Detailed information for compound 1528764

Basic information

Technical information
  • TDR Targets ID: 1528764
  • Name: 8-(3,4,5-trihydroxy-6-oxoxanthen-9-yl)naphtha lene-1-carboxylic acid
  • MW: 414.364 | Formula: C24H14O7
  • H donors: 4 H acceptors: 6 LogP: 3.19 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1c(=O)ccc2c1oc1c(c2c2cccc3c2c(ccc3)C(=O)O)ccc(c1O)O
  • InChi: 1S/C24H14O7/c25-16-9-7-13-19(12-5-1-3-11-4-2-6-15(18(11)12)24(29)30)14-8-10-17(26)21(28)23(14)31-22(13)20(16)27/h1-10,25,27-28H,(H,29,30)
  • InChiKey: NYLLADZYPUKUTH-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 8-(3,4,5-trihydroxy-6-oxo-xanthen-9-yl)naphthalene-1-carboxylic acid
  • 8-(3,4,5-trihydroxy-6-oxo-9-xanthenyl)-1-naphthalenecarboxylic acid
  • 8-(3,4,5-trihydroxy-6-keto-xanthen-9-yl)-1-naphthoic acid
  • 1-Naphthalenecarboxylic acid, 8-(4,5,6-trihydroxy-3-oxo-3H-xanthen-9-yl)-
  • AIDS-015094
  • NSC119893
  • AIDS015094

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens Werner syndrome, RecQ helicase-like Starlite/ChEMBL No references
Homo sapiens guanine nucleotide binding protein (G protein), gamma 2 No references
Trypanosoma brucei gambiense phosphoglycerate kinase, putative No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Homo sapiens EYA transcriptional coactivator and phosphatase 2 Starlite/ChEMBL No references
Human immunodeficiency virus type 1 group M subtype B (isolate HXB2)(HIV-1) Human immunodeficiency virus type 1 Tat protein Starlite/ChEMBL No references
Homo sapiens Bloom syndrome, RecQ helicase-like Starlite/ChEMBL No references
Dengue virus type 2 (strain Thailand/16681/1984) (DENV-2) Dengue virus type 2 NS3 protein Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens Rac GTPase activating protein 1 Starlite/ChEMBL No references
Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 4 No references
Homo sapiens glutaminase Starlite/ChEMBL No references
Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Trypanosoma brucei phosphoglycerate kinase Starlite/ChEMBL No references
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references
Homo sapiens flap structure-specific endonuclease 1 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) kappa Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei 2'-O-ribose RNA methyltransferase SPB1 homolog Get druggable targets OG5_126871 All targets in OG5_126871
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Theileria parva rRNA methyltransferase, putative Get druggable targets OG5_126871 All targets in OG5_126871
Trypanosoma brucei DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Brugia malayi rRNA methyltransferase Get druggable targets OG5_126871 All targets in OG5_126871
Plasmodium yoelii FtsJ cell division protein, putative Get druggable targets OG5_126871 All targets in OG5_126871
Mycobacterium leprae Probable phosphoglycerate kinase Pgk Get druggable targets OG5_126776 All targets in OG5_126776
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major phosphoglycerate kinase B, cytosolic Get druggable targets OG5_126776 All targets in OG5_126776
Cryptosporidium hominis flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus granulosus F box protein 36 Get druggable targets OG5_127973 All targets in OG5_127973
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Theileria parva ribosomal RNA methyltransferase, putative Get druggable targets OG5_126871 All targets in OG5_126871
Schistosoma mansoni glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans potential FtsJ-like methyltransferase similar to S. cerevisiae SPB1 (YCL054W) putative rRNA methyltransferase Get druggable targets OG5_126871 All targets in OG5_126871
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei large subunit rRNA methyltransferase, putative Get druggable targets OG5_126871 All targets in OG5_126871
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana FtsJ cell division protein, putative Get druggable targets OG5_126871 All targets in OG5_126871
Schistosoma mansoni guanine nucleotide-binding protein beta 1 4 (G protein beta1 4) Get druggable targets OG5_127973 All targets in OG5_127973
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium vivax phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma congolense FtsJ cell division protein, putative Get druggable targets OG5_126871 All targets in OG5_126871
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium tuberculosis Probable DNA polymerase IV DinX (pol IV 1) (DNA nucleotidyltransferase (DNA-directed)) Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma mansoni guanine nucleotide-binding protein beta 1 4 (G protein beta1 4) Get druggable targets OG5_127973 All targets in OG5_127973
Toxoplasma gondii ribosomal RNA large subunit methyltransferase J protein Get druggable targets OG5_126871 All targets in OG5_126871
Loa Loa (eye worm) flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Toxoplasma gondii phosphoglycerate kinase PGKI Get druggable targets OG5_126776 All targets in OG5_126776
Onchocerca volvulus Putative ribosomal RNA methyltransferase Get druggable targets OG5_126871 All targets in OG5_126871
Leishmania mexicana DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA polymerase eta, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum IPR000437,Prokaryotic membrane lipoprotein lipid attachment site;IPR008936,Rho GTPase activation protein,domain-containing Get druggable targets OG5_132551 All targets in OG5_132551
Plasmodium vivax ribosomal RNA large subunit methyltransferase J, putative Get druggable targets OG5_126871 All targets in OG5_126871
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum Rac GTPase-activating protein 1, putative Get druggable targets OG5_132551 All targets in OG5_132551
Plasmodium knowlesi phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus granulosus rrna methyltransferase 3 Get druggable targets OG5_126871 All targets in OG5_126871
Candida albicans 3-phosphoglycerate kinase similar to S. cerevisiae PGK1 (YCR012W) Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127973 All targets in OG5_127973
