Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | euchromatic histone-lysine N-methyltransferase 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.0963 | 0.0932 |
Trypanosoma brucei | hexokinase | 0.0511 | 1 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0963 | 0.0963 |
Brugia malayi | Hexokinase family protein | 0.0158 | 0.3002 | 0.2978 |
Echinococcus granulosus | voltage gated potassium channel | 0.0012 | 0.0112 | 0.0078 |
Treponema pallidum | hexokinase (hxk) | 0.0511 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.032 | 0.6224 | 0.6211 |
Onchocerca volvulus | 0.032 | 0.6224 | 0.5991 | |
Echinococcus granulosus | hexokinase type 2 | 0.0511 | 1 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0036 | 0.0582 | 0.055 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.004 | 0.0656 | 0.1129 |
Trypanosoma brucei | hexokinase | 0.0511 | 1 | 0.5 |
Brugia malayi | hexokinase type II | 0.0162 | 0.3089 | 0.3065 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0043 | 0.0711 | 0.068 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0963 | 0.0932 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0112 | 0.0078 |
Trichomonas vaginalis | set domain proteins, putative | 0.0286 | 0.5543 | 1 |
Leishmania major | hexokinase, putative | 0.0511 | 1 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0043 | 0.0711 | 0.068 |
Onchocerca volvulus | 0.0511 | 1 | 1 | |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0036 | 0.0582 | 0.055 |
Leishmania major | hexokinase, putative | 0.0511 | 1 | 0.5 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0008 | 0.0034 | 0.0034 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0963 | 0.0963 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0035 | 0.0556 | 0.0524 |
Plasmodium falciparum | hexokinase | 0.0511 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0511 | 1 | 1 |
Trypanosoma brucei | hexokinase, putative | 0.0511 | 1 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.004 | 0.0656 | 0.1129 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0963 | 0.0932 |
Brugia malayi | Hexokinase family protein | 0.032 | 0.6224 | 0.6211 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0008 | 0.0034 | 0.0034 |
Loa Loa (eye worm) | hexokinase | 0.0158 | 0.3002 | 0.2978 |
Plasmodium vivax | hexokinase, putative | 0.0511 | 1 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0036 | 0.0582 | 0.0582 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0012 | 0.0112 | 0.0112 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0012 | 0.0112 | 0.0078 |
Echinococcus granulosus | hexokinase | 0.0511 | 1 | 1 |
Onchocerca volvulus | 0.0511 | 1 | 1 | |
Entamoeba histolytica | hexokinase 2 | 0.0511 | 1 | 0.5 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0043 | 0.0711 | 0.068 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0251 | 0.4854 | 0.4837 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0046 | 0.0789 | 0.0789 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0963 | 0.0963 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.06 | 0.0568 |
Echinococcus multilocularis | hexokinase | 0.0511 | 1 | 1 |
Echinococcus multilocularis | hexokinase type 2 | 0.0511 | 1 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0036 | 0.0582 | 0.0582 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0008 | 0.0034 | 0.0034 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.3089 | 0.3065 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0963 | 0.0932 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0008 | 0.0034 | 0.0034 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0036 | 0.0582 | 0.055 |
Brugia malayi | Hexokinase family protein | 0.0511 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0348 | 0.6778 | 0.6767 |
Echinococcus granulosus | hexokinase | 0.0511 | 1 | 1 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0012 | 0.0112 | 0.0078 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0008 | 0.0034 | 0.0034 |
Onchocerca volvulus | 0.0286 | 0.5543 | 0.5268 | |
Trypanosoma cruzi | hexokinase, putative | 0.0511 | 1 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.0963 | 0.0932 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.3089 | 0.3065 |
Onchocerca volvulus | 0.0511 | 1 | 1 | |
Schistosoma mansoni | hexokinase | 0.0511 | 1 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0036 | 0.0582 | 0.0582 |
Toxoplasma gondii | hexokinase | 0.0511 | 1 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0036 | 0.0582 | 0.055 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0582 | 0.055 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0012 | 0.0112 | 0.0078 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0012 | 0.0112 | 0.0078 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0036 | 0.0582 | 0.0582 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0046 | 0.0789 | 0.0789 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0963 | 0.0932 |
Entamoeba histolytica | hexokinase 1 | 0.0511 | 1 | 0.5 |
Onchocerca volvulus | Hexokinase homolog | 0.032 | 0.6224 | 0.5991 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0008 | 0.0034 | 0.0034 |
Echinococcus granulosus | hexokinase | 0.0511 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0511 | 1 | 1 |
Loa Loa (eye worm) | hexokinase type II | 0.0511 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0511 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.0511 | 1 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0043 | 0.0711 | 0.068 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0012 | 0.0112 | 0.0112 |
Trypanosoma cruzi | hexokinase, putative | 0.0511 | 1 | 0.5 |
Brugia malayi | Pre-SET motif family protein | 0.0251 | 0.4854 | 0.4837 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.3981 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 1.7783 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 8.2753 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.