Detailed information for compound 1529303

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 550.689 | Formula: C31H42N4O5
  • H donors: 2 H acceptors: 3 LogP: 2.46 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1cccc(c1)NC(=O)C1C2C=CC3(C1C(=O)N(C3C(=O)NC1CCCCC1)CCCN1CCCCC1)O2
  • InChi: 1S/C31H42N4O5/c1-39-23-13-8-12-22(20-23)33-28(36)25-24-14-15-31(40-24)26(25)30(38)35(19-9-18-34-16-6-3-7-17-34)27(31)29(37)32-21-10-4-2-5-11-21/h8,12-15,20-21,24-27H,2-7,9-11,16-19H2,1H3,(H,32,37)(H,33,36)
  • InChiKey: IOOKOVSIRAEBPQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.027 0.0873
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0066 0.0521 0.1646
Brugia malayi Protein kinase domain containing protein 0.0023 0.0122 0.0344
Loa Loa (eye worm) hypothetical protein 0.0023 0.0119 0.0409
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0501 0.1009
Schistosoma mansoni dihydroorotate dehydrogenase 0.0338 0.308 0.6328
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0217 0.0703
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.003 0.0184 0.0133
Plasmodium falciparum acetyl-CoA synthetase, putative 0.003 0.0184 0.0547
Leishmania major dihydroorotate dehydrogenase 0.0338 0.308 1
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0066 0.0521 0.169
Loa Loa (eye worm) hypothetical protein 0.0076 0.0619 0.2124
Brugia malayi RNA recognition motif domain containing protein 0.0201 0.1796 0.5809
Schistosoma mansoni acetyl-CoA synthetase 0.003 0.0184 0.0356
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0132 0.1143 0.1143
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0012 0.0012
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0102 0.0861 0.2757
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0076 0.0619 0.1614
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.0813 0.1652
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0132 0.1143 0.445
Loa Loa (eye worm) hypothetical protein 0.0023 0.0119 0.0409
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0132 0.1143 0.1143
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0012 0.0017 0.0052
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.003 0.0184 0.0547
Loa Loa (eye worm) hypothetical protein 0.003 0.0184 0.0633
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0813 0.2916
Echinococcus granulosus TRP transient receptor potential channel 0.0037 0.0251 0.0251
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.0217 0.0703
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0259 0.234 0.8026
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0097 0.0813 0.2637
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.003 0.0184 0.0596
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.027 0.0873
Plasmodium vivax acetyl-CoA synthetase, putative 0.003 0.0184 0.0547
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0203 0.0657
Loa Loa (eye worm) oxidoreductase 0.003 0.0184 0.0633
Trypanosoma cruzi hexokinase, putative 0.032 0.2915 0.9466
Echinococcus granulosus dihydrofolate reductase 0.0172 0.1519 0.1519
Trypanosoma brucei polo-like protein kinase 0.0097 0.0813 0.2637
Schistosoma mansoni cpg binding protein 0.0029 0.018 0.0346
Brugia malayi Immunoglobulin I-set domain containing protein 0.0023 0.0119 0.0334
Entamoeba histolytica deoxycytidyl transferase, putative 0.0039 0.027 0.0312
Brugia malayi hypothetical protein 0.0073 0.0586 0.1859
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.003 0.0184 0.0184
Schistosoma mansoni tumor necrosis factor receptor related 0.0035 0.0233 0.0456
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.027 0.0873
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0146 0.0421
Brugia malayi Latrophilin receptor protein 2 0.0082 0.0674 0.2146
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0813 0.2916
Plasmodium vivax SET domain protein, putative 0.0033 0.0215 0.0648
Mycobacterium ulcerans acyl-CoA synthetase 0.003 0.0184 0.0547
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.027 0.0873
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.003 0.0184 0.0547
Schistosoma mansoni hypothetical protein 0.0177 0.1569 0.3211
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0215 0.042
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0344 0.0344
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0344 0.0684
Brugia malayi isocitrate dehydrogenase 0.0032 0.0203 0.0608
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0203 0.0203
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.027 0.0873
Schistosoma mansoni smad1 5 8 and 0.0016 0.0058 0.0094