Echinococcus granulosus dna polymerase kappa Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Cryptosporidium parvum Spb1p-like, FtsJ methylase Get druggable targets OG5_126871 All targets in OG5_126871
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni ribosomal RNA methyltransferase Get druggable targets OG5_126871 All targets in OG5_126871
Leishmania donovani FtsJ cell division protein, putative Get druggable targets OG5_126871 All targets in OG5_126871
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma mansoni cell division protein ftsj Get druggable targets OG5_126871 All targets in OG5_126871
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania braziliensis PGKC, phosphoglycerate kinase C Get druggable targets OG5_126776 All targets in OG5_126776
Trichomonas vaginalis DNA polymerase IV / kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Plasmodium falciparum phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Entamoeba histolytica Flap nuclease, putative Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania major phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium berghei phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania donovani phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium ulcerans glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium ulcerans phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum expressed protein Get druggable targets OG5_126871 All targets in OG5_126871
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum phosphoglycerate kinase 1 Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma japonicum ko:K01104 protein-tyrosine phosphatase [EC3.1.3.48], putative Get druggable targets OG5_129664 All targets in OG5_129664
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma brucei DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Giardia lamblia DINP protein human, muc B family Get druggable targets OG5_127393 All targets in OG5_127393
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi GGL domain containing protein Get druggable targets OG5_139210 All targets in OG5_139210
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GGL domain-containing protein Get druggable targets OG5_139210 All targets in OG5_139210
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi Guanine nucleotide-binding protein beta subunit 1, putative Get druggable targets OG5_127973 All targets in OG5_127973
Schistosoma mansoni G-protein beta subunit Get druggable targets OG5_127973 All targets in OG5_127973
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans G-beta repeat protein similar to S. cerevisiae STE4 (YOR212W) beta subunit of heterotrimeric G protein coupled to pheromone rece Get druggable targets OG5_127973 All targets in OG5_127973
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum Guanine nucleotide-binding protein subunit beta-1, putative Get druggable targets OG5_127973 All targets in OG5_127973
Trypanosoma congolense phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium falciparum ribosomal RNA methyltransferase, putative Get druggable targets OG5_126871 All targets in OG5_126871
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Onchocerca volvulus Get druggable targets OG5_139210 All targets in OG5_139210
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis XPG N-terminal domain and XPG I-region domain containing protein Get druggable targets OG5_127472 All targets in OG5_127472
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Neospora caninum Phosphoglycerate kinase (EC 2.7.2.3), related Get druggable targets OG5_126776 All targets in OG5_126776
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania infantum DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense FtsJ cell division protein, putative Get druggable targets OG5_126871 All targets in OG5_126871
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Neospora caninum ftsJ-like methyltransferase domain-containing protein, putative Get druggable targets OG5_126871 All targets in OG5_126871
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Plasmodium yoelii FtsJ cell division protein Get druggable targets OG5_126871 All targets in OG5_126871
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Treponema pallidum phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma brucei phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Entamoeba histolytica phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium yoelii phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis Rac GTPase activating protein 1 Get druggable targets OG5_132551 All targets in OG5_132551
Trichomonas vaginalis phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii flap endonuclease-1-related Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Toxoplasma gondii phosphoglycerate kinase PGKII Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania donovani flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania braziliensis FtsJ cell division protein, putative Get druggable targets OG5_126871 All targets in OG5_126871
Trypanosoma congolense FtsJ cell division protein, putative Get druggable targets OG5_126871 All targets in OG5_126871
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis FtsJ cell division protein Get druggable targets OG5_126871 All targets in OG5_126871
Plasmodium vivax FtsJ-like methyltransferase, putative Get druggable targets OG5_126871 All targets in OG5_126871
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Treponema pallidum cell division protein (ftsJ) Get druggable targets OG5_126871 All targets in OG5_126871
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129664 All targets in OG5_129664
Candida albicans 3-phosphoglycerate kinase similar to S. cerevisiae PGK1 (YCR012W) Get druggable targets OG5_126776 All targets in OG5_126776
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129664 All targets in OG5_129664
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) GTP-binding regulatory protein beta chain Get druggable targets OG5_127973 All targets in OG5_127973
