Detailed information for compound 1528917

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 518.465 | Formula: C22H30O14
  • H donors: 8 H acceptors: 9 LogP: -2.16 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 3
  • SMILES: OCC1OC(C(C1O)O)(CO)O[C@H]1O[C@H](COC(=O)/C=C/c2ccc(c(c2)OC)O)[C@H]([C@@H]([C@H]1O)O)O
  • InChi: 1S/C22H30O14/c1-32-12-6-10(2-4-11(12)25)3-5-15(26)33-8-14-16(27)18(29)19(30)21(34-14)36-22(9-24)20(31)17(28)13(7-23)35-22/h2-6,13-14,16-21,23-25,27-31H,7-9H2,1H3/b5-3+/t13?,14-,16-,17?,18+,19-,20?,21-,22?/m1/s1
  • InChiKey: XMBZZLUIFFOAHR-WVUOLQOHSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Protein kinase domain containing protein 0.0482 0.3122 0.3121
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0029 0.0029 0.0029
Echinococcus granulosus dual specificity 0.0277 0.1717 0.1717
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0098 0.0501 0.0501
Loa Loa (eye worm) hypothetical protein 0.0083 0.0393 0.0393
Echinococcus granulosus dual specificity protein kinase clk2 0.0188 0.1115 0.1115
Loa Loa (eye worm) hypothetical protein 0.009 0.0445 0.0444
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0065 0.0274 0.0274
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0041 0.0111 0.0111
Echinococcus multilocularis tyrosine kinase 0.0031 0.0042 0.0042
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0135 0.0752 0.0752
Echinococcus multilocularis roundabout 2 0.009 0.0445 0.0445
Schistosoma mansoni microtubule-associated protein tau 0.0696 0.4576 0.4576
Loa Loa (eye worm) hypothetical protein 0.0065 0.0274 0.0274
Echinococcus granulosus cyclin dependent kinase 0.0135 0.0752 0.0752
Echinococcus granulosus tyrosine protein kinase HCK 0.0078 0.0362 0.0362
Loa Loa (eye worm) TK/FER protein kinase 0.0031 0.0042 0.0041
Onchocerca volvulus 0.0031 0.0042 0.0224
Brugia malayi Protein kinase domain containing protein 0.0031 0.0042 0.0041
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.1287 0.8611 0.8611
Schistosoma mansoni nephrin 0.0073 0.0326 0.0326
Onchocerca volvulus Tyrosine kinase homolog 0.0296 0.185 1
Loa Loa (eye worm) TK/FER protein kinase 0.0031 0.0042 0.0041
Brugia malayi cell division control protein 2 homolog 0.0135 0.0752 0.0752
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0135 0.0752 0.1464
Loa Loa (eye worm) hypothetical protein 0.0031 0.0042 0.0041
Schistosoma mansoni tyrosine kinase 0.084 0.5561 0.5561
Brugia malayi Protein kinase domain containing protein 0.0031 0.0042 0.0041
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0188 0.1115 0.217
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0277 0.1717 0.3343
Onchocerca volvulus 0.0268 0.1657 0.8956
Toxoplasma gondii fructose-bisphospatase I 0.0289 0.1803 0.351
Brugia malayi Immunoglobulin I-set domain containing protein 0.0065 0.0274 0.0274
Brugia malayi Tyrosine-protein kinase abl-1 0.0119 0.0644 0.0643
Echinococcus multilocularis tyrosine protein kinase Blk 0.0088 0.0432 0.0432
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0482 0.3122 0.3122
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0135 0.0752 0.0752
Echinococcus granulosus cyclin dependent kinase 5 0.0135 0.0752 0.0752
Echinococcus granulosus tyrosine protein kinase ABL1 0.0235 0.1435 0.1435
Loa Loa (eye worm) TK/ABL protein kinase 0.0235 0.1435 0.1435
Onchocerca volvulus 0.0031 0.0042 0.0224
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0065 0.0274 0.0274
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.0785 0.5187 0.5187
Schistosoma mansoni tyrosine kinase 0.0861 0.5702 0.5702
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0031 0.0042 0.0042
Loa Loa (eye worm) TK/FER protein kinase 0.0031 0.0042 0.0041
Echinococcus granulosus tyrosine protein kinase Srms 0.0031 0.0042 0.0042
Brugia malayi hypothetical protein 0.0065 0.0274 0.0274
Entamoeba histolytica protein kinase, putative 0.0277 0.1717 1
Giardia lamblia Kinase, CMGC CLK 0.0188 0.1115 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0274 0.0274
Loa Loa (eye worm) hypothetical protein 0.0785 0.5187 0.5187
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0088 0.0432 0.0432
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0098 0.0501 0.0501
Echinococcus granulosus tyrosine protein kinase Fyn 0.0098 0.0501 0.0501