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0058 0.0094
Loa Loa (eye worm) hexokinase 0.032 0.2915 1
Schistosoma mansoni hypothetical protein 0.0527 0.486 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0082 0.0674 0.0674
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0012 0.0017 0.0052
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0072 0.058 0.1481
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0132 0.1143 0.3512
Trypanosoma brucei DNA damage repair protein, putative 0.0012 0.0017 0.0052
Echinococcus granulosus transient receptor potential ion channel A 0.0096 0.0807 0.0807
Leishmania major hypothetical protein, conserved 0.0026 0.0146 0.0471
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0259 0.234 0.7584
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.0217 0.0703
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0132 0.1143 0.1143
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0203 0.0203
Loa Loa (eye worm) dihydrofolate reductase 0.0172 0.1519 0.5212
Echinococcus multilocularis netrin receptor unc 5 0.0023 0.0119 0.0119
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.0338 0.308 1
Schistosoma mansoni hypothetical protein 0.0419 0.3842 0.7901
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.003 0.0184 0.0184
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0203 0.0608
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.027 0.0873
Schistosoma mansoni smad1 5 8 and 0.0016 0.0058 0.0094
Loa Loa (eye worm) hypothetical protein 0.0102 0.0861 0.2953
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0198 0.0198
Loa Loa (eye worm) MH2 domain-containing protein 0.0241 0.217 0.7446
Loa Loa (eye worm) hypothetical protein 0.0102 0.0861 0.2955
Brugia malayi AMP-binding enzyme family protein 0.003 0.0184 0.0547
Schistosoma mansoni hypothetical protein 0.0527 0.486 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0102 0.0861 0.2479
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0172 0.1519 0.4683
Entamoeba histolytica hypothetical protein 0.0073 0.0586 0.1472
Schistosoma mansoni cellular tumor antigen P53 0.0157 0.1381 0.2824
Echinococcus multilocularis smad 0.0016 0.0058 0.0058
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.003 0.0184 0.0133
Schistosoma mansoni hypothetical protein 0.0082 0.0674 0.1366
Leishmania major 4-coumarate:coa ligase-like protein 0.0102 0.0861 0.2794
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0066 0.0521 0.169
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0353 0.0784
Echinococcus granulosus short transient receptor potential channel 6 0.0066 0.0521 0.0521
Onchocerca volvulus 0.0102 0.0861 0.2654
Onchocerca volvulus 0.0157 0.1381 0.4513
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0807 0.7494 0.7494
Brugia malayi MH2 domain containing protein 0.0016 0.0058 0.0133
Brugia malayi dihydrofolate reductase family protein 0.0172 0.1519 0.4906
Trypanosoma cruzi DNA polymerase eta, putative 0.0012 0.0017 0.0052
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0132 0.1143 0.1143
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.003 0.0184 0.0547
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0023 0.0119 0.0119
Trypanosoma brucei chrX additional, unordered contigs 0.0012 0.0017 0.0052
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0338 0.308 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.027 0.0873
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0082 0.0674 0.0674
Trypanosoma cruzi DNA damage repair protein, putative 0.0012 0.0017 0.0052
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.0338 0.308 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0586 0.0586
Leishmania major acetyl-CoA synthetase, putative 0.003 0.0184 0.0596
Echinococcus granulosus Ankyrin 0.0023 0.0119 0.0119
Trypanosoma brucei hexokinase 0.032 0.2915 0.9466
Schistosoma mansoni transient receptor potential channel 4 0.0099 0.0838 0.1704
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.003 0.0184 0.0133
Echinococcus multilocularis short transient receptor potential channel 6 0.0066 0.0521 0.0521
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0586 0.0586
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0072 0.058 0.1481
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.003 0.0184 0.0596
Echinococcus multilocularis hexokinase 0.032 0.2915 0.2915
Schistosoma mansoni hypothetical protein 0.0073 0.0586 0.1185
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.027 0.0825
Loa Loa (eye worm) RNA binding protein 0.0201 0.1796 0.6161
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0097 0.0813 0.0813
