Detailed information for compound 1529450

Basic information

Technical information
  • TDR Targets ID: 1529450
  • Name: (5E)-1-[2-(3,4-dimethoxyphenyl)ethyl]-5-[(3-d imethylaminopropylamino)methylidene]-1,3-diaz inane-2,4,6-trione
  • MW: 404.46 | Formula: C20H28N4O5
  • H donors: 2 H acceptors: 3 LogP: 2.13 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(CCN2C(=O)NC(=O)/C(=C\NCCCN(C)C)/C2=O)ccc1OC
  • InChi: 1S/C20H28N4O5/c1-23(2)10-5-9-21-13-15-18(25)22-20(27)24(19(15)26)11-8-14-6-7-16(28-3)17(12-14)29-4/h6-7,12-13,21H,5,8-11H2,1-4H3,(H,22,25,27)/b15-13+
  • InChiKey: FFGIRUSSEVGZKZ-FYWRMAATSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (5E)-1-[2-(3,4-dimethoxyphenyl)ethyl]-5-[(3-dimethylaminopropylamino)methylene]hexahydropyrimidine-2,4,6-trione
  • (5E)-1-[2-(3,4-dimethoxyphenyl)ethyl]-5-[(3-dimethylaminopropylamino)methylene]barbituric acid
  • MLS000040947
  • STOCK4S-10142
  • SMR000043343

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0017 0.0013 0.0136
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0099 0.1063
Echinococcus multilocularis snurportin 1 0.0315 0.0563 0.6102
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0015 0.0007 0.0078
Schistosoma mansoni cysteinyl-tRNA synthetase 0.0079 0.0126 0.1367
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0017 0.0013 0.0136
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.002 0.0599
Schistosoma mansoni ran 0.0022 0.002 0.0219
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0015 0.0868
Loa Loa (eye worm) hypothetical protein 0.0016 0.001 0.0105
Schistosoma mansoni organic anion transporter 0.0057 0.0086 0.0928
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0021 0.002 0.0213
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0021 0.002 0.1112
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0011 0 0.0002
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0015 0.0166
Onchocerca volvulus 0.0053 0.0079 0.6264
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0069 0.0108 0.6154
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.0079 0.0126 0.7065
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0021 0.002 0.0385
Schistosoma mansoni transcription factor btf3 0.0105 0.0175 0.1892
Loa Loa (eye worm) hypothetical protein 0.0055 0.0083 0.0895
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0017 0.0013 0.0134
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0015 0.0868
Echinococcus multilocularis neuropeptides capa receptor 0.0055 0.0083 0.0899
Loa Loa (eye worm) hypothetical protein 0.0055 0.0083 0.0895
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0017 0.0013 0.0134
Plasmodium falciparum thioredoxin reductase 0.0061 0.0094 0.5367
Brugia malayi Latrophilin receptor protein 2 0.0016 0.001 0.0102
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0017 0.0013 0.0137
Echinococcus multilocularis g-protein coupled receptor 0.0055 0.0083 0.0899
Loa Loa (eye worm) hypothetical protein 0.0035 0.0045 0.0487
Echinococcus granulosus multidrug resistance protein 1 0.0011 0 0.0002
Echinococcus granulosus sex peptide receptor 0.0055 0.0083 0.0899
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0055 0.0083 0.0897
Onchocerca volvulus 0.0035 0.0045 0.3563
Loa Loa (eye worm) hypothetical protein 0.0055 0.0083 0.0895
Echinococcus granulosus g protein coupled receptor 0.0055 0.0083 0.0899
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0017 0.0013 0.0137
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0083 0.0899
Brugia malayi beta-lactamase family protein 0.0035 0.0045 0.0485
Brugia malayi hypothetical protein 0.0055 0.0083 0.0893
Wolbachia endosymbiont of Brugia malayi cysteinyl-tRNA synthetase 0.0079 0.0126 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0083 0.0899
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0015 0.0868
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0045 0.2145
Loa Loa (eye worm) hypothetical protein 0.0055 0.0083 0.0895
Brugia malayi Steroid receptor seven-up type 2 0.0017 0.0013 0.0134
Brugia malayi RNA binding protein 0.0064 0.0099 0.1061
Loa Loa (eye worm) multidrug resistance protein 3 0.0011 0 0.0002
Trypanosoma cruzi transcription factor btf3, putative 0.0105 0.0175 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0055 0.0083 0.0893
Echinococcus granulosus transcription factor btf3 0.0105 0.0175 0.1893
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0083 0.0897
Entamoeba histolytica hypothetical protein 0.0105 0.0175 1
Schistosoma mansoni hypothetical protein 0.0055 0.0083 0.0897
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0136
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.001 0.0106
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0055 0.0083 0.0897
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0073 0.0791
Trypanosoma cruzi cytochrome P450, putative 0.0037 0.0049 0.2359
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0045 0.003
Echinococcus multilocularis GPCR, family 2 0.0016 0.001 0.0105
Mycobacterium ulcerans beta-lactamase 0.0035 0.0045 0.003
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0074 0.0117 0.1256
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0013 0.0137
Schistosoma mansoni amine GPCR 0.0055 0.0083 0.0897
Mycobacterium tuberculosis Conserved protein 0.0035 0.0045 0.0045
Onchocerca volvulus 0.0055 0.0083 0.6563
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0017 0.0013 0.0136
Onchocerca volvulus 0.0055 0.0083 0.6563
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0011 0 0.0002
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0055 0.0083 0.0899
Schistosoma mansoni neuropeptide F-like receptor 0.0055 0.0083 0.0897
Echinococcus multilocularis thioredoxin glutathione reductase 0.0061 0.0094 0.1017
Loa Loa (eye worm) hypothetical protein 0.0055 0.0083 0.0895
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0045 0.2574
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0021 0.002 0.0019
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0021 0.002 0.0385
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0073 0.0789
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0055 0.0083 0.6563
Schistosoma mansoni RAR-like nuclear receptor 0.0017 0.0013 0.0134
Brugia malayi Serotonin receptor 0.0055 0.0083 0.0893
Onchocerca volvulus 0.0057 0.0086 0.6791