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0188 0.1115 0.217
Schistosoma mansoni serine/threonine protein kinase 0.0135 0.0752 0.0752
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0188 0.1115 0.217
Trypanosoma cruzi cdc2-related kinase 3 0.0135 0.0752 0.1464
Leishmania major 0.0778 0.5136 1
Echinococcus multilocularis neuroglian 0.0073 0.0326 0.0326
Plasmodium falciparum protein serine/threonine kinase-1 0.0188 0.1115 1
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0098 0.0501 0.0501
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0277 0.1717 0.3343
Echinococcus granulosus epidermal growth factor receptor 0.1491 1 1
Loa Loa (eye worm) hypothetical protein 0.0184 0.1086 0.1085
Loa Loa (eye worm) hypothetical protein 0.0065 0.0274 0.0274
Entamoeba histolytica cell division protein kinase 2, putative 0.0135 0.0752 0.438
Loa Loa (eye worm) TK/FER protein kinase 0.0031 0.0042 0.0041
Echinococcus multilocularis tyrosine protein kinase Srms 0.0088 0.0432 0.0432
Echinococcus multilocularis cyclin dependent kinase 1 0.0135 0.0752 0.0752
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0068 0.0291 0.0291
Entamoeba histolytica cell division protein kinase 2, putative 0.0135 0.0752 0.438
Schistosoma mansoni tyrosine kinase 0.0098 0.0501 0.0501
Loa Loa (eye worm) TK/FER protein kinase 0.0031 0.0042 0.0041
Onchocerca volvulus 0.0031 0.0042 0.0224
Brugia malayi SH2 domain containing protein 0.0031 0.0042 0.0041
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0098 0.0501 0.0501
Trypanosoma brucei fructose-1,6-bisphosphatase 0.0778 0.5136 1
Brugia malayi Protein kinase domain containing protein 0.0031 0.0042 0.0041
Brugia malayi SH2 domain containing protein 0.0031 0.0042 0.0041
Echinococcus granulosus c src tyrosine kinase 0.0041 0.0111 0.0111
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0277 0.1717 0.1717
Echinococcus granulosus tyrosine kinase 0.0031 0.0042 0.0042
Echinococcus multilocularis tyrosine protein kinase HCK 0.0078 0.0362 0.0362
Schistosoma mansoni tyrosine kinase 0.0031 0.0042 0.0042
Echinococcus granulosus tyrosine protein kinase Fyn 0.0098 0.0501 0.0501
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 0.0778 0.5136 0.5136
Echinococcus granulosus microtubule associated protein 2 0.0696 0.4576 0.4576
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0041 0.0111 0.0111
Schistosoma mansoni tyrosine kinase 0.084 0.5561 0.5561
Echinococcus multilocularis cyclin dependent kinase 1 0.0135 0.0752 0.0752
Echinococcus multilocularis c src tyrosine kinase 0.0041 0.0111 0.0111
Loa Loa (eye worm) SRC-1 0.0098 0.0501 0.0501
Loa Loa (eye worm) hypothetical protein 0.0376 0.2394 0.2394
Brugia malayi Fibronectin type III domain containing protein 0.0065 0.0274 0.0274
Entamoeba histolytica protein kinase, putative 0.0277 0.1717 1
Loa Loa (eye worm) TK protein kinase 0.0088 0.0432 0.0432
Echinococcus multilocularis dual specificity protein kinase clk2 0.0188 0.1115 0.1115
Echinococcus granulosus defective proboscis extension response 0.0065 0.0274 0.0274
Schistosoma mansoni tyrosine kinase 0.0031 0.0042 0.0042
Schistosoma mansoni tyrosine kinase 0.0118 0.0637 0.0637
Schistosoma mansoni tyrosine kinase 0.0861 0.5702 0.5702
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.0785 0.5187 0.5187
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0188 0.1115 0.1114
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0482 0.3122 0.3122
Toxoplasma gondii fructose-bisphospatase II 0.0778 0.5136 1
Echinococcus multilocularis cyclin dependent kinase 5 0.0135 0.0752 0.0752
Schistosoma mansoni serine/threonine protein kinase 0.0277 0.1717 0.1717
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0028 0.0023 0.0023
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0098 0.0501 0.0501
Schistosoma mansoni tyrosine kinase 0.0046 0.0142 0.0142
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0118 0.0637 0.0637
Onchocerca volvulus 0.0031 0.0042 0.0224
Echinococcus granulosus twitchin 0.0077 0.0354 0.0354
Loa Loa (eye worm) TK/EGFR protein kinase 0.1491 1 1
Brugia malayi Protein kinase domain containing protein 0.0135 0.0752 0.0752
Loa Loa (eye worm) TK/FER protein kinase 0.0031 0.0042 0.0041
