0.0212
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0074 0.0103
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0085 0.098 0.152
Trichomonas vaginalis ABC transporter, putative 0.0085 0.098 0.416
Loa Loa (eye worm) hypothetical protein 0.0021 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0273 0.3653 0.3653
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0085 0.098 0.1364
Trichomonas vaginalis xanthine dehydrogenase, putative 0.0168 0.2159 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0037 0.0299 0.0299
Loa Loa (eye worm) doublecortin family protein 0.003 0.0199 0.0199
Loa Loa (eye worm) carboxylesterase 0.0037 0.0296 0.0296
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0085 0.098 0.416
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0037 0.0296 0.0412
Loa Loa (eye worm) hypothetical protein 0.0027 0.0152 0.0152
Echinococcus granulosus BC026374 protein S09 family 0.0037 0.0296 0.0412
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0085 0.098 0.1364
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0074 0.0131
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0174 0.0262
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0085 0.098 0.416
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0209 0.0325
Schistosoma mansoni carbonic anhydrase-related 0.0273 0.3653 0.5086
Schistosoma mansoni multidrug resistance protein 0.0085 0.098 0.1364
Giardia lamblia ABC transporter, putative 0.0027 0.0152 0.1883
Schistosoma mansoni ap endonuclease 0.0029 0.0184 0.0256
Echinococcus multilocularis follistatin 0.0043 0.0389 0.0541
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0031 0.0209 0.0128
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0043 0.0389 0.0675
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0027 0.0152 0.0224
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0306 0.044
Mycobacterium ulcerans DNA polymerase IV 0.0046 0.0424 0.3127
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0074 0.0103
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0046 0.0427 0.0595
Brugia malayi hypothetical protein 0.0027 0.0152 0.0269
Loa Loa (eye worm) hypothetical protein 0.0037 0.0296 0.0296
Loa Loa (eye worm) hypothetical protein 0.0037 0.0296 0.0296
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0074 0.0131
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0093 0.109 1
Echinococcus granulosus Polycystic kidney disease protein 0.003 0.0199 0.0277
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0273 0.3653 0.6439
Onchocerca volvulus 0.0027 0.0162 0.0572
Echinococcus granulosus TGF beta signal transducer SmadC 0.0021 0.0069 0.0096
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0074 0.0131
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0074 0.0103
Loa Loa (eye worm) ABC transporter 0.0027 0.0152 0.0152
Trypanosoma cruzi ABC transporter of the mitochondrion, putative 0.0027 0.0152 0.0026
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0217 0.2854 0.3974

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.