Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0847 | 0.67 | 0.67 |
Echinococcus granulosus | hexokinase | 0.1242 | 1 | 1 |
Schistosoma mansoni | hexokinase | 0.1242 | 1 | 1 |
Leishmania major | hexokinase, putative | 0.1242 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0395 | 0.292 | 0.292 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0157 | 0.0934 | 0.0934 |
Trypanosoma brucei | hexokinase, putative | 0.1242 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0779 | 0.6132 | 0.6132 |
Brugia malayi | Hexokinase family protein | 0.1242 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.1242 | 1 | 1 |
Trypanosoma brucei | hexokinase | 0.1242 | 1 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0157 | 0.0934 | 0.0934 |
Plasmodium falciparum | hexokinase | 0.1242 | 1 | 0.5 |
Entamoeba histolytica | hexokinase 2 | 0.1242 | 1 | 0.5 |
Toxoplasma gondii | hexokinase | 0.1242 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.1242 | 1 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0157 | 0.0934 | 0.0934 |
Echinococcus multilocularis | hexokinase | 0.1242 | 1 | 1 |
Trypanosoma cruzi | hexokinase, putative | 0.1242 | 1 | 0.5 |
Onchocerca volvulus | 0.1242 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.076 | 0.076 |
Loa Loa (eye worm) | hypothetical protein | 0.0395 | 0.292 | 0.292 |
Trypanosoma cruzi | hexokinase, putative | 0.1242 | 1 | 0.5 |
Plasmodium vivax | hexokinase, putative | 0.1242 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase type II | 0.1242 | 1 | 1 |
Onchocerca volvulus | 0.1242 | 1 | 1 | |
Brugia malayi | hexokinase type II | 0.0395 | 0.292 | 0.292 |
Loa Loa (eye worm) | hexokinase | 0.0384 | 0.2831 | 0.2831 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0172 | 0.1054 | 0.1054 |
Echinococcus multilocularis | hexokinase type 2 | 0.1242 | 1 | 1 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0157 | 0.0934 | 0.0934 |
Loa Loa (eye worm) | hexokinase | 0.1242 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0172 | 0.1054 | 0.1054 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0147 | 0.0847 | 0.5 |
Trypanosoma brucei | hexokinase | 0.1242 | 1 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0147 | 0.0847 | 0.5 |
Echinococcus granulosus | hexokinase type 2 | 0.1242 | 1 | 1 |
Treponema pallidum | hexokinase (hxk) | 0.1242 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.1242 | 1 | 1 |
Entamoeba histolytica | hexokinase 1 | 0.1242 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.1242 | 1 | 1 |
Onchocerca volvulus | 0.1242 | 1 | 1 | |
Brugia malayi | Hexokinase family protein | 0.0384 | 0.2831 | 0.2831 |
Brugia malayi | Hexokinase family protein | 0.0779 | 0.6132 | 0.6132 |
Leishmania major | hexokinase, putative | 0.1242 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.1242 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 23.1093 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.