Detailed information for compound 1528278

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 559.12 | Formula: C28H35ClN4O4S
  • H donors: 2 H acceptors: 4 LogP: 3.06 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(N[C@@H]1CCCc2c1ccc(c2)CN1CCCCC1)CC1C(=O)NCCN1S(=O)(=O)c1ccc(cc1)Cl
  • InChi: 1S/C28H35ClN4O4S/c29-22-8-10-23(11-9-22)38(36,37)33-16-13-30-28(35)26(33)18-27(34)31-25-6-4-5-21-17-20(7-12-24(21)25)19-32-14-2-1-3-15-32/h7-12,17,25-26H,1-6,13-16,18-19H2,(H,30,35)(H,31,34)/t25-,26?/m1/s1
  • InChiKey: CPWRRSSZELRMHM-DCWQJPKNSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens bradykinin receptor B1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0048 0.1744 0.2544
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0048 0.1744 0.2544
Brugia malayi multidrug Resistance Protein family member (mrp-5), putative 0.0029 0.0838 0.1134
Echinococcus multilocularis g protein coupled receptor 0.0048 0.1744 0.2544
Echinococcus multilocularis allatostatin A receptor 0.0048 0.1744 0.2544
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0092 0.3839 0.5918
Brugia malayi hypothetical protein 0.0048 0.1744 0.2358
Echinococcus granulosus biogenic amine 5HT receptor 0.0048 0.1744 0.2544
Entamoeba histolytica P-glycoprotein 5, putative 0.0028 0.079 0.0812
Echinococcus granulosus 3'partial|arginase 2 mitochondrial 0.0145 0.6373 1
Brugia malayi ABC transporter transmembrane region family protein 0.0028 0.079 0.1069
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0048 0.1744 0.2544
Echinococcus multilocularis arginase 2, mitochondrial 0.0145 0.6373 1
Brugia malayi putative neuropeptide receptor NPR1 0.0048 0.1744 0.2358
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0029 0.0838 0.1047
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0092 0.3839 0.5901
Echinococcus granulosus neuropeptide receptor A26 0.0048 0.1744 0.2544
Loa Loa (eye worm) hypothetical protein 0.0048 0.1744 0.2185
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0048 0.1744 0.2544
Entamoeba histolytica P-glycoprotein-2 0.0092 0.3839 0.5829
Loa Loa (eye worm) hypothetical protein 0.0048 0.1744 0.2185
Loa Loa (eye worm) glutathione reductase 0.0044 0.1547 0.1913
Loa Loa (eye worm) hypothetical protein 0.0048 0.1744 0.2185
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0046 0.1659 0.2244
Loa Loa (eye worm) hypothetical protein 0.0048 0.1744 0.2185
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0099 0.4205 0.8837
Trypanosoma brucei trypanothione reductase 0.0044 0.1547 0.7566
Loa Loa (eye worm) hypothetical protein 0.0029 0.0838 0.0932
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.1744 0.2544
Loa Loa (eye worm) hypothetical protein 0.0046 0.1659 0.2068
Entamoeba histolytica P-glycoprotein 6, putative 0.0029 0.0838 0.089
Schistosoma mansoni hypothetical protein 0.0031 0.0967 0.0817
Plasmodium falciparum ABC transporter B family member 4, putative 0.0029 0.0838 0.1047
Brugia malayi ABC transporter family protein 0.0029 0.0838 0.1134
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0048 0.1744 0.1606
Loa Loa (eye worm) MH2 domain-containing protein 0.011 0.471 0.6289
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0048 0.1744 0.1606
Echinococcus multilocularis sex peptide receptor 0.0048 0.1744 0.2544
Loa Loa (eye worm) hypothetical protein 0.0048 0.1744 0.2185
Echinococcus granulosus ATP binding cassette sub family B 0.0029 0.0838 0.1086
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0092 0.3839 0.5918
Leishmania major pentamidine resistance protein 1 0.0029 0.0838 0.1047
Brugia malayi AKH receptor 0.0048 0.1744 0.2358
Brugia malayi G protein-coupled receptor 0.0048 0.1744 0.2358
Trypanosoma cruzi agmatinase, putative 0.0053 0.1983 1
Echinococcus multilocularis g-protein coupled receptor 0.0048 0.1744 0.2544
Echinococcus multilocularis neuropeptide receptor A26 0.0048 0.1744 0.2544
Wolbachia endosymbiont of Brugia malayi ABC-type protease secretion system, ATPase and permease component, AprD 0.0029 0.0838 1
Trypanosoma cruzi arginase, putative 0.0053 0.1983 1
Toxoplasma gondii ATP-binding cassette sub-family B member 5 0.0029 0.0838 0.1774
Leishmania major agmatinase-like protein 0.0053 0.1983 0.2898
Echinococcus multilocularis fmrfamide receptor 0.0048 0.1744 0.2544
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.1744 0.2544
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0017 0.0297 0.1641
Echinococcus granulosus multidrug resistance associated protein 7 0.0029 0.0838 0.1086
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.1744 0.2544
