Detailed information for compound 1528417

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 387.41 | Formula: C18H17N3O5S
  • H donors: 3 H acceptors: 5 LogP: 2.11 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccccc1/C(=N/NC(=O)C1=C(O)c2ccccc2S(=O)(=O)N1C)/C
  • InChi: 1S/C18H17N3O5S/c1-11(12-7-3-5-9-14(12)22)19-20-18(24)16-17(23)13-8-4-6-10-15(13)27(25,26)21(16)2/h3-10,22-23H,1-2H3,(H,20,24)/b19-11+
  • InChiKey: UQIATHSNKXHPAK-YBFXNURJSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi protein disulphide isomerase 0.0007 0.0039 0.0109
Brugia malayi MH1 domain containing protein 0.0007 0.0037 0.0103
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0081 0.1632 0.1627
Loa Loa (eye worm) latrophilin receptor protein 2 0.0013 0.017 0.0542
Echinococcus granulosus GPCR family 2 0.0013 0.017 0.0165
Echinococcus multilocularis protein disulfide isomerase A3 0.0007 0.0039 0.0033
Trypanosoma cruzi bloodstream- specific protein 2 precursor 0.0007 0.0039 0.0093
Giardia lamblia Hypothetical protein 0.0024 0.0419 0.9526
Giardia lamblia NADH oxidase lateral transfer candidate 0.0013 0.0181 0.356
Entamoeba histolytica ATP-binding cassette protein, putative 0.0025 0.0438 0.0433
Entamoeba histolytica P-glycoprotein-2, putative 0.0081 0.1632 0.1627
Brugia malayi hypothetical protein 0.0129 0.2661 0.8735
Brugia malayi ABC transporter family protein 0.0025 0.0438 0.1424
Leishmania major agmatinase-like protein 0.0171 0.3571 0.3547
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0181 0.0176
Trichomonas vaginalis ABC transporter, putative 0.0081 0.1632 0.1627
Loa Loa (eye worm) hypothetical protein 0.0081 0.1632 0.535
Mycobacterium tuberculosis Probable dehydrogenase 0.0088 0.1778 0.8837
Schistosoma mansoni hypothetical protein 0.0013 0.017 0.017
Echinococcus granulosus smad 0.0007 0.0037 0.0031
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0025 0.0438 0.2509
Entamoeba histolytica P-glycoprotein-2, putative 0.0024 0.0419 0.0414
Entamoeba histolytica Arginase, putative 0.0471 1 1
Entamoeba histolytica ATP-binding cassette protein, putative 0.0025 0.0438 0.0433
Trypanosoma brucei multidrug resistance protein E 0.0025 0.0438 0.1132
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0088 0.1778 0.8644
Echinococcus multilocularis protein disulfide isomerase 0.0007 0.0039 0.0033
Echinococcus granulosus mothers against decapentaplegic 5 0.0007 0.0037 0.0031
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0013 0.0181 0.0143
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0015 0.0223 0.0522
Loa Loa (eye worm) hypothetical protein 0.008 0.1613 0.5287
Entamoeba histolytica P-glycoprotein 6, putative 0.0025 0.0438 0.0433
Trypanosoma cruzi ABC transporter of the mitochondrion, putative 0.0025 0.0438 0.1214
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0181 0.0492
Echinococcus multilocularis regulator of G protein signaling 7 0.0007 0.005 0.0045
Leishmania major arginase 0.0471 1 1
Leishmania major p-glycoprotein 0.0081 0.1632 0.16
Echinococcus multilocularis regulator of G protein signaling 7 0.0007 0.005 0.0045
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0007 0.005 0.0146
Entamoeba histolytica P-glycoprotein-5 0.0081 0.1632 0.1627
Trichomonas vaginalis abcb9, putative 0.0081 0.1632 0.1627
Loa Loa (eye worm) hypothetical protein 0.0081 0.1632 0.535
Echinococcus granulosus arginase 2 mitochondrial 0.0471 1 1
Echinococcus granulosus ATP binding cassette sub family B 0.0024 0.0419 0.0414
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0081 0.1632 0.1627
Echinococcus granulosus protein disulfide isomerase 0.0007 0.0039 0.0033
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0013 0.0181 0.0143
Schistosoma mansoni multidrug resistance protein 0.0025 0.0438 0.0438
Echinococcus multilocularis multidrug resistance protein 1 0.0081 0.1632 0.1627
Trypanosoma cruzi agmatinase, putative 0.0171 0.3571 1
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0005 0.0005 0.0005
Plasmodium falciparum ABC transporter B family member 4, putative 0.0025 0.0438 0.0401
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.072 0.2004
