Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | DNA polymerase eta | 0.0023 | 0.0814 | 0.0814 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.0814 | 0.753 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0011 | 0.0214 | 0.061 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.17 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0018 | 0.0539 | 0.1537 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0011 | 0.0214 | 0.061 |
Trypanosoma brucei | unspecified product | 0.0016 | 0.0448 | 0.4141 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0039 | 0.1591 | 0.4533 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0011 | 0.0214 | 0.0171 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0539 | 0.0498 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0016 | 0.0448 | 0.4141 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0011 | 0.0214 | 0.061 |
Schistosoma mansoni | coup transcription factor | 0.0011 | 0.0214 | 0.0214 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0011 | 0.0214 | 0.0171 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0011 | 0.0214 | 0.0171 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0214 | 0.061 |
Trypanosoma brucei | unspecified product | 0.0023 | 0.0814 | 0.753 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0023 | 0.0814 | 0.5 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0023 | 0.0814 | 0.0774 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0041 | 0.17 | 0.17 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0011 | 0.0214 | 0.061 |
Schistosoma mansoni | nuclear hormone receptor | 0.0011 | 0.0214 | 0.0214 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0011 | 0.0214 | 0.0171 |
Onchocerca volvulus | 0.0033 | 0.1283 | 1 | |
Loa Loa (eye worm) | steroid hormone receptor | 0.0011 | 0.0214 | 0.061 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0018 | 0.0539 | 0.1537 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0057 | 0.2497 | 0.7115 |
Schistosoma mansoni | hypothetical protein | 0.0013 | 0.0283 | 0.0283 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0214 | 0.061 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.1081 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0539 | 0.0539 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0011 | 0.0214 | 0.061 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0016 | 0.0448 | 0.4141 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0011 | 0.0214 | 0.0171 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0013 | 0.0283 | 0.0241 |
Echinococcus multilocularis | geminin | 0.0205 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0214 | 0.061 |
Echinococcus multilocularis | cpg binding protein | 0.0034 | 0.1377 | 0.1339 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0057 | 0.2497 | 0.7115 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.17 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0011 | 0.0214 | 0.0214 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.17 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0041 | 0.17 | 0.1664 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3509 | 0.3509 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0539 | 0.0539 |
Schistosoma mansoni | thyroid hormone receptor | 0.0011 | 0.0214 | 0.0214 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0814 | 0.753 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.001 | 0.0137 | 0.0391 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0011 | 0.0214 | 0.061 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.3509 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0029 | 0.1081 | 1 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0023 | 0.0814 | 0.0774 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.0814 | 0.753 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.3509 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.0814 | 0.753 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0011 | 0.0214 | 0.061 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0539 | 0.1537 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0016 | 0.0448 | 0.4141 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.0814 | 0.753 |
Brugia malayi | ecdysteroid receptor | 0.0011 | 0.0214 | 0.061 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0008 | 0.0043 | 0.0043 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0011 | 0.0214 | 0.061 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0011 | 0.0214 | 0.0171 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.1591 | 0.1591 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0539 | 0.0539 |
Brugia malayi | RNA binding protein | 0.0076 | 0.3509 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0062 | 0.2758 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0034 | 0.1377 | 0.1377 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.1283 | 0.1283 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1591 | 0.4533 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0011 | 0.0214 | 0.061 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0011 | 0.0214 | 0.0214 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.3509 | 0.3481 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0814 | 0.753 |
Echinococcus granulosus | dna polymerase kappa | 0.0023 | 0.0814 | 0.0774 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0814 | 0.753 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0023 | 0.0814 | 0.232 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0023 | 0.0814 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0011 | 0.0214 | 0.0171 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0214 | 0.061 |
Schistosoma mansoni | thyroid hormone receptor | 0.0011 | 0.0214 | 0.0214 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0214 | 0.061 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0011 | 0.0214 | 0.0171 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0041 | 0.17 | 0.1664 |
Brugia malayi | CXXC zinc finger family protein | 0.0033 | 0.1283 | 0.3656 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.001 | 0.0144 | 0.0101 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3509 | 0.3509 |
Brugia malayi | nuclear hormone receptor | 0.0011 | 0.0214 | 0.061 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0011 | 0.0214 | 0.0171 |