Trypanosoma brucei hexokinase 0.032 0.2915 0.9466
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.0338 0.308 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0076 0.0619 0.1966
Loa Loa (eye worm) hypothetical protein 0.0099 0.0838 0.2875
Leishmania major 4-coumarate:coa ligase-like protein 0.0102 0.0861 0.2794
Loa Loa (eye worm) hypothetical protein 0.0033 0.0215 0.0739
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.003 0.0184 0.0547
Brugia malayi Pre-SET motif family protein 0.0228 0.2045 0.6621
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0203 0.0657
Brugia malayi Hexokinase family protein 0.0099 0.0835 0.2671
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.003 0.0184 0.0596
Brugia malayi hypothetical protein 0.0017 0.006 0.014
Loa Loa (eye worm) AMP-binding enzyme family protein 0.003 0.0184 0.0633
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.0217 0.0703
Trypanosoma brucei hexokinase, putative 0.032 0.2915 0.9466
Loa Loa (eye worm) hypothetical protein 0.0034 0.022 0.0754
Leishmania major 4-coumarate:coa ligase-like protein 0.0102 0.0861 0.2794
Brugia malayi MH1 domain containing protein 0.0016 0.0058 0.0133
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0023 0.0119 0.0119
Echinococcus multilocularis tar DNA binding protein 0.0201 0.1796 0.1796
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0097 0.0813 0.0813
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.003 0.0184 0.0547
Echinococcus multilocularis geminin 0.0527 0.486 0.486
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0058 0.0058
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0076 0.0619 0.1966
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0344 0.1179
Onchocerca volvulus Serine\/threonine kinase homolog 0.0097 0.0813 0.2481
Schistosoma mansoni hypothetical protein 0.0082 0.0674 0.1366
Onchocerca volvulus 0.003 0.0184 0.0233
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0156 0.0503
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0039 0.027 0.0531
Trypanosoma brucei unspecified product 0.0027 0.0156 0.0503
Schistosoma mansoni DNA polymerase IV / kappa 0.0012 0.0017 0.001
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.027 0.0825
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0039 0.027 0.027
Echinococcus multilocularis cpg binding protein 0.0031 0.0196 0.0196
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0225 0.0187
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.003 0.0184 0.0547
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.003 0.0184 0.0133
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0102 0.0861 0.244
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0586 0.1185
Loa Loa (eye worm) AMP-binding enzyme family protein 0.003 0.0184 0.0633
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.027 0.0873
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0058 0.0058
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0338 0.308 1
Leishmania major DNA damage repair protein, putative 0.0012 0.0017 0.0052
Leishmania major DNA polymerase kappa, putative 0.0012 0.0017 0.0052
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0203 0.0203
Treponema pallidum hexokinase (hxk) 0.032 0.2915 0.5
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0203 0.0657
Onchocerca volvulus 0.032 0.2915 1
Onchocerca volvulus 0.032 0.2915 1
Schistosoma mansoni tar DNA-binding protein 0.0201 0.1796 0.368
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0102 0.0861 0.2338
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0132 0.1143 0.445
Mycobacterium ulcerans acyl-CoA synthetase 0.0102 0.0861 0.2757
Loa Loa (eye worm) hypothetical protein 0.0026 0.0146 0.0501
Giardia lamblia DINP protein human, muc B family 0.0039 0.027 0.3175
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0813 0.2916
Entamoeba histolytica hexokinase 2 0.032 0.2915 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0082 0.0674 0.2312
Brugia malayi hypothetical protein 0.0026 0.0146 0.0421
Echinococcus multilocularis short transient receptor potential channel 6 0.0066 0.0521 0.0521
Schistosoma mansoni transient receptor potential channel 0.0066 0.0521 0.1051
Chlamydia trachomatis dihydrofolate reductase 0.0172 0.1519 1
Brugia malayi Zinc finger, C2H2 type family protein 0.0132 0.1143 0.3678
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.0058
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0203 0.0203
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0132 0.1143 0.445
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.003 0.0184 0.0596
