Detailed information for compound 1528985

Basic information

Technical information
  • TDR Targets ID: 1528985
  • Name: 6-amino-5-[2-[1-(2-methoxyethyl)benzimidazol- 2-yl]sulfanylacetyl]-1,3-dimethylpyrimidine-2 ,4-dione
  • MW: 403.455 | Formula: C18H21N5O4S
  • H donors: 1 H acceptors: 4 LogP: 1.24 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCn1c(SCC(=O)c2c(N)n(C)c(=O)n(c2=O)C)nc2c1cccc2
  • InChi: 1S/C18H21N5O4S/c1-21-15(19)14(16(25)22(2)18(21)26)13(24)10-28-17-20-11-6-4-5-7-12(11)23(17)8-9-27-3/h4-7H,8-10,19H2,1-3H3
  • InChiKey: FFSRWNOCKGZCGO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-amino-5-[2-[1-(2-methoxyethyl)benzimidazol-2-yl]sulfanylacetyl]-1,3-dimethyl-pyrimidine-2,4-dione
  • 6-amino-5-[2-[[1-(2-methoxyethyl)-2-benzimidazolyl]thio]-1-oxoethyl]-1,3-dimethylpyrimidine-2,4-dione
  • 6-amino-5-[2-[[1-(2-methoxyethyl)benzimidazol-2-yl]thio]acetyl]-1,3-dimethyl-pyrimidine-2,4-quinone
  • 6-amino-5-[2-[1-(2-methoxyethyl)benzimidazol-2-yl]sulfanylethanoyl]-1,3-dimethyl-pyrimidine-2,4-dione
  • T5281956
  • ZINC03356155
  • MLS001003417
  • SMR000344869

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni organic anion transporter 0.0056 0.696 0.6955
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0018
Entamoeba histolytica hypothetical protein 0.0043 0.4988 1
Echinococcus multilocularis peptidyl prolyl cis trans isomerase 2 0.0011 0.0055 0.0055
Plasmodium vivax cyclophilin, putative 0.0011 0.0055 1
Schistosoma mansoni peptidyl-prolyl cis-trans isomerase G ppig 0.0011 0.0055 0.0038
Toxoplasma gondii cyclophilin, putative 0.0011 0.0055 0.0054
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0055 0.5
Giardia lamblia Peptidyl-prolyl cis-trans isomerase B precursor 0.0011 0.0055 0.5
Plasmodium vivax cyclophilin, putative 0.0011 0.0055 1
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0039 0.4244 0.4234
Trichomonas vaginalis peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0055 1
Leishmania major cyclophilin 3, putative 0.0011 0.0055 1
Loa Loa (eye worm) multidrug resistance protein 3 0.0011 0.0018 0.0018
Schistosoma mansoni cyclophilin E 0.0011 0.0055 0.0038
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0039 0.4244 0.4234
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0055 1
Loa Loa (eye worm) cytosolic cyclophilin 0.0011 0.0055 0.0055
Toxoplasma gondii peptidylprolyl isomerase domain-containing protein 0.0011 0.0055 0.0054
Onchocerca volvulus 0.0056 0.696 1
Echinococcus granulosus peptidyl prolyl cis trans isomerase 6 0.0011 0.0055 0.0055
Plasmodium vivax cyclophilin, putative 0.0011 0.0055 1
Entamoeba histolytica hypothetical protein 0.0043 0.4988 1
Trypanosoma brucei Peptidyl-prolyl cis-trans isomerase C, mitochondrial, putative 0.0011 0.0055 0.5
Giardia lamblia Peptidyl-prolyl cis-trans isomerase B precursor 0.0011 0.0055 0.5
Schistosoma mansoni peptidyl-prolyl cis-trans isomerase-like 1 ppil1 0.0011 0.0055 0.0038
Schistosoma mansoni follistatin 0.0039 0.4244 0.4234
Mycobacterium tuberculosis Probable peptidyl-prolyl cis-trans isomerase B PpiB (cyclophilin) (PPIase) (rotamase) (peptidylprolyl isomerase) 0.0011 0.0055 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.4244 0.4244
Brugia malayi sodium-independent organic anion transporter family protein 0.0056 0.696 0.6955
Brugia malayi cyclophilin-type peptidyl-prolyl cis-trans isomerase-2, Bmcyp-2 0.0011 0.0055 0.0038
Onchocerca volvulus Putative organic anion transporter 0.0056 0.696 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.4244 0.4244
Echinococcus multilocularis agrin 0.0039 0.4244 0.4244
Loa Loa (eye worm) cyclophilin 0.0011 0.0055 0.0055
Brugia malayi RNA recognition motif domain containing protein 0.0076 1 1
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase 0.0011 0.0055 1
Trichomonas vaginalis peptidyl-prolyl cis-trans isomerase D, ppid, putative 0.0011 0.0055 1
Brugia malayi SPARC precursor 0.0039 0.4244 0.4234
Echinococcus granulosus peptidyl prolyl cis trans isomerase 2 0.0011 0.0055 0.0055
Echinococcus granulosus Solute carrier organic anion transporter family 0.0056 0.696 0.696
Schistosoma mansoni peptidyl-prolyl cis-trans isomerase (cyclophilin) 0.0011 0.0055 0.0038