Trypanosoma cruzi cdc2-related kinase 1 0.0135 0.0752 0.1464
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0135 0.0752 0.1464
Schistosoma mansoni tyrosine kinase 0.0041 0.0111 0.0111
Schistosoma mansoni tyrosine kinase 0.1491 1 1
Plasmodium falciparum protein kinase 5 0.0135 0.0752 0.6747
Brugia malayi Protein kinase domain containing protein 0.0277 0.1717 0.1717
Echinococcus granulosus tyrosine protein kinase Fyn 0.0098 0.0501 0.0501
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0118 0.0637 0.0637
Loa Loa (eye worm) TK/FER protein kinase 0.0031 0.0042 0.0041
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0041 0.0111 0.0111
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0098 0.0501 0.0501
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0031 0.0042 0.0243
Trypanosoma cruzi cdc2-related kinase 1 0.0135 0.0752 0.1464
Toxoplasma gondii sedoheptulose-1,7-bisphosphatase 0.0289 0.1803 0.351
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0098 0.0501 0.0501
Schistosoma mansoni tyrosine kinase 0.084 0.5561 0.5561
Leishmania major protein kinase, putative 0.0188 0.1115 0.217
Brugia malayi Tyrosine-protein kinase abl-1 0.0126 0.069 0.069
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0135 0.0752 0.1464
Loa Loa (eye worm) fructose-1,6-bisphosphatase 0.0778 0.5136 0.5136
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0188 0.1115 0.217
Loa Loa (eye worm) hypothetical protein 0.0272 0.1688 0.1688
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0098 0.0501 0.0501
Loa Loa (eye worm) TK protein kinase 0.0126 0.0688 0.0688
Brugia malayi Protein kinase domain containing protein 0.0031 0.0042 0.0041
Plasmodium vivax serine/threonine kinase-1, putative 0.0188 0.1115 1
Loa Loa (eye worm) hypothetical protein 0.0376 0.2394 0.2394
Trypanosoma brucei sedoheptulose-1,7-bisphosphatase 0.0289 0.1803 0.351
Loa Loa (eye worm) hypothetical protein 0.0099 0.0504 0.0503
Echinococcus granulosus tyrosine protein kinase Src42A 0.0068 0.0291 0.0291
Echinococcus multilocularis dual specificity 0.0277 0.1717 0.1717
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0135 0.0752 0.0752
Entamoeba histolytica protein kinase domain containing protein 0.0277 0.1717 1
Trypanosoma brucei cdc2-related kinase 1 0.0135 0.0752 0.1464
Schistosoma mansoni fructose-16-bisphosphatase-related 0.0778 0.5136 0.5136
Echinococcus multilocularis Immunoglobulin 0.0065 0.0274 0.0274
Schistosoma mansoni tyrosine kinase 0.0098 0.0501 0.0501
Entamoeba histolytica hypothetical protein 0.0277 0.1717 1
Loa Loa (eye worm) TK/FER protein kinase 0.0031 0.0042 0.0041
Loa Loa (eye worm) hypothetical protein 0.0272 0.1688 0.1688
Trypanosoma cruzi cdc2-related kinase 3 0.0135 0.0752 0.1464
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0118 0.0637 0.0637
Echinococcus granulosus tyrosine protein kinase Blk 0.0088 0.0432 0.0432
Schistosoma mansoni tyrosine kinase 0.0482 0.3122 0.3122
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0861 0.5702 0.5702
Loa Loa (eye worm) hypothetical protein 0.0065 0.0274 0.0274
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0098 0.0501 0.0501
Schistosoma mansoni tyrosine kinase 0.0041 0.0111 0.0111
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0235 0.1435 0.1435
Brugia malayi protein-tyrosine kinase 0.0088 0.0432 0.0432
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0371 0.2363 0.2362
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0028 0.0023 0.0023
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0289 0.1803 0.351
Loa Loa (eye worm) hypothetical protein 0.0065 0.0274 0.0274
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0065 0.0274 0.0274
Echinococcus granulosus epidermal growth factor receptor 0.0861 0.5702 0.5702
Echinococcus granulosus tyrosine protein kinase Src42A 0.0098 0.0501 0.0501
Loa Loa (eye worm) TK/FER protein kinase 0.0031 0.0042 0.0041
Echinococcus granulosus Immunoglobulin 0.0065 0.0274 0.0274
Loa Loa (eye worm) hypothetical protein 0.009 0.0445 0.0444
Echinococcus multilocularis epidermal growth factor receptor 0.1491 1 1
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0188 0.1115 0.217
Trichomonas vaginalis CMGC family protein kinase 0.0188 0.1115 1
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0088 0.0432 0.0432