Plasmodium berghei ribosomal RNA methyltransferase, putative Get druggable targets OG5_126871 All targets in OG5_126871
Leishmania major DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Brugia malayi Phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma japonicum Guanine nucleotide-binding protein subunit beta, putative Get druggable targets OG5_127973 All targets in OG5_127973
Trypanosoma brucei gambiense phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania mexicana phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Cryptosporidium hominis phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania mexicana flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma congolense flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Brugia malayi RhoGAP domain containing protein Get druggable targets OG5_132551 All targets in OG5_132551
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus putative ribosomal RNA methyltransferase/cell division FtsJ protein Get druggable targets OG5_126871 All targets in OG5_126871
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126871 All targets in OG5_126871
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania mexicana phosphoglycerate kinase B, cytosolic Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Guanine nucleotide-binding protein subunit beta-1, putative Get druggable targets OG5_127973 All targets in OG5_127973
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium berghei flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma japonicum ko:K02427 cell division protein methyltransferase FtsJ, putative Get druggable targets OG5_126871 All targets in OG5_126871
Chlamydia trachomatis phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Cryptosporidium parvum flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ribosomal RNA methyltransferase Get druggable targets OG5_126871 All targets in OG5_126871
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum expressed protein Get druggable targets OG5_132551 All targets in OG5_132551
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania donovani DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans potential FtsJ-like methyltransferase similar to S. cerevisiae SPB1 (YCL054W) putative rRNA methyltransferase Get druggable targets OG5_126871 All targets in OG5_126871
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis ribosomal RNA methyltransferase, putative Get druggable targets OG5_126871 All targets in OG5_126871
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis rrna methyltransferase 3 Get druggable targets OG5_126871 All targets in OG5_126871
Plasmodium falciparum flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Candida albicans similar to S. cerevisiae MRM2 (YGL136C) mitochondrial rRNA methyltransferase Get druggable targets OG5_126871 All targets in OG5_126871
Echinococcus granulosus guanine nucleotide binding protein subunit Get druggable targets OG5_127973 All targets in OG5_127973
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Guanine nucleotide-binding protein subunit beta, putative Get druggable targets OG5_127973 All targets in OG5_127973
Echinococcus multilocularis guanine nucleotide binding protein subunit Get druggable targets OG5_127973 All targets in OG5_127973
Neospora caninum flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus multilocularis ribosomal RNA large subunit methyltransferase Get druggable targets OG5_126871 All targets in OG5_126871
Entamoeba histolytica ribosomal RNA methyltransferase, putative Get druggable targets OG5_126871 All targets in OG5_126871
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium knowlesi large subunit rRNA methyltransferase, putative Get druggable targets OG5_126871 All targets in OG5_126871
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum ko:K00599 rRNA methyltransferase Spb1 [EC:2.1.1.-], putative Get druggable targets OG5_126871 All targets in OG5_126871
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis glutaminase, putative Get druggable targets OG5_129245 All targets in OG5_129245
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum ko:K04799 flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) glutaminase 2 Get druggable targets OG5_129245 All targets in OG5_129245
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126871 All targets in OG5_126871
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis phosphoglycerate kinase 1 Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126776 All targets in OG5_126776
Babesia bovis ribosomal RNA large subunit methyltransferase J protein, putative Get druggable targets OG5_126871 All targets in OG5_126871
Echinococcus granulosus flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium ulcerans DNA polymerase IV Get druggable targets OG5_127393 All targets in OG5_127393
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) Get druggable targets OG5_127393 All targets in OG5_127393
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Toxoplasma gondii flap structure-specific endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Brugia malayi polk-prov protein Get druggable targets OG5_127393 All targets in OG5_127393
Brugia malayi RhoGAP domain containing protein Get druggable targets OG5_132551 All targets in OG5_132551
Brugia malayi hypothetical protein Get druggable targets OG5_129664 All targets in OG5_129664
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus phosphoglycerate kinase 1 Get druggable targets OG5_126776 All targets in OG5_126776
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132551 All targets in OG5_132551
Brugia malayi glutaminase DH11.1 Get druggable targets OG5_129245 All targets in OG5_129245
Plasmodium vivax flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127973 All targets in OG5_127973
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus multilocularis F box protein 36 Get druggable targets OG5_127973 All targets in OG5_127973
Trypanosoma cruzi phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) ribosomal RNA methyltransferase Get druggable targets OG5_126871 All targets in OG5_126871