Loa Loa (eye worm) hypothetical protein 0.0048 0.1744 0.2185
Brugia malayi ORL1-like opioid receptor 0.0048 0.1744 0.2358
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0029 0.0838 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.1744 0.2185
Echinococcus multilocularis dro:myosuppressin receptor 0.0048 0.1744 0.2544
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0048 0.1744 0.1606
Giardia lamblia MRP-like ABC transporter 0.0029 0.0838 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0048 0.1744 0.2358
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.1744 0.2544
Leishmania major ATP-binding cassette protein subfamily C, member 8, putative 0.0029 0.0838 0.1047
Loa Loa (eye worm) hypothetical protein 0.0048 0.1744 0.2185
Loa Loa (eye worm) hypothetical protein 0.0028 0.079 0.0867
Brugia malayi Tachykinin-like peptides receptor 99D 0.0048 0.1744 0.2358
Loa Loa (eye worm) hypothetical protein 0.0048 0.1744 0.2185
Schistosoma mansoni multidrug resistance protein 0.0092 0.3839 0.3736
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0092 0.3839 0.5901
Loa Loa (eye worm) multidrug resistance protein 3 0.0092 0.3839 0.5083
Echinococcus granulosus 7tm_1 domain containing protein 0.0048 0.1744 0.2544
Toxoplasma gondii ABC transporter, putative 0.0029 0.0838 0.1774
Echinococcus granulosus hypothetical protein 0.0048 0.1744 0.2544
Plasmodium falciparum ABC transporter B family member 3, putative 0.0029 0.0838 0.1047
Loa Loa (eye worm) hypothetical protein 0.0048 0.1744 0.2185
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0044 0.1547 0.2985
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.1744 0.1606
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0048 0.1744 0.2544
Trypanosoma cruzi arginase, putative 0.0053 0.1983 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.1744 0.2544
Loa Loa (eye worm) hypothetical protein 0.0031 0.0967 0.1111
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0048 0.1744 0.1606
Trichomonas vaginalis ABC transporter, putative 0.0092 0.3839 0.5901
Entamoeba histolytica P-glycoprotein 6, putative 0.0029 0.0838 0.089
Loa Loa (eye worm) hypothetical protein 0.0166 0.7393 1
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0092 0.3839 0.8031
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0092 0.3839 0.5901
Schistosoma mansoni multidrug resistance protein 0.0029 0.0838 0.0685
Entamoeba histolytica P-glycoprotein-1 0.0092 0.3839 0.5829
Schistosoma mansoni neuropeptide F-like receptor 0.0048 0.1744 0.1606
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0092 0.3839 0.5918
Echinococcus granulosus neuropeptide receptor 0.0048 0.1744 0.2544
Trypanosoma cruzi agmatinase, putative 0.0053 0.1983 1
Trichomonas vaginalis ap endonuclease, putative 0.0017 0.0297 0.0172
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0048 0.1744 0.2544
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.1744 0.2544
Echinococcus granulosus g-protein coupled receptor 0.0048 0.1744 0.2544
Brugia malayi ABC transporter family protein 0.0092 0.3839 0.5192
Trichomonas vaginalis abcb9, putative 0.0092 0.3839 0.5901
Echinococcus granulosus multidrug resistance protein 1 0.0092 0.3839 0.5918
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0092 0.3839 0.5918
Brugia malayi glutathione reductase 0.0044 0.1547 0.2092
Plasmodium vivax multidrug resistance-associated protein 2, putative 0.0029 0.0838 0.1047
Schistosoma mansoni multidrug resistance protein 0.0029 0.0838 0.0685
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0048 0.1744 0.2544
Schistosoma mansoni hypothetical protein 0.0048 0.1744 0.1606
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.1744 0.1606
Schistosoma mansoni adenoreceptor 0.0048 0.1744 0.1606
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0099 0.4205 0.8837
Giardia lamblia ABC transporter, putative 0.0029 0.0838 1
Schistosoma mansoni ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6) 0.0028 0.079 0.0637
Brugia malayi hypothetical protein 0.0048 0.1744 0.2358
Loa Loa (eye worm) hypothetical protein 0.0048 0.1744 0.2185
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0164 0.0222
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0092 0.3839 0.5918
Brugia malayi hypothetical protein 0.0048 0.1744 0.2358
Loa Loa (eye worm) hypothetical protein 0.0048 0.1744 0.2185
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0048 0.1744 0.2185
Echinococcus multilocularis ATP binding cassette sub family B 0.0029 0.0838 0.1086
Brugia malayi exodeoxyribonuclease III family protein 0.0017 0.0297 0.0402