Leishmania major protein kinase, putative 0.0188 0.1115 0.217
Echinococcus multilocularis 0.0538 0.3498 0.3498
Loa Loa (eye worm) TK protein kinase 0.0078 0.0362 0.0361
Brugia malayi fructose-1,6-bisphosphatase 0.0778 0.5136 0.5136
Echinococcus multilocularis tyrosine protein kinase Abl 0.0119 0.0644 0.0644
Loa Loa (eye worm) TK/INSR protein kinase 0.0482 0.3122 0.3121
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0188 0.1115 0.217
Echinococcus multilocularis Immunoglobulin 0.0065 0.0274 0.0274
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0289 0.1803 0.351
Echinococcus granulosus fibroblast growth factor receptor 4 0.0118 0.0637 0.0637
Schistosoma mansoni serine/threonine protein kinase 0.0188 0.1115 0.1115
Echinococcus multilocularis epidermal growth factor receptor 0.0861 0.5702 0.5702
Echinococcus multilocularis insulin receptor 0.0482 0.3122 0.3122
Loa Loa (eye worm) TK/FER protein kinase 0.0031 0.0042 0.0041
Echinococcus multilocularis microtubule associated protein 2 0.0696 0.4576 0.4576
Schistosoma mansoni cell adhesion molecule 0.0083 0.0393 0.0393
Schistosoma mansoni tyrosine kinase 0.0225 0.1364 0.1364
Onchocerca volvulus 0.0031 0.0042 0.0224
Brugia malayi Immunoglobulin I-set domain containing protein 0.0126 0.0688 0.0688
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0778 0.5136 1
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0277 0.1717 0.3343
Echinococcus multilocularis cyclin dependent kinase 0.0135 0.0752 0.0752
Echinococcus granulosus fructose 16 bisphosphatase 1 0.0778 0.5136 0.5136
Entamoeba histolytica protein kinase, putative 0.0078 0.0362 0.2105
Echinococcus granulosus tyrosine protein kinase Src64B 0.0098 0.0501 0.0501
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0188 0.1115 0.217
Echinococcus granulosus neuroglian 0.0073 0.0326 0.0326
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0277 0.1717 0.3343
Schistosoma mansoni serine/threonine protein kinase 0.0188 0.1115 0.1115
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0778 0.5136 1
Trypanosoma brucei cdc2-related kinase 3 0.0135 0.0752 0.1464
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0031 0.0042 0.0042
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.0785 0.5187 0.5187
Schistosoma mansoni serine/threonine protein kinase 0.0135 0.0752 0.0752
Schistosoma mansoni tyrosine kinase 0.0482 0.3122 0.3122
Echinococcus granulosus tyrosine kinase 0.0088 0.0432 0.0432
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0098 0.0501 0.0501
Schistosoma mansoni vesicular amine transporter 0.0065 0.0274 0.0274
Echinococcus granulosus tyrosine protein kinase Lyn 0.0103 0.053 0.053
Echinococcus granulosus cyclin dependent kinase 1 0.0135 0.0752 0.0752
Echinococcus granulosus hypothetical protein 0.0184 0.1086 0.1086
Brugia malayi SRC-1 0.0098 0.0501 0.0501
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0135 0.0752 0.0752
Brugia malayi hypothetical protein 0.0376 0.2394 0.2394
Echinococcus multilocularis tyrosine protein kinase shark 0.0031 0.0042 0.0042
Echinococcus multilocularis 0.0184 0.1086 0.1086
Echinococcus granulosus tyrosine protein kinase shark 0.0031 0.0042 0.0042
Brugia malayi Protein kinase domain containing protein 0.0031 0.0042 0.0041
Loa Loa (eye worm) hypothetical protein 0.0065 0.0274 0.0274
Loa Loa (eye worm) TK/ROR protein kinase 0.0028 0.0023 0.0022
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0083 0.0393 0.0393
Echinococcus granulosus insulin receptor 0.0482 0.3122 0.3122
Loa Loa (eye worm) hypothetical protein 0.0131 0.0723 0.0723
Brugia malayi Immunoglobulin I-set domain containing protein 0.0371 0.2363 0.2362
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0098 0.0501 0.0501
Onchocerca volvulus 0.0031 0.0042 0.0224
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.004 0.004
Brugia malayi hypothetical protein 0.0031 0.0042 0.0041
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.6511 0.6511
Echinococcus granulosus roundabout 2 0.009 0.0445 0.0445
Brugia malayi Protein kinase domain containing protein 0.0188 0.1115 0.1114

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 16.3535 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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