Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | G protein-coupled receptor 55 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | hexokinase | 0.093 | 1 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0145 | 0.1133 | 0.5 |
Entamoeba histolytica | hexokinase 1 | 0.093 | 1 | 0.5 |
Trypanosoma brucei | hexokinase, putative | 0.093 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.093 | 1 | 1 |
Treponema pallidum | hexokinase (hxk) | 0.093 | 1 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.017 | 0.141 | 0.141 |
Loa Loa (eye worm) | hexokinase type II | 0.093 | 1 | 1 |
Trypanosoma brucei | hexokinase | 0.093 | 1 | 0.5 |
Brugia malayi | Hexokinase family protein | 0.0288 | 0.2742 | 0.2742 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0156 | 0.1249 | 0.1249 |
Entamoeba histolytica | hexokinase 2 | 0.093 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase type 2 | 0.093 | 1 | 1 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0156 | 0.1249 | 0.1249 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0145 | 0.1133 | 0.5 |
Brugia malayi | hexokinase type II | 0.0296 | 0.2832 | 0.2832 |
Loa Loa (eye worm) | hexokinase | 0.093 | 1 | 1 |
Toxoplasma gondii | hexokinase | 0.093 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.093 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.093 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.093 | 1 | 1 |
Brugia malayi | Hexokinase family protein | 0.093 | 1 | 1 |
Onchocerca volvulus | 0.093 | 1 | 1 | |
Brugia malayi | Hexokinase family protein | 0.0583 | 0.6084 | 0.6084 |
Trypanosoma brucei | hexokinase | 0.093 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.1017 | 0.1017 |
Schistosoma mansoni | voltage-gated potassium channel | 0.017 | 0.141 | 0.141 |
Loa Loa (eye worm) | hexokinase | 0.0288 | 0.2742 | 0.2742 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0156 | 0.1249 | 0.1249 |
Schistosoma mansoni | hexokinase | 0.093 | 1 | 1 |
Onchocerca volvulus | 0.093 | 1 | 1 | |
Onchocerca volvulus | 0.093 | 1 | 1 | |
Trypanosoma cruzi | hexokinase, putative | 0.093 | 1 | 0.5 |
Echinococcus granulosus | hexokinase type 2 | 0.093 | 1 | 1 |
Plasmodium vivax | hexokinase, putative | 0.093 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.093 | 1 | 1 |
Plasmodium falciparum | hexokinase | 0.093 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0296 | 0.2832 | 0.2832 |
Leishmania major | hexokinase, putative | 0.093 | 1 | 0.5 |
Leishmania major | hexokinase, putative | 0.093 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0583 | 0.6084 | 0.6084 |
Loa Loa (eye worm) | hypothetical protein | 0.0634 | 0.6659 | 0.6659 |
Echinococcus multilocularis | hexokinase | 0.093 | 1 | 1 |
Trypanosoma cruzi | hexokinase, putative | 0.093 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0296 | 0.2832 | 0.2832 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0156 | 0.1249 | 0.1249 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 16.4 uM | PUBCHEM_BIOASSAY: SAR Analysis of Selective Antagonists of GPR55 using an Image-Based Assay - Set 3. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2058, AID2079] | ChEMBL. | No reference |
IC50 (functional) | > 32 uM | PUBCHEM_BIOASSAY: SAR analysis of Antagonists of the GPR35 Receptor using an Image-Based Assay - Set 5. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2058, AID2079] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.