Detailed information for compound 1529615

Basic information

Technical information
  • TDR Targets ID: 1529615
  • Name: 2-[2-(4-amino-1,2,5-oxadiazol-3-yl)benzimidaz ol-1-yl]-1-(3,5-dimethylpiperidin-1-yl)ethano ne
  • MW: 354.406 | Formula: C18H22N6O2
  • H donors: 1 H acceptors: 4 LogP: 1.97 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1CC(C)CN(C1)C(=O)Cn1c(nc2c1cccc2)c1nonc1N
  • InChi: 1S/C18H22N6O2/c1-11-7-12(2)9-23(8-11)15(25)10-24-14-6-4-3-5-13(14)20-18(24)16-17(19)22-26-21-16/h3-6,11-12H,7-10H2,1-2H3,(H2,19,22)
  • InChiKey: LPHVJHMBHQIMEH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[2-(4-amino-1,2,5-oxadiazol-3-yl)benzimidazol-1-yl]-1-(3,5-dimethyl-1-piperidyl)ethanone
  • 2-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-benzimidazolyl]-1-(3,5-dimethyl-1-piperidinyl)ethanone
  • 2-[2-(4-aminofurazan-3-yl)benzimidazol-1-yl]-1-(3,5-dimethyl-1-piperidyl)ethanone
  • MLS000121720
  • SMR000119205
  • STK064178
  • Oprea1_045257
  • BAS 03258550
  • 2-[2-(4-Amino-furazan-3-yl)-benzoimidazol-1-yl]-1-(3,5-dimethyl-piperidin-1-yl)-ethanone

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0037 0.003 0.0058
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.0396 0.0391
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0101 0.0396 0.0391
Brugia malayi von Willebrand factor type A domain containing protein 0.0035 0.0013 0.0019
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0035 0.0013 0.0008
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0406 0.2147 0.2143
Trichomonas vaginalis conserved hypothetical protein 0.0169 0.0789 0.271
Brugia malayi larval opioid receptor 0.0101 0.0396 0.0582
Loa Loa (eye worm) hexokinase 0.0376 0.1976 0.2906
Loa Loa (eye worm) hypothetical protein 0.0035 0.0013 0.0019
Schistosoma mansoni neuropeptide receptor 0.0825 0.4559 0.4556
Echinococcus multilocularis histone lysine n methyltransferase setd8 0.0066 0.0192 0.0188
Brugia malayi Integrin alpha cytoplasmic region family protein 0.012 0.0504 0.0741
Loa Loa (eye worm) proprotein convertase 2 0.0207 0.1004 0.1476
Giardia lamblia Transcriptional regulator, Sir2 family 0.0082 0.0285 0.117
Schistosoma mansoni amine GPCR 0.0101 0.0396 0.0391
Loa Loa (eye worm) hypothetical protein 0.0101 0.0396 0.0582
Echinococcus multilocularis thyroid hormone receptor alpha 0.0148 0.0663 0.0659
Echinococcus multilocularis neuropeptide FF receptor 2 0.0101 0.0396 0.0391
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.0396 0.0391
Trypanosoma brucei polo-like protein kinase 0.0187 0.0888 0.1305
Echinococcus granulosus furin 0.0876 0.4851 0.4849
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0207 0.1004 0.3462
Loa Loa (eye worm) hypothetical protein 0.0035 0.0013 0.0019
Echinococcus granulosus integrin alpha ps 0.0071 0.0223 0.0218
Schistosoma mansoni hypothetical protein 0.0101 0.0396 0.0391
Brugia malayi putative neuropeptide receptor 0.0101 0.0396 0.0582
Echinococcus granulosus somatostatin receptor 0.0101 0.0396 0.0391
Brugia malayi Tachykinin-like peptides receptor 99D 0.0101 0.0396 0.0582
Loa Loa (eye worm) hypothetical protein 0.0101 0.0396 0.0582
Echinococcus multilocularis G protein coupled receptor 139 0.0825 0.4559 0.4556
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0037 0.003 0.0058
Toxoplasma gondii rhoptry neck protein RON1 0.006 0.0157 0.0224
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0187 0.0888 0.0883
Schistosoma mansoni cathepsin D (A01 family) 0.0145 0.0647 0.0643
Echinococcus multilocularis voltage gated potassium channel 0.0054 0.0127 0.0123
Brugia malayi transcriptional regulator, Sir2 family protein 0.0272 0.1378 0.2027
Leishmania major silent information regulator 2, putative 0.0272 0.1378 0.1992
Echinococcus granulosus hexokinase type 2 0.1215 0.6801 0.6799
Echinococcus multilocularis hexokinase 0.1215 0.6801 0.6799
Giardia lamblia Hypothetical protein 0.0272 0.1378 0.6356
Toxoplasma gondii exonuclease III APE 0.0039 0.0039 0.005
Loa Loa (eye worm) transcriptional regulator 0.0082 0.0285 0.0419
Onchocerca volvulus 0.0101 0.0396 0.0576
Brugia malayi von Willebrand factor type A domain containing protein 0.0035 0.0013 0.0019
Echinococcus granulosus rhodopsin orphan GPCR 0.0101 0.0396 0.0391
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0037 0.0028 0.0023
Schistosoma mansoni biogenic amine receptor 0.0101 0.0396 0.0391
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0169 0.0789 0.271
Schistosoma mansoni biogenic amine (5HT) receptor 0.0101 0.0396 0.0391
Treponema pallidum hexokinase (hxk) 0.1215 0.6801 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0236 0.0231
Loa Loa (eye worm) hypothetical protein 0.0054 0.0127 0.0187
Loa Loa (eye worm) hypothetical protein 0.0101 0.0396 0.0582
Echinococcus granulosus Furin 1 0.0207 0.1004 0.0999
Brugia malayi Zona pellucida-like domain containing protein 0.0035 0.0013 0.0019
Brugia malayi RE15519p 0.0101 0.0396 0.0582
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.006 0.0044
Brugia malayi hypothetical protein 0.006 0.0157 0.0231
Schistosoma mansoni alpha-1 adrenergic receptor 0.0101 0.0396 0.0391
Loa Loa (eye worm) hexokinase 0.0763 0.4197 0.6172
Echinococcus granulosus membrane bound transcription factor site 1 0.0037 0.003 0.0025
Brugia malayi Melatonin receptor type 1A 0.0101 0.0396 0.0582
Loa Loa (eye worm) hypothetical protein 0.0101 0.0396 0.0582
Loa Loa (eye worm) hypothetical protein 0.0324 0.1676 0.2464
Toxoplasma gondii histone deacetylase SIR2 0.0082 0.0285 0.0413
Brugia malayi von Willebrand factor type A domain containing protein 0.0035 0.0013 0.0019
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.1772 1 1
Brugia malayi Sushi domain 0.006 0.0157 0.0231
Schistosoma mansoni neuropeptide receptor 0.0101 0.0396 0.0391
Loa Loa (eye worm) CUTiclin family member 0.0035 0.0013 0.0019
Mycobacterium ulcerans aminopeptidase N PepN 0.0069 0.0214 0.7201
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0035 0.0013 0.0019
Onchocerca volvulus 0.0101 0.0396 0.0576
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0039 0.0013
Onchocerca volvulus 0.1215 0.6801 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.0039 0.5
Brugia malayi hypothetical protein 0.006 0.0157 0.0231
Echinococcus multilocularis hyperpolarization activated cyclic 0.0037 0.0028 0.0023
Echinococcus granulosus g protein coupled receptor 0.0101 0.0396 0.0391
Brugia malayi hypothetical protein 0.0035 0.0013 0.0019
Echinococcus multilocularis integrin alpha ps 0.0034 0.001 0.0005
Loa Loa (eye worm) hypothetical protein 0.0101 0.0396 0.0582
Onchocerca volvulus 0.1215 0.6801 1
Schistosoma mansoni neuropeptide receptor 0.0101 0.0396 0.0391