Leishmania major importin beta-1 subunit, putative 0.0024 0.0025 0.1393
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0045 0.0045
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.002 0.0599
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0015 0.0007 0.0402
Leishmania major trypanothione reductase 0.0061 0.0094 0.5367
Echinococcus multilocularis fmrfamide receptor 0.0055 0.0083 0.0899
Brugia malayi Cytochrome P450 family protein 0.0037 0.0049 0.0523
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0016 0.0009 0.0097
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0015 0.0015
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0055 0.0083 0.0897
Brugia malayi Dopamine receptor protein 2 0.0055 0.0083 0.0893
Brugia malayi intermediate filament protein 0.0053 0.0079 0.0852
Echinococcus granulosus snurportin 1 0.0315 0.0563 0.6102
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.002 0.0458
Echinococcus granulosus tachykinin peptides receptor 99D 0.0055 0.0083 0.0899
Loa Loa (eye worm) ICD-1 protein 0.0105 0.0175 0.1885
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0021 0.002 0.0599
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.0395 0.0395
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0061 0.0094 0.0094
Schistosoma mansoni neuropeptide receptor 0.0055 0.0083 0.0897
Schistosoma mansoni amine GPCR 0.0055 0.0083 0.0897
Entamoeba histolytica transcription factor BTF3, putative 0.0105 0.0175 1
Schistosoma mansoni hypothetical protein 0.0509 0.0923 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0045 0.0487
Loa Loa (eye worm) hypothetical protein 0.0055 0.0083 0.0895
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0015 0.0868
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0017 0.0013 0.0134
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.002 0.1159
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0045 0.0026
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0015 0.0007 0.0078
Loa Loa (eye worm) cytochrome P450 family protein 0.0037 0.0049 0.0525
Echinococcus granulosus leucyl tRNA synthetase 0.0079 0.0126 0.1369
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0055 0.0083 0.0899
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0045 0.2574
Schistosoma mansoni hypothetical protein 0.0016 0.001 0.0103
Plasmodium falciparum importin beta, putative 0.0029 0.0035 0.1985
Onchocerca volvulus 0.0035 0.0045 0.3563
Loa Loa (eye worm) hypothetical protein 0.0055 0.0083 0.0895
Loa Loa (eye worm) hypothetical protein 0.0055 0.0083 0.0895
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0017 0.0013 0.0137
Loa Loa (eye worm) CYP4Cod1 0.0037 0.0049 0.0525
Loa Loa (eye worm) hypothetical protein 0.0055 0.0083 0.0895
Echinococcus multilocularis neuropeptide s receptor 0.0055 0.0083 0.0899
Onchocerca volvulus 0.0039 0.0052 0.4134
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.002 0.1159
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.001 0.0106
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0055 0.0083 0.0895
Loa Loa (eye worm) hypothetical protein 0.0026 0.0028 0.0302
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0136
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0017 0.0013 0.0137
Echinococcus multilocularis geminin 0.0509 0.0923 1
Loa Loa (eye worm) beta-lactamase 0.0035 0.0045 0.0487
Loa Loa (eye worm) hypothetical protein 0.0055 0.0083 0.0895
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0039 0.0052 0.2987
Echinococcus granulosus alpha 1A adrenergic receptor 0.0055 0.0083 0.0899
Onchocerca volvulus 0.0057 0.0086 0.6791
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0117 0.0197 0.2131
Echinococcus multilocularis G protein coupled receptor 139 0.0055 0.0083 0.0899
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.0077 0.5532
Trichomonas vaginalis mercuric reductase, putative 0.0021 0.002 0.1112
Echinococcus granulosus hypothetical protein 0.0055 0.0083 0.0899
Echinococcus granulosus hyperpolarization activated cyclic 0.0015 0.0007 0.0078
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0045 0.0045
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0015 0.0868
Echinococcus granulosus neuropeptide Y receptor 0.0055 0.0083 0.0899
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0055 0.0083 0.0899
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.002 0.0221
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0021 0.002 0.0004
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0045 0.2574
Loa Loa (eye worm) G-protein coupled receptor 0.0055 0.0083 0.0895
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0017 0.0013 0.0134
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0021 0.002 0.1112
Loa Loa (eye worm) hypothetical protein 0.0029 0.0035 0.0376
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0099 0.1065
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0021 0.002 0.1112
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0083 0.0899
Loa Loa (eye worm) hypothetical protein 0.0053 0.0079 0.0854
Loa Loa (eye worm) hypothetical protein 0.0055 0.0083 0.0895
Schistosoma mansoni thyroid hormone receptor 0.0017 0.0013 0.0134
Loa Loa (eye worm) hypothetical protein 0.0055 0.0083 0.0895
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.001 0.0106
Schistosoma mansoni importin beta-1 0.0029 0.0035 0.0375
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.001 0.0105
Mycobacterium ulcerans hypothetical protein 0.0035 0.0045 0.003
Echinococcus multilocularis FTZ F1 alpha 0.0017 0.0013 0.0137
Brugia malayi hypothetical protein 0.0055 0.0083 0.0893
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0055 0.0083 0.0897
Loa Loa (eye worm) hypothetical protein 0.0035 0.0045 0.0487
Trypanosoma cruzi trypanothione reductase, putative 0.0061 0.0094 0.5099
Onchocerca volvulus 0.0055 0.0083 0.6563
Plasmodium vivax cysteine--tRNA ligase, putative 0.0079 0.0126 0.7225
Echinococcus multilocularis transcription factor btf3 0.0105 0.0175 0.1893
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.002 0.0599
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0055 0.0083 0.0899
Echinococcus granulosus somatostatin receptor 0.0055 0.0083 0.0899
Echinococcus multilocularis g protein coupled receptor 0.0055 0.0083 0.0899
Echinococcus multilocularis hyperpolarization activated cyclic 0.0015 0.0007 0.0078
