Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0018 | 0.0038 | 0.0051 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0018 | 0.0038 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0018 | 0.0038 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0018 | 0.0038 | 1 |
Brugia malayi | steroid hormone receptor | 0.0018 | 0.0038 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0038 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0018 | 0.0038 | 0.0056 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0018 | 0.0038 | 0.0056 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0018 | 0.0038 | 0.0056 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0018 | 0.0038 | 0.0051 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0018 | 0.0038 | 0.0051 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0119 | 0.7419 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0018 | 0.0038 | 0.0056 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0018 | 0.0038 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0018 | 0.0038 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0018 | 0.0038 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0018 | 0.0038 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0018 | 0.0038 | 0.0056 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0038 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0018 | 0.0038 | 0.0051 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0038 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0154 | 1 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0119 | 0.7419 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0018 | 0.0038 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0018 | 0.0038 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0018 | 0.0038 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0018 | 0.0038 | 0.0051 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0018 | 0.0038 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0018 | 0.0038 | 0.0051 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0018 | 0.0038 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0018 | 0.0038 | 0.0051 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0018 | 0.0038 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0018 | 0.0038 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0018 | 0.0038 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0018 | 0.0038 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0038 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0018 | 0.0038 | 0.0056 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0018 | 0.0038 | 0.0051 |
Onchocerca volvulus | 0.0018 | 0.0038 | 1 | |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0018 | 0.0038 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0018 | 0.0038 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0018 | 0.0038 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0018 | 0.0038 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0018 | 0.0038 | 0.0051 |
Brugia malayi | nuclear hormone receptor | 0.0018 | 0.0038 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0038 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0018 | 0.0038 | 0.0051 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0018 | 0.0038 | 0.0056 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0038 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0018 | 0.0038 | 0.0051 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0109 | 0.6719 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0018 | 0.0038 | 0.0051 |
Schistosoma mansoni | nuclear hormone receptor | 0.0018 | 0.0038 | 0.0051 |
Brugia malayi | ecdysteroid receptor | 0.0018 | 0.0038 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0018 | 0.0038 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0038 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0018 | 0.0038 | 0.0051 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0018 | 0.0038 | 0.0051 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0018 | 0.0038 | 0.0056 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0018 | 0.0038 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0018 | 0.0038 | 0.0056 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0018 | 0.0038 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0018 | 0.0038 | 0.0051 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0038 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0018 | 0.0038 | 0.0051 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0018 | 0.0038 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0018 | 0.0038 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0018 | 0.0038 | 0.0051 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0018 | 0.0038 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0018 | 0.0038 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0018 | 0.0038 | 0.0051 |
Schistosoma mansoni | thyroid hormone receptor | 0.0018 | 0.0038 | 0.0051 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0018 | 0.0038 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0018 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 460 uM | Assayed against human skin fibroblast Collagenase using the spectrophotometric assay with the thiol ester substrate at pH 6.5. | ChEMBL. | 2153207 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.