Plasmodium falciparum multidrug resistance-associated protein 1 0.0029 0.0838 0.1047
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0048 0.1744 0.2185
Brugia malayi neuropeptide F receptor 0.0048 0.1744 0.2358
Loa Loa (eye worm) hypothetical protein 0.0048 0.1744 0.2185
Echinococcus multilocularis ATP binding cassette sub family B 0.0029 0.0838 0.1086
Mycobacterium tuberculosis Probable reductase 0.0099 0.4205 0.8837
Schistosoma mansoni myosin xvIII 0.0048 0.1744 0.1606
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.079 0.097
Echinococcus granulosus neuropeptide receptor 0.0048 0.1744 0.2544
Entamoeba histolytica ABC transporter, putative 0.0029 0.0838 0.089
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0092 0.3839 1
Schistosoma mansoni neuropeptide receptor 0.0048 0.1744 0.1606
Echinococcus multilocularis multidrug resistance protein 1 0.0064 0.252 0.3795
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0029 0.0838 0.1774
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.1744 0.1606
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.1744 0.1606
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0048 0.1744 0.2544
Loa Loa (eye worm) ABC transporter 0.0029 0.0838 0.0932
Loa Loa (eye worm) hypothetical protein 0.0048 0.1744 0.2185
Entamoeba histolytica P-glyco protein 6, putative 0.0092 0.3839 0.5829
Mycobacterium tuberculosis Probable oxidoreductase 0.011 0.4733 1
Plasmodium vivax ABC transporter B family member 7, putative 0.0029 0.0838 0.1047
Echinococcus multilocularis somatostatin receptor 0.0048 0.1744 0.2544
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0092 0.3839 0.5901
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0017 0.0297 0.0593
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0017 0.0297 0.0172
Loa Loa (eye worm) thioredoxin reductase 0.0044 0.1547 0.1913
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0029 0.0838 0.1774
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0017 0.0297 0.0593
Brugia malayi G-protein coupled receptor 0.0048 0.1744 0.2358
Echinococcus multilocularis G-protein coupled receptor, putative 0.0048 0.1744 0.2544
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0092 0.3839 0.5918
Loa Loa (eye worm) hypothetical protein 0.0029 0.0838 0.0932
Schistosoma mansoni biogenic amine receptor 0.0048 0.1744 0.1606
Echinococcus multilocularis neuropeptides capa receptor 0.0048 0.1744 0.2544
Plasmodium falciparum ABC transporter B family member 7, putative 0.0029 0.0838 0.1047
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.1744 0.2544
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0028 0.079 0.097
Trichomonas vaginalis ap endonuclease, putative 0.0017 0.0297 0.0172
Brugia malayi hypothetical protein 0.0048 0.1744 0.2358
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0092 0.3839 0.5918
Leishmania major p-glycoprotein 0.0092 0.3839 0.5901
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.1744 0.2544
Echinococcus multilocularis multidrug resistance protein 1 0.0092 0.3839 0.5918
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0029 0.0838 0.1047
Loa Loa (eye worm) neuropeptide F receptor 0.0048 0.1744 0.2185
Loa Loa (eye worm) hypothetical protein 0.0048 0.1744 0.2185
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0092 0.3839 0.5901
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0048 0.1744 0.2358
Schistosoma mansoni biogenic amine receptor 0.0048 0.1744 0.1606
Toxoplasma gondii exonuclease III APE 0.0017 0.0297 0.0291
Echinococcus granulosus ATP binding cassette sub family B 0.0029 0.0838 0.1086
Echinococcus granulosus allatostatin A receptor 0.0048 0.1744 0.2544
Giardia lamblia Multidrug resistance-associated protein 1 0.0029 0.0838 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0048 0.1744 0.2544
Plasmodium vivax multidrug resistance-associated protein 1, putative 0.0029 0.0838 0.1047
Echinococcus multilocularis neuropeptides capa receptor 0.0048 0.1744 0.2544
Brugia malayi Dopamine receptor protein 1 0.0048 0.1744 0.2358
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0048 0.1744 0.1606
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0092 0.3839 0.5918
Echinococcus multilocularis serotonin receptor 0.0048 0.1744 0.2544
Schistosoma mansoni amine GPCR 0.0048 0.1744 0.1606
Brugia malayi ABC transporter 0.0029 0.0838 0.1134
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0048 0.1744 0.2544
Echinococcus granulosus neuropeptide Y receptor 0.0048 0.1744 0.2544