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0039 0.0052 0.2987
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0021 0.002 0.0019
Echinococcus multilocularis thyroid hormone receptor alpha 0.0017 0.0013 0.0137
Echinococcus granulosus geminin 0.0509 0.0923 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0021 0.002 0.0599
Echinococcus multilocularis orexin receptor type 2 0.0055 0.0083 0.0899
Loa Loa (eye worm) hypothetical protein 0.0055 0.0083 0.0895
Echinococcus granulosus neuropeptide receptor 0.0055 0.0083 0.0899
Schistosoma mansoni voltage-gated potassium channel 0.0015 0.0007 0.0076
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.002 0.0221
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0057 0.0086 0.093
Echinococcus multilocularis serotonin receptor 0.0055 0.0083 0.0899
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0017 0.0013 0.0136
Loa Loa (eye worm) hypothetical protein 0.0057 0.0086 0.0926
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0045 0.2145
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0136
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0021 0.002 0.0209
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.002 0.0599
Plasmodium falciparum basic transcription factor 3b, putative 0.0105 0.0175 1
Loa Loa (eye worm) intermediate filament protein 0.0053 0.0079 0.0854
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0035 0.0378
Mycobacterium tuberculosis Probable oxidoreductase 0.0021 0.002 0.0019
Echinococcus granulosus hyperpolarization activated cyclic 0.0015 0.0007 0.0078
Mycobacterium tuberculosis Conserved protein 0.0035 0.0045 0.0045
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0315 0.0563 0.6075
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0015 0.0007 0.0078
Onchocerca volvulus Protein ultraspiracle homolog 0.0017 0.0013 0.0983
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.001 0.0546
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0045 0.0489
Brugia malayi G protein-coupled receptor F59B2.13 0.0055 0.0083 0.0893
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.001 0.0102
Trypanosoma brucei transcription factor BTF3, putative 0.0105 0.0175 1
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0099 0.1063
Schistosoma mansoni biogenic amine receptor 0.0055 0.0083 0.0897
Loa Loa (eye worm) hypothetical protein 0.0055 0.0083 0.0895
Loa Loa (eye worm) hypothetical protein 0.0055 0.0083 0.0895
Brugia malayi ecdysteroid receptor 0.0017 0.0013 0.0134
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0017 0.0013 0.0134
Trichomonas vaginalis cysteinyl-tRNA synthetase, putative 0.0079 0.0126 0.7225
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0045 0.0487
Schistosoma mansoni opsin-like receptor 0.0055 0.0083 0.0897
Entamoeba histolytica cysteinyl-tRNA synthetase, putative 0.0079 0.0126 0.7225
Echinococcus multilocularis g protein coupled receptor 0.0055 0.0083 0.0899
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0033 0.0359
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0015 0.034
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0055 0.0083 0.0899
Echinococcus multilocularis neuropeptide FF receptor 2 0.0055 0.0083 0.0899
Trypanosoma cruzi trypanothione reductase, putative 0.0021 0.002 0.0599
Brugia malayi hypothetical protein 0.0055 0.0083 0.0893
Schistosoma mansoni biogenic amine receptor 0.0055 0.0083 0.0897
Loa Loa (eye worm) hypothetical protein 0.0055 0.0083 0.0895
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0053 0.0079 0.0854
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0017 0.0013 0.0134
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0083 0.0899
Loa Loa (eye worm) hypothetical protein 0.0052 0.0077 0.0835
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0099 0.1065
Toxoplasma gondii NADPH-glutathione reductase 0.0021 0.002 0.1112
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0055 0.0083 0.0899
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0055 0.0083 0.0899
Brugia malayi Isocitrate dehydrogenase 0.0016 0.001 0.0103
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0017 0.0013 0.0134
Loa Loa (eye worm) steroid hormone receptor 0.0017 0.0013 0.0136
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0055 0.0083 0.0897
Echinococcus granulosus voltage gated potassium channel 0.0021 0.002 0.0214
Schistosoma mansoni hypothetical protein 0.0016 0.001 0.0103
Schistosoma mansoni histamine h1 receptor 0.0055 0.0083 0.0897
Loa Loa (eye worm) hypothetical protein 0.0055 0.0083 0.0895
Trichomonas vaginalis esterase, putative 0.0035 0.0045 0.2574
Schistosoma mansoni lamin 0.0053 0.0079 0.0856
Echinococcus granulosus tm gpcr rhodopsin 0.0055 0.0083 0.0899
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.001 0.0103
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0021 0.002 0.021
Schistosoma mansoni neuropeptide receptor 0.0055 0.0083 0.0897
Schistosoma mansoni opsin-like receptor 0.0055 0.0083 0.0897
Loa Loa (eye worm) hypothetical protein 0.0055 0.0083 0.0895
Brugia malayi sodium-independent organic anion transporter family protein 0.0057 0.0086 0.0924
Schistosoma mansoni hypothetical protein 0.0055 0.0083 0.0897
Onchocerca volvulus 0.0055 0.0083 0.6563
Brugia malayi GnHR receptor homolog 0.0055 0.0083 0.0893
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0213
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0011 0 0.0002
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0021 0.002 0.1112
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.0175 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0083 0.0895
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.0077 0.0832
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0055 0.0083 0.0897
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0055 0.0083 0.0893
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0017 0.0013 0.0136
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0055 0.0083 0.0899
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.0079 0.0126 0.0111
Brugia malayi Dopamine receptor protein 1 0.0055 0.0083 0.0893
Brugia malayi sodium-independent organic anion transporter family protein 0.0057 0.0086 0.0924
Loa Loa (eye worm) hypothetical protein 0.0039 0.0052 0.0565
Loa Loa (eye worm) hypothetical protein 0.0055 0.0083 0.0895
