Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ATPase family, AAA domain containing 5 | Starlite/ChEMBL | No references |
Homo sapiens | tumor protein p53 | Starlite/ChEMBL | No references |
Homo sapiens | ubiquitin specific peptidase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | Get druggable targets OG5_139225 | All targets in OG5_139225 |
Echinococcus granulosus | tumor protein p63 | Get druggable targets OG5_140038 | All targets in OG5_140038 |
Echinococcus multilocularis | tumor protein p63 | Get druggable targets OG5_140038 | All targets in OG5_140038 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | voltage-gated potassium channel | 0.0424 | 0.1712 | 0.1712 |
Toxoplasma gondii | hexokinase | 0.2104 | 1 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0388 | 0.1536 | 0.1536 |
Trypanosoma brucei | hexokinase | 0.2104 | 1 | 0.5 |
Brugia malayi | hexokinase type II | 0.0669 | 0.2921 | 0.2921 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0424 | 0.1712 | 0.1712 |
Echinococcus multilocularis | hexokinase | 0.2104 | 1 | 1 |
Onchocerca volvulus | 0.2104 | 1 | 1 | |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0363 | 0.141 | 1 |
Onchocerca volvulus | 0.2104 | 1 | 1 | |
Leishmania major | hexokinase, putative | 0.2104 | 1 | 0.5 |
Trypanosoma brucei | hexokinase | 0.2104 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.2104 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0669 | 0.2921 | 0.2921 |
Trypanosoma cruzi | hexokinase, putative | 0.2104 | 1 | 0.5 |
Brugia malayi | Hexokinase family protein | 0.2104 | 1 | 1 |
Echinococcus granulosus | voltage gated potassium channel | 0.0112 | 0.0176 | 0.0176 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0176 | 0.0176 |
Loa Loa (eye worm) | hypothetical protein | 0.0337 | 0.1283 | 0.1283 |
Trypanosoma cruzi | hexokinase, putative | 0.2104 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1435 | 0.67 | 0.67 |
Brugia malayi | Hexokinase family protein | 0.132 | 0.6132 | 0.6132 |
Echinococcus multilocularis | hexokinase | 0.2104 | 1 | 1 |
Leishmania major | hexokinase, putative | 0.2104 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0669 | 0.2921 | 0.2921 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0112 | 0.0176 | 0.0176 |
Echinococcus multilocularis | tumor protein p63 | 0.0408 | 0.1634 | 0.1634 |
Echinococcus granulosus | hexokinase type 2 | 0.2104 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0112 | 0.0176 | 0.0176 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0112 | 0.0176 | 0.0176 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0388 | 0.1536 | 0.1536 |
Entamoeba histolytica | hexokinase 1 | 0.2104 | 1 | 0.5 |
Entamoeba histolytica | hexokinase 2 | 0.2104 | 1 | 0.5 |
Trypanosoma brucei | hexokinase, putative | 0.2104 | 1 | 0.5 |
Brugia malayi | Hexokinase family protein | 0.0651 | 0.2833 | 0.2833 |
Echinococcus granulosus | hexokinase | 0.2104 | 1 | 1 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0112 | 0.0176 | 0.0176 |
Loa Loa (eye worm) | hexokinase | 0.2104 | 1 | 1 |
Plasmodium vivax | hexokinase, putative | 0.2104 | 1 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0112 | 0.0176 | 0.0176 |
Loa Loa (eye worm) | hexokinase | 0.0651 | 0.2833 | 0.2833 |
Echinococcus granulosus | tumor protein p63 | 0.0408 | 0.1634 | 0.1634 |
Treponema pallidum | hexokinase (hxk) | 0.2104 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.2104 | 1 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0363 | 0.141 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0388 | 0.1536 | 0.1536 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0388 | 0.1536 | 0.1536 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0979 | 0.4453 | 0.4453 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0112 | 0.0176 | 0.0176 |
Loa Loa (eye worm) | hexokinase type II | 0.2104 | 1 | 1 |
Schistosoma mansoni | hexokinase | 0.2104 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.2104 | 1 | 1 |
Echinococcus multilocularis | hexokinase type 2 | 0.2104 | 1 | 1 |
Onchocerca volvulus | 0.2104 | 1 | 1 | |
Plasmodium falciparum | hexokinase | 0.2104 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.2104 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.132 | 0.6132 | 0.6132 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 7.9433 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 9.1962 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.