Echinococcus granulosus | FTZ F1 alpha | 0.0011 | 0.0214 | 0.0171 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0011 | 0.0214 | 0.0171 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0023 | 0.0814 | 0.0814 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0539 | 0.0498 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.0814 | 1 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0023 | 0.0814 | 0.0814 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0214 | 0.061 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0011 | 0.0214 | 0.061 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0011 | 0.0214 | 0.0214 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0814 | 0.753 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0011 | 0.0214 | 0.061 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0011 | 0.0214 | 0.061 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0023 | 0.0814 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0029 | 0.1081 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0539 | 0.0498 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0023 | 0.0814 | 0.753 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.0814 | 0.753 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0029 | 0.1081 | 0.392 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.0814 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0018 | 0.0539 | 0.0498 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0023 | 0.0814 | 0.753 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.3509 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.1081 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3509 | 0.3509 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0011 | 0.0214 | 0.061 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0011 | 0.0214 | 0.0171 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0011 | 0.0214 | 0.061 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.17 | 0.17 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0814 | 0.753 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.3509 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.1081 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0011 | 0.0214 | 0.061 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0011 | 0.0214 | 0.0214 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.001 | 0.0144 | 0.0101 |
Echinococcus granulosus | GPCR family 2 | 0.0018 | 0.0539 | 0.0498 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0011 | 0.0214 | 0.0214 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0011 | 0.0214 | 0.061 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0023 | 0.0814 | 0.753 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0018 | 0.0539 | 0.1537 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0011 | 0.0214 | 0.0214 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0011 | 0.0214 | 0.061 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0011 | 0.0214 | 0.061 |
Trypanosoma brucei | unspecified product | 0.0016 | 0.0448 | 0.4141 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0814 | 0.753 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0011 | 0.0214 | 0.061 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 0.0814 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0814 | 0.753 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0011 | 0.0214 | 0.0171 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0011 | 0.0214 | 0.061 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0033 | 0.1283 | 0.3656 |
Echinococcus granulosus | cpg binding protein | 0.0034 | 0.1377 | 0.1339 |
Leishmania major | DNA polymerase kappa, putative | 0.0023 | 0.0814 | 0.753 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.0814 | 0.753 |
Brugia malayi | hypothetical protein | 0.0018 | 0.0568 | 0.1619 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0011 | 0.0214 | 0.0171 |
Echinococcus multilocularis | dna polymerase kappa | 0.0023 | 0.0814 | 0.0774 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0011 | 0.0214 | 0.061 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0023 | 0.0814 | 0.232 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0814 | 0.232 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.2497 | 0.7115 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.3509 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.0023 | 0.0814 | 0.0774 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0011 | 0.0214 | 0.061 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0814 | 0.753 |
Brugia malayi | hypothetical protein | 0.0029 | 0.1081 | 0.3081 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0011 | 0.0214 | 0.0171 |
Loa Loa (eye worm) | histone methyltransferase | 0.001 | 0.0144 | 0.041 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0011 | 0.0214 | 0.0214 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0029 | 0.1081 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0011 | 0.0214 | 0.0214 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0023 | 0.0814 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0214 | 0.061 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3509 | 0.3509 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0214 | 0.061 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0539 | 0.0498 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0069 | 0.3132 | 0.3132 |
Brugia malayi | nuclear receptor NHR-88 | 0.0011 | 0.0214 | 0.061 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0814 | 0.753 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0814 | 0.753 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0011 | 0.0214 | 0.061 |
Brugia malayi | hypothetical protein | 0.0041 | 0.17 | 0.4844 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.17 | 1 |
Brugia malayi | steroid hormone receptor | 0.0011 | 0.0214 | 0.061 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.1081 | 1 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0013 | 0.0283 | 0.0241 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.1081 | 0.3081 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0539 | 0.0539 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0057 | 0.2497 | 0.7115 |
Leishmania major | DNA polymerase eta, putative | 0.0023 | 0.0814 | 0.753 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0011 | 0.0214 | 0.0171 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0011 | 0.0214 | 0.0214 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3509 | 0.3509 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0011 | 0.0214 | 0.0171 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.0814 | 0.753 |
Schistosoma mansoni | cpg binding protein | 0.0034 | 0.1377 | 0.1377 |
Echinococcus granulosus | dna polymerase eta | 0.0023 | 0.0814 | 0.0774 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0023 | 0.0814 | 0.232 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.3509 | 0.3481 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0011 | 0.0214 | 0.0171 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.