Echinococcus multilocularis tar DNA binding protein 0.0076 1 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0011 0.0018 0.0018
Onchocerca volvulus 0.0056 0.696 1
Brugia malayi sodium-independent organic anion transporter family protein 0.0056 0.696 0.6955
Echinococcus granulosus peptidyl prolyl cis trans isomerase E 0.0011 0.0055 0.0055
Mycobacterium leprae Probable peptidyl-prolyl cis-trans isomerase PpiA (PPIase A) (Rotamase A) 0.0011 0.0055 0.5
Echinococcus granulosus agrin 0.0039 0.4244 0.4244
Leishmania major cyclophilin 8, putative 0.0011 0.0055 1
Trichomonas vaginalis peptidyl-prolyl cis-trans isomerase B precursor, putative 0.0011 0.0055 1
Brugia malayi cyclophilin-type peptidyl-prolyl cis-trans isomerase-12, Bmcyp-12 0.0011 0.0055 0.0038
Onchocerca volvulus 0.0011 0.0055 0.0054
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0056 0.696 0.696
Trypanosoma brucei cyclophilin-type peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0055 0.5
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.4988 0.4979
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0011 0.0018 0.5
Echinococcus granulosus multidrug resistance protein 1 0.0011 0.0018 0.0018
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase 0.0011 0.0055 0.0054
Toxoplasma gondii cyclophilin, putative 0.0011 0.0055 0.0054
Brugia malayi peptidyl-prolyl cis-trans isomerase 11 0.0011 0.0055 0.0038
Leishmania major cyclophilin 14, putative 0.0011 0.0055 1
Brugia malayi TAR-binding protein 0.0076 1 1
Plasmodium vivax cyclophilin, putative 0.0011 0.0055 1
Trypanosoma brucei cyclophilin-type peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0055 0.5
Trypanosoma brucei cyclophilin-type peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0055 0.5
Toxoplasma gondii cyclophilin, putative 0.0011 0.0055 0.0054
Leishmania major cyclophilin 9, putative 0.0011 0.0055 1
Echinococcus granulosus peptidyl prolyl isomerase G 0.0011 0.0055 0.0055
Trypanosoma brucei cyclophilin type peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0055 0.5
Trichomonas vaginalis peptidyl-prolyl cis-trans isomerase A, ppia, putative 0.0011 0.0055 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0055 0.0055
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0039 0.4244 0.4234
Onchocerca volvulus Putative organic anion transporter 0.0056 0.696 1
Echinococcus multilocularis expressed protein 0.0039 0.4244 0.4244
Loa Loa (eye worm) hypothetical protein 0.0056 0.696 0.696
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0011 0.0018 0.0018
Onchocerca volvulus 0.0011 0.0055 0.0054
Plasmodium vivax cyclophilin, putative 0.0011 0.0055 1
Plasmodium vivax peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0055 1
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase family 1 0.0011 0.0055 0.0054
Echinococcus granulosus expressed protein 0.0011 0.0055 0.0055
Brugia malayi cyclophilin-type peptidyl-prolyl cis-trans isomerase-18, Bmcyp-18 0.0011 0.0055 0.0038
Brugia malayi cyclophilin-type peptidyl-prolyl cis-trans isomerase-3, Bmcyp-3 0.0011 0.0055 0.0038
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0039 0.4244 0.6088
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0055 0.0076
Brugia malayi prostaglandin transporter 0.0056 0.696 0.6955
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.4988 0.4988
Echinococcus granulosus follistatin 0.0039 0.4244 0.4244
Toxoplasma gondii cyclophilin 0.0011 0.0055 0.0054
Trichomonas vaginalis peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0055 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0011 0.0018 0.0018
Loa Loa (eye worm) cyclophilin-type peptidyl-prolyl cis-trans isomerase-2 0.0011 0.0055 0.0055
Leishmania major cyclophilin 4, putative 0.0011 0.0055 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.696 0.696
Loa Loa (eye worm) hypothetical protein 0.0039 0.4244 0.4244
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase 0.0011 0.0055 1
Toxoplasma gondii transporter, major facilitator family protein 0.0056 0.696 1
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0055 0.0076
Leishmania major cyclophilin 5, putative 0.0011 0.0055 1
Schistosoma mansoni cyclophilin 0.0011 0.0055 0.0038