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0181 0.0403
Echinococcus multilocularis multidrug resistance protein 1 0.0057 0.1107 0.1103
Mycobacterium ulcerans drugs-transport transmembrane ATP-binding protein ABC transporter 0.0025 0.0438 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0081 0.1632 0.1627
Loa Loa (eye worm) hypothetical protein 0.0024 0.0419 0.1362
Schistosoma mansoni arginase 0.0471 1 1
Leishmania major ATP-binding cassette protein subfamily B, member 1, putative 0.0025 0.0438 0.0401
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0015 0.0223 0.0716
Loa Loa (eye worm) hypothetical protein 0.0025 0.0438 0.1424
Plasmodium falciparum ABC transporter B family member 3, putative 0.0025 0.0438 0.0401
Brugia malayi latrophilin 2 splice variant baaae 0.0028 0.049 0.1593
Mycobacterium tuberculosis Iron-regulated transporter IrtA 0.0025 0.0438 0.1425
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0081 0.1632 0.1627
Brugia malayi Calcitonin receptor-like protein seb-1 0.0041 0.0765 0.2498
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0007 0.0037 0.0037
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0081 0.1632 0.1627
Trypanosoma brucei ABC transporter, mitochondrial, putative 0.0025 0.0438 0.1132
Echinococcus granulosus multidrug resistance associated protein 1 0.0025 0.0438 0.0433
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0081 0.1632 0.1627
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0007 0.005 0.0146
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0081 0.1632 1
Schistosoma mansoni ap endonuclease 0.0015 0.0223 0.0223
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.0419 0.0414
Brugia malayi hypothetical protein 0.0007 0.005 0.0146
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0098 0.1988 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0041 0.0765 0.2498
Echinococcus multilocularis smad 0.0007 0.0037 0.0031
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0081 0.1632 0.1627
Loa Loa (eye worm) transcription factor SMAD2 0.0097 0.1979 0.649
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0181 0.0492
Plasmodium falciparum ABC transporter B family member 5, putative 0.0025 0.0438 0.0401
Toxoplasma gondii hypothetical protein 0.0007 0.005 0.0071
Entamoeba histolytica P-glycoprotein 5, putative 0.0081 0.1632 0.1627
Schistosoma mansoni Smad4 0.0007 0.0037 0.0037
Brugia malayi ABC transporter 0.0024 0.0419 0.1362
Entamoeba histolytica ATP-binding cassette protein, putative 0.0025 0.0438 0.0433
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0181 0.0492
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0081 0.1632 0.1627
Echinococcus multilocularis ATP binding cassette sub family B 0.0025 0.0438 0.0433
Plasmodium vivax ABC transporter B family member 6, putative 0.0025 0.0438 0.0401
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0098 0.1988 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0081 0.1632 0.1627
Schistosoma mansoni ap endonuclease 0.0015 0.0223 0.0223
Onchocerca volvulus 0.0007 0.005 0.0146
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0081 0.1632 0.535
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0081 0.1632 0.1627
Echinococcus multilocularis Smad4 0.0007 0.0037 0.0031
Trichomonas vaginalis protein disulfide isomerase, putative 0.0007 0.0039 0.0033
Loa Loa (eye worm) MH1 domain-containing protein 0.0007 0.0037 0.0103
Loa Loa (eye worm) hypothetical protein 0.0147 0.3046 1
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0007 0.005 0.0146
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0081 0.1632 0.1627
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0025 0.0438 0.0401
Echinococcus multilocularis multidrug resistance associated protein 1 0.0025 0.0438 0.0433
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0013 0.017 0.0165
Brugia malayi ABC transporter family protein 0.0025 0.0438 0.1424
Loa Loa (eye worm) MH2 domain-containing protein 0.0097 0.1979 0.649
Plasmodium vivax arginase, putative 0.0471 1 1
Plasmodium falciparum thioredoxin reductase 0.0038 0.072 0.0684
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0041 0.0765 0.2498