Schistosoma mansoni hypothetical protein 0.0048 0.1744 0.1606
Schistosoma mansoni amine GPCR 0.0048 0.1744 0.1606
Plasmodium vivax ABC transporter B family member 5, putative 0.0029 0.0838 0.1047
Brugia malayi multidrug resistance protein 3 0.0092 0.3839 0.5192
Brugia malayi hypothetical protein 0.0048 0.1744 0.2358
Echinococcus multilocularis ATP binding cassette sub family B 0.0091 0.3791 0.5842
Plasmodium falciparum multidrug resistance protein 2 0.0029 0.0838 0.1047
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0028 0.079 0.097
Echinococcus multilocularis neuropeptide Y receptor 0.0048 0.1744 0.2544
Loa Loa (eye worm) hypothetical protein 0.0048 0.1744 0.2185
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.1744 0.2544
Echinococcus granulosus biogenic amine 5HT receptor 0.0048 0.1744 0.2544
Brugia malayi hypothetical protein 0.0048 0.1744 0.2358
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0029 0.0838 0.1047
Plasmodium vivax glutathione reductase, putative 0.0044 0.1547 0.2193
Echinococcus granulosus tm gpcr rhodopsin 0.0048 0.1744 0.2544
Wolbachia endosymbiont of Brugia malayi ABC-type multidrug transport system, ATPase and permease component 0.0029 0.0838 1
Loa Loa (eye worm) hypothetical protein 0.0092 0.3839 0.5083
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0017 0.0297 0.0172
Echinococcus granulosus somatostatin receptor 0.0048 0.1744 0.2544
Entamoeba histolytica P-glycoprotein-5 0.0092 0.3839 0.5829
Mycobacterium ulcerans component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD 0.0029 0.0838 1
Echinococcus multilocularis orexin receptor type 2 0.0048 0.1744 0.2544
Brugia malayi N-terminal motif family protein 0.0166 0.7393 1
Echinococcus granulosus multidrug resistance protein 1 0.0064 0.252 0.3795
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0092 0.3839 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.1744 0.2185
Brugia malayi latrophilin 2 splice variant baaae 0.0031 0.0967 0.1308
Schistosoma mansoni arginase 0.0145 0.6373 0.6313
Echinococcus multilocularis neuropeptide receptor 0.0048 0.1744 0.2544
Trypanosoma brucei multidrug resistance protein E 0.0029 0.0838 0.3612
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0048 0.1744 0.2544
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0092 0.3839 0.5901
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0092 0.3839 0.5901
Schistosoma mansoni growth hormone secretagogue receptor 0.0048 0.1744 0.1606
Loa Loa (eye worm) ABC transporter 0.0029 0.0838 0.0932
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0048 0.1744 0.2358
Trichomonas vaginalis ABC transporter, putative 0.0092 0.3839 0.5901
Entamoeba histolytica P-glycoprotein 5, putative 0.0092 0.3839 0.5829
Brugia malayi hypothetical protein 0.0048 0.1744 0.2358
Leishmania major ABC-thiol transporter 0.0029 0.0838 0.1047
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0029 0.0838 0.3612
Brugia malayi Dopamine receptor 0.0048 0.1744 0.2358
Trypanosoma cruzi ABC transporter, mitochondrial, putative 0.0029 0.0838 0.3612
Schistosoma mansoni multidrug resistance protein 0.0029 0.0838 0.0685
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0092 0.3839 0.5918
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.1744 0.2544
Echinococcus granulosus neuropeptide FF receptor 2 0.0048 0.1744 0.2544
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0048 0.1744 0.2544
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.1744 0.2544
Schistosoma mansoni alpha-1 adrenergic receptor 0.0048 0.1744 0.1606
Trichomonas vaginalis conserved hypothetical protein 0.0145 0.6373 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.1744 0.2185
Echinococcus granulosus multidrug resistance associated protein 1 0.0029 0.0838 0.1086
Entamoeba histolytica ATP-binding cassette protein, putative 0.0029 0.0838 0.089
Brugia malayi Dopamine receptor protein 2 0.0048 0.1744 0.2358
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0048 0.1744 0.2544
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0048 0.1744 0.2544
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.1744 0.2544
Entamoeba histolytica P-glycoprotein-2 0.0092 0.3839 0.5829
Trichomonas vaginalis ABC transporter, putative 0.0092 0.3839 0.5901
Trypanosoma cruzi ABC transporter of the mitochondrion, putative 0.0029 0.0838 0.3612
Loa Loa (eye worm) hypothetical protein 0.0048 0.1744 0.2185
Schistosoma mansoni neuropeptide f receptor 76f 0.0048 0.1744 0.1606
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.011 0.4733 1