Leishmania major cyclophilin 40 0.0011 0.0055 1
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase 0.0011 0.0055 1
Loa Loa (eye worm) agrin synaptic family protein 0.0039 0.4244 0.4244
Mycobacterium leprae Probable peptidyl-prolyl cis-trans isomerase B PpiB (Cyclopphilin) (Ppiase) (Rotamase) (Peptidylprolyl isomerase) 0.0011 0.0055 0.5
Loa Loa (eye worm) hypothetical protein 0.0011 0.0055 0.0055
Trichomonas vaginalis cyclophillin, putative 0.0011 0.0055 1
Mycobacterium tuberculosis Probable iron-regulated peptidyl-prolyl cis-trans isomerase A PpiA (PPIase A) (rotamase A) 0.0011 0.0055 1
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0056 0.696 0.696
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0018
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0011 0.0018 0.0018
Trypanosoma brucei cyclophilin type peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0055 0.5
Loa Loa (eye worm) hypothetical protein 0.0056 0.696 0.696
Echinococcus granulosus peptidyl prolyl cis trans isomerase 3 0.0011 0.0055 0.0055
Leishmania major cyclophilin 12, putative 0.0011 0.0055 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.4244 0.4244
Schistosoma mansoni cyclophilin 0.0011 0.0055 0.0038
Trypanosoma brucei cyclophilin, putative 0.0011 0.0055 0.5
Echinococcus multilocularis peptidyl prolyl cis trans isomerase 4 0.0011 0.0055 0.0055
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase 0.0011 0.0055 1
Echinococcus multilocularis peptidylprolyl isomerase domain and WD40 repeat 0.0011 0.0055 0.0055
Toxoplasma gondii cyclophilin 1, putative 0.0011 0.0055 0.0054
Trypanosoma cruzi MFS transporter, putative 0.0056 0.696 1
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0056 0.696 0.696
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase 0.0011 0.0055 1
Schistosoma mansoni peptidyl-prolyl cis-trans isomerase 0.0011 0.0055 0.0038
Trichomonas vaginalis cyclophilin, putative 0.0011 0.0055 1
Leishmania major cyclosporin 16, putative 0.0011 0.0055 1
Echinococcus granulosus multidrug resistance protein 1 0.0011 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0011 0.0055 0.0055
Brugia malayi secreted modular calcium-binding protein 1 0.0039 0.4244 0.4234
Plasmodium vivax peptidyl-prolyl cis-trans isomerase 11, putative 0.0011 0.0055 1
Echinococcus granulosus peptidyl prolyl cis trans isomerase 1 0.0011 0.0055 0.0055
Echinococcus multilocularis peptidyl prolyl cis trans isomerase E 0.0011 0.0055 0.0055
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 1 1
Plasmodium vivax cyclophilin, putative 0.0011 0.0055 1
Toxoplasma gondii cyclophilin precursor 0.0011 0.0055 0.0054
Trypanosoma brucei cyclophilin-type peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0055 0.5
Trypanosoma brucei cyclophilin-type peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0055 0.5
Loa Loa (eye worm) hypothetical protein 0.0056 0.696 0.696
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0039 0.4244 0.6088
Echinococcus multilocularis peptidyl prolyl cis trans isomerase 6 0.0011 0.0055 0.0055
Entamoeba histolytica hypothetical protein 0.0043 0.4988 1
Brugia malayi sodium-independent organic anion transporter family protein 0.0056 0.696 0.6955
Trichomonas vaginalis peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0055 1
Toxoplasma gondii peptidyl-prolyl isomerase 0.0011 0.0055 0.0054
Echinococcus multilocularis peptidyl prolyl cis trans isomerase CWC27 0.0011 0.0055 0.0055
Schistosoma mansoni hypothetical protein 0.0043 0.4988 0.4979
Schistosoma mansoni agrin 0.0039 0.4244 0.4234
Leishmania major cyclophilin 10, putative 0.0011 0.0055 1
Trypanosoma brucei cyclophilin, putative 0.0011 0.0055 0.5
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0011 0.0018 0.0018
Schistosoma mansoni tar DNA-binding protein 0.0076 1 1
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase 0.0011 0.0055 1
Onchocerca volvulus 0.0056 0.696 1
Loa Loa (eye worm) cyclophilin Ovcyp-2 0.0011 0.0055 0.0055
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0039 0.4244 0.6088
Loa Loa (eye worm) CYN-5 protein 0.0011 0.0055 0.0055
Brugia malayi hypothetical protein 0.0056 0.696 0.6955