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0136
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0055 0.0083 0.0897
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.001 0.0546
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0017 0.0013 0.0137
Loa Loa (eye worm) hypothetical protein 0.0055 0.0083 0.0895
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0015 0.0166
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0011 0 0.0002
Schistosoma mansoni neuropeptide receptor 0.0055 0.0083 0.0897
Onchocerca volvulus 0.0055 0.0083 0.6563
Brugia malayi RNA, U transporter 1 0.0084 0.0136 0.146
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0055 0.0083 0.0899
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0108 0.018 0.1946
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0017 0.0013 0.0136
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0099 0.1061
Loa Loa (eye worm) cysteinyl tRNA synthetase 1 0.0079 0.0126 0.1363
Echinococcus granulosus 7tm_1 domain containing protein 0.0055 0.0083 0.0899
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0077 0.406
Toxoplasma gondii cysteine-tRNA synthetase (CysRS) 0.0079 0.0126 0.7225
Plasmodium falciparum cysteine--tRNA ligase 0.0079 0.0126 0.7225
Echinococcus multilocularis dro:myosuppressin receptor 0.0055 0.0083 0.0899
Loa Loa (eye worm) hypothetical protein 0.0055 0.0083 0.0895
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0015 0.0007 0.0076
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0035 0.1522
Brugia malayi sulfakinin receptor protein 0.0055 0.0083 0.0893
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0045 0.0487
Schistosoma mansoni neuropeptide receptor 0.0055 0.0083 0.0897
Echinococcus multilocularis hyperpolarization activated cyclic 0.0015 0.0007 0.0078
Trypanosoma brucei cysteinyl-tRNA synthetase, putative 0.0079 0.0126 0.7065
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0083 0.0899
Plasmodium falciparum glutathione reductase 0.0061 0.0094 0.5367
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0055 0.0083 0.0897
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0045 0.2574
Leishmania major basic transcription factor 3a, putative 0.0105 0.0175 1
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.001 0.001
Onchocerca volvulus 0.0079 0.0126 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.001 0.0105
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.002 0.0218
Echinococcus granulosus G protein coupled receptor 139 0.0055 0.0083 0.0899
Onchocerca volvulus Putative organic anion transporter 0.0057 0.0086 0.6791
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0015 0.0007 0.0402
Onchocerca volvulus 0.0055 0.0083 0.6563
Loa Loa (eye worm) hypothetical protein 0.0039 0.0052 0.0565
Loa Loa (eye worm) hypothetical protein 0.005 0.0073 0.0791
Loa Loa (eye worm) neuropeptide F receptor 0.0055 0.0083 0.0895
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0039 0.0052 0.2987
Entamoeba histolytica Ran family GTPase 0.0022 0.002 0.1159
Toxoplasma gondii exonuclease III APE 0.0019 0.0015 0.0868
Brugia malayi Serotonin receptor 0.0055 0.0083 0.0893
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0015 0.0007 0.0076
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0083 0.0899
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0045 0.0045
Echinococcus granulosus peptide allatostatin:somatostatin 0.0055 0.0083 0.0899
Echinococcus multilocularis follistatin 0.0039 0.0052 0.0567
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0017 0.0013 0.0134
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0011 0 0.0002
Trichomonas vaginalis ran, putative 0.0022 0.002 0.1159
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0037 0.0049 0.0033
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0055 0.0083 0.0899
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0015 0.0007 0.0078
Schistosoma mansoni voltage-gated potassium channel 0.008 0.0129 0.1397
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0045 0.0487
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.001 0.0105
Mycobacterium tuberculosis Conserved protein 0.0035 0.0045 0.0045
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0055 0.0083 0.0897
Brugia malayi nuclear hormone receptor 0.0017 0.0013 0.0134
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0035 0.1985
Brugia malayi AKH receptor 0.0055 0.0083 0.0893
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0015 0.034
Brugia malayi hypothetical protein 0.0055 0.0083 0.0893
Brugia malayi putative neuropeptide receptor 0.0055 0.0083 0.0893
Brugia malayi Cytochrome P450 family protein 0.0037 0.0049 0.0523
Loa Loa (eye worm) melatonin receptor type 1A 0.0055 0.0083 0.0895
Treponema pallidum NADH oxidase 0.0021 0.002 0.0385
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0015 0.0868
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.002 0.022
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.0077 0.0832
Leishmania major cytochrome p450-like protein 0.0037 0.0049 0.2777
Loa Loa (eye worm) hypothetical protein 0.0064 0.0099 0.1063
Loa Loa (eye worm) hypothetical protein 0.0057 0.0086 0.0926
Schistosoma mansoni coup transcription factor 0.0017 0.0013 0.0134
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0136
Echinococcus granulosus serotonin receptor 0.0055 0.0083 0.0899
Mycobacterium ulcerans lipase LipD 0.0035 0.0045 0.003
Echinococcus granulosus g protein coupled receptor 0.0055 0.0083 0.0899
Loa Loa (eye worm) hypothetical protein 0.0055 0.0083 0.0895
Echinococcus granulosus biogenic amine 5HT receptor 0.0055 0.0083 0.0899
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0039 0.0052 0.0565
Treponema pallidum cysteinyl-tRNA synthetase 0.0079 0.0126 1
Echinococcus granulosus multidrug resistance protein 1 0.0011 0 0.0002
Echinococcus granulosus tm gpcr rhodopsin 0.0055 0.0083 0.0899
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0015 0.0007 0.0076
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0055 0.0083 0.0899
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.002 0.1159
Echinococcus granulosus GPCR family 2 0.0016 0.001 0.0105
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0055 0.0083 0.0893
Trypanosoma brucei cytochrome P450, putative 0.0037 0.0049 0.2359