Trichomonas vaginalis Arginase, putative 0.0145 0.6373 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0092 0.3839 0.5901
Echinococcus granulosus multidrug resistance protein 1 0.0092 0.3839 0.5918
Loa Loa (eye worm) hypothetical protein 0.0048 0.1744 0.2185
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0029 0.0838 0.1774
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.1744 0.1606
Loa Loa (eye worm) hypothetical protein 0.0048 0.1744 0.2185
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0092 0.3839 0.5901
Echinococcus granulosus neuropeptide s receptor 0.0048 0.1744 0.2544
Giardia lamblia Hypothetical protein 0.0028 0.079 0.9264
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0092 0.3839 0.5901
Brugia malayi RE15519p 0.0048 0.1744 0.2358
Loa Loa (eye worm) hypothetical protein 0.0048 0.1744 0.2185
Brugia malayi multidrug resistance related protein 1 0.0029 0.0838 0.1134
Schistosoma mansoni opsin-like receptor 0.0048 0.1744 0.1606
Giardia lamblia Multidrug resistance-associated protein 1 0.0028 0.079 0.9264
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0029 0.0838 0.3612
Loa Loa (eye worm) hypothetical protein 0.0048 0.1744 0.2185
Loa Loa (eye worm) hypothetical protein 0.0048 0.1744 0.2185
Trichomonas vaginalis taga, putative 0.0092 0.3839 0.5901
Echinococcus multilocularis multidrug resistance associated protein 1 0.0029 0.0838 0.1086
Loa Loa (eye worm) hypothetical protein 0.0048 0.1744 0.2185
Schistosoma mansoni amine GPCR 0.0048 0.1744 0.1606
Echinococcus granulosus dro:myosuppressin receptor 0.0048 0.1744 0.2544
Loa Loa (eye worm) hypothetical protein 0.0048 0.1744 0.2185
Schistosoma mansoni histamine h1 receptor 0.0048 0.1744 0.1606
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0099 0.4205 0.8644
Entamoeba histolytica P-glycoprotein-2, putative 0.0092 0.3839 0.5829
Mycobacterium tuberculosis Probable dehydrogenase 0.0099 0.4205 0.8837
Schistosoma mansoni hypothetical protein 0.0048 0.1744 0.1606
Schistosoma mansoni biogenic amine receptor 0.0048 0.1744 0.1606
Loa Loa (eye worm) hypothetical protein 0.0048 0.1744 0.2185
Entamoeba histolytica ATP-binding cassette protein, putative 0.0029 0.0838 0.089
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.011 0.4733 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.1744 0.2185
Brugia malayi ABC transporter 0.0028 0.079 0.1069
Toxoplasma gondii ABC transporter family protein 0.0029 0.0838 0.1774
Trypanosoma brucei ABC transporter, mitochondrial, putative 0.0029 0.0838 0.3612
Echinococcus multilocularis multidrug resistance protein 1 0.0092 0.3839 0.5918
Loa Loa (eye worm) hypothetical protein 0.0029 0.0838 0.0932
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0048 0.1744 0.2358
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0029 0.0838 0.0932
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0048 0.1744 0.2185
Plasmodium falciparum glutathione reductase 0.0044 0.1547 0.2193
Loa Loa (eye worm) hypothetical protein 0.0048 0.1744 0.2185
Plasmodium vivax arginase, putative 0.0145 0.6373 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0048 0.1744 0.2358
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0017 0.0297 0.0234
Plasmodium falciparum multidrug resistance protein 1 0.0092 0.3839 0.5901
Trypanosoma cruzi trypanothione reductase, putative 0.0044 0.1547 0.7566
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0029 0.0838 0.1047
Echinococcus granulosus sex peptide receptor 0.0048 0.1744 0.2544
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0029 0.0838 0.3612
Trypanosoma brucei agmatinase, putative 0.0053 0.1983 1
Trypanosoma brucei ABC transporter of the mitochondrion, putative 0.0029 0.0838 0.3612
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0092 0.3839 0.5901
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0029 0.0838 0.1774
Schistosoma mansoni ap endonuclease 0.0017 0.0297 0.0135
Schistosoma mansoni opsin-like receptor 0.0048 0.1744 0.1606
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0046 0.1659 0.2068
Giardia lamblia Multidrug resistance-associated protein Mrp2 0.0028 0.079 0.9264
Schistosoma mansoni hypothetical protein 0.0048 0.1744 0.1606
Loa Loa (eye worm) ABC transporter 0.0029 0.0838 0.0932
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.011 0.4733 1
Plasmodium falciparum arginase 0.0145 0.6373 1
Trichomonas vaginalis ABC transporter, putative 0.0092 0.3839 0.5901
Echinococcus multilocularis 0.0029 0.0838 0.1086
Echinococcus granulosus arginase 2 mitochondrial 0.0145 0.6373 1
Echinococcus granulosus serotonin receptor 0.0048 0.1744 0.2544
