Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | polymerase (DNA directed), eta | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0054 | 1 | 1 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0038 | 0.533 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 1 | 1 |
Schistosoma mansoni | DNA polymerase eta | 0.0054 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0038 | 0.533 | 0.4775 |
Echinococcus granulosus | dna polymerase eta | 0.0054 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.003 | 0.3135 | 0.3135 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0023 | 0.1062 | 0.5 |
Echinococcus multilocularis | dna polymerase eta | 0.0054 | 1 | 1 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0023 | 0.1062 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.3135 | 0.2319 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.3135 | 0.2319 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.1062 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.0054 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.3135 | 0.2319 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0023 | 0.1062 | 0.5 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0023 | 0.1062 | 0.1062 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0054 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0023 | 0.1062 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.0038 | 0.533 | 0.4775 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.1062 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.3135 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.3135 | 0.2319 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 0.1062 | 0.5 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0023 | 0.1062 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.3135 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.3135 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.3135 | 0.2319 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 4.6535 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 29.081 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 95.2834 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.