Schistosoma mansoni integrin alpha-ps 0.0071 0.0223 0.0218
Echinococcus granulosus neuropeptide Y receptor 0.0101 0.0396 0.0391
Echinococcus multilocularis hyperpolarization activated cyclic 0.0037 0.0028 0.0023
Onchocerca volvulus Neuropeptide F receptor homolog 0.0101 0.0396 0.0576
Loa Loa (eye worm) hypothetical protein 0.0101 0.0396 0.0582
Plasmodium vivax apical sushi protein, putative 0.006 0.0157 0.0224
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0187 0.0888 0.1305
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0037 0.0028 0.0023
Schistosoma mansoni chromatin regulatory protein sir2 0.0082 0.0285 0.028
Echinococcus multilocularis g protein coupled receptor 0.0101 0.0396 0.0391
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0037 0.003 0.0058
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0101 0.0396 0.0391
Loa Loa (eye worm) hypothetical protein 0.0035 0.0013 0.0019
Toxoplasma gondii subtilisin SUB5 0.0037 0.003 0.0036
Loa Loa (eye worm) hypothetical protein 0.0101 0.0396 0.0582
Echinococcus multilocularis G-protein coupled receptor, putative 0.0101 0.0396 0.0391
Echinococcus multilocularis rhodopsin orphan GPCR 0.0101 0.0396 0.0391
Loa Loa (eye worm) hypothetical protein 0.0101 0.0396 0.0582
Schistosoma mansoni biogenic amine receptor 0.0101 0.0396 0.0391
Brugia malayi hypothetical protein 0.006 0.0157 0.0231
Schistosoma mansoni voltage-gated potassium channel 0.0054 0.0127 0.0123
Loa Loa (eye worm) hypothetical protein 0.0101 0.0396 0.0582
Echinococcus multilocularis neuropeptide s receptor 0.0101 0.0396 0.0391
Loa Loa (eye worm) hypothetical protein 0.0101 0.0396 0.0582
Entamoeba histolytica aminopeptidase, putative 0.0069 0.0214 0.0296
Echinococcus multilocularis protein will die slowly 0.0066 0.0193 0.0188
Toxoplasma gondii rhoptry neck protein RON9 0.006 0.0157 0.0224
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0069 0.0214 0.0272
Toxoplasma gondii subtilisin SUB2 0.0037 0.003 0.0036
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0037 0.003 0.0043
Echinococcus multilocularis C type lectin domian containing protein 0.006 0.0157 0.0152
Onchocerca volvulus 0.006 0.0157 0.0224
Echinococcus granulosus hyperpolarization activated cyclic 0.0037 0.0028 0.0023
Brugia malayi Protein set-1 0.0066 0.0192 0.0283
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0069 0.0214 0.0209
Plasmodium falciparum plasmepsin I 0.0049 0.0097 0.0124
Loa Loa (eye worm) hypothetical protein 0.0049 0.0097 0.0142
Loa Loa (eye worm) hypothetical protein 0.0035 0.0013 0.0019
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0101 0.0396 0.0391
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0406 0.2147 0.7454
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.006 0.0088
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0101 0.0396 0.0582
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.0396 0.0391
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0037 0.003 0.0058
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0236 0.0231
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0236 0.0231
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.006 0.0088
Echinococcus granulosus tm gpcr rhodopsin 0.0101 0.0396 0.0391
Brugia malayi Hexokinase family protein 0.0763 0.4197 0.6172
Onchocerca volvulus 0.006 0.0157 0.0224
Onchocerca volvulus 0.0101 0.0396 0.0576
Loa Loa (eye worm) TYRA-2 protein 0.0101 0.0396 0.0582
Schistosoma mansoni hexokinase 0.1215 0.6801 0.6799
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0272 0.1378 0.2027
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0207 0.1004 0.3462
Schistosoma mansoni hypothetical protein 0.0035 0.0013 0.0008
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0272 0.1378 0.1992
Onchocerca volvulus Serine\/threonine kinase homolog 0.0187 0.0888 0.1299
Echinococcus multilocularis membrane bound transcription factor site 1 0.0037 0.003 0.0025
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0101 0.0396 0.0391
Plasmodium vivax SET domain protein, putative 0.0066 0.0192 0.0276
Loa Loa (eye worm) hypothetical protein 0.0101 0.0396 0.0582
Echinococcus granulosus neuropeptide FF receptor 2 0.0101 0.0396 0.0391
Trypanosoma brucei hexokinase 0.1215 0.6801 1
Loa Loa (eye worm) peptidase family M1 containing protein 0.0108 0.0433 0.0637
Echinococcus granulosus neuropeptide receptor 0.0101 0.0396 0.0391
Echinococcus multilocularis g-protein coupled receptor 0.0101 0.0396 0.0391
Loa Loa (eye worm) CUTiclin-Like family member 0.0035 0.0013 0.0019
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0037 0.0028 0.0023
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0037 0.003 0.0058
Echinococcus multilocularis serotonin receptor 0.0101 0.0396 0.0391
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0236 0.0231
Loa Loa (eye worm) hypothetical protein 0.0101 0.0396 0.0582
Brugia malayi Hexokinase family protein 0.0376 0.1976 0.2906
Echinococcus granulosus dna polymerase kappa 0.0043 0.006 0.0055
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.1772 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.0396 0.0391
Echinococcus granulosus neuroendocrine convertase 2 0.0551 0.2979 0.2976
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0039 0.0034
Echinococcus granulosus neuropeptide s receptor 0.0101 0.0396 0.0391
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0101 0.0396 0.0582
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0037 0.003 0.0058
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0045 0.0073 0.0065
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0101 0.0396 0.0391
Onchocerca volvulus 0.0101 0.0396 0.0576
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0101 0.0396 0.0391
Brugia malayi ORL1-like opioid receptor 0.0101 0.0396 0.0582
Trichomonas vaginalis CAMK family protein kinase 0.0187 0.0888 0.3056
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0218 0.1069 0.1571
Plasmodium falciparum apical sushi protein 0.006 0.0157 0.0212
Toxoplasma gondii subtilisin SUB8 0.0037 0.003 0.0036
Loa Loa (eye worm) hypothetical protein 0.0035 0.0013 0.0019
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0082 0.0285 0.0951
Leishmania major hexokinase, putative 0.1215 0.6801 1
Trypanosoma brucei Aminopeptidase M1, putative 0.0069 0.0214 0.0314
Echinococcus granulosus 7TM GPCR rhodopsin 0.0101 0.0396 0.0391
Onchocerca volvulus 0.0763 0.4197 0.6169
Leishmania major hexokinase, putative 0.1215 0.6801 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0207 0.1004 0.3462
Loa Loa (eye worm) hypothetical protein 0.0033 0.0005 0.0007
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0082 0.0285 0.0951
