Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | hexokinase | 0.0979 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0979 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0979 | 1 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0137 | 0.1009 | 0.5 |
Brugia malayi | hexokinase type II | 0.0311 | 0.287 | 0.287 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0147 | 0.1113 | 0.1113 |
Echinococcus multilocularis | hexokinase type 2 | 0.0979 | 1 | 1 |
Brugia malayi | Hexokinase family protein | 0.0614 | 0.6105 | 0.6105 |
Onchocerca volvulus | 0.0979 | 1 | 1 | |
Brugia malayi | Hexokinase family protein | 0.0979 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.0979 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.0979 | 1 | 1 |
Loa Loa (eye worm) | hexokinase type II | 0.0979 | 1 | 1 |
Trypanosoma brucei | hexokinase, putative | 0.0979 | 1 | 0.5 |
Entamoeba histolytica | hexokinase 1 | 0.0979 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0979 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.016 | 0.1256 | 0.1256 |
Treponema pallidum | hexokinase (hxk) | 0.0979 | 1 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0137 | 0.1009 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0979 | 1 | 1 |
Entamoeba histolytica | hexokinase 2 | 0.0979 | 1 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0147 | 0.1113 | 0.1113 |
Trypanosoma brucei | hexokinase | 0.0979 | 1 | 0.5 |
Brugia malayi | Hexokinase family protein | 0.0303 | 0.2781 | 0.2781 |
Leishmania major | hexokinase, putative | 0.0979 | 1 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0147 | 0.1113 | 0.1113 |
Echinococcus multilocularis | hexokinase | 0.0979 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.287 | 0.287 |
Trypanosoma cruzi | hexokinase, putative | 0.0979 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0668 | 0.6676 | 0.6676 |
Loa Loa (eye worm) | hexokinase | 0.0614 | 0.6105 | 0.6105 |
Onchocerca volvulus | 0.0979 | 1 | 1 | |
Onchocerca volvulus | 0.0979 | 1 | 1 | |
Loa Loa (eye worm) | hexokinase | 0.0303 | 0.2781 | 0.2781 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0147 | 0.1113 | 0.1113 |
Schistosoma mansoni | hexokinase | 0.0979 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.016 | 0.1256 | 0.1256 |
Trypanosoma brucei | hexokinase | 0.0979 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.0906 | 0.0906 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.287 | 0.287 |
Leishmania major | hexokinase, putative | 0.0979 | 1 | 0.5 |
Plasmodium falciparum | hexokinase | 0.0979 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0979 | 1 | 1 |
Plasmodium vivax | hexokinase, putative | 0.0979 | 1 | 0.5 |
Echinococcus granulosus | hexokinase type 2 | 0.0979 | 1 | 1 |
Trypanosoma cruzi | hexokinase, putative | 0.0979 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | > 54.69 uM | PUBCHEM_BIOASSAY: Counterscreen for IDE activators: Fluorescence polarization-based biochemical high throughput dose response assay for activators of recombinant IDE. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493087, AID493124, AID588439, AID588440, AID588442] | ChEMBL. | No reference |
EC50 (functional) | > 54.69 uM | PUBCHEM_BIOASSAY: Fluorescence polarization-based cell-based high throughput dose response assay to identify activators of insulin-degrading enzyme (IDE). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493087, AID493124, AID588681] | ChEMBL. | No reference |
EC50 (functional) | > 54.69 uM | PUBCHEM_BIOASSAY: Counterscreen for IDE activators: Fluorescence polarization-based biochemical high throughput dose response assay to identify fluorescent artifacts and/or optically active compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493087, AID493124, AID588681] | ChEMBL. | No reference |
IC50 (functional) | > 89.183 uM | PUBCHEM_BIOASSAY: Counterscreen for activators of insulin-degrading enzyme (IDE): fluorescence-based cell-based high throughput dose response LDH release assay to identify compounds that are cytotoxic to HEK cells or compromise cell membrane permeability. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493087, AID493124, AID588681] | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.