TDR Targets

Basic information

Technical information

TDR Targets ID: 1529336
Name: 3-acetamido-N-[2-(2-methoxyphenoxy)-5-piperid in-1-ylsulfonylphenyl]propanamide
MW: 475.558 | Formula: C23H29N3O6S
H donors: 2 H acceptors: 4 LogP: 1.84 Rotable bonds: 11
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccccc1Oc1ccc(cc1NC(=O)CCNC(=O)C)S(=O)(=O)N1CCCCC1
InChi: 1S/C23H29N3O6S/c1-17(27)24-13-12-23(28)25-19-16-18(33(29,30)26-14-6-3-7-15-26)10-11-20(19)32-22-9-5-4-8-21(22)31-2/h4-5,8-11,16H,3,6-7,12-15H2,1-2H3,(H,24,27)(H,25,28)
InChiKey: GPYHQHGUROAGGK-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

3-acetamido-N-[2-(2-methoxyphenoxy)-5-(1-piperidylsulfonyl)phenyl]propanamide
3-acetamido-N-[2-(2-methoxyphenoxy)-5-piperidinosulfonyl-phenyl]propionamide
3-acetamido-N-[2-(2-methoxyphenoxy)-5-piperidin-1-ylsulfonyl-phenyl]propanamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.007	0.0325	0.0325
Brugia malayi	fibroinase precursor	0.007	0.0325	0.0325
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0326	0.5761	1
Entamoeba histolytica	cysteine proteinase, putative	0.0174	0.2529	0.4054
Trypanosoma cruzi	cysteine peptidase, putative	0.0326	0.5761	0.6186
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0326	0.5761	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0326	0.5761	1
Leishmania major	cathepsin L-like protease	0.0326	0.5761	1
Toxoplasma gondii	cathepsin B	0.0198	0.3043	0.4999
Entamoeba histolytica	cysteine protease, putative	0.0174	0.2529	0.4054
Giardia lamblia	Cathepsin B precursor	0.0198	0.3043	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0103	0.1027	0.0799
Echinococcus granulosus	cysteine protease	0.0174	0.2529	0.2775
Trypanosoma cruzi	cysteine peptidase, putative	0.0326	0.5761	0.6186
Plasmodium vivax	vivapain-2	0.0326	0.5761	1
Brugia malayi	Cathepsin L-like precursor	0.0222	0.3557	0.3557
Schistosoma mansoni	cathepsin B (C01 family)	0.007	0.0325	0.0357
Entamoeba histolytica	cysteine proteinase, putative	0.0326	0.5761	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0483	0.9112	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.007	0.0325	0.0325
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0326	0.5761	1
Brugia malayi	RNA, U transporter 1	0.008	0.0531	0.0531
Trypanosoma cruzi	cysteine peptidase, putative	0.0326	0.5761	0.6186
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0174	0.2529	0.2775
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0174	0.2529	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0326	0.5761	1
Loa Loa (eye worm)	ctsf protein	0.0326	0.5761	0.5761
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0483	0.9112	1
Echinococcus granulosus	cathepsin l1	0.0326	0.5761	0.6322
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0326	0.5761	1
Onchocerca volvulus		0.0326	0.5761	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.007	0.0325	0.0325
Echinococcus granulosus	cathepsin L	0.0174	0.2529	0.2775
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0326	0.5761	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0483	0.9112	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0326	0.5761	1
Onchocerca volvulus	Prolyl endopeptidase homolog	0.0268	0.4524	0.7725
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0326	0.5761	1
Echinococcus granulosus	snurportin 1	0.0301	0.5235	0.5745
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1027	0.1027
Loa Loa (eye worm)	cysteine protease	0.0326	0.5761	0.5761
Echinococcus granulosus	cathepsin l1	0.0222	0.3557	0.3904
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0174	0.2529	0.2508
Brugia malayi	Papain family cysteine protease containing protein	0.0174	0.2529	0.2529
Loa Loa (eye worm)	hypothetical protein	0.007	0.0325	0.0325
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.007	0.0325	0.0357
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0326	0.5761	1
Brugia malayi	Papain family cysteine protease containing protein	0.007	0.0325	0.0325
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0268	0.4524	0.4965
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0326	0.5761	1
Brugia malayi	Papain family cysteine protease containing protein	0.007	0.0325	0.0325