Schistosoma mansoni phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania infantum FtsJ cell division protein, putative Get druggable targets OG5_126871 All targets in OG5_126871
Leishmania donovani DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Theileria parva phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma japonicum Guanine nucleotide-binding protein subunit beta-1, putative Get druggable targets OG5_127973 All targets in OG5_127973
Echinococcus granulosus Rac GTPase activating protein 1 Get druggable targets OG5_132551 All targets in OG5_132551
Echinococcus multilocularis flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Echinococcus multilocularis dna polymerase kappa Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni rac gtpase activating protein Get druggable targets OG5_132551 All targets in OG5_132551
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis guanine nucleotide binding protein subunit beta Get druggable targets OG5_127973 All targets in OG5_127973
Giardia lamblia FtsJ cell division protein, putative Get druggable targets OG5_126871 All targets in OG5_126871
Plasmodium knowlesi ribosomal RNA methyltransferase, putative Get druggable targets OG5_126871 All targets in OG5_126871
Plasmodium yoelii FtsJ cell division protein, putative Get druggable targets OG5_126871 All targets in OG5_126871
Candida albicans G-beta repeat protein similar to S. cerevisiae STE4 (YOR212W) beta subunit of heterotrimeric G protein coupled to pheromone rece Get druggable targets OG5_127973 All targets in OG5_127973
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus granulosus guanine nucleotide binding protein subunit beta Get druggable targets OG5_127973 All targets in OG5_127973
Schistosoma mansoni phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132551 All targets in OG5_132551
Theileria parva flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma japonicum ko:K10312 F-box protein 36, putative Get druggable targets OG5_127973 All targets in OG5_127973
Giardia lamblia Rho GAP, putative Get druggable targets OG5_132551 All targets in OG5_132551
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania braziliensis DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03511 DNA polymerase kappa subunit, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma japonicum ko:K07972 guanine nucleotide binding protein (G protein), beta, other, putative Get druggable targets OG5_127973 All targets in OG5_127973
Toxoplasma gondii ribosomal RNA methyltransferase (FtsJ) family protein Get druggable targets OG5_126871 All targets in OG5_126871
Schistosoma japonicum ko:K00927 phosphoglycerate kinase [EC2.7.2.3], putative Get druggable targets OG5_126776 All targets in OG5_126776
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei gambiense flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma cruzi phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Babesia bovis ribosomal RNA large subunit methyltransferase J family protein Get druggable targets OG5_126871 All targets in OG5_126871
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum ribosomal RNA large subunit methyltransferase J, putative Get druggable targets OG5_126871 All targets in OG5_126871
Leishmania braziliensis DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania major flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum phosphoglycerate kinase B, cytosolic Get druggable targets OG5_126776 All targets in OG5_126776
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni eyes absent homolog Get druggable targets OG5_129664 All targets in OG5_129664
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Putative rRNA methyltransferase 3, putative Get druggable targets OG5_126871 All targets in OG5_126871
Plasmodium falciparum large subunit rRNA methyltransferase, putative Get druggable targets OG5_126871 All targets in OG5_126871
Brugia malayi Flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Mycobacterium ulcerans DNA polymerase IV Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Giardia lamblia Flap structure-specific endonuclease Get druggable targets OG5_127472 All targets in OG5_127472
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis squamous cell carcinoma antigen Human immunodeficiency virus type 1 Tat protein   86 aa 79 aa 30.4 %
Trypanosoma brucei exonuclease, putative flap structure-specific endonuclease 1 380 aa 322 aa 24.5 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0014 0.0028 0.0028
Schistosoma mansoni serine/threonine protein kinase 0.0013 0.0005 0.0008
Brugia malayi Protein kinase domain containing protein 0.0013 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0095 0.1558 0.1558
Schistosoma mansoni chromobox protein 0.0014 0.0028 0.0047
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.1583 0.4111
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0029 0.032 0.0504
Trichomonas vaginalis chromobox protein, putative 0.0084 0.1356 0.2224
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0028 0.00000000061472
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0075 0.1192 0.2993
Echinococcus granulosus guanine nucleotide binding protein subunit beta 0.0026 0.0267 0.0733
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0072 0.1128 0.0563
Loa Loa (eye worm) hypothetical protein 0.0035 0.0432 0.0432
Schistosoma mansoni eyes absent homolog 0.0106 0.1776 0.2961
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0014 0.0028 0.0047
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.032 0.0489
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0572 0.0954
Loa Loa (eye worm) hypothetical protein 0.006 0.0907 0.0907
Echinococcus granulosus tar DNA binding protein 0.0076 0.1212 0.3323
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0028 0.00000000037262
Toxoplasma gondii ImpB/MucB/SamB family protein 0.002 0.0143 0.0319
Loa Loa (eye worm) helicase 0.0014 0.0028 0.0028
Giardia lamblia Flap structure-specific endonuclease 0.0031 0.0361 0.0623
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0693 0.1899