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0102 0.0861 0.2757
Echinococcus multilocularis dihydrofolate reductase 0.0172 0.1519 0.1519
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0017 0.0052
Brugia malayi AMP-binding enzyme family protein 0.003 0.0184 0.0547
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0203 0.0203
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0066 0.0521 0.169
Loa Loa (eye worm) hypothetical protein 0.0062 0.049 0.1682
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.027 0.0873
Echinococcus multilocularis hexokinase 0.032 0.2915 0.2915
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.027 0.0873
Brugia malayi AMP-binding enzyme family protein 0.0102 0.0861 0.2757
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.0813 0.2637
Brugia malayi RNA binding protein 0.0201 0.1796 0.5809
Schistosoma mansoni hexokinase 0.032 0.2915 0.5988
Echinococcus granulosus hexokinase 0.032 0.2915 0.2915
Mycobacterium ulcerans acyl-CoA synthetase 0.0102 0.0861 0.2757
Brugia malayi hexokinase 0.032 0.2915 0.9463
Plasmodium falciparum acyl-CoA synthetase 0.0076 0.0619 0.1966
Brugia malayi AMP-binding enzyme family protein 0.003 0.0184 0.0547
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0813 0.2916
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.027 0.0873
Echinococcus multilocularis transient receptor potential gamma protein 0.0099 0.0838 0.0838
Trypanosoma brucei acetyl-CoA synthetase, putative 0.003 0.0184 0.0596
Entamoeba histolytica acyl-CoA synthetase, putative 0.0102 0.0861 0.2479
Brugia malayi hypothetical protein 0.0155 0.1358 0.438
Plasmodium falciparum dihydroorotate dehydrogenase 0.0338 0.308 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0012 0.0012
Onchocerca volvulus Hexokinase homolog 0.0201 0.1793 0.5986
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0102 0.0861 0.244
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0203 0.0203
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.027 0.0873
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0039 0.027 0.0395
Trypanosoma brucei DNA damage repair protein, putative 0.0012 0.0017 0.0052
Trichomonas vaginalis rotamase, putative 0.0034 0.0225 0.0187
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.003 0.0184 0.0596
Brugia malayi Dihydrofolate reductase 0.0172 0.1519 0.4906
Loa Loa (eye worm) TAR-binding protein 0.0201 0.1796 0.6161
Plasmodium vivax hexokinase, putative 0.032 0.2915 0.9463
Mycobacterium ulcerans acetyl-CoA synthetase 0.003 0.0184 0.0547
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0201 0.1796 0.6161
Echinococcus granulosus hexokinase 0.032 0.2915 0.2915
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0023 0.0119 0.0409
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.003 0.0184 0.0596
Onchocerca volvulus 0.0201 0.1793 0.5986
Leishmania major DNA polymerase kappa, putative 0.0039 0.027 0.0873
Schistosoma mansoni tar DNA-binding protein 0.0201 0.1796 0.368
Echinococcus multilocularis Smad4 0.0016 0.0058 0.0058
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0146 0.0421
Schistosoma mansoni cpg binding protein 0.0031 0.0196 0.0378
Leishmania major acetyl-CoA synthetase, putative 0.003 0.0184 0.0596
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0058 0.0198
Mycobacterium ulcerans hypothetical protein 0.0102 0.0861 0.2757
Brugia malayi Hexokinase family protein 0.0201 0.1793 0.5798
Echinococcus granulosus GPCR family 2 0.0082 0.0674 0.0674
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.0338 0.308 1
Entamoeba histolytica hypothetical protein 0.0073 0.0586 0.1472
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0034 0.0225 0.0679
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.003 0.0184 0.0596
Echinococcus multilocularis GPCR, family 2 0.0082 0.0674 0.0674
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0034 0.0225 0.0771
Echinococcus granulosus death domain containing protein 0.0023 0.0119 0.0119
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.003 0.0184 0.0133
Brugia malayi acetyl-Coenzyme A synthetase 2 0.003 0.0184 0.0547
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0344 0.0344
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0203 0.0657
Onchocerca volvulus 0.0033 0.0215 0.0344
Mycobacterium ulcerans acyl-CoA synthetase 0.0102 0.0861 0.2757
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.003 0.0184 0.0133
Schistosoma mansoni tar DNA-binding protein 0.0201 0.1796 0.368
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0813 0.2916
Echinococcus multilocularis expressed protein 0.0034 0.0225 0.0225