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0007 0.005 0.0045
Plasmodium falciparum glutathione reductase 0.0038 0.072 0.0684
Mycobacterium ulcerans component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD 0.0025 0.0438 1
Onchocerca volvulus 0.0129 0.2661 0.8735
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0015 0.0223 0.0611
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0081 0.1632 0.1627
Schistosoma mansoni multidrug resistance protein 0.0081 0.1632 0.1632
Brugia malayi MH1 domain containing protein 0.0007 0.0037 0.0103
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0007 0.005 0.0146
Echinococcus multilocularis 0.0471 1 1
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.0181 0.0893
Giardia lamblia Multidrug resistance-associated protein 1 0.0025 0.0438 1
Entamoeba histolytica P-glycoprotein-2 0.0081 0.1632 0.1627
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0081 0.1632 0.1627
Brugia malayi hypothetical protein 0.0025 0.0438 0.1424
Plasmodium vivax ABC transporter B family member 4, putative 0.0025 0.0438 0.0401
Trichomonas vaginalis conserved hypothetical protein 0.0471 1 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0015 0.0223 0.0218
Echinococcus granulosus regulator of G protein signaling 7 0.0007 0.005 0.0045
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0081 0.1632 0.1627
Trypanosoma cruzi arginase, putative 0.0171 0.3571 1
Schistosoma mansoni multidrug resistance protein 0.0025 0.0438 0.0438
Plasmodium falciparum multidrug resistance-associated protein 1 0.0025 0.0438 0.0401
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0081 0.1632 0.1627
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0025 0.0438 1
Mycobacterium tuberculosis Probable reductase 0.0088 0.1778 0.8837
Brugia malayi ABC transporter 0.0025 0.0438 0.1424
Trichomonas vaginalis protein disulfide isomerase, putative 0.0007 0.0039 0.0033
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0181 0.0143
Loa Loa (eye worm) ABC transporter 0.0025 0.0438 0.1424
Brugia malayi ABC transporter family protein 0.0081 0.1632 0.535
Schistosoma mansoni smad 0.0007 0.0037 0.0037
Brugia malayi multidrug Resistance Protein family member (mrp-5), putative 0.0025 0.0438 0.1424
Entamoeba histolytica thioredoxin, putative 0.0007 0.0039 0.0033
Plasmodium vivax ABC transporter B family member 5, putative 0.0025 0.0438 0.0401
Echinococcus multilocularis multidrug resistance associated protein 7 0.0025 0.0438 0.0433
Leishmania major ABC-thiol transporter 0.0025 0.0438 0.0401
Schistosoma mansoni z-protein (S1r protein) 0.0007 0.005 0.005
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0081 0.1632 0.1627
Mycobacterium tuberculosis Probable oxidoreductase 0.0098 0.1988 1
Trypanosoma cruzi trypanothione reductase, putative 0.0013 0.0181 0.0492
Loa Loa (eye worm) hypothetical protein 0.0025 0.0438 0.1424
Loa Loa (eye worm) hypothetical protein 0.0025 0.0438 0.1424
Brugia malayi probable protein disulfide-isomerase 0.0007 0.0039 0.0109
Plasmodium falciparum glutathione reductase 0.0013 0.0181 0.0143
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0007 0.005 0.005
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0025 0.0438 0.1424
Brugia malayi MH2 domain containing protein 0.0007 0.0037 0.0103
Brugia malayi Smad1 0.0007 0.0037 0.0103
Toxoplasma gondii ABC transporter, putative 0.0025 0.0438 0.2509
Echinococcus granulosus regulator of G protein signaling 7 0.0007 0.005 0.0045
Trichomonas vaginalis ABC transporter, putative 0.0081 0.1632 0.1627
Echinococcus granulosus ATP binding cassette sub family B 0.0025 0.0438 0.0433
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0025 0.0438 1
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0025 0.0438 0.2509
Brugia malayi DIX domain containing protein 0.0007 0.005 0.0146
Schistosoma mansoni ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6) 0.0024 0.0419 0.0419
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0147 0.3046 1
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0181 0.0176
Loa Loa (eye worm) hypothetical protein 0.0028 0.049 0.1593
Brugia malayi MH2 domain containing protein 0.0097 0.1979 0.649