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1921 0.3171
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.081 0.081
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1212 0.202
Loa Loa (eye worm) CHromoDomain protein family member 0.0014 0.0028 0.0028
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0013 0.0005 0.0013
Echinococcus multilocularis flap endonuclease 1 0.0031 0.0361 0.0991
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.1944 0.5331
Entamoeba histolytica Flap nuclease, putative 0.0031 0.0361 0.0922
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.1921 0.5073
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.1212 0.1212
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0013 0.0005 0.0005
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1212 0.202
Brugia malayi protein kinase C3,putative 0.0013 0.0005 0.0005
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0834 0.135
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0028 0.00000000037262
Schistosoma mansoni DNA polymerase eta 0.0095 0.1558 0.2598
Schistosoma mansoni G-protein beta subunit 0.0026 0.0267 0.0446
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1921 0.3171
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0432 0.1186
Schistosoma mansoni phosphoglycerate kinase 0.0206 0.3646 0.608
Onchocerca volvulus 0.0037 0.0466 0.0439
Brugia malayi CHD4 protein 0.0014 0.0028 0.0028
Entamoeba histolytica recQ family helicase, putative 0.0029 0.032 0.0807
Echinococcus granulosus chromobox protein 1 0.0084 0.1356 0.3718
Brugia malayi jmjC domain containing protein 0.0043 0.0572 0.0572
Schistosoma mansoni blooms syndrome DNA helicase 0.0043 0.0584 0.0974
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0206 0.3646 0.5
Loa Loa (eye worm) hypothetical protein 0.0023 0.0195 0.0195
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0013 0.0005 0.0013
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.0749 0.173
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0023 0.0195 0.0461
Plasmodium falciparum DNA repair protein REV1, putative 0.002 0.0143 0.0319
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0195 0.0195
Brugia malayi hypothetical protein 0.0106 0.1776 0.1776
Schistosoma mansoni terminal deoxycytidyl transferase 0.0064 0.0977 0.163
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0075 0.1192 0.2993
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.1921 0.5073
Loa Loa (eye worm) hypothetical protein 0.0037 0.0466 0.0466
Echinococcus multilocularis bloom syndrome protein 0.0055 0.0801 0.2198
Leishmania major phosphoglycerate kinase C, glycosomal 0.0206 0.3646 1
Trichomonas vaginalis glutaminase, putative 0.033 0.5997 1
Giardia lamblia Phosphoglycerate kinase 0.0206 0.3646 1
Giardia lamblia PHD finger protein 15 0.0035 0.0432 0.0825
Schistosoma mansoni protein kinase C mu 0.0013 0.0005 0.0008
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0028 0.00000000037262
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0398 0.062
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.1921 0.5231
Schistosoma mansoni chromobox protein 0.0084 0.1356 0.2261
Echinococcus granulosus Chromobox protein 3 0.0014 0.0028 0.0077
Brugia malayi Guanine nucleotide-binding protein beta subunit 1, putative 0.0026 0.0267 0.0267
Echinococcus granulosus bloom syndrome protein 0.0055 0.0801 0.2198
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.1583 0.4111
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1921 0.3171
Brugia malayi Valyl-tRNA synthetase 0.0014 0.0028 0.0028
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.0749 0.173
Plasmodium vivax hypothetical protein, conserved 0.0014 0.0028 0.00000000061472
Loa Loa (eye worm) hypothetical protein 0.0206 0.3646 0.3646
Schistosoma mansoni DNA polymerase IV / kappa 0.002 0.0143 0.0239
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0014 0.0028 0.0047
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.1921 0.1898
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0206 0.3646 1
Trypanosoma brucei DNA polymerase IV, putative 0.0096 0.1583 0.4111
Trypanosoma brucei DNA polymerase IV, putative 0.0088 0.1433 0.3682
Trypanosoma cruzi DNA polymerase kappa, putative 0.0096 0.1583 0.4111
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.1921 0.3202
Loa Loa (eye worm) flap endonuclease-1 0.0031 0.0361 0.0361
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0026 0.0267 0.0733
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0031 0.0361 0.0623
Loa Loa (eye worm) hypothetical protein 0.0014 0.0028 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0658 0.1056
Schistosoma mansoni hypothetical protein 0.0014 0.0028 0.0047
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.0572 0.1569
Brugia malayi hypothetical protein 0.0014 0.0028 0.0028
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0064 0.0977 0.2681
Loa Loa (eye worm) glutaminase 2 0.033 0.5997 0.5997
Brugia malayi protein kinase C II. 0.0013 0.0005 0.0005
Echinococcus multilocularis Rac GTPase activating protein 1 0.0089 0.1444 0.396
Echinococcus multilocularis protein kinase c iota type 0.0013 0.0005 0.0013
Trichomonas vaginalis DNA helicase recq1, putative 0.0055 0.0801 0.1296
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.081 0.2223
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0432 0.1118
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0028 0.00000000037262
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1212 0.202
Loa Loa (eye worm) hypothetical protein 0.0026 0.0267 0.0267
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0028 0.00000000037262
Leishmania major DNA polymerase eta, putative 0.0095 0.1558 0.4038
Loa Loa (eye worm) TAR-binding protein 0.0076 0.1212 0.1212
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.1356 0.1356
Plasmodium falciparum phd finger protein, putative 0.0035 0.0432 0.1118
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0072 0.1128 0.281
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0031 0.0361 0.0623
Echinococcus multilocularis chromobox protein 1 0.0084 0.1356 0.3718