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0101 0.0396 0.0391
Loa Loa (eye worm) hypothetical protein 0.0101 0.0396 0.0582
Trypanosoma brucei Aminopeptidase M1, putative 0.0069 0.0214 0.0314
Toxoplasma gondii histone lysine methyltransferase SET8 0.0066 0.0192 0.0276
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.006 0.0088
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.006 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0169 0.0789 0.271
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0101 0.0396 0.0391
Brugia malayi hypothetical protein 0.0101 0.0396 0.0582
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.006 0.0088
Echinococcus multilocularis hexokinase 0.1215 0.6801 0.6799
Schistosoma mansoni site-1 peptidase (S08 family) 0.0037 0.003 0.0025
Schistosoma mansoni furin-1 (S08 family) 0.0381 0.2005 0.2001
Trypanosoma cruzi hexokinase, putative 0.1215 0.6801 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.0028 0.0053
Brugia malayi Will die slowly protein 0.0066 0.0193 0.0283
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0101 0.0396 0.0391
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0069 0.0214 0.0209
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0035 0.0013 0.0012
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0069 0.0214 0.0209
Brugia malayi von Willebrand factor type A domain containing protein 0.0035 0.0013 0.0019
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0037 0.003 0.5
Loa Loa (eye worm) hypothetical protein 0.0037 0.003 0.0043
Brugia malayi Integrin alpha pat-2 precursor 0.0159 0.0726 0.1068
Loa Loa (eye worm) hypothetical protein 0.0101 0.0396 0.0582
Loa Loa (eye worm) hypothetical protein 0.0101 0.0396 0.0582
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0272 0.1378 0.1992
Brugia malayi Serotonin receptor 0.0101 0.0396 0.0582
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0082 0.0285 0.0419
Echinococcus granulosus integrin alpha ps 0.0034 0.001 0.0005
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0169 0.0789 0.271
Plasmodium falciparum plasmepsin IV 0.0049 0.0097 0.0124
Toxoplasma gondii subtilisin SUB1 0.0037 0.003 0.0036
Echinococcus granulosus rhodopsin orphan GPCR 0.0101 0.0396 0.0391
Onchocerca volvulus 0.0101 0.0396 0.0576
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0101 0.0396 0.0391
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0236 0.8066
Echinococcus multilocularis beta adrenergic receptor kinase 0.0098 0.038 0.0375
Loa Loa (eye worm) hypothetical protein 0.006 0.0157 0.0231
Onchocerca volvulus 0.0037 0.003 0.0036
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0082 0.0285 0.0378
Onchocerca volvulus 0.0035 0.0013 0.0012
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.006 0.0088
Schistosoma mansoni neuropeptide F-like receptor 0.0101 0.0396 0.0391
Brugia malayi proprotein convertase 2 0.0551 0.2979 0.4381
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0035 0.0013 0.0019
Plasmodium vivax thrombospondin-related anonymous protein 0.0035 0.0013 0.0012
Toxoplasma gondii subtilisin SUB4 0.0037 0.003 0.0036
Entamoeba histolytica hexokinase 2 0.1215 0.6801 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0157 0.0231
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0101 0.0396 0.0391
Trichomonas vaginalis DNA polymerase eta, putative 0.0043 0.006 0.0163
Loa Loa (eye worm) hypothetical protein 0.0101 0.0396 0.0582
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0049 0.0097 0.0142
Onchocerca volvulus 0.0035 0.0013 0.0012
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0101 0.0396 0.0391
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0188 0.0895 0.1316
Onchocerca volvulus 0.0101 0.0396 0.0576
Brugia malayi NAD-dependent deacetylase SIRT1 0.0406 0.2147 0.3156
Loa Loa (eye worm) hypothetical protein 0.0101 0.0396 0.0582
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0037 0.0028 0.0023
Echinococcus multilocularis integrin alpha ps 0.0071 0.0223 0.0218
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0037 0.003 0.5
Loa Loa (eye worm) hypothetical protein 0.0876 0.4851 0.7133
Echinococcus granulosus beta-adrenergic receptor kinase 0.0098 0.038 0.0375
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0037 0.0028 0.0023
Plasmodium vivax hypothetical protein, conserved 0.0082 0.0285 0.0413
Loa Loa (eye worm) sirtuin 4 0.0082 0.0285 0.0419
Echinococcus granulosus hexokinase 0.1215 0.6801 0.6799
Echinococcus granulosus neuropeptides capa receptor 0.0101 0.0396 0.0391
Loa Loa (eye worm) hypothetical protein 0.006 0.0157 0.0231
Plasmodium vivax hexokinase, putative 0.1215 0.6801 1
Trichomonas vaginalis CAMK family protein kinase 0.0187 0.0888 0.3056
Plasmodium falciparum subtilisin-like protease 3 0.0037 0.003 0.0025
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0035 0.0013 0.0019
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0054 0.0127 0.0123
Brugia malayi neuropeptide F receptor 0.0101 0.0396 0.0582
Schistosoma mansoni kinase 0.0095 0.0361 0.0356
Loa Loa (eye worm) WD40 repeat protein 0.0066 0.0193 0.0283
Echinococcus multilocularis rhodopsin orphan GPCR 0.0101 0.0396 0.0391
Loa Loa (eye worm) hypothetical protein 0.0045 0.0073 0.0108
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0101 0.0396 0.0582
Echinococcus multilocularis hexokinase 0.1215 0.6801 0.6799
Loa Loa (eye worm) hypothetical protein 0.0128 0.0552 0.0812
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0054 0.0127 0.0123
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0037 0.0028 0.0023
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0207 0.1004 0.0999
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0101 0.0396 0.0582
Onchocerca volvulus 0.1215 0.6801 1
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0406 0.2147 0.2143
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0082 0.0285 0.0951
Echinococcus multilocularis survival motor neuron protein 1 0.0245 0.1225 0.1221
Brugia malayi GnHR receptor homolog 0.0101 0.0396 0.0582
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.0396 0.0391
Loa Loa (eye worm) hypothetical protein 0.0406 0.2147 0.3156
Loa Loa (eye worm) aminopeptidase N 0.0069 0.0214 0.0314
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0101 0.0396 0.0391
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.0035 0.0013 0.0012
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0069 0.0214 0.0209
Toxoplasma gondii hexokinase 0.1215 0.6801 1
Trichomonas vaginalis conserved hypothetical protein 0.0169 0.0789 0.271
Schistosoma mansoni ap endonuclease 0.0039 0.0039 0.0034
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0069 0.0214 0.0209
Onchocerca volvulus 0.0035 0.0013 0.0012