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0077 0.4385
Loa Loa (eye worm) hypothetical protein 0.0025 0.0026 0.0283
Brugia malayi putative neuropeptide receptor NPR1 0.0055 0.0083 0.0893
Echinococcus multilocularis neuropeptide receptor 0.0055 0.0083 0.0899
Loa Loa (eye worm) hypothetical protein 0.0055 0.0083 0.0895
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0021 0.002 0.1112
Schistosoma mansoni ran 0.0022 0.002 0.0219
Schistosoma mansoni adenoreceptor 0.0055 0.0083 0.0897
Schistosoma mansoni cysteinyl-tRNA synthetase 0.0079 0.0126 0.1367
Loa Loa (eye worm) hypothetical protein 0.0055 0.0083 0.0895
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.0077 0.0832
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0039 0.0052 0.0563
Echinococcus multilocularis agrin 0.0039 0.0052 0.0567
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0055 0.0083 0.0899
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0021 0.002 0.0004
Mycobacterium tuberculosis Cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC 0.541 1 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0083 0.0895
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0077 0.4385
Mycobacterium leprae Probable lipase LipE 0.0035 0.0045 0.0026
Schistosoma mansoni ap endonuclease 0.0019 0.0015 0.0164
Plasmodium falciparum thioredoxin reductase 0.0021 0.002 0.1112
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.001 0.0546
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0021 0.002 0.0004
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0045 0.0045
Brugia malayi beta-lactamase family protein 0.0035 0.0045 0.0485
Brugia malayi hypothetical protein 0.0055 0.0083 0.0893
Onchocerca volvulus Neuropeptide F receptor homolog 0.0055 0.0083 0.6563
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0055 0.0083 0.0897
Schistosoma mansoni amine GPCR 0.0055 0.0083 0.0897
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0017 0.0013 0.0134
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0044 0.0471
Onchocerca volvulus 0.0017 0.0013 0.0983
Onchocerca volvulus 0.0055 0.0083 0.6563
Loa Loa (eye worm) hypothetical protein 0.0055 0.0083 0.0895
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0021 0.002 0.0213
Onchocerca volvulus 0.0057 0.0086 0.6791
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.001 0.0546
Brugia malayi G-protein coupled receptor 0.0055 0.0083 0.0893
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.002 0.0648
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0021 0.002 0.1112
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0055 0.0083 0.0899
Onchocerca volvulus 0.0055 0.0083 0.6563
Loa Loa (eye worm) thioredoxin reductase 0.0061 0.0094 0.1013
Echinococcus granulosus tm gpcr rhodopsin 0.0055 0.0083 0.0899
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.002 0.0648
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0013 0.0134
Loa Loa (eye worm) hypothetical protein 0.0035 0.0045 0.0487
Leishmania major hypothetical protein, conserved 0.0035 0.0045 0.2574
Schistosoma mansoni retinoic acid receptor RXR 0.0117 0.0197 0.2129
Echinococcus multilocularis neuropeptide receptor 0.0055 0.0083 0.0899
Brugia malayi G protein-coupled receptor 0.0055 0.0083 0.0893
Schistosoma mansoni hypothetical protein 0.0509 0.0923 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0055 0.0083 0.0897
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0083 0.0897
Schistosoma mansoni 60S ribosomal protein L21 0.0012 0.0002 0.0017
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0057 0.0086 0.093
Echinococcus granulosus lamin 0.0053 0.0079 0.0858
Onchocerca volvulus 0.0057 0.0086 0.6791
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.001 0.0106
Brugia malayi beta-NAC-like protein 0.0105 0.0175 0.1883
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0025 0.1393
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.001 0.0105
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0017 0.0013 0.0137
Brugia malayi Dopamine receptor 0.0055 0.0083 0.0893
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0077 0.0829
Echinococcus granulosus 7TM GPCR rhodopsin 0.0055 0.0083 0.0899
Onchocerca volvulus 0.0055 0.0083 0.6563
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.002 0.0599
Loa Loa (eye worm) hypothetical protein 0.0079 0.0126 0.1363
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0083 0.0899
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0021 0.002 0.0599
Loa Loa (eye worm) hypothetical protein 0.0055 0.0083 0.0895
Echinococcus granulosus allatostatin A receptor 0.0055 0.0083 0.0899
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0017 0.0013 0.0134
Brugia malayi larval opioid receptor 0.0055 0.0083 0.0893
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0055 0.0083 0.0899
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0083 0.0899
Echinococcus granulosus neuropeptide receptor 0.0055 0.0083 0.0899
Onchocerca volvulus 0.0055 0.0083 0.6563
Echinococcus granulosus tar DNA binding protein 0.0064 0.0099 0.1067
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0077 0.4385
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.0077 0.406
Loa Loa (eye worm) glutathione reductase 0.0061 0.0094 0.1013
Loa Loa (eye worm) hypothetical protein 0.0055 0.0083 0.0895
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0017 0.0013 0.0134
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0011 0 0.0002
Loa Loa (eye worm) hypothetical protein 0.0055 0.0083 0.0895
Schistosoma mansoni organic anion transporter 0.0057 0.0086 0.0928
Loa Loa (eye worm) hypothetical protein 0.0039 0.0052 0.0565
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0039 0.0052 0.2987
Loa Loa (eye worm) hypothetical protein 0.0055 0.0083 0.0895
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0083 0.0897
Onchocerca volvulus Bile acid receptor homolog 0.0017 0.0013 0.0983
Echinococcus multilocularis lamin dm0 0.0053 0.0079 0.0858
Giardia lamblia NADH oxidase lateral transfer candidate 0.0021 0.002 0.0385
Schistosoma mansoni amine GPCR 0.0055 0.0083 0.0897
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.0175 1
Echinococcus multilocularis somatostatin receptor 0.0055 0.0083 0.0899
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0083 0.0897
Echinococcus multilocularis ecdysone induced protein 78C 0.0017 0.0013 0.0137