Leishmania major hexokinase, putative 0.032 0.2915 0.9466
Onchocerca volvulus 0.0259 0.234 0.7942
Trypanosoma brucei hypothetical protein, conserved 0.0012 0.0017 0.0052
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0338 0.308 1
Loa Loa (eye worm) hexokinase type II 0.032 0.2915 1
Mycobacterium ulcerans acyl-CoA synthetase 0.003 0.0184 0.0547
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.003 0.0184 0.0133
Entamoeba histolytica acyl-coA synthetase, putative 0.0102 0.0861 0.2479
Schistosoma mansoni kinase 0.0049 0.0366 0.0729
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0102 0.0861 0.2338
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.003 0.0184 0.0133
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0215 0.042
Schistosoma mansoni smad1 5 8 and 0.0016 0.0058 0.0094
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.027 0.0825
Schistosoma mansoni cpg binding protein 0.0031 0.0196 0.0378
Mycobacterium ulcerans acyl-CoA synthetase 0.003 0.0184 0.0547
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.027 0.0873
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0344 0.1067
Entamoeba histolytica hypothetical protein 0.0073 0.0586 0.1472
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0217 0.0703
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0102 0.0861 0.2757
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0072 0.058 0.1481
Echinococcus granulosus Smad4 0.0016 0.0058 0.0058
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0039 0.027 0.0925
Brugia malayi AMP-binding enzyme family protein 0.0102 0.0861 0.2757
Schistosoma mansoni rotamase 0.0034 0.0225 0.0439
Schistosoma mansoni smad 0.0016 0.0058 0.0094
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0338 0.308 1
Schistosoma mansoni hypothetical protein 0.0023 0.0119 0.0221
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.0203 0.0197
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0146 0.0421
Onchocerca volvulus 0.003 0.0184 0.0233
Echinococcus multilocularis hexokinase type 2 0.032 0.2915 0.2915
Trypanosoma brucei hypothetical protein, conserved 0.0012 0.0017 0.0052
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0017 0.0052
Echinococcus multilocularis tumor necrosis factor receptor superfamily 0.0035 0.0233 0.0233
Loa Loa (eye worm) hypothetical protein 0.0037 0.0251 0.086
Onchocerca volvulus 0.003 0.0184 0.0233
Loa Loa (eye worm) hypothetical protein 0.0076 0.0619 0.2124
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0344 0.0684
Entamoeba histolytica serine/threonine protein kinase, putative 0.0097 0.0813 0.2301
Loa Loa (eye worm) hypothetical protein 0.0177 0.1569 0.5381
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0017 0.0052
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0344 0.0344
Brugia malayi Death domain containing protein 0.0023 0.0119 0.0334
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0203 0.0657
Loa Loa (eye worm) hypothetical protein 0.0102 0.0861 0.2955
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0215 0.0215
Echinococcus granulosus netrin receptor unc 5 0.0023 0.0119 0.0119
Echinococcus granulosus cpg binding protein 0.0031 0.0196 0.0196
Trichomonas vaginalis set domain proteins, putative 0.0259 0.234 1
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0033 0.0217 0.012
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0215 0.0215
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.027 0.0873
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0058 0.0058
Brugia malayi AMP-binding enzyme family protein 0.0102 0.0861 0.2757
Echinococcus granulosus smad 0.0016 0.0058 0.0058
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0344 0.0684
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.027 0.0424
Echinococcus multilocularis tumor protein p63 0.1074 1 1
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0338 0.308 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0203 0.0657
Brugia malayi Uncoordinated protein 44 0.0023 0.0119 0.0334
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0132 0.1143 0.3711
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0082 0.0674 0.0674
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0017 0.0052
Giardia lamblia Kinase, PLK 0.0097 0.0813 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.027 0.0925
Loa Loa (eye worm) transcription factor SMAD2 0.0241 0.217 0.7446
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0146 0.0471
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0156 0.0503
Loa Loa (eye worm) hypothetical protein 0.0076 0.0619 0.2124