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0181 0.0492
Brugia malayi transglutaminase 0.0007 0.0039 0.0109
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0015 0.0223 0.0611
Loa Loa (eye worm) hypothetical protein 0.0129 0.2661 0.8735
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0081 0.1632 0.1627
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0005 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0007 0.005 0.0146
Onchocerca volvulus 0.0081 0.1632 0.535
Echinococcus multilocularis ATP binding cassette sub family B 0.008 0.1613 0.1608
Trypanosoma brucei p-glycoprotein 0.0025 0.0438 0.1132
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0013 0.0181 0.0143
Trypanosoma cruzi arginase, putative 0.0171 0.3571 1
Brugia malayi ABC transporter family protein 0.0025 0.0438 0.1424
Schistosoma mansoni ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7) 0.0025 0.0438 0.0438
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.008 0.1613 0.1608
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0081 0.1632 0.1627
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0181 0.0577
Entamoeba histolytica P-glycoprotein-1 0.0081 0.1632 0.1627
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.072 0.0684
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0025 0.0438 0.0401
Trypanosoma brucei agmatinase, putative 0.0171 0.3571 1
Schistosoma mansoni protein disulfide-isomerase er-60 precursor (erp60) 0.0007 0.0039 0.0039
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0057 0.1107 0.1103
Loa Loa (eye worm) DIX domain-containing protein 0.0007 0.005 0.0146
Mycobacterium tuberculosis Probable drugs-transport transmembrane ATP-binding protein ABC transporter 0.0025 0.0438 0.1425
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0025 0.0438 0.2509
Trichomonas vaginalis protein disulfide isomerase, putative 0.0007 0.0039 0.0033
Leishmania major pentamidine resistance protein 1 0.0025 0.0438 0.0401
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.001 0.0105 0.0327
Schistosoma mansoni smad1 5 8 and 0.0007 0.0037 0.0037
Brugia malayi Latrophilin receptor protein 2 0.0013 0.017 0.0542
Trypanosoma cruzi multidrug resistance protein E, putative 0.0025 0.0438 0.1214
Loa Loa (eye worm) hypothetical protein 0.0007 0.005 0.0146
Toxoplasma gondii ABC transporter family protein 0.0025 0.0438 0.2509
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0181 0.0492
Plasmodium falciparum multidrug resistance protein 1 0.0081 0.1632 0.16
Loa Loa (eye worm) ABC transporter 0.0025 0.0438 0.1424
Echinococcus granulosus multidrug resistance protein 1 0.0057 0.1107 0.1103
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0081 0.1632 0.1627
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0015 0.0223 0.0218
Echinococcus granulosus multidrug resistance protein 1 0.0081 0.1632 0.1627
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0015 0.0223 0.1641
Trichomonas vaginalis ap endonuclease, putative 0.0015 0.0223 0.0218
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0088 0.1778 0.8837
Echinococcus multilocularis ATP binding cassette sub family B 0.0025 0.0438 0.0433
Echinococcus granulosus protein disulfide isomerase A3 0.0007 0.0039 0.0033
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0025 0.0438 0.2509
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0025 0.0438 0.1214
Schistosoma mansoni protein disulfide-isomerase 0.0007 0.0039 0.0039
Leishmania major ATP-binding cassette protein subfamily C, member 8, putative 0.0025 0.0438 0.0401
Schistosoma mansoni hypothetical protein 0.0013 0.017 0.017
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0013 0.0181 0.0143
Echinococcus multilocularis ATP binding cassette sub family B 0.0025 0.0438 0.0433
Trypanosoma brucei ABC transporter of the mitochondrion, putative 0.0025 0.0438 0.1132
Loa Loa (eye worm) hypothetical protein 0.0013 0.017 0.0542
Entamoeba histolytica hypothetical protein 0.0025 0.0438 0.0433
Trypanosoma cruzi ABC transporter, mitochondrial, putative 0.0025 0.0438 0.1214
Plasmodium falciparum multidrug resistance protein 2 0.0025 0.0438 0.0401