Brugia malayi M-phase phosphoprotein, mpp8 0.0014 0.0028 0.0028
Trypanosoma brucei polo-like protein kinase 0.0114 0.1921 0.5073
Leishmania major DNA polymerase eta, putative 0.0051 0.0724 0.1657
Giardia lamblia Kinase, PLK 0.0114 0.1921 0.5073
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0075 0.1192 0.2993
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0028 0.00000000061472
Trypanosoma cruzi DNA polymerase kappa, putative 0.0096 0.1583 0.4111
Loa Loa (eye worm) GGL domain-containing protein 0.0542 1 1
Loa Loa (eye worm) hypothetical protein 0.0106 0.1776 0.1776
Echinococcus granulosus flap endonuclease 1 0.0031 0.0361 0.0991
Trypanosoma cruzi DNA polymerase eta, putative 0.0095 0.1558 0.4038
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0432 0.0721
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0028 0.0294 0.0735
Leishmania major phosphoglycerate kinase B, cytosolic 0.0206 0.3646 1
Brugia malayi Associated with TFs and helicases family protein 0.0014 0.0028 0.0028
Echinococcus granulosus dna polymerase kappa 0.0096 0.1583 0.4342
Echinococcus granulosus protein kinase c iota type 0.0013 0.0005 0.0013
Trypanosoma cruzi DNA polymerase kappa, putative 0.0096 0.1583 0.4111
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.1921 0.5267
Entamoeba histolytica deoxycytidyl transferase, putative 0.0064 0.0977 0.2624
Brugia malayi Bromodomain containing protein 0.0035 0.0432 0.0432
Loa Loa (eye worm) hypothetical protein 0.0047 0.0658 0.0658
Brugia malayi C1-like domain containing protein 0.0013 0.0005 0.0005
Plasmodium falciparum flap endonuclease 1 0.0031 0.0361 0.0922
Loa Loa (eye worm) RecQ helicase 0.0055 0.0801 0.0801
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0023 0.0195 0.0534
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0014 0.0028 0.0047
Echinococcus granulosus peregrin 0.0035 0.0432 0.1186
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0014 0.0028 0.00000000061472
Brugia malayi Protein kinase c protein 2 0.0013 0.0005 0.0005
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0029 0.032 0.0504
Schistosoma mansoni phosphoglycerate kinase 0.0206 0.3646 0.608
Brugia malayi jmjC domain containing protein 0.0115 0.1944 0.1944
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0028 0.00000000037262
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.1583 0.4111
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0028 0.00000000037262
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0028 0.00000000037262
Loa Loa (eye worm) RNA binding protein 0.0076 0.1212 0.1212
Echinococcus multilocularis Chromobox protein 3 0.0014 0.0028 0.0077
Entamoeba histolytica phosphoglycerate kinase, putative 0.0206 0.3646 1
Brugia malayi Heterochromatin protein 1 0.0084 0.1356 0.1356
Giardia lamblia DINP protein human, muc B family 0.0072 0.1128 0.281
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0037 0.0467 0.1213
Echinococcus granulosus phosphoglycerate kinase 1 0.0206 0.3646 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1212 0.202
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0726 0.1169
Brugia malayi Phosphoglycerate kinase 0.0206 0.3646 0.3646
Loa Loa (eye worm) hypothetical protein 0.0014 0.0028 0.0028
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0195 0.0461
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0031 0.0361 0.0922
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0693 0.1899
Trypanosoma brucei phosphoglycerate kinase 0.0206 0.3646 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0658 0.0632
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0023 0.0195 0.0534
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.114 0.114
Trichomonas vaginalis DNA polymerase eta, putative 0.0096 0.1583 0.2606
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0014 0.0028 0.0077
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.1583 0.4111
Loa Loa (eye worm) hypothetical protein 0.0077 0.1214 0.1214
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0195 0.0461
Loa Loa (eye worm) hypothetical protein 0.0014 0.0028 0.0028
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.0752 0.1739
Brugia malayi PHD-finger family protein 0.0035 0.0432 0.0432
Schistosoma mansoni guanine nucleotide-binding protein beta 1 4 (G protein beta1 4) 0.0026 0.0267 0.0446
Echinococcus multilocularis protein kinase c epsilon type 0.0013 0.0005 0.0013
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0014 0.0028 0.0047
Trichomonas vaginalis chromobox protein, putative 0.0084 0.1356 0.2224
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1212 0.202
Plasmodium vivax phosphoglycerate kinase, putative 0.0206 0.3646 1
Trypanosoma brucei phosphoglycerate kinase, putative 0.0075 0.1192 0.2993
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0028 0.00000000037262
Treponema pallidum phosphoglycerate kinase 0.0206 0.3646 0.5
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0572 0.0954
Brugia malayi TAR-binding protein 0.0076 0.1212 0.1212
Echinococcus granulosus F box protein 36 0.0026 0.0267 0.0733
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0432 0.1118
Onchocerca volvulus 0.0542 1 1
Loa Loa (eye worm) GTP-binding regulatory protein beta chain 0.0026 0.0267 0.0267
Schistosoma mansoni serine/threonine protein kinase 0.0013 0.0005 0.0008
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0206 0.3646 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0028 0.00000000037262
Entamoeba histolytica hypothetical protein 0.0026 0.0267 0.0661
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0658 0.1056
Echinococcus granulosus chromobox protein 1 0.0084 0.1356 0.3718
Loa Loa (eye worm) hypothetical protein 0.0014 0.0028 0.0028
Trypanosoma brucei phosphoglycerate kinase 0.0075 0.1192 0.2993
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0014 0.0028 0.0047
Trypanosoma brucei DNA polymerase kappa, putative 0.0072 0.1128 0.281
Schistosoma mansoni guanine nucleotide-binding protein beta 1 4 (G protein beta1 4) 0.0026 0.0267 0.0446
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0014 0.0028 0.0077
Loa Loa (eye worm) hypothetical protein 0.0014 0.0028 0.0028