Mycobacterium tuberculosis Conserved hypothetical protein 0.0039 0.027 0.0424
Schistosoma mansoni ankyrin 23/unc44 0.0023 0.0119 0.0221
Brugia malayi latrophilin 2 splice variant baaae 0.0177 0.1569 0.5067
Loa Loa (eye worm) hexokinase 0.0099 0.0835 0.2865
Echinococcus granulosus dna polymerase eta 0.0039 0.027 0.027
Onchocerca volvulus 0.032 0.2915 1
Echinococcus granulosus transient receptor potential gamma protein 0.0099 0.0838 0.0838
Loa Loa (eye worm) hypothetical protein 0.0076 0.0619 0.2124
Loa Loa (eye worm) Smad1 0.0016 0.0058 0.0198
Entamoeba histolytica hypothetical protein 0.0073 0.0586 0.1472
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0215 0.042
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0132 0.1143 0.445
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0203 0.0608
Toxoplasma gondii hexokinase 0.032 0.2915 0.9466
Loa Loa (eye worm) hypothetical protein 0.003 0.0184 0.0633
Echinococcus granulosus expressed protein 0.0034 0.0225 0.0225
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0344 0.0344
Mycobacterium ulcerans acyl-CoA synthetase 0.003 0.0184 0.0547
Loa Loa (eye worm) hypothetical protein 0.0259 0.234 0.8026
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0097 0.0813 0.2789
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0066 0.0521 0.169
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0146 0.0471
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0203 0.0608
Brugia malayi Smad1 0.0016 0.0058 0.0133
Mycobacterium ulcerans acyl-CoA synthetase 0.003 0.0184 0.0547
Trypanosoma cruzi DNA polymerase eta, putative 0.0039 0.027 0.0873
Echinococcus granulosus hexokinase 0.032 0.2915 0.2915
Trypanosoma brucei unspecified product 0.0039 0.027 0.0873
Mycobacterium ulcerans acyl-CoA synthetase 0.003 0.0184 0.0547
Brugia malayi Pre-SET motif family protein 0.0033 0.0215 0.0648
Brugia malayi Transient-receptor-potential like protein 0.0037 0.0251 0.0764
Onchocerca volvulus 0.0155 0.1358 0.4432
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.018 0.0617
Brugia malayi serine/threonine-protein kinase plk-2 0.0097 0.0813 0.2599
Trypanosoma brucei unspecified product 0.0027 0.0156 0.0503
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0353 0.0784
Brugia malayi Calcitonin receptor-like protein seb-1 0.0259 0.234 0.7584
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.003 0.0184 0.0547
Loa Loa (eye worm) hexokinase 0.0201 0.1793 0.615
Loa Loa (eye worm) hypothetical protein 0.0082 0.0674 0.2312
Trichomonas vaginalis rotamase, putative 0.0033 0.0217 0.0152
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0058 0.0058
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.003 0.0184 0.0547
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.0338 0.308 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0146 0.0471
Brugia malayi TAR-binding protein 0.0201 0.1796 0.5809
Schistosoma mansoni hypothetical protein 0.0082 0.0674 0.1366
Entamoeba histolytica hexokinase 1 0.032 0.2915 1
Schistosoma mansoni tar DNA-binding protein 0.0201 0.1796 0.368
Schistosoma mansoni Smad4 0.0016 0.0058 0.0094
Trypanosoma cruzi DNA damage repair protein, putative 0.0012 0.0017 0.0052
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0813 0.2916
Loa Loa (eye worm) hypothetical protein 0.0076 0.0619 0.2124
Echinococcus granulosus dnaJ subfamily B 0.0419 0.3842 0.3842
Onchocerca volvulus 0.003 0.0184 0.0233
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0203 0.0657
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0023 0.0119 0.0221
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.003 0.0184 0.0133
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.0338 0.308 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0012 0.0017 0.0052
Schistosoma mansoni transient receptor potential channel 0.0099 0.0838 0.1704
Brugia malayi AMP-binding enzyme family protein 0.003 0.0184 0.0547
Echinococcus multilocularis Ankyrin 0.0023 0.0119 0.0119
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0132 0.1143 0.445
Schistosoma mansoni terminal deoxycytidyl transferase 0.0039 0.027 0.0531
Echinococcus multilocularis hexokinase 0.032 0.2915 0.2915
Echinococcus granulosus short transient receptor potential channel 6 0.0066 0.0521 0.0521
Echinococcus multilocularis dna polymerase eta 0.0039 0.027 0.027
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0215 0.042
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0082 0.0674 0.0674
Leishmania major DNA polymerase eta, putative 0.0039 0.027 0.0873
Loa Loa (eye worm) hypothetical protein 0.0155 0.1358 0.466