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0005 0.0005 0.0005
Brugia malayi ABC transporter transmembrane region family protein 0.0025 0.0438 0.1424
Echinococcus granulosus TGF beta signal transducer SmadC 0.0007 0.0037 0.0031
Schistosoma mansoni dishevelled 0.0007 0.005 0.005
Trichomonas vaginalis ABC transporter, putative 0.0081 0.1632 0.1627
Schistosoma mansoni multidrug resistance protein 0.0081 0.1632 0.1632
Plasmodium vivax ABC transporter B family member 3, putative 0.0025 0.0438 0.0401
Loa Loa (eye worm) Smad1 0.0007 0.0037 0.0103
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0081 0.1632 0.1627
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0081 0.1632 0.1627
Schistosoma mansoni hypothetical protein 0.0028 0.049 0.049
Wolbachia endosymbiont of Brugia malayi ABC-type protease secretion system, ATPase and permease component, AprD 0.0025 0.0438 1
Trichomonas vaginalis protein disulfide isomerase, putative 0.0007 0.0038 0.0033
Trichomonas vaginalis ap endonuclease, putative 0.0015 0.0223 0.0218
Echinococcus multilocularis mothers against decapentaplegic 5 0.0007 0.0037 0.0031
Plasmodium falciparum arginase 0.0471 1 1
Schistosoma mansoni smad1 5 8 and 0.0007 0.0037 0.0037
Echinococcus granulosus Smad4 0.0007 0.0037 0.0031
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0025 0.0438 0.1132
Trichomonas vaginalis Arginase, putative 0.0471 1 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0081 0.1632 0.1627
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0025 0.0438 0.2509
Schistosoma mansoni smdr2 0.0081 0.1632 0.1632
Giardia lamblia ABC transporter, putative 0.0025 0.0438 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0081 0.1632 0.1627
Brugia malayi P-glycoprotein-like protein 0.0025 0.0438 0.1424
Schistosoma mansoni hypothetical protein 0.0013 0.017 0.017
Schistosoma mansoni ras GTP exchange factor 0.0005 0.0005 0.0005
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0025 0.0438 0.2509
Echinococcus granulosus multidrug resistance protein 1 0.0081 0.1632 0.1627
Giardia lamblia Multidrug resistance-associated protein 1 0.0024 0.0419 0.9526
Brugia malayi hypothetical protein 0.0007 0.005 0.0146
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0081 0.1632 0.1627
Entamoeba histolytica multidrug resistance protein, putative 0.0025 0.0438 0.0433
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0081 0.1632 0.16
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0015 0.0223 0.0185
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0081 0.1632 0.1627
Echinococcus multilocularis arginase 2, mitochondrial 0.0471 1 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0181 0.0403
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0088 0.1778 0.8837
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0419 0.0414
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0013 0.0181 0.0143
Wolbachia endosymbiont of Brugia malayi ABC-type multidrug transport system, ATPase and permease component 0.0025 0.0438 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0015 0.0223 0.1641
Echinococcus multilocularis GPCR, family 2 0.0013 0.017 0.0165
Brugia malayi regulator of G-protein signaling egl-10 0.0007 0.005 0.0146
Entamoeba histolytica P-glyco protein 6, putative 0.0081 0.1632 0.1627
Loa Loa (eye worm) transglutaminase 0.0007 0.0039 0.0109
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0013 0.0181 0.0403
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.072 0.2985
Schistosoma mansoni smdr1 0.0025 0.0438 0.0438
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0007 0.0037 0.0031
Loa Loa (eye worm) glutathione reductase 0.0038 0.072 0.2351
Schistosoma mansoni multidrug resistance protein 0.0025 0.0438 0.0438
Brugia malayi Thioredoxin reductase 0.0038 0.072 0.2351
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0025 0.0438 0.0401
Treponema pallidum exodeoxyribonuclease (exoA) 0.0015 0.0223 1
Brugia malayi exodeoxyribonuclease III family protein 0.0015 0.0223 0.0716
Trichomonas vaginalis conserved hypothetical protein 0.0471 1 1
Echinococcus granulosus multidrug resistance protein 1 0.0057 0.1107 0.1103