Echinococcus multilocularis U snRNP-associated cyclophilin protein 0.0011 0.0055 0.0055
Leishmania major cyclophilin 6, putative 0.0011 0.0055 1
Echinococcus multilocularis follistatin 0.0039 0.4244 0.4244
Echinococcus granulosus tar DNA binding protein 0.0076 1 1
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase 0.0011 0.0055 1
Echinococcus granulosus U snRNP-associated cyclophilin protein 0.0011 0.0055 0.0055
Brugia malayi cyclophilin-type peptidyl-prolyl cis-trans isomerase-4, Bmcyp-4 0.0011 0.0055 0.0038
Trypanosoma brucei cyclophilin-type peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0055 0.5
Onchocerca volvulus 0.0056 0.696 1
Brugia malayi cyclophilin-type peptidyl-prolyl cis-trans isomerase-6, Bmcyp-6 0.0011 0.0055 0.0038
Brugia malayi cyclophilin-type peptidyl-prolyl cis-trans isomerase-15, Bmcyp-5 0.0011 0.0055 0.0038
Onchocerca volvulus 0.0056 0.696 1
Echinococcus multilocularis multidrug resistance protein 1 0.0011 0.0018 0.0018
Toxoplasma gondii protease inhibitor PI2 0.0039 0.4244 0.6088
Leishmania major cyclophilin a 0.0011 0.0055 1
Mycobacterium ulcerans peptidyl-prolyl cis-trans isomerase B PpiB 0.0011 0.0055 0.5
Loa Loa (eye worm) hypothetical protein 0.0056 0.696 0.696
Brugia malayi hypothetical protein 0.0043 0.4988 0.4979
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase 0.0011 0.0055 1
Plasmodium vivax peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0055 1
Loa Loa (eye worm) peptidyl-prolyl cis-trans isomerase 11 0.0011 0.0055 0.0055
Trypanosoma brucei cyclophilin type peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0055 0.5
Echinococcus multilocularis peptidyl prolyl cis trans isomerase 4 0.0011 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0056 0.696 0.696
Entamoeba histolytica peptidyl prolyl cis-trans isomerase, putative 0.0011 0.0055 0.0076
Trichomonas vaginalis cyclophilin, putative 0.0011 0.0055 1
Loa Loa (eye worm) cyclophilin-type peptidyl-prolyl cis-trans isomerase-16 0.0011 0.0055 0.0055
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.4988 0.4988
Trypanosoma brucei cyclophilin-type peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0055 0.5
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, cyclophilin-type domain-containing protein 0.0011 0.0055 0.0054
Trypanosoma brucei cyclophilin type peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0055 0.5
Schistosoma mansoni peptidyl-prolyl cis-trans isomerase h ppih 0.0011 0.0055 0.0038
Schistosoma mansoni peptidyl-prolyl cis-trans isomerase-like 1 ppil1 0.0011 0.0055 0.0038
Echinococcus granulosus peptidyl prolyl cis trans isomerase CWC27 0.0011 0.0055 0.0055
Echinococcus multilocularis expressed protein 0.0011 0.0055 0.0055
Echinococcus multilocularis peptidyl prolyl cis trans isomerase 1 0.0011 0.0055 0.0055
Loa Loa (eye worm) SIG-7 protein 0.0011 0.0055 0.0055
Treponema pallidum peptidyl-prolyl cis-trans isomerase, cyclophilin-binding (cyp) 0.0011 0.0055 0.5
Schistosoma mansoni peptidyl-prolyl cis-trans isomerase G ppig 0.0011 0.0055 0.0038
Schistosoma mansoni peptidyl-prolyl cis-trans isomerase 0.0011 0.0055 0.0038
Leishmania major cyclophilin 2 0.0011 0.0055 1
Onchocerca volvulus Putative organic anion transporter 0.0056 0.696 1
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0055 0.0076
Brugia malayi cyclophilin-type peptidyl-prolyl cis-trans isomerase-13, Bmcyp-13 0.0011 0.0055 0.0038
Trypanosoma brucei cyclophilin-type peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0055 0.5
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, cyclophilin-type domain-containing protein 0.0011 0.0055 0.0054
Leishmania major cyclophilin 7, putative 0.0011 0.0055 1
Trichomonas vaginalis cyclophilin, putative 0.0011 0.0055 1
Plasmodium vivax peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0055 1
Trichomonas vaginalis peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0055 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0011 0.0018 0.0018
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0011 0.0018 0.0018
Entamoeba histolytica hypothetical protein 0.0043 0.4988 1
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0055 0.5
Schistosoma mansoni tar DNA-binding protein 0.0076 1 1