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0092 0.3839 0.5901
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.1744 0.1606
Brugia malayi follicle stimulating hormone receptor 0.0048 0.1744 0.2358
Echinococcus granulosus neuropeptides capa receptor 0.0048 0.1744 0.2544
Brugia malayi neuropeptide F receptor 0.0048 0.1744 0.2358
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0017 0.0297 0.0214
Brugia malayi hypothetical protein 0.0048 0.1744 0.2358
Schistosoma mansoni multidrug resistance protein 0.0092 0.3839 0.3736
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0164 0.0222
Brugia malayi Calcitonin receptor-like protein seb-1 0.0046 0.1659 0.2244
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0029 0.0838 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0048 0.1744 0.2544
Plasmodium falciparum thioredoxin reductase 0.0044 0.1547 0.2193
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0048 0.1744 0.1606
Mycobacterium tuberculosis Iron-regulated transporter IrtA 0.0029 0.0838 0.1425
Echinococcus granulosus orexin receptor type 2 0.0048 0.1744 0.2544
Leishmania major arginase 0.0145 0.6373 1
Plasmodium falciparum ABC transporter B family member 6, putative 0.0029 0.0838 0.1047
Plasmodium vivax ABC transporter B family member 3, putative 0.0029 0.0838 0.1047
Schistosoma mansoni opsin-like receptor 0.0048 0.1744 0.1606
Echinococcus granulosus g protein coupled receptor 0.0048 0.1744 0.2544
Echinococcus granulosus multidrug resistance protein 1 0.0064 0.252 0.3795
Plasmodium vivax ABC transporter B family member 6, putative 0.0029 0.0838 0.1047
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.1744 0.2544
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0048 0.1744 0.2185
Echinococcus multilocularis 0.0145 0.6373 1
Brugia malayi P-glycoprotein-like protein 0.0029 0.0838 0.1134
Loa Loa (eye worm) hypothetical protein 0.0048 0.1744 0.2185
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0048 0.1744 0.1606
Loa Loa (eye worm) hypothetical protein 0.0048 0.1744 0.2185
Plasmodium falciparum ABC transporter B family member 5, putative 0.0029 0.0838 0.1047
Entamoeba histolytica Arginase, putative 0.0145 0.6373 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.1744 0.2185
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0048 0.1744 0.2544
Loa Loa (eye worm) hypothetical protein 0.0048 0.1744 0.2185
Echinococcus multilocularis serotonin receptor 0.0048 0.1744 0.2544
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.1744 0.1606
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0015 0.0191 0.0043
Plasmodium vivax multidrug resistance protein 2, putative 0.0029 0.0838 0.1047
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0092 0.3839 0.5901
Brugia malayi ABC transporter family protein 0.0029 0.0838 0.1134
Echinococcus multilocularis ATP binding cassette sub family B 0.0029 0.0838 0.1086
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0028 0.079 0.097
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0048 0.1744 0.1606
Trichomonas vaginalis abcb9, putative 0.0092 0.3839 0.5901
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0092 0.3839 0.5083
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0099 0.4205 0.8837
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0048 0.1744 0.1606
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0017 0.0297 0.0184
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0048 0.1744 0.2544
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0092 0.3839 0.5901
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0048 0.1744 0.1606
Toxoplasma gondii thioredoxin reductase 0.0044 0.1547 0.3717
Schistosoma mansoni biogenic amine (5HT) receptor 0.0048 0.1744 0.1606
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0092 0.3839 0.5901
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0092 0.3839 0.5901
Loa Loa (eye worm) hypothetical protein 0.0028 0.079 0.0867
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0064 0.252 0.3768
Entamoeba histolytica P-glycoprotein-2, putative 0.0028 0.079 0.0812
Loa Loa (eye worm) G-protein coupled receptor 0.0048 0.1744 0.2185
Trypanosoma brucei p-glycoprotein 0.0029 0.0838 0.3612
Brugia malayi MH2 domain containing protein 0.011 0.471 0.6371
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0015 0.0191 0.0043
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0029 0.0838 0.1774
Trichomonas vaginalis conserved hypothetical protein 0.0145 0.6373 1
Brugia malayi ABC transporter transmembrane region family protein 0.0029 0.0838 0.1134