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0174	0.2529	0.2775
Brugia malayi	Papain family cysteine protease containing protein	0.0326	0.5761	0.5761
Brugia malayi	cathepsin Z-like cysteine proteinase	0.007	0.0325	0.0325
Plasmodium vivax	vivapain-2	0.0326	0.5761	1
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0174	0.2529	0.4054
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0198	0.3043	0.3093
Trypanosoma cruzi	oligopeptidase B-like protein, putative	0.0106	0.109	0.0871
Trypanosoma cruzi	cruzipain precursor, putative	0.0326	0.5761	0.6186
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0483	0.9112	1
Entamoeba histolytica	cysteine proteinase, putative	0.0222	0.3557	0.5946
Trypanosoma cruzi	cysteine peptidase, putative	0.0174	0.2529	0.2508
Trypanosoma cruzi	cysteine proteinase, putative	0.0174	0.2529	0.2508
Loa Loa (eye worm)	hypothetical protein	0.0326	0.5761	0.5761
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0103	0.1027	0.1027
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0326	0.5761	1
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.007	0.0325	0.0357
Echinococcus granulosus	cathepsin b	0.0483	0.9112	1
Loa Loa (eye worm)	hypothetical protein	0.0483	0.9112	0.9112
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0326	0.5761	1
Brugia malayi	Papain family cysteine protease containing protein	0.007	0.0325	0.0325
Onchocerca volvulus		0.0326	0.5761	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0326	0.5761	0.6322
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0326	0.5761	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0326	0.5761	1
Leishmania major	cathepsin L-like protease	0.0326	0.5761	1
Schistosoma mansoni	cathepsin C	0.007	0.0325	0.0357
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0326	0.5761	0.6322
Brugia malayi	Cathepsin L-like precursor	0.0326	0.5761	0.5761
Loa Loa (eye worm)	hypothetical protein	0.007	0.0325	0.0325
Entamoeba histolytica	cysteine proteinase, putative	0.0326	0.5761	1
Leishmania major	cathepsin L-like protease	0.0326	0.5761	1
Plasmodium vivax	unspecified product	0.0174	0.2529	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0326	0.5761	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0326	0.5761	0.6322
Schistosoma mansoni	cathepsin s	0.0103	0.1027	0.1127
Schistosoma mansoni	cathepsin F (C01 family)	0.0326	0.5761	0.6322
Schistosoma mansoni	cathepsin F (C01 family)	0.0326	0.5761	0.6322
Entamoeba histolytica	cysteine protease, putative	0.0174	0.2529	0.4054
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0198	0.3043	0.418
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0326	0.5761	1
Loa Loa (eye worm)	hypothetical protein	0.0222	0.3557	0.3557
Onchocerca volvulus	Cathepsin F homolog	0.0326	0.5761	1
Brugia malayi	Cathepsin L-like precursor	0.0326	0.5761	0.5761
Entamoeba histolytica	cysteine protease, putative	0.0326	0.5761	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.007	0.0325	0.0357
Brugia malayi	prolyl oligopeptidase family protein	0.0268	0.4524	0.4524
Trypanosoma cruzi	cysteine protease, putative	0.0174	0.2529	0.2508
Leishmania major	cathepsin L-like protease	0.0326	0.5761	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0326	0.5761	1
Entamoeba histolytica	cysteine proteinase, putative	0.0174	0.2529	0.4054
Mycobacterium tuberculosis	Probable protease II PtrBa [first part] (oligopeptidase B)	0.024	0.3926	1
Entamoeba histolytica	cysteine protease, putative	0.0174	0.2529	0.4054
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.007	0.0325	0.0325
Onchocerca volvulus		0.0326	0.5761	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0198	0.3043	0.4999
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0198	0.3043	0.3339
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0326	0.5761	1
Onchocerca volvulus		0.0326	0.5761	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.007	0.0325	0.0357
Plasmodium vivax	vivapain-3	0.0174	0.2529	0.4054
Trypanosoma cruzi	cysteine proteinase, putative	0.0174	0.2529	0.2508
Trypanosoma cruzi	oligopeptidase b	0.0106	0.109	0.0871
Trypanosoma cruzi	oligopeptidase b	0.0106	0.109	0.0871
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0326	0.5761	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0326	0.5761	0.6322