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0037 0.003 0.0058
Brugia malayi Cyclic-nucleotide gated cation channel 0.0037 0.0028 0.0041
Onchocerca volvulus 0.006 0.0157 0.0224
Echinococcus granulosus g protein coupled receptor 0.0101 0.0396 0.0391
Entamoeba histolytica hexokinase 1 0.1215 0.6801 1
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0272 0.1378 0.1374
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0098 0.038 0.0558
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0037 0.003 0.0058
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0069 0.0214 0.0701
Schistosoma mansoni chromatin regulatory protein sir2 0.0082 0.0285 0.028
Echinococcus multilocularis fmrfamide receptor 0.0101 0.0396 0.0391
Toxoplasma gondii subtilisin SUB9 0.0037 0.003 0.0036
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0037 0.003 0.0025
Loa Loa (eye worm) hypothetical protein 0.0101 0.0396 0.0582
Loa Loa (eye worm) hypothetical protein 0.0088 0.0318 0.0467
Onchocerca volvulus 0.005 0.0102 0.0143
Loa Loa (eye worm) neuropeptide F receptor 0.0101 0.0396 0.0582
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0037 0.003 0.0025
Brugia malayi AKH receptor 0.0101 0.0396 0.0582
Loa Loa (eye worm) hypothetical protein 0.0101 0.0396 0.0582
Schistosoma mansoni cathepsin D (A01 family) 0.0145 0.0647 0.0643
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0069 0.0214 0.0701
Schistosoma mansoni amine GPCR 0.0101 0.0396 0.0391
Schistosoma mansoni histone-lysine n-methyltransferase seto7 0.0066 0.0192 0.0188
Giardia lamblia Furin precursor putative serine protease 0.0169 0.0789 0.3558
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0069 0.0214 0.0209
Onchocerca volvulus 0.0101 0.0396 0.0576
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0406 0.2147 0.7454
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0533 0.2875 0.2872
Trichomonas vaginalis conserved hypothetical protein 0.0169 0.0789 0.271
Loa Loa (eye worm) hypothetical protein 0.006 0.0157 0.0231
Schistosoma mansoni hypothetical protein 0.0066 0.0193 0.0188
Schistosoma mansoni thyroid hormone receptor 0.0148 0.0663 0.0659
Loa Loa (eye worm) transcriptional regulator 0.0082 0.0285 0.0419
Brugia malayi hypothetical protein 0.0101 0.0396 0.0582
Echinococcus granulosus neuropeptides capa receptor 0.0101 0.0396 0.0391
Loa Loa (eye worm) hypothetical protein 0.0035 0.0013 0.0019
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0188 0.0895 0.089
Loa Loa (eye worm) hypothetical protein 0.0125 0.053 0.078
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.038 0.0375
Trichomonas vaginalis conserved hypothetical protein 0.0169 0.0789 0.271
Schistosoma mansoni chromatin regulatory protein sir2 0.0272 0.1378 0.1374
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0037 0.0028 0.0023
Toxoplasma gondii subtilisin SUB11 0.0037 0.003 0.0036
Schistosoma mansoni chromatin regulatory protein sir2 0.0272 0.1378 0.1374
Echinococcus granulosus neuropeptide receptor 0.0825 0.4559 0.4556
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0037 0.003 0.0025
Echinococcus multilocularis neuropeptide receptor A26 0.0101 0.0396 0.0391
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.0396 0.0391
Schistosoma mansoni myosin xvIII 0.0101 0.0396 0.0391
Trypanosoma cruzi polo-like protein kinase, putative 0.0187 0.0888 0.1267
Echinococcus multilocularis g protein coupled receptor 0.0101 0.0396 0.0391
Loa Loa (eye worm) hypothetical protein 0.0344 0.179 0.2632
Brugia malayi Hexokinase family protein 0.1215 0.6801 1
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0272 0.1378 0.1374
Brugia malayi G protein-coupled receptor F59B2.13 0.0101 0.0396 0.0582
Brugia malayi G-protein coupled receptor 0.0101 0.0396 0.0582
Echinococcus granulosus hexokinase 0.1215 0.6801 0.6799
Loa Loa (eye worm) hypothetical protein 0.0035 0.0013 0.0019
Giardia lamblia High cysteine membrane protein Group 2 0.0326 0.1686 0.7815
Echinococcus multilocularis sex peptide receptor 0.0101 0.0396 0.0391
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0037 0.0028 0.0023
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0131 0.0567 0.0562
Trypanosoma brucei DNA polymerase IV, putative 0.0036 0.002 0.003
Echinococcus granulosus chromatin regulatory protein sir2 0.0272 0.1378 0.1374
Echinococcus granulosus rhodopsin orphan GPCR 0.0101 0.0396 0.0391
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.006 0.0044
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0054 0.0127 0.0187
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0207 0.1004 0.3462
Trichomonas vaginalis WD repeat domain, putative 0.0066 0.0193 0.0628
Echinococcus multilocularis fmrfamide receptor 0.0101 0.0396 0.0391
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.006 0.0088
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0037 0.003 0.0043
Onchocerca volvulus 0.0035 0.0013 0.0012
Echinococcus granulosus collagen alpha 1VII chain 0.0035 0.0013 0.0008
Trichomonas vaginalis CAMK family protein kinase 0.0187 0.0888 0.3056
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0037 0.003 0.0058
Schistosoma mansoni voltage-gated potassium channel 0.0205 0.0994 0.099
Echinococcus multilocularis neuropeptide receptor 0.0101 0.0396 0.0391
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0039 0.0038
Echinococcus granulosus biogenic amine 5HT receptor 0.0101 0.0396 0.0391
Echinococcus granulosus neuropeptide Y receptor 0.0101 0.0396 0.0391
Loa Loa (eye worm) hypothetical protein 0.0101 0.0396 0.0582
Brugia malayi G protein-coupled receptor 0.0101 0.0396 0.0582
Loa Loa (eye worm) hypothetical protein 0.0163 0.0752 0.1106
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0101 0.0396 0.0391
Toxoplasma gondii subtilisin SUB12 0.0037 0.003 0.0036
Loa Loa (eye worm) hypothetical protein 0.006 0.0157 0.0231
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0346 0.1165
Loa Loa (eye worm) melatonin receptor type 1A 0.0101 0.0396 0.0582
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0082 0.0285 0.0378
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0131 0.0567 0.0562
Schistosoma mansoni neuropeptide f receptor 76f 0.0101 0.0396 0.0391
Loa Loa (eye worm) hexokinase type II 0.1215 0.6801 1
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0037 0.0028 0.0023
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0272 0.1378 0.2012
Echinococcus multilocularis rhodopsin orphan GPCR 0.0101 0.0396 0.0391
Schistosoma mansoni integrin alpha-ps 0.0037 0.0027 0.0022
Echinococcus granulosus sex peptide receptor 0.0101 0.0396 0.0391
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0045 0.0073 0.0068