Mycobacterium ulcerans phosphoglycerate kinase 0.0206 0.3646 0.5984
Loa Loa (eye worm) hypothetical protein 0.0014 0.0028 0.0028
Trypanosoma brucei unspecified product 0.0044 0.0602 0.1309
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0064 0.0977 0.2681
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0572 0.0572
Brugia malayi Flap endonuclease-1 0.0031 0.0361 0.0361
Loa Loa (eye worm) glutaminase 0.033 0.5997 0.5997
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.1583 0.4111
Echinococcus multilocularis peregrin 0.0035 0.0432 0.1186
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.1921 0.5073
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0031 0.0361 0.0623
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0206 0.3646 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.081 0.2223
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0572 0.1569
Trypanosoma cruzi DNA polymerase kappa, putative 0.0096 0.1583 0.4111
Trichomonas vaginalis DNA helicase recq, putative 0.0055 0.0801 0.1296
Echinococcus multilocularis phosphoglycerate kinase 1 0.0206 0.3646 1
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0206 0.3646 1
Schistosoma mansoni DNA helicase recq1 0.0023 0.0195 0.0324
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0834 0.135
Brugia malayi Bloom's syndrome protein homolog 0.0055 0.0801 0.0801
Echinococcus granulosus Rac GTPase activating protein 1 0.0089 0.1444 0.396
Giardia lamblia Rho GAP, putative 0.0077 0.1214 0.3057
Trypanosoma brucei unspecified product 0.0088 0.1433 0.3682
Loa Loa (eye worm) hypothetical protein 0.0014 0.0028 0.0028
Schistosoma mansoni chromobox protein 0.0014 0.0028 0.0047
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0075 0.1192 0.2993
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0014 0.0028 0.0077
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.1583 0.4111
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.1583 0.4111
Echinococcus multilocularis dna polymerase kappa 0.0096 0.1583 0.4342
Echinococcus multilocularis Chromo domain 0.0014 0.0028 0.0077
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0028 0.00000000061472
Plasmodium falciparum phosphoglycerate kinase 0.0206 0.3646 1
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0013 0.0005 0.0005
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.1212 0.1212
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0075 0.1192 0.2993
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0075 0.1192 0.2993
Trypanosoma brucei phosphoglycerate kinase 0.0206 0.3646 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.1944 0.5331
Schistosoma mansoni flap endonuclease-1 0.0028 0.0304 0.0508
Brugia malayi RhoGAP domain containing protein 0.0077 0.1214 0.1214
Trichomonas vaginalis flap endonuclease-1, putative 0.0031 0.0361 0.0559
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0013 0.0005 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.1583 0.4111
Schistosoma mansoni serine/threonine protein kinase 0.0013 0.0005 0.0008
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0014 0.0028 0.0077
Brugia malayi RhoGAP domain containing protein 0.0089 0.1444 0.1444
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.0752 0.1739
Trypanosoma brucei DNA polymerase IV, putative 0.0096 0.1583 0.4111
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0726 0.1169
Mycobacterium ulcerans glutaminase 0.033 0.5997 1
Brugia malayi Phosphoglycerate kinase 0.0075 0.1192 0.1192
Brugia malayi polk-prov protein 0.0052 0.0749 0.0749
Schistosoma mansoni serine/threonine protein kinase 0.0013 0.0005 0.0008
Trypanosoma brucei unspecified product 0.0044 0.0602 0.1309
Entamoeba histolytica hypothetical protein 0.0014 0.0028 0.00000000061472
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.081 0.081
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.0726 0.07
Trypanosoma cruzi DNA polymerase eta, putative 0.0051 0.0724 0.1657
Schistosoma mansoni glutaminase 0.033 0.5997 1
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0432 0.0432
Brugia malayi ImpB/MucB/SamB family protein 0.0095 0.1558 0.1558
Echinococcus granulosus chromobox protein 2 0.0014 0.0028 0.0077
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0029 0.032 0.0504
Trypanosoma brucei DNA polymerase eta, putative 0.0095 0.1558 0.4038
Schistosoma mansoni DNA helicase recq5 0.0023 0.0195 0.0324
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0023 0.0195 0.0195
Schistosoma mansoni rac gtpase activating protein 0.0089 0.1444 0.2408
Mycobacterium ulcerans DNA polymerase IV 0.0096 0.1583 0.246
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1921 0.3171
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0023 0.0195 0.0534
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0013 0.0005 0.0013
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0206 0.3646 0.6062
Echinococcus multilocularis tar DNA binding protein 0.0076 0.1212 0.3323
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0028 0.00000000037262
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0028 0.00000000037262
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.1921 0.5267
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0014 0.0028 0.00000000061472
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.081 0.1351
Giardia lamblia Sgs1 DNA helicase, putative 0.0023 0.0195 0.0146
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0096 0.1583 0.2606
Brugia malayi Protein cec-1. 0.0014 0.0028 0.0028
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.0752 0.1739
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0051 0.0724 0.1923
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0064 0.0977 0.0977
Mycobacterium ulcerans DNA polymerase IV 0.0096 0.1583 0.246
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.081 0.2223
Echinococcus multilocularis dna polymerase eta 0.0095 0.1558 0.4272
Schistosoma mansoni chromobox protein 0.0084 0.1356 0.2261
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0013 0.0005 0.0005
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0195 0.0195
