Detailed information for compound 1528218

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 342.176 | Formula: C18H9Cl2NO2
  • H donors: 0 H acceptors: 2 LogP: 4.91 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1c(=O)oc2c(c1/C=C/c1ccc(cc1)Cl)cc(cc2)Cl
  • InChi: 1S/C18H9Cl2NO2/c19-12-4-1-11(2-5-12)3-7-14-15-9-13(20)6-8-17(15)23-18(22)16(14)10-21/h1-9H/b7-3+
  • InChiKey: LJYJGXSZGPAJOF-XVNBXDOJSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0299 0.0553 0.8616
Schistosoma mansoni hypothetical protein 0.0048 0.0063 0.0964
Onchocerca volvulus 0.0105 0.0174 0.3038
Brugia malayi nuclear receptor NHR-88 0.0021 0.0009 0.0155
Plasmodium vivax hypothetical protein, conserved 0.004 0.0047 0.2301
Entamoeba histolytica hypothetical protein 0.0024 0.0014 0.0109
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0009 0.0155
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0063 0.1131
Loa Loa (eye worm) hypothetical protein 0.004 0.0047 0.0843
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0009 0.0122
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0014 0.0109
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0009 0.0122
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0009 0.0155
Schistosoma mansoni importin beta-1 0.0028 0.0023 0.0347
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0009 0.0155
Echinococcus granulosus importin subunit beta 1 0.0028 0.0023 0.0347
Loa Loa (eye worm) hypothetical protein 0.0152 0.0266 0.4809
Brugia malayi glutaminase DH11.1 0.0264 0.0485 0.8779
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0155
Trichomonas vaginalis esterase, putative 0.004 0.0047 0.0699
Schistosoma mansoni hypothetical protein 0.0344 0.0642 1
Loa Loa (eye worm) beta-lactamase 0.004 0.0047 0.0843
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0105 0.0174 0.3038
Toxoplasma gondii ABC1 family protein 0.004 0.0047 0.0038
Mycobacterium ulcerans aminopeptidase N PepN 0.0299 0.0553 0.0539
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0009 0.0122
Loa Loa (eye worm) intermediate filament protein 0.003 0.0027 0.0495
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0013 0.0075
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0027 0.0495
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0047 0.0699
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0194 0.0347 0.5409
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0047 0.0716
Entamoeba histolytica aminopeptidase, putative 0.0299 0.0553 1
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0105 0.0174 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0063 0.0964
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0105 0.0174 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0047 0.0843
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0105 0.0174 0.2702
Toxoplasma gondii aminopeptidase n, putative 0.0105 0.0174 0.0166
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0063 0.0964
Brugia malayi follicle stimulating hormone receptor 0.0259 0.0474 0.8579
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0009 0.0122
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0009 0.0155
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0063 0.1131
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0009 0.0155
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0023 0.0347
Onchocerca volvulus 0.003 0.0027 0.0345
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0047 0.0699
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0072 0.1109
Loa Loa (eye worm) hypothetical protein 0.0084 0.0132 0.239
Brugia malayi beta-lactamase family protein 0.004 0.0047 0.0843
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0105 0.0174 0.2702
Loa Loa (eye worm) hypothetical protein 0.0123 0.021 0.3792
Loa Loa (eye worm) hypothetical protein 0.0105 0.0174 0.3146
Toxoplasma gondii pantoate-beta-alanine ligase 0.5133 1 1
Onchocerca volvulus 0.004 0.0047 0.0699
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0299 0.0553 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0009 0.0122
Trypanosoma cruzi aminopeptidase, putative 0.0299 0.0553 1
Mycobacterium leprae Probable lipase LipE 0.004 0.0047 0.0032
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0299 0.0553 1
Schistosoma mansoni hypothetical protein 0.0051 0.0069 0.1062
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0047 0.0699
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0047 0.0716
Echinococcus granulosus intermediate filament protein 0.003 0.0027 0.0415
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0009 0.0122
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0259 0.0474 0.8579
Brugia malayi MH1 domain containing protein 0.0017 0.0001 0.0014
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0105 0.0174 0.3038
Brugia malayi MH2 domain containing protein 0.0017 0.0001 0.0014
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0009 0.0155
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0299 0.0553 0.8616
Trypanosoma cruzi Aminopeptidase M1, putative 0.0299 0.0553 1
Onchocerca volvulus Huntingtin homolog 0.0123 0.021 0.3694
Loa Loa (eye worm) hypothetical protein 0.0252 0.0461 0.8332
Brugia malayi MH1 domain containing protein 0.0017 0.0001 0.0014
Schistosoma mansoni hypothetical protein 0.0104 0.0172 0.2668
Loa Loa (eye worm) hypothetical protein 0.0104 0.0172 0.3107
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0047 0.0699
Loa Loa (eye worm) hypothetical protein 0.0105 0.0174 0.3146
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0105 0.0174 0.3038
Mycobacterium tuberculosis Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.5133 1 1