Echinococcus granulosus orexin receptor type 2 0.0101 0.0396 0.0391
Loa Loa (eye worm) hypothetical protein 0.0101 0.0396 0.0582
Echinococcus granulosus rhodopsin orphan GPCR 0.0101 0.0396 0.0391
Loa Loa (eye worm) hypothetical protein 0.0386 0.2036 0.2993
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0082 0.0285 0.0378
Trichomonas vaginalis conserved hypothetical protein 0.0169 0.0789 0.271
Entamoeba histolytica hypothetical protein, conserved 0.0082 0.0285 0.0401
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0236 0.0305
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0082 0.0285 0.0401
Echinococcus granulosus dro:myosuppressin receptor 0.0101 0.0396 0.0391
Plasmodium falciparum plasmepsin VI 0.0049 0.0097 0.0124
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0101 0.0396 0.0391
Loa Loa (eye worm) hypothetical protein 0.0035 0.0013 0.0019
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0013 0.0012
Brugia malayi Subtilase family protein 0.0037 0.003 0.0043
Echinococcus granulosus integrin alpha 3 0.0122 0.0514 0.0509
Onchocerca volvulus 0.006 0.0157 0.0224
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0069 0.0214 0.0314
Brugia malayi putative neuropeptide receptor NPR1 0.0101 0.0396 0.0582
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0101 0.0396 0.0391
Schistosoma mansoni growth hormone secretagogue receptor 0.0101 0.0396 0.0391
Brugia malayi transcriptional regulator, Sir2 family protein 0.0082 0.0285 0.0419
Brugia malayi hexokinase 0.1215 0.6801 1
Trypanosoma cruzi Aminopeptidase M1, putative 0.0069 0.0214 0.0272
Onchocerca volvulus 0.0101 0.0396 0.0576
Echinococcus granulosus hyperpolarization activated cyclic 0.0037 0.0028 0.0023
Schistosoma mansoni hypothetical protein 0.005 0.0102 0.0097
Schistosoma mansoni amine GPCR 0.0101 0.0396 0.0391
Schistosoma mansoni histamine h1 receptor 0.0101 0.0396 0.0391
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0039 0.009
Schistosoma mansoni neuropeptide receptor 0.0101 0.0396 0.0391
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0037 0.003 0.0058
Loa Loa (eye worm) hypothetical protein 0.0101 0.0396 0.0582
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0035 0.0013 0.0008
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0037 0.003 0.0058
Loa Loa (eye worm) hypothetical protein 0.0035 0.0013 0.0019
Brugia malayi pregnancy-associated plasma protein-A 0.006 0.0157 0.0231
Echinococcus multilocularis integrin alpha 3 0.0122 0.0514 0.0509
Loa Loa (eye worm) integrin alpha pat-2 0.0245 0.122 0.1795
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0069 0.0214 0.0209
Loa Loa (eye worm) hypothetical protein 0.0083 0.0293 0.0431
Echinococcus granulosus G protein coupled receptor 139 0.0101 0.0396 0.0391
Echinococcus granulosus alpha 1A adrenergic receptor 0.0101 0.0396 0.0391
Plasmodium falciparum plasmepsin II 0.0049 0.0097 0.0124
Echinococcus granulosus g protein coupled receptor 0.0101 0.0396 0.0391
Plasmodium falciparum subtilisin-like protease 2 0.0037 0.003 0.0025
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0236 0.034
Brugia malayi serine/threonine-protein kinase plk-2 0.0187 0.0888 0.1305
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0039 0.009
Echinococcus granulosus tm gpcr rhodopsin 0.0101 0.0396 0.0391
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0101 0.0396 0.0582
Trichomonas vaginalis CAMK family protein kinase 0.0187 0.0888 0.3056
Onchocerca volvulus 0.0069 0.0214 0.0307
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0207 0.1004 0.3462
Brugia malayi Immunoglobulin I-set domain containing protein 0.0035 0.0013 0.0019
Toxoplasma gondii aspartyl protease ASP1 0.0049 0.0097 0.0135
Brugia malayi hypothetical protein 0.006 0.0157 0.0231
Echinococcus granulosus serotonin receptor 0.0101 0.0396 0.0391
Loa Loa (eye worm) hypothetical protein 0.0101 0.0396 0.0582
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.006 0.0044
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0037 0.003 0.0025
Echinococcus granulosus histone lysine n methyltransferase setd8 0.0066 0.0192 0.0188
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0187 0.0888 0.1267
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.0396 0.0391
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0187 0.0888 0.0883
Loa Loa (eye worm) hypothetical protein 0.0101 0.0396 0.0582
Schistosoma mansoni survival motor neuron protein 0.005 0.0102 0.0097
Schistosoma mansoni integrin alpha 0.0159 0.0726 0.0722
Echinococcus granulosus tachykinin peptides receptor 99D 0.0101 0.0396 0.0391
Echinococcus multilocularis 0.0707 0.3877 0.3874
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0069 0.0214 0.0272
Trichomonas vaginalis CAMK family protein kinase 0.0187 0.0888 0.3056
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0101 0.0396 0.0391
Loa Loa (eye worm) hypothetical protein 0.0101 0.0396 0.0582
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0037 0.003 0.0043
Mycobacterium ulcerans NAD-dependent deacetylase 0.0082 0.0285 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0272 0.1378 0.477
Echinococcus multilocularis c4b binding protein beta chain 0.006 0.0157 0.0152
Schistosoma mansoni ap endonuclease 0.0039 0.0039 0.0034
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0101 0.0396 0.0582
Plasmodium vivax subtilisin-like protease 2, putative 0.0037 0.003 0.0036
Echinococcus multilocularis neuropeptide receptor 0.0825 0.4559 0.4556
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0207 0.1004 0.3462
Brugia malayi hypothetical protein 0.0101 0.0396 0.0582
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0035 0.0013 0.0008
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0039 0.0057
Onchocerca volvulus 0.0101 0.0396 0.0576
Schistosoma mansoni hypothetical protein 0.0101 0.0396 0.0391
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0039 0.0057
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0236 0.8066
Echinococcus multilocularis orexin receptor type 2 0.0101 0.0396 0.0391
Brugia malayi Peptidase family M1 containing protein 0.0069 0.0214 0.0314
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0049 0.0097 0.0092
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.0396 0.0391
Echinococcus granulosus hexokinase 0.1215 0.6801 0.6799
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.5443 0.5441
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.006 0.0088
Loa Loa (eye worm) hypothetical protein 0.0037 0.0027 0.004
Echinococcus multilocularis g protein coupled receptor 0.0101 0.0396 0.0391
Schistosoma mansoni chromatin regulatory protein sir2 0.0406 0.2147 0.2143
Echinococcus multilocularis rhodopsin orphan GPCR 0.0101 0.0396 0.0391