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.027 0.0873
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0156 0.0503
Brugia malayi MH2 domain containing protein 0.0241 0.217 0.7032
Onchocerca volvulus 0.0029 0.018 0.0216
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0082 0.0674 0.2146
Loa Loa (eye worm) hypothetical protein 0.0157 0.1381 0.4738
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0102 0.0861 0.2757
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.003 0.0184 0.0133
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0438 0.1421
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.003 0.0184 0.0133
Loa Loa (eye worm) hexokinase 0.032 0.2915 1
Schistosoma mansoni DNA polymerase eta 0.0039 0.027 0.0531
Schistosoma mansoni tar DNA-binding protein 0.0201 0.1796 0.368
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.0813 0.2637
Loa Loa (eye worm) hypothetical protein 0.0219 0.1957 0.6715
Echinococcus multilocularis TNFR CD27 30 40 95 cysteine rich region 0.0035 0.0233 0.0233
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0172 0.1519 0.4906
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0058 0.0198
Loa Loa (eye worm) hypothetical protein 0.0102 0.0861 0.2953
Brugia malayi Hexokinase family protein 0.032 0.2915 0.9463
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0215 0.0215
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0072 0.058 0.1481
Echinococcus granulosus TNFR CD27 30 40 95 cysteine rich region 0.0035 0.0233 0.0233
Brugia malayi CXXC zinc finger family protein 0.0029 0.018 0.0532
Echinococcus granulosus hexokinase type 2 0.032 0.2915 0.2915
Loa Loa (eye worm) hypothetical protein 0.0102 0.0861 0.2955
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0172 0.1519 0.4611
Trichomonas vaginalis DNA polymerase eta, putative 0.0039 0.027 0.0395
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.027 0.0873
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0146 0.0471
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.027 0.0873
Echinococcus granulosus tumor necrosis factor receptor superfamily 0.0035 0.0233 0.0233
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0813 0.2916
Mycobacterium ulcerans acyl-CoA synthetase 0.003 0.0184 0.0547
Echinococcus granulosus geminin 0.0527 0.486 0.486
Leishmania major DNA polymerase eta, putative 0.0012 0.0017 0.0052
Mycobacterium ulcerans acyl-CoA synthetase 0.003 0.0184 0.0547
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0066 0.0521 0.1646
Brugia malayi hexokinase type II 0.0102 0.0861 0.2755
Trypanosoma brucei DNA polymerase eta, putative 0.0039 0.027 0.0873
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.027 0.0873
Brugia malayi MH1 domain containing protein 0.0016 0.0058 0.0133
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0228 0.2045 0.7014
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0132 0.1143 0.445
Schistosoma mansoni transient receptor potential channel 0.0066 0.0521 0.1051
Toxoplasma gondii propionate-CoA ligase 0.003 0.0184 0.0596
Leishmania major hexokinase, putative 0.032 0.2915 0.9466
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0203 0.0697
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.027 0.0825
Schistosoma mansoni netrin receptor unc5 0.0023 0.0119 0.0221
Echinococcus multilocularis dnaJ subfamily B 0.0419 0.3842 0.3842
Schistosoma mansoni dihydrofolate reductase 0.0172 0.1519 0.3109
Trypanosoma cruzi hexokinase, putative 0.032 0.2915 0.9466
Brugia malayi MH2 domain containing protein 0.0016 0.0058 0.0133
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.0338 0.308 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0039 0.027 0.027
Schistosoma mansoni hypothetical protein 0.0082 0.0674 0.1366
Plasmodium falciparum hexokinase 0.032 0.2915 0.9463
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.003 0.0184 0.0596
Echinococcus granulosus dna polymerase kappa 0.0039 0.027 0.027
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0215 0.0697
Echinococcus multilocularis dna polymerase kappa 0.0039 0.027 0.027
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0037 0.0251 0.0251
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0203 0.0394
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.003 0.0184 0.0547
Echinococcus granulosus tar DNA binding protein 0.0201 0.1796 0.1796
Echinococcus multilocularis transient receptor potential ion channel A 0.0096 0.0807 0.0807

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.6511 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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