Loa Loa (eye worm) peptidase family M1 containing protein 0.0105 0.0174 0.3146
Mycobacterium ulcerans lipase LipD 0.004 0.0047 0.0032
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0009 0.0122
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0009 0.0155
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0014 0.0006
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0009 0.0122
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0009 0.0155
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0047 0.0032
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.0072 0.1299
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0299 0.0553 1
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.026 0.0477 0.8626
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0009 0.0122
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0302 0.5392
Echinococcus multilocularis snurportin 1 0.0298 0.0551 0.8579
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0105 0.0174 0.3038
Loa Loa (eye worm) glutaminase 0.0264 0.0485 0.8779
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0009 0.0122
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0105 0.0174 0.2702
Brugia malayi hypothetical protein 0.0105 0.0174 0.3146
Mycobacterium ulcerans glutaminase 0.0264 0.0485 0.0472
Schistosoma mansoni hypothetical protein 0.0048 0.0063 0.0964
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0194 0.0347 0.5409
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0009 0.0155
Mycobacterium ulcerans beta-lactamase 0.004 0.0047 0.0032
Onchocerca volvulus 0.0084 0.0132 0.227
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0299 0.0553 0.8616
Schistosoma mansoni survival motor neuron protein 0.0051 0.0069 0.1062
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0047 0.0032
Echinococcus multilocularis aminopeptidase N 0.0299 0.0553 0.8616
Onchocerca volvulus 0.0051 0.0069 0.1107
Loa Loa (eye worm) Smad1 0.0017 0.0001 0.0014
Loa Loa (eye worm) MH2 domain-containing protein 0.0243 0.0443 0.8007
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0009 0.0122
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0299 0.0553 0.8616
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0155
Brugia malayi TATA binding protein associated factor 0.0105 0.0174 0.3146
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0009 0.0155
Schistosoma mansoni hypothetical protein 0.0344 0.0642 1
Schistosoma mansoni hypothetical protein 0.0048 0.0063 0.0964
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.032 0.5722
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0047 0.0032
Echinococcus granulosus GPCR family 2 0.0048 0.0063 0.0964
Mycobacterium tuberculosis Conserved protein 0.004 0.0047 0.0032
Brugia malayi Importin beta-1 subunit 0.0028 0.0023 0.0415
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0299 0.0553 1
Leishmania major importin beta-1 subunit, putative 0.0023 0.0013 0.0075
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0013 0.0075
Onchocerca volvulus 0.0299 0.0553 1
Mycobacterium tuberculosis Conserved protein 0.004 0.0047 0.0032
Toxoplasma gondii aminopeptidase N protein 0.0105 0.0174 0.0166
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0194 0.0347 0.6225
Echinococcus multilocularis L aminoadipate semialdehyde 0.0084 0.0132 0.205
Schistosoma mansoni hypothetical protein 0.0298 0.0551 0.8579
Trichomonas vaginalis glucosylceramidase, putative 0.026 0.0477 0.8605
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0047 0.0032
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0105 0.0174 0.3038
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0009 0.0122
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0072 0.1109
Loa Loa (eye worm) hypothetical protein 0.004 0.0047 0.0843
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0299 0.0553 1
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0105 0.0174 0.2702
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0072 0.1109
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0302 0.5392
Leishmania major hypothetical protein, conserved 0.004 0.0047 0.0699
Trichomonas vaginalis glutaminase, putative 0.0264 0.0485 0.8759
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0014 0.0358
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0047 0.0032
Schistosoma mansoni aminopeptidase A (M01 family) 0.0105 0.0174 0.2702
Echinococcus granulosus lamin dm0 0.003 0.0027 0.0415
Loa Loa (eye worm) hypothetical protein 0.003 0.0026 0.0475
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0105 0.0174 1
Echinococcus granulosus L aminoadipate semialdehyde 0.0084 0.0132 0.205
Trypanosoma cruzi aminopeptidase, putative 0.0105 0.0174 0.3038
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0009 0.0155
Brugia malayi Calcitonin receptor-like protein seb-1 0.0152 0.0266 0.4809
Loa Loa (eye worm) hypothetical protein 0.003 0.0027 0.0495
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0001 0.0014
Echinococcus multilocularis lamin 0.003 0.0027 0.0415
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0009 0.0122
Loa Loa (eye worm) hypothetical protein 0.004 0.0047 0.0843
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0155
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0023 0.0014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0009 0.0155
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0256 0.0468 0.0454
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0009 0.0122
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0299 0.0553 0.8616
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0302 0.5392