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0181 0.0176
Loa Loa (eye worm) ABC transporter 0.0025 0.0438 0.1424
Schistosoma mansoni Probable protein disulfide-isomerase ER-60 precursor (ERP60) 0.0007 0.0039 0.0039
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0025 0.0438 0.0433
Plasmodium vivax multidrug resistance-associated protein 1, putative 0.0025 0.0438 0.0401
Entamoeba histolytica P-glycoprotein 5, putative 0.0024 0.0419 0.0414
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0013 0.017 0.0165
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0005 0.0005 0.0005
Entamoeba histolytica ATP-binding cassette protein, putative 0.0025 0.0438 0.0433
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0025 0.0438 0.1214
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0015 0.0223 0.0185
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0081 0.1632 0.1627
Plasmodium falciparum multidrug resistance-associated protein 2 0.0025 0.0438 0.0401
Brugia malayi multidrug resistance related protein 1 0.0025 0.0438 0.1424
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0015 0.0223 0.0234
Brugia malayi multidrug resistance protein 3 0.0081 0.1632 0.535
Loa Loa (eye worm) MH2 domain-containing protein 0.0007 0.0037 0.0103
Toxoplasma gondii ATP-binding cassette sub-family B member 5 0.0025 0.0438 0.2509
Echinococcus multilocularis ATP binding cassette sub family B 0.0025 0.0438 0.0433
Echinococcus granulosus multidrug resistance protein 1 0.0081 0.1632 0.1627
Echinococcus multilocularis 0.0025 0.0438 0.0433
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0024 0.0419 0.0414
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0015 0.0223 0.0185
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.072 0.2351
Brugia malayi MH2 domain containing protein 0.0007 0.0037 0.0103
Plasmodium falciparum thioredoxin reductase 0.0013 0.0181 0.0143
Echinococcus granulosus multidrug resistance associated protein 7 0.0025 0.0438 0.0433
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0098 0.1988 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0181 0.0492
Schistosoma mansoni regulator of G protein signaling 0.0007 0.005 0.005
Plasmodium falciparum ABC transporter B family member 6, putative 0.0025 0.0438 0.0401
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.072 0.0715
Schistosoma mansoni multidrug resistance protein 0.0081 0.1632 0.1632
Trypanosoma brucei trypanothione reductase 0.0038 0.072 0.1929
Brugia malayi N-terminal motif family protein 0.0147 0.3046 1
Echinococcus granulosus segment polarity protein dishevelled 0.0007 0.005 0.0045
Schistosoma mansoni smad1 5 8 and 0.0007 0.0037 0.0037
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0081 0.1632 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0765 0.2498
Schistosoma mansoni multidrug resistance protein 0.0025 0.0438 0.0438
Giardia lamblia Multidrug resistance-associated protein Mrp2 0.0024 0.0419 0.9526
Loa Loa (eye worm) hypothetical protein 0.0007 0.005 0.0146
Echinococcus granulosus segment polarity protein dishevelled 0.0007 0.005 0.0045
Plasmodium vivax multidrug resistance protein 2, putative 0.0025 0.0438 0.0401
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0081 0.1632 1
Schistosoma mansoni multidrug resistance protein 0.0025 0.0438 0.0438
Echinococcus granulosus Pleckstrin G protein interacting region 0.0007 0.005 0.0045
Schistosoma mansoni dep domain containing protein 0.0007 0.005 0.005
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0081 0.1632 0.1627
Giardia lamblia Multidrug resistance-associated protein 1 0.0025 0.0438 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0013 0.0181 0.0403
Brugia malayi glutathione reductase 0.0038 0.072 0.2351
Leishmania major ATP-binding cassette protein subfamily B, member 3, putative 0.0025 0.0438 0.0401
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0013 0.017 0.0542
Loa Loa (eye worm) Pdia4 protein 0.0007 0.0039 0.0109
Echinococcus multilocularis segment polarity protein dishevelled 0.0007 0.005 0.0045
Leishmania major trypanothione reductase 0.0038 0.072 0.0684
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0025 0.0438 1