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0028 0.0303
Echinococcus multilocularis multidrug resistance protein 1 0.0011 0 0.0002
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0083 0.0899
Echinococcus multilocularis fmrfamide receptor 0.0055 0.0083 0.0899
Echinococcus multilocularis musashi 0.0053 0.0079 0.0858
Schistosoma mansoni opsin-like receptor 0.0055 0.0083 0.0897
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.001 0.0106
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0015 0.0007 0.0078
Trichomonas vaginalis glutathione reductase, putative 0.0021 0.002 0.1112
Echinococcus granulosus g-protein coupled receptor 0.0055 0.0083 0.0899
Echinococcus granulosus ecdysone induced protein 78C 0.0017 0.0013 0.0137
Onchocerca volvulus 0.0057 0.0086 0.6791
Echinococcus granulosus agrin 0.0039 0.0052 0.0567
Onchocerca volvulus Putative organic anion transporter 0.0057 0.0086 0.6791
Loa Loa (eye worm) hypothetical protein 0.0055 0.0083 0.0895
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0077 0.4385
Loa Loa (eye worm) hypothetical protein 0.0057 0.0086 0.0926
Echinococcus granulosus biogenic amine 5HT receptor 0.0055 0.0083 0.0899
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0015 0.034
Echinococcus granulosus neuropeptide receptor A26 0.0055 0.0083 0.0899
Echinococcus multilocularis lamin 0.0053 0.0079 0.0858
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0015 0.0163
Echinococcus granulosus Solute carrier organic anion transporter family 0.0057 0.0086 0.093
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0045 0.2574
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0045 0.0045
Echinococcus multilocularis sex peptide receptor 0.0055 0.0083 0.0899
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0099 0.1065
Toxoplasma gondii NAC domain-containing protein 0.0105 0.0175 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0055 0.0083 0.0897
Leishmania major cysteinyl-tRNA synthetase, putative 0.0079 0.0126 0.7225
Loa Loa (eye worm) hypothetical protein 0.0055 0.0083 0.0895
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0039 0.0052 0.0563
Echinococcus multilocularis neuropeptide Y receptor 0.0055 0.0083 0.0899
Entamoeba histolytica hypothetical protein 0.0024 0.0025 0.1393
Brugia malayi neuropeptide F receptor 0.0055 0.0083 0.0893
Schistosoma mansoni biogenic amine (5HT) receptor 0.0055 0.0083 0.0897
Brugia malayi hypothetical protein 0.0055 0.0083 0.0893
Toxoplasma gondii protease inhibitor PI2 0.0039 0.0052 0.2987
Echinococcus multilocularis allatostatin A receptor 0.0055 0.0083 0.0899
Onchocerca volvulus 0.0055 0.0083 0.6563
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0021 0.002 0.1112
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0017 0.0013 0.0137
Brugia malayi hypothetical protein 0.0055 0.0083 0.0893
Loa Loa (eye worm) hypothetical protein 0.0035 0.0045 0.0487
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0083 0.0897
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0028 0.0303
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0077 0.0828
Echinococcus multilocularis serotonin receptor 0.0055 0.0083 0.0899
Leishmania major GTP-binding protein, putative 0.0022 0.002 0.1159
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0017 0.0013 0.0137
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.0077 0.4385
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0069 0.0108 0.6154
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0055 0.0083 0.0893
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.002 0.0212
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.001 0.0105
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0083 0.0899
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0057 0.0086 0.0926
Trypanosoma brucei trypanothione reductase 0.0061 0.0094 0.5099
Schistosoma mansoni alpha-1 adrenergic receptor 0.0055 0.0083 0.0897
Brugia malayi hypothetical protein 0.0057 0.0086 0.0924
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0016 0.0009 0.0097
Onchocerca volvulus 0.0055 0.0083 0.6563
Loa Loa (eye worm) hypothetical protein 0.0055 0.0083 0.0895
Brugia malayi TAR-binding protein 0.0064 0.0099 0.1061
Brugia malayi Thioredoxin reductase 0.0061 0.0094 0.1011
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.002 0.0212
Echinococcus granulosus thioredoxin glutathione reductase 0.0061 0.0094 0.1017
Brugia malayi SPARC precursor 0.0039 0.0052 0.0563
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.541 1 1
Toxoplasma gondii transporter, major facilitator family protein 0.0057 0.0086 0.4906
Toxoplasma gondii ABC1 family protein 0.0035 0.0045 0.2574
Schistosoma mansoni hypothetical protein 0.005 0.0073 0.0794
Plasmodium vivax basic transcription factor 3b, putative 0.0105 0.0175 1
Schistosoma mansoni follistatin 0.0039 0.0052 0.0565
Brugia malayi Tachykinin-like peptides receptor 99D 0.0055 0.0083 0.0893
Brugia malayi ORL1-like opioid receptor 0.0055 0.0083 0.0893
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0017 0.0013 0.0134
Schistosoma mansoni neuropeptide F-like receptor 0.0055 0.0083 0.0897
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0017 0.0013 0.0134
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0017 0.0013 0.0134
Brugia malayi beta-lactamase 0.0035 0.0045 0.0485
Loa Loa (eye worm) neuropeptide F receptor 0.0055 0.0083 0.0895
Brugia malayi Importin beta-1 subunit 0.0029 0.0035 0.0374
Echinococcus granulosus neuropeptides capa receptor 0.0055 0.0083 0.0899
Schistosoma mansoni hypothetical protein 0.0055 0.0083 0.0897
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0045 0.0489
Echinococcus granulosus neuropeptide s receptor 0.0055 0.0083 0.0899
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0011 0 0.0002
Echinococcus multilocularis g protein coupled receptor 0.0055 0.0083 0.0899
Echinococcus granulosus cysteinyl tRNA synthetase 0.0079 0.0126 0.1369
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0074 0.0117 0.1258
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0099 0.1065
Onchocerca volvulus 0.0055 0.0083 0.6563
Plasmodium falciparum cysteine--tRNA ligase 0.0079 0.0126 0.7225
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0039 0.0052 0.0563
Echinococcus granulosus neuropeptides capa receptor 0.0055 0.0083 0.0899