Loa Loa (eye worm) hypothetical protein 0.004 0.0047 0.0843
Brugia malayi RNA, U transporter 1 0.0079 0.0124 0.2234
Trichomonas vaginalis glucosylceramidase, putative 0.026 0.0477 0.8605
Echinococcus granulosus aminopeptidase N 0.0299 0.0553 0.8616
Trypanosoma brucei aminopeptidase, putative 0.0105 0.0174 0.3038
Schistosoma mansoni lamin 0.003 0.0027 0.0415
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0105 0.0174 0.3038
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0014 0.5
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0009 0.0155
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0023 0.0264
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0009 0.0122
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0009 0.0122
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0013 0.0075
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0009 0.0122
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0009 0.5
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0299 0.0553 0.8616
Loa Loa (eye worm) hypothetical protein 0.0194 0.0347 0.6284
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0105 0.0174 0.2702
Loa Loa (eye worm) glutaminase 2 0.0264 0.0485 0.8779
Loa Loa (eye worm) transcription factor SMAD2 0.0243 0.0443 0.8007
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0009 0.0122
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0302 0.5392
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0302 0.5392
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0047 0.0032
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0299 0.0553 0.8616
Onchocerca volvulus Glucosylceramidase homolog 0.0171 0.0302 0.5392
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0084 0.0132 0.205
Brugia malayi MH2 domain containing protein 0.0017 0.0001 0.0014
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0009 0.0122
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0047 0.0032
Echinococcus granulosus leukotriene A 4 hydrolase 0.0105 0.0174 0.2702
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0009 0.0122
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0299 0.0553 1
Echinococcus multilocularis GPCR, family 2 0.0048 0.0063 0.0964
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0023 0.0264
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0047 0.0699
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0014 0.5
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0047 0.0032
Brugia malayi hypothetical protein 0.0252 0.0461 0.8332
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0009 0.0155
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0072 0.1109
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0152 0.0266 0.4809
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0009 0.0155
Mycobacterium ulcerans aminopeptidase N PepN 0.0105 0.0174 0.016
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0047 0.0699
Mycobacterium ulcerans hypothetical protein 0.004 0.0047 0.0032
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0063 0.0964
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0298 0.0551 0.9957
Brugia malayi nuclear hormone receptor 0.0021 0.0009 0.0155
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0299 0.0553 0.8616
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0001 0.0014
Echinococcus granulosus lamin 0.003 0.0027 0.0415
Brugia malayi beta-lactamase 0.004 0.0047 0.0843
Trichomonas vaginalis glucosylceramidase, putative 0.026 0.0477 0.8605
Echinococcus multilocularis musashi 0.003 0.0027 0.0415
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0009 0.0122
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0014 0.0006
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0072 0.1109
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0155
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0047 0.0716
Mycobacterium tuberculosis Conserved protein 0.004 0.0047 0.0032
Schistosoma mansoni ran 0.0021 0.0009 0.0122
Brugia malayi latrophilin 2 splice variant baaae 0.0104 0.0172 0.3107
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0155
Brugia malayi Peptidase family M1 containing protein 0.0299 0.0553 1
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0009 0.0122
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0009 0.0155
Trypanosoma brucei Aminopeptidase M1, putative 0.0299 0.0553 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0152 0.0266 0.4809
Schistosoma mansoni hypothetical protein 0.0048 0.0063 0.0964
Schistosoma mansoni lamin 0.003 0.0027 0.0415
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0047 0.0716
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0009 0.0122
Brugia malayi Smad1 0.0017 0.0001 0.0014
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0072 0.1109
Brugia malayi intermediate filament protein 0.003 0.0027 0.0495
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0009 0.0155
Trichomonas vaginalis glucosylceramidase, putative 0.026 0.0477 0.8605
Plasmodium vivax importin-beta 2, putative 0.0028 0.0023 0.0871
Toxoplasma gondii aminopeptidase N, putative 0.0105 0.0174 0.0166
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0009 0.0122
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0155
Mycobacterium ulcerans pantoate--beta-alanine ligase 0.5133 1 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0155
Brugia malayi hypothetical protein 0.0299 0.0553 1
Trichomonas vaginalis glucosylceramidase, putative 0.026 0.0477 0.8605
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0105 0.0174 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0009 0.0122