Loa Loa (eye worm) neuropeptide F receptor 0.0048 0.1744 0.2185
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0092 0.3839 0.5901
Loa Loa (eye worm) hypothetical protein 0.0048 0.1744 0.2185
Loa Loa (eye worm) melatonin receptor type 1A 0.0048 0.1744 0.2185
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0015 0.0191 0.0258
Loa Loa (eye worm) hypothetical protein 0.0048 0.1744 0.2185
Trypanosoma cruzi multidrug resistance protein E, putative 0.0029 0.0838 0.3612
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0048 0.1744 0.2544
Loa Loa (eye worm) hypothetical protein 0.0048 0.1744 0.2185
Echinococcus multilocularis neuropeptide receptor 0.0048 0.1744 0.2544
Echinococcus granulosus 7TM GPCR rhodopsin 0.0048 0.1744 0.2544
Leishmania major ATP-binding cassette protein subfamily B, member 1, putative 0.0029 0.0838 0.1047
Leishmania major trypanothione reductase 0.0044 0.1547 0.2193
Echinococcus multilocularis g protein coupled receptor 0.0048 0.1744 0.2544
Echinococcus multilocularis neuropeptide s receptor 0.0048 0.1744 0.2544
Echinococcus granulosus thioredoxin glutathione reductase 0.0044 0.1547 0.2227
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0099 0.4205 0.8837
Brugia malayi hypothetical protein 0.0048 0.1744 0.2358
Echinococcus multilocularis neuropeptide FF receptor 2 0.0048 0.1744 0.2544
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.1744 0.1606
Echinococcus multilocularis multidrug resistance associated protein 7 0.0029 0.0838 0.1086
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0029 0.0838 0.1047
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0029 0.0838 0.3612
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0092 0.3839 0.5901
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.1744 0.2544
Brugia malayi Thioredoxin reductase 0.0044 0.1547 0.2092
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0048 0.1744 0.2185
Schistosoma mansoni ap endonuclease 0.0017 0.0297 0.0135
Echinococcus granulosus tachykinin peptides receptor 99D 0.0048 0.1744 0.2544
Mycobacterium ulcerans drugs-transport transmembrane ATP-binding protein ABC transporter 0.0029 0.0838 1
Echinococcus granulosus neuropeptide Y receptor 0.0048 0.1744 0.2544
Brugia malayi sulfakinin receptor protein 0.0048 0.1744 0.2358
Echinococcus multilocularis G protein coupled receptor 139 0.0048 0.1744 0.2544
Loa Loa (eye worm) hypothetical protein 0.0048 0.1744 0.2185
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0092 0.3839 0.5901
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0048 0.1744 0.1606
Echinococcus granulosus g protein coupled receptor 0.0048 0.1744 0.2544
Loa Loa (eye worm) transcription factor SMAD2 0.011 0.471 0.6289
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.1744 0.1606
Loa Loa (eye worm) hypothetical protein 0.0048 0.1744 0.2185
Trichomonas vaginalis abcb9, putative 0.0092 0.3839 0.5901
Plasmodium vivax multidrug resistance protein 1, putative 0.0092 0.3839 0.5901
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0048 0.1744 0.2544
Brugia malayi ABC transporter transmembrane region family protein 0.0029 0.0838 0.1134
Onchocerca volvulus 0.0092 0.3839 0.3709
Brugia malayi hypothetical protein 0.0048 0.1744 0.2358
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0092 0.3839 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0017 0.0297 0.1641
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0048 0.1744 0.2544
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0015 0.0191 0.0027
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0048 0.1744 0.1606
Schistosoma mansoni neuropeptide receptor 0.0048 0.1744 0.1606
Mycobacterium tuberculosis Probable drugs-transport transmembrane ATP-binding protein ABC transporter 0.0029 0.0838 0.1425
Echinococcus granulosus tm gpcr rhodopsin 0.0048 0.1744 0.2544
Brugia malayi Melatonin receptor type 1A 0.0048 0.1744 0.2358
Schistosoma mansoni neuropeptide receptor 0.0048 0.1744 0.1606
Entamoeba histolytica hypothetical protein 0.0029 0.0838 0.089
Giardia lamblia Multidrug resistance-associated protein 1 0.0029 0.0838 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0092 0.3839 0.5901
Loa Loa (eye worm) hypothetical protein 0.0048 0.1744 0.2185
Schistosoma mansoni multidrug resistance protein 0.0092 0.3839 0.3736
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0092 0.3839 0.5901
Echinococcus granulosus alpha 1A adrenergic receptor 0.0048 0.1744 0.2544
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0017 0.0297 0.1641
Loa Loa (eye worm) hypothetical protein 0.0048 0.1744 0.2185