Trypanosoma brucei cyclophilin-type peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0055 0.5
Brugia malayi peptidyl-prolyl cis-trans isomerase, cyclophilin-type family protein 0.0011 0.0055 0.0038
Echinococcus multilocularis protein S isoprenylcysteine O methyltransferase 0.0011 0.0055 0.0055
Schistosoma mansoni peptidyl-prolyl cis-trans isomerase-like 0.0011 0.0055 0.0038
Brugia malayi cyclophilin-type peptidyl-prolyl cis-trans isomerase-15, Bmcyp-15 0.0011 0.0055 0.0038
Schistosoma mansoni peptidyl-prolyl cis-trans isomerase-like 2 ppil2 0.0011 0.0055 0.0038
Schistosoma mansoni tar DNA-binding protein 0.0076 1 1
Schistosoma mansoni organic anion transporter 0.0056 0.696 0.6955
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0039 0.4244 0.4244
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase 0.0011 0.0055 1
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0055 0.5
Trypanosoma brucei cyclophilin a 0.0011 0.0055 0.5
Leishmania major cyclophilin 11, putative 0.0011 0.0055 1
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase 0.0011 0.0055 1
Echinococcus multilocularis peptidyl prolyl cis trans isomerase B 0.0011 0.0055 0.0055
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0011 0.0018 0.0018
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0011 0.0018 0.0018
Loa Loa (eye worm) cyclophilin-type peptidyl-prolyl cis-trans isomerase-15 0.0011 0.0055 0.0055
Leishmania major cyclophilin 13, putative 0.0011 0.0055 1
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0039 0.4244 0.6088
Plasmodium vivax unspecified product 0.0011 0.0055 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0055 0.0055
Trypanosoma brucei RNA-binding protein, putative 0.0011 0.0055 0.5
Loa Loa (eye worm) hypothetical protein 0.0011 0.0055 0.0055
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase 0.0011 0.0055 1
Plasmodium vivax cyclophilin, putative 0.0011 0.0055 1
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0055 0.0076
Echinococcus granulosus peptidyl prolyl cis trans isomerase B 0.0011 0.0055 0.0055
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0011 0.0018 0.0018
Loa Loa (eye worm) RNA binding protein 0.0076 1 1
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0055 0.5
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0056 0.696 0.696
Trypanosoma brucei cyclophilin type peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0055 0.5
Loa Loa (eye worm) TAR-binding protein 0.0076 1 1
Brugia malayi hypothetical protein 0.0056 0.696 0.6955
Loa Loa (eye worm) cyclophilin-type peptidyl-prolyl cis-trans isomerase-18 0.0011 0.0055 0.0055
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase (cyclophilin- 40), putative 0.0011 0.0055 0.5
Schistosoma mansoni cyclophilin B 0.0011 0.0055 0.0038
Trypanosoma brucei cyclophilin-type peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0055 0.5
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0039 0.4244 0.4234
Echinococcus multilocularis multidrug resistance protein 1 0.0011 0.0018 0.0018
Echinococcus granulosus peptidylprolyl isomerase domain and WD40 repeat 0.0011 0.0055 0.0055
Toxoplasma gondii U-snRNP-associated cyclophilin family protein 0.0011 0.0055 0.0054
Schistosoma mansoni tar DNA-binding protein 0.0076 1 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.696 0.696
Mycobacterium ulcerans peptidyl-prolyl cis-trans isomerase A, PpiA 0.0011 0.0055 0.5
Onchocerca volvulus 0.0039 0.4244 0.6088
Echinococcus multilocularis peptidyl prolyl isomerase G 0.0011 0.0055 0.0055
Onchocerca volvulus 0.0011 0.0055 0.0054
Schistosoma mansoni tar DNA-binding protein 0.0076 1 1
Echinococcus granulosus multidrug resistance protein 1 0.0011 0.0018 0.0018
Trypanosoma brucei cyclophilin 15, putative 0.0011 0.0055 0.5
Trichomonas vaginalis peptidyl-prolyl cis-trans isomerase A, ppia, putative 0.0011 0.0055 1
Brugia malayi cyclophilin-type peptidyl-prolyl cis-trans isomerase-16, Bmcyp-16 0.0011 0.0055 0.0038

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.7308 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 6.3096 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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