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0037 0.0458 0.119
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1921 0.3171
Echinococcus multilocularis F box protein 36 0.0026 0.0267 0.0733
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0064 0.0977 0.163
Echinococcus granulosus Chromo domain 0.0014 0.0028 0.0077
Loa Loa (eye worm) hypothetical protein 0.0089 0.1444 0.1444
Plasmodium vivax flap endonuclease 1, putative 0.0031 0.0361 0.0922
Loa Loa (eye worm) hypothetical protein 0.0166 0.2909 0.2909
Echinococcus granulosus protein kinase c epsilon type 0.0013 0.0005 0.0013
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0432 0.1186
Schistosoma mansoni kinase 0.0058 0.0862 0.1437
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1921 0.3171
Echinococcus multilocularis chromobox protein 2 0.0014 0.0028 0.0077
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.081 0.1351
Plasmodium vivax DNA repair protein REV1, putative 0.002 0.0143 0.0319
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1921 0.3171
Brugia malayi glutaminase DH11.1 0.033 0.5997 0.5997
Chlamydia trachomatis phosphoglycerate kinase 0.0206 0.3646 0.5
Onchocerca volvulus Alhambra homolog 0.0035 0.0432 0.0406
Loa Loa (eye worm) hypothetical protein 0.0052 0.0749 0.0749
Brugia malayi SET domain containing protein 0.0014 0.0028 0.0028
Schistosoma mansoni jumonji domain containing protein 0.0092 0.1497 0.2496
Brugia malayi ImpB/MucB/SamB family protein 0.0064 0.0977 0.0977
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0026 0.0267 0.0733
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0206 0.3646 0.5
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0048 0.0676 0.1791
Echinococcus multilocularis chromobox protein 1 0.0084 0.1356 0.3718
Leishmania major DNA polymerase kappa, putative 0.0072 0.1128 0.281
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.1921 0.1921
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0398 0.062
Brugia malayi RNA binding protein 0.0076 0.1212 0.1212
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.1921 0.1921
Echinococcus granulosus Protein kinase C brain isozyme 0.0013 0.0005 0.0013
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0023 0.0195 0.0534
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0432 0.1118
Schistosoma mansoni serine/threonine protein kinase 0.0013 0.0005 0.0008
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.081 0.1351
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0028 0.00000000037262
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0206 0.3646 1
Loa Loa (eye worm) hypothetical protein 0.0106 0.1776 0.1776
Schistosoma mansoni hypothetical protein 0.0035 0.0432 0.0721
Brugia malayi chromobox protein homolog 3 0.0047 0.0658 0.0658
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0206 0.3646 0.6062
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.1583 0.4111
Echinococcus granulosus dna polymerase eta 0.0095 0.1558 0.4272
Echinococcus multilocularis guanine nucleotide binding protein subunit beta 0.0026 0.0267 0.0733
Schistosoma mansoni atypical protein kinase C 0.0013 0.0005 0.0008
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.081 0.2223

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.13 uM Inhibition of SIGKAFKILGYPDYD binding to biotinylated Gbeta1gamma2 (unknown origin) incubated for 1 hr by phage ELISA ChEMBL. No reference
IC50 (functional) 3.38 uM PubChem BioAssay. An HIV-1 Tat-TAR Fluorescence Polarization (FP) Counter Screen to evaluate Inhibitors Targeting HIV-1 Vif-dependent Degradation of Human APOBEC3G. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 13.26 uM PubChem BioAssay. Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein MgcRacGAP - Primary and Confirmatory Screens. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 14.64 uM PUBCHEM_BIOASSAY: Primary and Confirmatory Screening for Flavivirus Genomic Capping Enzyme Inhibition. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588708, AID588742] ChEMBL. No reference
IC50 (binding) 122.486 uM PubChem BioAssay. Counterscreen for inhibitors of phospholipase C isozymes (PLC-B3): Fluorescence-based biochemical high throughput dose response assay to identify inhibitors of phospholipase C isozymes (PLC-gamma1). (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) 122.486 uM PubChem BioAssay. Fluorescence-based biochemical high throughput dose response assay to identify inhibitors of phospholipase C isozymes (PLC-B3). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.3261 uM PubChem BioAssay. qHTS for inhibitors of Phosphogylcerate Kinase: Hit Validation Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.3827 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase: BLM Helicase Counterscreen for WRN Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.6702 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Iota: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.7079 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 0.7943 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 0.8913 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.9528 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.122 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 1.122 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference
Potency (functional) 1.5237 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase: Confirmatory Assay for Cherry-picked Compounds.. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.7783 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.5119 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of Phosphoglycerate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.3808 uM PubChem BioAssay. qHTS Assay for the Inhibitors of FEN1: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.7939 uM PubChem BioAssay. qHTS for Inhibitors of the Phosphatase Activity of Eya2: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.7444 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 32.6427 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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