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0091 0.3791 0.5842
Schistosoma mansoni ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7) 0.0029 0.0838 0.0685
Loa Loa (eye worm) TYRA-2 protein 0.0048 0.1744 0.2185
Echinococcus granulosus multidrug resistance protein 1 0.0092 0.3839 0.5918
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0017 0.0297 0.0172
Schistosoma mansoni smdr2 0.0092 0.3839 0.3736
Treponema pallidum exodeoxyribonuclease (exoA) 0.0017 0.0297 1
Echinococcus granulosus fmrfamide receptor 0.0048 0.1744 0.2544
Plasmodium vivax thioredoxin reductase, putative 0.0044 0.1547 0.2193
Loa Loa (eye worm) hypothetical protein 0.0048 0.1744 0.2185
Plasmodium vivax ABC transporter B family member 4, putative 0.0029 0.0838 0.1047
Entamoeba histolytica ATP-binding cassette protein, putative 0.0029 0.0838 0.089
Loa Loa (eye worm) hypothetical protein 0.0048 0.1744 0.2185
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0048 0.1744 0.2358
Schistosoma mansoni multidrug resistance protein 0.0029 0.0838 0.0685
Loa Loa (eye worm) hypothetical protein 0.0048 0.1744 0.2185
Echinococcus granulosus ATP binding cassette sub family B 0.0028 0.079 0.1009
Loa Loa (eye worm) hypothetical protein 0.0091 0.3791 0.5017
Brugia malayi GnHR receptor homolog 0.0048 0.1744 0.2358
Echinococcus granulosus tm gpcr rhodopsin 0.0048 0.1744 0.2544
Loa Loa (eye worm) hypothetical protein 0.0048 0.1744 0.2185
Entamoeba histolytica multidrug resistance protein, putative 0.0029 0.0838 0.089
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0092 0.3839 0.5901
Loa Loa (eye worm) hypothetical protein 0.0048 0.1744 0.2185
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0048 0.1744 0.2544
Leishmania major p-glycoprotein e 0.0029 0.0838 0.1047
Brugia malayi hypothetical protein 0.0029 0.0838 0.1134
Brugia malayi Serotonin receptor 0.0048 0.1744 0.2358
Schistosoma mansoni amine GPCR 0.0048 0.1744 0.1606
Echinococcus multilocularis thioredoxin glutathione reductase 0.0044 0.1547 0.2227
Schistosoma mansoni multidrug resistance protein 0.0029 0.0838 0.0685
Entamoeba histolytica ATP-binding cassette protein, putative 0.0029 0.0838 0.089
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0092 0.3839 0.5901
Schistosoma mansoni biogenic amine (5HT) receptor 0.0048 0.1744 0.1606
Echinococcus granulosus neuropeptides capa receptor 0.0048 0.1744 0.2544
Echinococcus granulosus G protein coupled receptor 139 0.0048 0.1744 0.2544
Brugia malayi putative neuropeptide receptor 0.0048 0.1744 0.2358
Brugia malayi ABC transporter family protein 0.0029 0.0838 0.1134
Echinococcus multilocularis fmrfamide receptor 0.0048 0.1744 0.2544
Loa Loa (eye worm) hypothetical protein 0.0092 0.3839 0.5083
Loa Loa (eye worm) G-protein coupled receptor 0.0048 0.1744 0.2185
Plasmodium falciparum multidrug resistance-associated protein 2 0.0029 0.0838 0.1047
Schistosoma mansoni smdr1 0.0029 0.0838 0.0685
Echinococcus multilocularis ATP binding cassette sub family B 0.0029 0.0838 0.1086
Schistosoma mansoni neuropeptide F-like receptor 0.0048 0.1744 0.1606
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0029 0.0838 0.1774
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0166 0.7393 1
Schistosoma mansoni neuropeptide receptor 0.0048 0.1744 0.1606
Leishmania major ATP-binding cassette protein subfamily B, member 3, putative 0.0029 0.0838 0.1047
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0029 0.0838 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0017 0.0297 0.0593
Echinococcus multilocularis g protein coupled receptor 0.0048 0.1744 0.2544
Brugia malayi larval opioid receptor 0.0048 0.1744 0.2358
Echinococcus granulosus g protein coupled receptor 0.0048 0.1744 0.2544
Brugia malayi Serotonin receptor 0.0048 0.1744 0.2358
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.1744 0.2544
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0048 0.1744 0.1606
Brugia malayi G-protein coupled receptor 0.0048 0.1744 0.2358
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0017 0.0297 0.0214
Schistosoma mansoni multidrug resistance protein 0.0028 0.079 0.0637
Echinococcus multilocularis neuropeptide Y receptor 0.0048 0.1744 0.2544

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.49 nM Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay ChEMBL. 21514825
Ki (functional) = 0.6 nM Antagonist activity at human bradykinin B1 receptor ChEMBL. 21514825

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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