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0876 0.4851 0.4849
Brugia malayi celfurPC protein 0.0707 0.3877 0.57
Brugia malayi follicle stimulating hormone receptor 0.0101 0.0396 0.0582
Brugia malayi hypothetical protein 0.0101 0.0396 0.0582
Echinococcus granulosus peptide allatostatin:somatostatin 0.0101 0.0396 0.0391
Onchocerca volvulus 0.0101 0.0396 0.0576
Brugia malayi Zona pellucida-like domain containing protein 0.0035 0.0013 0.0019
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0101 0.0396 0.0391
Echinococcus multilocularis rhodopsin orphan GPCR 0.0101 0.0396 0.0391
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0272 0.1378 0.2012
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0045 0.0073 0.0068
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0101 0.0396 0.0391
Plasmodium falciparum SET domain protein, putative 0.0066 0.0192 0.0265
Loa Loa (eye worm) hypothetical protein 0.0101 0.0396 0.0582
Onchocerca volvulus 0.0248 0.124 0.1818
Brugia malayi hypothetical protein 0.006 0.0157 0.0231
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0082 0.0285 0.028
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0082 0.0285 0.0401
Brugia malayi Pre-SET motif family protein 0.0033 0.0005 0.0007
Brugia malayi hypothetical protein 0.006 0.0157 0.0231
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0069 0.0214 0.0209
Echinococcus multilocularis allatostatin A receptor 0.0101 0.0396 0.0391
Giardia lamblia Sirtuin type 2 0.0082 0.0285 0.117
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0082 0.0285 1
Onchocerca volvulus 0.0101 0.0396 0.0576
Schistosoma mansoni chromatin regulatory protein sir2 0.0082 0.0285 0.028
Schistosoma mansoni hypothetical protein 0.0035 0.0013 0.0008
Loa Loa (eye worm) G-protein coupled receptor 0.0101 0.0396 0.0582
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0082 0.0285 0.0401
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.003 0.0058
Trichomonas vaginalis set domain proteins, putative 0.0248 0.124 0.4288
Schistosoma mansoni opsin-like receptor 0.0101 0.0396 0.0391
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0406 0.2147 0.7454
Onchocerca volvulus 0.0101 0.0396 0.0576
Loa Loa (eye worm) hypothetical protein 0.0101 0.0396 0.0582
Trypanosoma brucei hexokinase 0.1215 0.6801 1
Schistosoma mansoni hypothetical protein 0.0034 0.001 0.0005
Toxoplasma gondii subtilisin SUB10 0.0037 0.003 0.0036
Trichomonas vaginalis hypothetical protein 0.0169 0.0789 0.271
Echinococcus multilocularis integrin alpha ps 0.0071 0.0223 0.0218
Onchocerca volvulus 0.0035 0.0013 0.0012
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0049 0.0097 0.0092
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0069 0.0214 0.0209
Onchocerca volvulus 0.0066 0.0193 0.0277
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.006 0.1178
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.006 0.0088
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0037 0.003 0.0058
Schistosoma mansoni hypothetical protein 0.0131 0.0567 0.0562
Brugia malayi neuropeptide F receptor 0.0101 0.0396 0.0582
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0101 0.0396 0.0576
Brugia malayi hypothetical protein 0.006 0.0157 0.0231
Loa Loa (eye worm) subtilase 0.0037 0.003 0.0043
Loa Loa (eye worm) hexokinase 0.1215 0.6801 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0101 0.0396 0.0391
Brugia malayi Serotonin receptor 0.0101 0.0396 0.0582
Loa Loa (eye worm) hypothetical protein 0.0035 0.0013 0.0019
Loa Loa (eye worm) hypothetical protein 0.006 0.0157 0.0231
Echinococcus granulosus allatostatin A receptor 0.0101 0.0396 0.0391
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0272 0.1378 0.477
Onchocerca volvulus 0.006 0.0157 0.0224
Schistosoma mansoni amine GPCR 0.0101 0.0396 0.0391
Echinococcus granulosus rhodopsin orphan GPCR 0.0101 0.0396 0.0391
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0037 0.0028 0.0023
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0037 0.003 0.0058
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.006 0.0088
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0101 0.0396 0.0391
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0069 0.0214 0.0209
Brugia malayi hexokinase type II 0.0386 0.2036 0.2993
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0406 0.2147 0.7454
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.0028 0.0053
Brugia malayi Peptidase family M1 containing protein 0.0153 0.0692 0.1018
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0037 0.0028 0.0023
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0236 0.8066
Brugia malayi GCC2 and GCC3 family protein 0.006 0.0157 0.0231
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0037 0.003 0.0058
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0037 0.003 0.0058
Trichomonas vaginalis CAMK family protein kinase 0.0187 0.0888 0.3056
Loa Loa (eye worm) hypothetical protein 0.0066 0.0192 0.0283
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.038 0.0375
Echinococcus multilocularis dna polymerase kappa 0.0043 0.006 0.0055
Giardia lamblia Kinase, PLK 0.0187 0.0888 0.4028
Brugia malayi Dopamine receptor protein 2 0.0101 0.0396 0.0582
Loa Loa (eye worm) hypothetical protein 0.0034 0.001 0.0015
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0236 0.8066
Plasmodium vivax subtilisin-like serine protease, putative 0.0037 0.003 0.0036
Brugia malayi Pre-SET motif family protein 0.0218 0.1069 0.1571
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.006 0.0088
Trypanosoma brucei subtilisin peptidase 0.0037 0.003 0.0043
Schistosoma mansoni voltage-gated potassium channel 0.0205 0.0994 0.099
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0533 0.2875 1
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0533 0.2875 0.2872
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.003 0.0058
Echinococcus granulosus rhodopsin orphan GPCR 0.0101 0.0396 0.0391
Schistosoma mansoni opsin-like receptor 0.0101 0.0396 0.0391
Toxoplasma gondii microneme protein MIC2 0.0035 0.0013 0.0012
Echinococcus granulosus C type lectin domian containing protein 0.006 0.0157 0.0152
Mycobacterium ulcerans Sir2-like regulatory protein 0.0082 0.0285 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0176 0.0824 0.2832
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0406 0.2147 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0082 0.0285 0.0951
Loa Loa (eye worm) hypothetical protein 0.0035 0.0013 0.0019
Onchocerca volvulus 0.0035 0.0013 0.0012
Echinococcus multilocularis hexokinase type 2 0.1215 0.6801 0.6799
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0101 0.0396 0.0582