Plasmodium vivax multidrug resistance-associated protein 2, putative 0.0025 0.0438 0.0401
Trichomonas vaginalis ABC transporter, putative 0.0081 0.1632 0.1627
Plasmodium vivax multidrug resistance protein 1, putative 0.0081 0.1632 0.16
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0015 0.0223 0.4617
Loa Loa (eye worm) hypothetical protein 0.0024 0.0419 0.1362
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0088 0.1778 0.8837
Trypanosoma cruzi agmatinase, putative 0.0171 0.3571 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0013 0.017 0.0165
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0181 0.0143
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.072 0.0715
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0181 0.0492
Toxoplasma gondii exonuclease III APE 0.0015 0.0223 0.1158
Schistosoma mansoni hypothetical protein 0.0013 0.017 0.017
Echinococcus multilocularis segment polarity protein dishevelled 0.0007 0.005 0.0045
Loa Loa (eye worm) protein disulfide isomerase 0.0007 0.0039 0.0109
Trichomonas vaginalis abcb9, putative 0.0081 0.1632 0.1627
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0013 0.0181 0.0143
Loa Loa (eye worm) multidrug resistance protein 3 0.0081 0.1632 0.535
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0081 0.1632 0.1627
Plasmodium vivax ABC transporter B family member 7, putative 0.0025 0.0438 0.0401
Toxoplasma gondii thioredoxin reductase 0.0038 0.072 0.4278
Loa Loa (eye worm) hypothetical protein 0.0006 0.0022 0.0054
Entamoeba histolytica P-glycoprotein-2 0.0081 0.1632 0.1627
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0181 0.0181
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0081 0.1632 0.8031
Trichomonas vaginalis abcb9, putative 0.0081 0.1632 0.1627
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0181 0.0176
Leishmania major p-glycoprotein e 0.0025 0.0438 0.0401
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0025 0.0438 0.0401
Brugia malayi ABC transporter transmembrane region family protein 0.0024 0.0419 0.1362
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0015 0.0223 0.0218
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0013 0.017 0.0165
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0024 0.0419 0.0414
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0181 0.0492
Schistosoma mansoni multidrug resistance protein 0.0024 0.0419 0.0419
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0081 0.1632 0.1627
Schistosoma mansoni dishevelled 0.0007 0.005 0.005
Echinococcus granulosus ATP binding cassette sub family B 0.0025 0.0438 0.0433
Entamoeba histolytica ABC transporter, putative 0.0025 0.0438 0.0433
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0088 0.1778 0.8837
Entamoeba histolytica P-glycoprotein 6, putative 0.0025 0.0438 0.0433
Trichomonas vaginalis taga, putative 0.0081 0.1632 0.1627
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.001 0.0105 0.0327
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0081 0.1632 0.1627
Brugia malayi ABC transporter transmembrane region family protein 0.0025 0.0438 0.1424
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.0181 0.0893
Plasmodium falciparum ABC transporter B family member 7, putative 0.0025 0.0438 0.0401
Echinococcus multilocularis multidrug resistance protein 1 0.0081 0.1632 0.1627
Giardia lamblia MRP-like ABC transporter 0.0025 0.0438 1
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0025 0.0438 0.1132
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0081 0.1632 0.1627
Plasmodium vivax glutathione reductase, putative 0.0038 0.072 0.0684

Activities

Activity type Activity value Assay description Source Reference
MBC (functional) = 39 10'-2umol Antibacterial activity against Escherichia coli assessed as 99.5% bacterial killing using 1 x 10'4 CFU/ml inoculum after 72 hrs by microdilution method ChEMBL. 21470723
MIC (functional) = 19.6 10'-2umol Antibacterial activity against Escherichia coli using 1 x 10'4 CFU/ml inoculum after 24 hrs by microdilution method ChEMBL. 21470723

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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