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0069 0.1245
Brugia malayi ecdysteroid receptor 0.0021 0.0009 0.0155
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0155
Echinococcus multilocularis lamin dm0 0.003 0.0027 0.0415
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0009 0.0155
Loa Loa (eye worm) TATA binding protein associated factor 0.0105 0.0174 0.3146
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0009 0.0122
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0047 0.0699
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0105 0.0174 0.3146
Onchocerca volvulus 0.004 0.0047 0.0699
Echinococcus multilocularis survival motor neuron protein 1 0.0252 0.0461 0.7177
Schistosoma mansoni intermediate filament proteins 0.003 0.0027 0.0415
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0084 0.0132 0.239
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0009 0.0122
Brugia malayi hypothetical protein 0.0123 0.021 0.3792
Brugia malayi steroid hormone receptor 0.0021 0.0009 0.0155
Brugia malayi MH2 domain containing protein 0.0243 0.0443 0.8007
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0063 0.1131
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0302 0.5392
Onchocerca volvulus 0.0299 0.0553 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0009 0.0155
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0014 0.0358
Schistosoma mansoni glutaminase 0.0264 0.0485 0.7562
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0009 0.0122
Loa Loa (eye worm) hypothetical protein 0.004 0.0047 0.0843
Loa Loa (eye worm) hypothetical protein 0.0105 0.0174 0.3146
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0009 0.0122
Onchocerca volvulus 0.003 0.0027 0.0345
Trichomonas vaginalis glucosylceramidase, putative 0.026 0.0477 0.8605
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0009 0.0122
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0047 0.0032
Loa Loa (eye worm) hypothetical protein 0.0194 0.0347 0.6284
Loa Loa (eye worm) hypothetical protein 0.004 0.0047 0.0843
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0299 0.0553 0.8616
Loa Loa (eye worm) hypothetical protein 0.0194 0.0347 0.6284
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0299 0.0553 0.8616
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.032 0.5722
Brugia malayi Peptidase family M1 containing protein 0.0299 0.0553 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0009 0.0122
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0047 0.0699
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0063 0.0964
Brugia malayi Peptidase family M1 containing protein 0.0105 0.0174 0.3146
Echinococcus granulosus survival motor neuron protein 1 0.0252 0.0461 0.7177
Schistosoma mansoni coup transcription factor 0.0021 0.0009 0.0122
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0299 0.0553 0.8616
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0027 0.0495
Echinococcus granulosus geminin 0.0344 0.0642 1
Onchocerca volvulus Huntingtin homolog 0.0123 0.021 0.3694
Loa Loa (eye worm) hypothetical protein 0.0028 0.0023 0.0415
Loa Loa (eye worm) aminopeptidase N 0.0299 0.0553 1
Trypanosoma brucei Aminopeptidase M1, putative 0.0299 0.0553 1
Plasmodium falciparum importin beta, putative 0.0028 0.0023 0.0871
Brugia malayi beta-lactamase family protein 0.004 0.0047 0.0843
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0302 0.5392
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0009 0.0155
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0009 0.0155
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0024 0.0014 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0009 0.0155
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0009 0.0122
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.026 0.0477 0.8626
Onchocerca volvulus 0.004 0.0047 0.0699
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0009 0.0155
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0299 0.0553 0.8616
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0105 0.0174 0.3038
Mycobacterium leprae conserved hypothetical protein 0.004 0.0047 0.0032
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0072 0.1109
Loa Loa (eye worm) hypothetical protein 0.0123 0.021 0.3792
Schistosoma mansoni ran 0.0021 0.0009 0.0122
Echinococcus granulosus snurportin 1 0.0298 0.0551 0.8579
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0009 0.0155
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0009 0.0155
Entamoeba histolytica hypothetical protein 0.0023 0.0013 0.0075
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0014 0.0109
Loa Loa (eye worm) hypothetical protein 0.0048 0.0063 0.1131
Echinococcus multilocularis geminin 0.0344 0.0642 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0009 0.0155
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.0072 0.1299
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0047 0.0843
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0013 0.0075

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) Antitubercular activity against Mycobacterium tuberculosis H37Rv ATCC 27294 at 6.25 ug/ml by microplate alamar blue assay ChEMBL. 21396814
Inhibition (functional) = 0 % Antiinflammatory activity in human THP1 cells assessed as inhibition of LPS-induced TNFalpha production at 10 uM after 24 hrs by ELISA ChEMBL. 21396814
Inhibition (functional) = 4 % Antiinflammatory activity in human THP1 cells assessed as inhibition of LPS-induced IL6 production at 10 uM after 24 hrs by ELISA ChEMBL. 21396814

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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