Echinococcus granulosus 7tm_1 domain containing protein 0.0101 0.0396 0.0391
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.003 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.0169 0.0789 0.271
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0069 0.0214 0.0209
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.0035 0.0013 0.0012
Echinococcus granulosus g-protein coupled receptor 0.0101 0.0396 0.0391
Schistosoma mansoni chromatin regulatory protein sir2 0.0272 0.1378 0.1374
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0037 0.003 0.0058
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0039 0.0013
Echinococcus granulosus G protein coupled receptor kinase 1 0.0088 0.0322 0.0317
Plasmodium vivax plasmepsin IV, putative 0.0049 0.0097 0.0135
Schistosoma mansoni hypothetical protein 0.0169 0.0789 0.0784
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0037 0.003 0.0058
Loa Loa (eye worm) hypothetical protein 0.0101 0.0396 0.0582
Brugia malayi hypothetical protein 0.0101 0.0396 0.0582
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0039 0.0355
Schistosoma mansoni hypothetical protein 0.0101 0.0396 0.0391
Loa Loa (eye worm) hypothetical protein 0.0386 0.2036 0.2993
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0039 0.0038
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0101 0.0396 0.0582
Echinococcus multilocularis rhodopsin orphan GPCR 0.0101 0.0396 0.0391
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0037 0.003 0.0058
Brugia malayi transcriptional regulator, Sir2 family protein 0.0082 0.0285 0.0419
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0533 0.2875 1
Brugia malayi von Willebrand Factor 0.0035 0.0013 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0169 0.0789 0.271
Loa Loa (eye worm) hypothetical protein 0.0101 0.0396 0.0582
Trichomonas vaginalis conserved hypothetical protein 0.0169 0.0789 0.271
Echinococcus granulosus protein will die slowly 0.0066 0.0193 0.0188
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0082 0.0285 0.0951
Onchocerca volvulus Hexokinase homolog 0.0763 0.4197 0.6169
Onchocerca volvulus 0.0101 0.0396 0.0576
Plasmodium vivax subtilisin-like protease 1 0.0037 0.003 0.0036
Brugia malayi hypothetical protein 0.0101 0.0396 0.0582
Trichomonas vaginalis conserved hypothetical protein 0.0169 0.0789 0.271
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0039 0.0355
Loa Loa (eye worm) hypothetical protein 0.0035 0.0013 0.0019
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0082 0.0285 0.028
Onchocerca volvulus 0.006 0.0157 0.0224
Brugia malayi hypothetical protein 0.0069 0.0214 0.0314
Loa Loa (eye worm) hypothetical protein 0.0101 0.0396 0.0582
Echinococcus multilocularis rhodopsin orphan GPCR 0.0101 0.0396 0.0391
Echinococcus multilocularis somatostatin receptor 0.0101 0.0396 0.0391
Loa Loa (eye worm) hypothetical protein 0.0101 0.0396 0.0582
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.0396 0.0391
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0037 0.003 0.0058
Onchocerca volvulus 0.006 0.0157 0.0224
Brugia malayi von Willebrand factor type A domain containing protein 0.0035 0.0013 0.0019
Entamoeba histolytica serine/threonine protein kinase, putative 0.0187 0.0888 0.1289
Brugia malayi G-protein coupled receptor 0.0101 0.0396 0.0582
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0101 0.0396 0.0391
Trypanosoma cruzi hexokinase, putative 0.1215 0.6801 1
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0037 0.0028 0.0041
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0049 0.0097 0.0135
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0346 0.1165
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0101 0.0396 0.0582
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.006 0.0157 0.0231
Loa Loa (eye worm) hypothetical protein 0.006 0.0157 0.0231
Echinococcus multilocularis neuropeptides capa receptor 0.0101 0.0396 0.0391
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.003 0.0058
Loa Loa (eye worm) hypothetical protein 0.0045 0.0073 0.0108
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.0035 0.0013 0.0012
Loa Loa (eye worm) hypothetical protein 0.0829 0.458 0.6734
Echinococcus multilocularis neuropeptides capa receptor 0.0101 0.0396 0.0391
Brugia malayi von Willebrand factor type A domain containing protein 0.0035 0.0013 0.0019
Echinococcus multilocularis dro:myosuppressin receptor 0.0101 0.0396 0.0391
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0101 0.0396 0.0391
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0039 0.0038
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0101 0.0396 0.0391
Echinococcus granulosus fmrfamide receptor 0.0101 0.0396 0.0391
Loa Loa (eye worm) hypothetical protein 0.0101 0.0396 0.0582
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0037 0.0028 0.0041
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0169 0.0789 0.271
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0049 0.0097 0.0092
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0176 0.0824 0.2832
Schistosoma mansoni adenoreceptor 0.0101 0.0396 0.0391
Trypanosoma brucei SIR2-like protein 4, putative 0.0082 0.0285 0.0419
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0101 0.0396 0.0391
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0043 0.006 0.0163
Echinococcus multilocularis Furin 1 0.0207 0.1004 0.0999
Loa Loa (eye worm) hypothetical protein 0.006 0.0157 0.0231
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0069 0.0214 0.0272
Plasmodium vivax aspartyl proteinase, putative 0.0049 0.0097 0.0135
Trypanosoma brucei hexokinase, putative 0.1215 0.6801 1
Schistosoma mansoni site-1 peptidase (S08 family) 0.0037 0.003 0.0025
Loa Loa (eye worm) hypothetical protein 0.0101 0.0396 0.0582
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0039 0.0057
Brugia malayi hypothetical protein 0.0101 0.0396 0.0582
Schistosoma mansoni voltage-gated potassium channel 0.0054 0.0127 0.0123
Echinococcus granulosus tm gpcr rhodopsin 0.0101 0.0396 0.0391
Loa Loa (eye worm) hypothetical protein 0.0101 0.0396 0.0582
Schistosoma mansoni biogenic amine (5HT) receptor 0.0101 0.0396 0.0391
Onchocerca volvulus 0.0101 0.0396 0.0576
Loa Loa (eye worm) hypothetical protein 0.012 0.0504 0.0741
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0101 0.0396 0.0391
Onchocerca volvulus 0.006 0.0157 0.0224
Echinococcus granulosus rhodopsin orphan GPCR 0.0101 0.0396 0.0391
Loa Loa (eye worm) hypothetical protein 0.0101 0.0396 0.0582
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0188 0.0895 0.089
Schistosoma mansoni c4b-binding protein beta chain 0.006 0.0157 0.0152