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.001 0.0546
Echinococcus multilocularis multidrug resistance protein 1 0.0011 0 0.0002
Schistosoma mansoni thyroid hormone receptor 0.0017 0.0013 0.0134
Trypanosoma cruzi transcription factor btf3, putative 0.0105 0.0175 1
Trypanosoma cruzi cytochrome P450, putative 0.0037 0.0049 0.2359
Loa Loa (eye worm) hypothetical protein 0.0055 0.0083 0.0895
Echinococcus granulosus g protein coupled receptor 0.0055 0.0083 0.0899
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0136
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0017 0.0013 0.0134
Loa Loa (eye worm) hypothetical protein 0.0025 0.0026 0.0283
Brugia malayi prostaglandin transporter 0.0057 0.0086 0.0924
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0055 0.0083 0.0895
Echinococcus multilocularis G-protein coupled receptor, putative 0.0055 0.0083 0.0899
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0055 0.0083 0.0899
Echinococcus granulosus intermediate filament protein 0.0053 0.0079 0.0858
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0035 0.1522
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.002 0.0648
Plasmodium falciparum glutathione reductase 0.0021 0.002 0.1112
Trypanosoma cruzi MFS transporter, putative 0.0057 0.0086 0.4612
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0011 0 0.0002
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0136
Brugia malayi nuclear receptor NHR-88 0.0017 0.0013 0.0134
Echinococcus granulosus follistatin 0.0039 0.0052 0.0567
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0011 0 0.0002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0083 0.0897
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0017 0.0013 0.0134
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0017 0.0013 0.0983
Brugia malayi G-protein coupled receptor 0.0055 0.0083 0.0893
Loa Loa (eye worm) hypothetical protein 0.0055 0.0083 0.0895
Brugia malayi RE15519p 0.0055 0.0083 0.0893
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0045 0.2145
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0025 0.1393
Schistosoma mansoni biogenic amine (5HT) receptor 0.0055 0.0083 0.0897
Loa Loa (eye worm) agrin synaptic family protein 0.0039 0.0052 0.0565
Loa Loa (eye worm) G-protein coupled receptor 0.0055 0.0083 0.0895
Echinococcus multilocularis cysteinyl tRNA synthetase 0.0079 0.0126 0.1369
Loa Loa (eye worm) hypothetical protein 0.0026 0.0029 0.0313
Loa Loa (eye worm) hypothetical protein 0.0034 0.0044 0.0473
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0021 0.002 0.1539
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0021 0.002 0.0599
Schistosoma mansoni hypothetical protein 0.0034 0.0044 0.0473
Onchocerca volvulus 0.0055 0.0083 0.6563
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.0077 0.4385
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0083 0.0897
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0021 0.002 0.0599
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0055 0.0083 0.0899
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.0077 0.406
Giardia lamblia Cysteinyl-tRNA synthetase 0.0079 0.0126 1
Brugia malayi isocitrate dehydrogenase 0.0016 0.001 0.0103
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.0175 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0074 0.0117 0.1263
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.0077 0.0832
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0055 0.0083 0.0899
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0015 0.0007 0.0078
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0017 0.0013 0.0134
Schistosoma mansoni amine GPCR 0.0055 0.0083 0.0897
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0074 0.0117 0.1263
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.0077 0.406
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0017 0.0013 0.0134
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0045 0.2574
Plasmodium vivax thioredoxin reductase, putative 0.0061 0.0094 0.5367
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0015 0.0007 0.0076
Echinococcus multilocularis neuropeptide receptor A26 0.0055 0.0083 0.0899
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0077 0.4385
Plasmodium vivax glutathione reductase, putative 0.0061 0.0094 0.5367
Loa Loa (eye worm) hypothetical protein 0.0057 0.0086 0.0926
Echinococcus granulosus neuropeptide FF receptor 2 0.0055 0.0083 0.0899
Echinococcus granulosus orexin receptor type 2 0.0055 0.0083 0.0899
Schistosoma mansoni hypothetical protein 0.0016 0.001 0.0103
Brugia malayi glutathione reductase 0.0061 0.0094 0.1011
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0021 0.002 0.0214
Onchocerca volvulus 0.0055 0.0083 0.6563
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0013 0.0134
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0077 0.406
Echinococcus granulosus importin subunit beta 1 0.0029 0.0035 0.0378
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0055 0.0083 0.0899
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0078
Loa Loa (eye worm) hypothetical protein 0.0055 0.0083 0.0895
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0021 0.002 0.0214
Onchocerca volvulus 0.0035 0.0045 0.3563
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0045 0.0045
Brugia malayi hypothetical protein 0.0055 0.0083 0.0893
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0055 0.0083 0.0899
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.001 0.0106
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.002 0.0599
Loa Loa (eye worm) hypothetical protein 0.0055 0.0083 0.0895
Brugia malayi MAP kinase sur-1 0.0052 0.0077 0.0826
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0057 0.0086 0.093
Schistosoma mansoni biogenic amine receptor 0.0055 0.0083 0.0897
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0055 0.0083 0.0899
Schistosoma mansoni voltage-gated potassium channel 0.0012 0.0002 0.0017
Schistosoma mansoni ap endonuclease 0.0019 0.0015 0.0164
Brugia malayi hypothetical protein 0.0055 0.0083 0.0893
Brugia malayi photoreceptor-specific nuclear receptor 0.0017 0.0013 0.0134
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0033 0.0357
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0015 0.0007 0.0078
Brugia malayi secreted modular calcium-binding protein 1 0.0039 0.0052 0.0563