Echinococcus granulosus	prolyl endopeptidase	0.0268	0.4524	0.4965
Brugia malayi	Cathepsin L-like precursor	0.0326	0.5761	0.5761
Entamoeba histolytica	cysteine protease, putative	0.0174	0.2529	0.4054
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0174	0.2529	0.2775
Brugia malayi	Cathepsin L-like precursor	0.0326	0.5761	0.5761
Entamoeba histolytica	cysteine protease, putative	0.0174	0.2529	0.4054
Onchocerca volvulus		0.0326	0.5761	1
Echinococcus multilocularis	cathepsin b	0.0483	0.9112	1
Echinococcus granulosus	cathepsin L	0.007	0.0325	0.0357
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0326	0.5761	1
Mycobacterium leprae	PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B)	0.0106	0.109	0.5
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0198	0.3043	0.418
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0326	0.5761	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.007	0.0325	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1027	0.1027
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0326	0.5761	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0174	0.2529	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0326	0.5761	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.0325	0.0325
Brugia malayi	cathepsin F-like cysteine proteinase	0.0103	0.1027	0.1027
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0326	0.5761	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.007	0.0325	0.0325
Brugia malayi	Papain family cysteine protease containing protein	0.0174	0.2529	0.2529
Onchocerca volvulus		0.0326	0.5761	1
Brugia malayi	Cathepsin L-like precursor	0.0103	0.1027	0.1027
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0326	0.5761	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0326	0.5761	0.5761
Echinococcus granulosus	cathepsin b	0.0483	0.9112	1
Echinococcus multilocularis	cysteine protease	0.0326	0.5761	0.6322
Trypanosoma cruzi	cysteine peptidase, putative	0.0326	0.5761	0.6186
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0326	0.5761	1
Entamoeba histolytica	cysteine protease, putative	0.0174	0.2529	0.4054
Leishmania major	cathepsin L-like protease	0.0326	0.5761	1
Echinococcus multilocularis	cathepsin L	0.0174	0.2529	0.2775
Entamoeba histolytica	cysteine protease, putative	0.0174	0.2529	0.4054
Leishmania major	cathepsin L-like protease	0.0326	0.5761	1
Brugia malayi	cathepsin B-like cysteine proteinase	0.0483	0.9112	0.9112
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0222	0.3557	0.5946
Entamoeba histolytica	cysteine protease, putative	0.0174	0.2529	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0174	0.2529	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0326	0.5761	1
Entamoeba histolytica	cysteine protease, putative	0.0174	0.2529	0.4054
Entamoeba histolytica	cysteine proteinase 1, putative	0.0174	0.2529	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0326	0.5761	1
Entamoeba histolytica	cysteine protease, putative	0.0174	0.2529	0.4054
Echinococcus granulosus	cathepsin L cysteine protease	0.0174	0.2529	0.2775
Onchocerca volvulus		0.0222	0.3557	0.5946
Echinococcus multilocularis	cathepsin L cysteine protease	0.0326	0.5761	0.6322
Leishmania major	cathepsin L-like protease	0.0326	0.5761	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0326	0.5761	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0326	0.5761	1
Brugia malayi	Cathepsin L-like precursor	0.0326	0.5761	0.5761
Loa Loa (eye worm)	hypothetical protein	0.0222	0.3557	0.3557
Giardia lamblia	Cathepsin B precursor	0.0198	0.3043	1
Toxoplasma gondii	prolyl endopeptidase	0.0268	0.4524	0.7725
Loa Loa (eye worm)	hypothetical protein	0.0222	0.3557	0.3557
Loa Loa (eye worm)	fibroinase	0.0326	0.5761	0.5761
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0326	0.5761	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0483	0.9112	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0222	0.3557	0.5946
Brugia malayi	Cathepsin L-like precursor	0.0326	0.5761	0.5761
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0174	0.2529	0.308
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0326	0.5761	0.6322