Echinococcus granulosus voltage gated potassium channel 0.0054 0.0127 0.0123
Echinococcus multilocularis serotonin receptor 0.0101 0.0396 0.0391
Schistosoma mansoni opsin-like receptor 0.0101 0.0396 0.0391
Onchocerca volvulus 0.0153 0.0692 0.1012
Trypanosoma brucei unspecified product 0.0036 0.002 0.003
Echinococcus multilocularis aminopeptidase N 0.0153 0.0692 0.0688
Loa Loa (eye worm) hypothetical protein 0.0037 0.0028 0.0041
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0082 0.0285 0.028
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0037 0.003 0.0058
Loa Loa (eye worm) hypothetical protein 0.0101 0.0396 0.0582
Loa Loa (eye worm) hexokinase 0.1215 0.6801 1
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.003 0.0058
Plasmodium falciparum hexokinase 0.1215 0.6801 1
Echinococcus granulosus voltage dependent calcium channel subunit 0.0035 0.0013 0.0008
Schistosoma mansoni thyroid hormone receptor 0.0148 0.0663 0.0659
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0049 0.0097 0.0293
Onchocerca volvulus 0.006 0.0157 0.0224
Trichomonas vaginalis conserved hypothetical protein 0.0169 0.0789 0.271
Echinococcus multilocularis rhodopsin orphan GPCR 0.0101 0.0396 0.0391
Echinococcus multilocularis G protein coupled receptor kinase 1 0.0088 0.0322 0.0317
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.006 0.1178
Schistosoma mansoni amine GPCR 0.0101 0.0396 0.0391
Echinococcus multilocularis neuropeptide Y receptor 0.0101 0.0396 0.0391
Toxoplasma gondii subtilisin SUB7 0.0037 0.003 0.0036
Brugia malayi hypothetical protein 0.0101 0.0396 0.0582
Trypanosoma cruzi polo-like protein kinase, putative 0.0187 0.0888 0.1267
Mycobacterium leprae Possible secreted protease 0.0037 0.003 0.5
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0037 0.003 0.0058
Brugia malayi hypothetical protein 0.0245 0.1225 0.1802
Loa Loa (eye worm) hypothetical protein 0.0101 0.0396 0.0582
Loa Loa (eye worm) hypothetical protein 0.0245 0.1225 0.1802
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.006 0.0088
Loa Loa (eye worm) hypothetical protein 0.0101 0.0396 0.0582
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0037 0.003 0.0058
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0037 0.0028 0.0023
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0101 0.0396 0.0391
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0039 0.0034
Onchocerca volvulus 0.0101 0.0396 0.0576
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0101 0.0396 0.0391
Schistosoma mansoni biogenic amine receptor 0.0101 0.0396 0.0391
Toxoplasma gondii subtilisin SUB6 0.0037 0.003 0.0036
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0039 0.0013
Schistosoma mansoni hypothetical protein 0.0101 0.0396 0.0391
Brugia malayi von Willebrand factor type A domain containing protein 0.0035 0.0013 0.0019
Brugia malayi neuroendocrine convertase 1 precursor 0.0551 0.2979 0.4381
Onchocerca volvulus 0.0101 0.0396 0.0576
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0082 0.0285 0.028
Onchocerca volvulus 0.006 0.0157 0.0224
Echinococcus granulosus hypothetical protein 0.0101 0.0396 0.0391
Brugia malayi Dopamine receptor 0.0101 0.0396 0.0582
Echinococcus granulosus biogenic amine 5HT receptor 0.0101 0.0396 0.0391
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0101 0.0396 0.0391
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0082 0.0285 0.0401
Echinococcus multilocularis neuropeptide Y receptor 0.0101 0.0396 0.0391
Loa Loa (eye worm) transcriptional regulator 0.0272 0.1378 0.2027
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0101 0.0396 0.0582
Schistosoma mansoni neuropeptide F-like receptor 0.0101 0.0396 0.0391
Plasmodium falciparum subtilisin-like protease 1 0.0037 0.003 0.0025
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0101 0.0396 0.0391
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0188 0.0895 0.1316
Echinococcus granulosus survival motor neuron protein 1 0.0245 0.1225 0.1221
Loa Loa (eye worm) hypothetical protein 0.006 0.0157 0.0231
Brugia malayi endoprotease bli-4 precursor 0.0876 0.4851 0.7133
Trichomonas vaginalis CAMK family protein kinase 0.0187 0.0888 0.3056
Brugia malayi von Willebrand factor type A domain containing protein 0.0035 0.0013 0.0019
Brugia malayi hypothetical protein 0.0101 0.0396 0.0582
Schistosoma mansoni serine/threonine protein kinase 0.0187 0.0888 0.0883
Loa Loa (eye worm) endoprotease bli-4 0.0876 0.4851 0.7133
Echinococcus multilocularis neuroendocrine convertase 2 0.0551 0.2979 0.2976
Leishmania major sir2-family protein-like protein 0.0082 0.0285 0.0378
Brugia malayi sulfakinin receptor protein 0.0101 0.0396 0.0582
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0039 0.005
Loa Loa (eye worm) hypothetical protein 0.0035 0.0013 0.0019
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0037 0.003 0.0058
Schistosoma mansoni voltage-gated potassium channel 0.0037 0.0028 0.0023
Echinococcus multilocularis chromatin regulatory protein sir2 0.0272 0.1378 0.1374
Plasmodium vivax NAD-dependent deacetylase, putative 0.0082 0.0285 0.0413
Loa Loa (eye worm) hypothetical protein 0.0101 0.0396 0.0582
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0102 0.015
Loa Loa (eye worm) hypothetical protein 0.0101 0.0396 0.0582
Brugia malayi hypothetical protein 0.0101 0.0396 0.0582
Echinococcus granulosus neuropeptide receptor A26 0.0101 0.0396 0.0391
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0085 0.0303 0.0298
Toxoplasma gondii histone deacetylase SIR2-like 0.0082 0.0285 0.0413
Loa Loa (eye worm) hypothetical protein 0.0101 0.0396 0.0582
Loa Loa (eye worm) hypothetical protein 0.0101 0.0396 0.0582
Loa Loa (eye worm) neuropeptide F receptor 0.0101 0.0396 0.0582
Echinococcus granulosus aminopeptidase N 0.0153 0.0692 0.0688
Loa Loa (eye worm) hypothetical protein 0.0035 0.0013 0.0019
Loa Loa (eye worm) hypothetical protein 0.0101 0.0396 0.0582
Onchocerca volvulus 0.0101 0.0396 0.0576
Loa Loa (eye worm) G-protein coupled receptor 0.0101 0.0396 0.0582
Loa Loa (eye worm) hypothetical protein 0.0101 0.0396 0.0582
Brugia malayi Dopamine receptor protein 1 0.0101 0.0396 0.0582
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0037 0.003 0.0058
Echinococcus granulosus c4b binding protein beta chain 0.006 0.0157 0.0152
Loa Loa (eye worm) hypothetical protein 0.0101 0.0396 0.0582
Onchocerca volvulus 0.0035 0.0013 0.0012
Trypanosoma cruzi aminopeptidase, putative 0.0069 0.0214 0.0272

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 8.2753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 10.3225 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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