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0045 0.0485
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0083 0.0899
Loa Loa (eye worm) hypothetical protein 0.0011 0 0.0002
Schistosoma mansoni neuropeptide f receptor 76f 0.0055 0.0083 0.0897
Schistosoma mansoni lamin 0.0053 0.0079 0.0856
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0013 0.0137
Loa Loa (eye worm) hypothetical protein 0.0057 0.0086 0.0926
Brugia malayi neuropeptide F receptor 0.0055 0.0083 0.0893
Echinococcus multilocularis neuropeptide Y receptor 0.0055 0.0083 0.0899
Onchocerca volvulus 0.0055 0.0083 0.6563
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0083 0.0899
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0013 0.0137
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0015 0.0007 0.0078
Echinococcus granulosus dro:myosuppressin receptor 0.0055 0.0083 0.0899
Loa Loa (eye worm) hypothetical protein 0.0055 0.0083 0.0895
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0015 0.0007 0.0078
Loa Loa (eye worm) hypothetical protein 0.0055 0.0083 0.0895
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0021 0.002 0.0599
Onchocerca volvulus 0.0055 0.0083 0.6563
Loa Loa (eye worm) hypothetical protein 0.0035 0.0045 0.0487
Brugia malayi hypothetical protein 0.0055 0.0083 0.0893
Brugia malayi sodium-independent organic anion transporter family protein 0.0057 0.0086 0.0924
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0055 0.0083 0.0893
Brugia malayi cysteinyl tRNA synthetase protein 1 0.0079 0.0126 0.1361
Brugia malayi Cyclic-nucleotide gated cation channel 0.0015 0.0007 0.0076
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0015 0.0007 0.0076
Echinococcus multilocularis voltage gated potassium channel 0.0021 0.002 0.0214
Echinococcus multilocularis expressed protein 0.0039 0.0052 0.0567
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0083 0.0899
Schistosoma mansoni steroid hormone receptor ad4bp 0.0017 0.0013 0.0134
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0045 0.003
Onchocerca volvulus Putative organic anion transporter 0.0057 0.0086 0.6791
Chlamydia trachomatis cysteine--tRNA ligase 0.0079 0.0126 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0083 0.0899
Schistosoma mansoni myosin xvIII 0.0055 0.0083 0.0897
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0511 0.0927 1
Brugia malayi follicle stimulating hormone receptor 0.0511 0.0927 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.001 0.0105
Brugia malayi Melatonin receptor type 1A 0.0055 0.0083 0.0893
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0013 0.0134
Echinococcus granulosus fmrfamide receptor 0.0055 0.0083 0.0899
Loa Loa (eye worm) cytochrome P450 family protein 0.0037 0.0049 0.0525
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0017 0.0013 0.0136
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0083 0.0897
Loa Loa (eye worm) hypothetical protein 0.0055 0.0083 0.0895
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0021 0.002 0.0019
Loa Loa (eye worm) hypothetical protein 0.0055 0.0083 0.0895
Trypanosoma brucei protein kinase, putative 0.0052 0.0077 0.406
Schistosoma mansoni hypothetical protein 0.0055 0.0083 0.0897
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.0079 0.0126 0.7065
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0021 0.002 0.1112
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0055 0.0083 0.0897
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0045 0.0045
Brugia malayi steroid hormone receptor 0.0017 0.0013 0.0134
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0021 0.002 0.0211
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0015 0.0166
Loa Loa (eye worm) RNA binding protein 0.0064 0.0099 0.1063
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0021 0.002 0.1112
Echinococcus granulosus lamin dm0 0.0053 0.0079 0.0858
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0136
Schistosoma mansoni intermediate filament proteins 0.0053 0.0079 0.0856
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0025 0.1393
Loa Loa (eye worm) hypothetical protein 0.0055 0.0083 0.0895
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0039 0.0052 0.0563
Onchocerca volvulus 0.0053 0.0079 0.6264
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0099 0.1067
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0025 0.0896
Schistosoma mansoni agrin 0.0039 0.0052 0.0565
Brugia malayi hypothetical protein 0.0057 0.0086 0.0924
Schistosoma mansoni hypothetical protein 0.0016 0.001 0.0103
Loa Loa (eye worm) hypothetical protein 0.0039 0.0052 0.0565
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0083 0.0899
Echinococcus granulosus FTZ F1 alpha 0.0017 0.0013 0.0137
Schistosoma mansoni voltage-gated potassium channel 0.008 0.0129 0.1397
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0013 0.0137
Echinococcus multilocularis neuropeptides capa receptor 0.0055 0.0083 0.0899
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0099 0.1065
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0011 0 0.0002
Loa Loa (eye worm) hypothetical protein 0.0055 0.0083 0.0895
Toxoplasma gondii thioredoxin reductase 0.0061 0.0094 0.5367
Brugia malayi Intermediate filament tail domain containing protein 0.0053 0.0079 0.0852
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0073 0.0789
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0055 0.0083 0.0895
Loa Loa (eye worm) TYRA-2 protein 0.0055 0.0083 0.0895
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0055 0.0083 0.0897
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0083 0.0897
Loa Loa (eye worm) hypothetical protein 0.0057 0.0086 0.0926
Loa Loa (eye worm) hypothetical protein 0.0057 0.0086 0.0926
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0055 0.0083 0.0895
Echinococcus granulosus multidrug resistance protein 1 0.0011 0 0.0002
Loa Loa (eye worm) hypothetical protein 0.0055 0.0083 0.0895
Schistosoma mansoni hypothetical protein 0.0315 0.0563 0.6101
Echinococcus granulosus neuropeptide Y receptor 0.0055 0.0083 0.0899
Plasmodium vivax importin-beta 2, putative 0.0029 0.0035 0.1985
Loa Loa (eye worm) hypothetical protein 0.0011 0 0.0002

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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