Echinococcus multilocularis	cathepsin b	0.0483	0.9112	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0103	0.1027	0.0799
Schistosoma mansoni	cathepsin S (C01 family)	0.007	0.0325	0.0357
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0301	0.5235	0.5235
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1027	0.1027
Loa Loa (eye worm)	hypothetical protein	0.007	0.0325	0.0325
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0326	0.5761	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.007	0.0325	0.0357
Brugia malayi	cathepsin L-like precursor	0.0222	0.3557	0.3557
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0222	0.3557	0.3557
Brugia malayi	Cathepsin L-like precursor	0.0222	0.3557	0.3557
Echinococcus multilocularis	cathepsin L	0.007	0.0325	0.0357
Leishmania major	cysteine peptidase A (CPA)	0.0326	0.5761	1
Leishmania major	cathepsin L-like protease	0.0326	0.5761	1
Onchocerca volvulus		0.0326	0.5761	1
Mycobacterium ulcerans	hydrolase/amidase	0.0275	0.4678	1
Brugia malayi	cathepsin L precursor	0.007	0.0325	0.0325
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0103	0.1027	0.1027
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0268	0.4524	0.4965
Entamoeba histolytica	cysteine protease, putative	0.0174	0.2529	0.4054
Loa Loa (eye worm)	cathepsin B	0.0198	0.3043	0.3043
Trypanosoma brucei	prolyl endopeptidase	0.0268	0.4524	0.7352
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0326	0.5761	1
Entamoeba histolytica	cysteine proteinase, putative	0.0174	0.2529	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.007	0.0325	0.0357
Onchocerca volvulus	Cathepsin L homolog	0.0326	0.5761	1
Onchocerca volvulus	Cathepsin L homolog	0.0326	0.5761	1
Echinococcus multilocularis	cysteine protease	0.0326	0.5761	0.6322
Loa Loa (eye worm)	hypothetical protein	0.007	0.0325	0.0325
Plasmodium vivax	vivapain-1	0.0174	0.2529	0.4054
Entamoeba histolytica	cysteine proteinase 2	0.0174	0.2529	0.4054
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0326	0.5761	0.5761
Loa Loa (eye worm)	hypothetical protein	0.0268	0.4524	0.4524
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0225	0.3614	0.8899
Loa Loa (eye worm)	hypothetical protein	0.0525	1	1
Plasmodium vivax	unspecified product	0.0103	0.1027	0.1291
Brugia malayi	cathepsin L-like cysteine proteinase	0.007	0.0325	0.0325
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0326	0.5761	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0326	0.5761	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0326	0.5761	1
Schistosoma mansoni	hypothetical protein	0.0301	0.5235	0.5745
Loa Loa (eye worm)	hypothetical protein	0.007	0.0325	0.0325
Entamoeba histolytica	cysteine proteinase, putative	0.0174	0.2529	0.4054
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0222	0.3557	0.3678
Leishmania major	prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative	0.0268	0.4524	0.7352
Giardia lamblia	Cathepsin B precursor	0.0198	0.3043	1
Echinococcus multilocularis	prolyl endopeptidase	0.0268	0.4524	0.4965
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.007	0.0325	0.0357
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.007	0.0325	0.0357
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.007	0.0325	0.0325
Trypanosoma cruzi	prolyl endopeptidase	0.0268	0.4524	0.4779
Echinococcus multilocularis	snurportin 1	0.0301	0.5235	0.5745
Schistosoma mansoni	cathepsin F (C01 family)	0.0222	0.3557	0.3904
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0174	0.2529	0.308
Toxoplasma gondii	cathepsin CPL	0.0326	0.5761	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0326	0.5761	1
Entamoeba histolytica	cysteine protease, putative	0.0174	0.2529	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0326	0.5761	1
Trypanosoma cruzi	serine peptidase, clan SC, family S9A-like protein, putative	0.0106	0.109	0.0871

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	5.0119 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	5.8584 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	11.6891 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	44.6684 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1721312

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1529336